CN101918369B - 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 - Google Patents
治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 Download PDFInfo
- Publication number
- CN101918369B CN101918369B CN200880116208.2A CN200880116208A CN101918369B CN 101918369 B CN101918369 B CN 101918369B CN 200880116208 A CN200880116208 A CN 200880116208A CN 101918369 B CN101918369 B CN 101918369B
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- Prior art keywords
- tert
- butyl
- phenyl
- dioxo
- methanesulfonamide
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 *C(C(N1*)=O)=C(*)NC1=O Chemical compound *C(C(N1*)=O)=C(*)NC1=O 0.000 description 21
- KLRKUHAYVXPMPR-UHFFFAOYSA-N CC(C)(C)c(cc(cc1C)N(C(N2)O)C=CC2O)c1OC Chemical compound CC(C)(C)c(cc(cc1C)N(C(N2)O)C=CC2O)c1OC KLRKUHAYVXPMPR-UHFFFAOYSA-N 0.000 description 1
- TZOFFLZEYSSPKZ-VOTSOKGWSA-N CC(C)(C)c1cc(N(CCC(N2)=O)C2=O)cc(/C=C/c(ccc(NC/[O]=S/C)c2)c2OC)c1O Chemical compound CC(C)(C)c1cc(N(CCC(N2)=O)C2=O)cc(/C=C/c(ccc(NC/[O]=S/C)c2)c2OC)c1O TZOFFLZEYSSPKZ-VOTSOKGWSA-N 0.000 description 1
- DYPXHCGOGZFKGJ-JFVNZWERSA-N CC(C)CCNCc1cc(NS(C)(=O)=O)ccc1/C=C/c(cc(cc1C(C)(C)C)N(C=CCOCN2)C2=O)c1OC Chemical compound CC(C)CCNCc1cc(NS(C)(=O)=O)ccc1/C=C/c(cc(cc1C(C)(C)C)N(C=CCOCN2)C2=O)c1OC DYPXHCGOGZFKGJ-JFVNZWERSA-N 0.000 description 1
- AQKYCMMUMPTELX-UHFFFAOYSA-O CC(CCN1c2cc(C=Cc(cc3)ccc3[NH3+])cc(C(C)(C)C)c2)NC1=O Chemical compound CC(CCN1c2cc(C=Cc(cc3)ccc3[NH3+])cc(C(C)(C)C)c2)NC1=O AQKYCMMUMPTELX-UHFFFAOYSA-O 0.000 description 1
- AVVSJWUWBATQBX-UHFFFAOYSA-N CC1(OC(C)(C2)OC3(C)C1)OC2(C)P3c1ccccc1 Chemical compound CC1(OC(C)(C2)OC3(C)C1)OC2(C)P3c1ccccc1 AVVSJWUWBATQBX-UHFFFAOYSA-N 0.000 description 1
- RMOODACIVICURL-ZZXKWVIFSA-N COc(c(/C=C/c(cc1)ccc1NS(C)(=O)=O)cc(N(C=CC(N1)=O)C1=O)c1)c1-c1ccncc1 Chemical compound COc(c(/C=C/c(cc1)ccc1NS(C)(=O)=O)cc(N(C=CC(N1)=O)C1=O)c1)c1-c1ccncc1 RMOODACIVICURL-ZZXKWVIFSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610091594.0A CN105693626A (zh) | 2007-09-17 | 2008-09-17 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
| CN201510508424.3A CN105294569A (zh) | 2007-09-17 | 2008-09-17 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97288707P | 2007-09-17 | 2007-09-17 | |
| US60/972,887 | 2007-09-17 | ||
| US9679408P | 2008-09-13 | 2008-09-13 | |
| US61/096,794 | 2008-09-13 | ||
| PCT/US2008/076594 WO2009039135A1 (en) | 2007-09-17 | 2008-09-17 | N-phenyl-dioxo-hydropyrimidines useful as hepatitis c virus (hcv) inhibitors |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510508424.3A Division CN105294569A (zh) | 2007-09-17 | 2008-09-17 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
| CN201610091594.0A Division CN105693626A (zh) | 2007-09-17 | 2008-09-17 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101918369A CN101918369A (zh) | 2010-12-15 |
| CN101918369B true CN101918369B (zh) | 2016-02-24 |
Family
ID=40091991
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880116208.2A Expired - Fee Related CN101918369B (zh) | 2007-09-17 | 2008-09-17 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
| CN201510508424.3A Pending CN105294569A (zh) | 2007-09-17 | 2008-09-17 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
| CN201610091594.0A Pending CN105693626A (zh) | 2007-09-17 | 2008-09-17 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510508424.3A Pending CN105294569A (zh) | 2007-09-17 | 2008-09-17 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
| CN201610091594.0A Pending CN105693626A (zh) | 2007-09-17 | 2008-09-17 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8178548B2 (https=) |
| EP (3) | EP2377854A1 (https=) |
| JP (1) | JP5726527B2 (https=) |
| CN (3) | CN101918369B (https=) |
| AT (1) | ATE512954T1 (https=) |
| CA (1) | CA2699989C (https=) |
| DK (1) | DK2203430T3 (https=) |
| HR (1) | HRP20110632T1 (https=) |
| MX (1) | MX2010002904A (https=) |
| PL (1) | PL2203430T3 (https=) |
| PT (1) | PT2203430E (https=) |
| RU (1) | RU2542099C2 (https=) |
| WO (1) | WO2009039135A1 (https=) |
| ZA (1) | ZA201002690B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105693626A (zh) * | 2007-09-17 | 2016-06-22 | 艾伯维巴哈马有限公司 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2639226T3 (pl) | 2007-09-17 | 2017-02-28 | Abbvie Bahamas Ltd. | Pirymidyny o działaniu przeciw zakaźnym oraz ich zastosowania |
| PA8796201A1 (es) | 2007-09-17 | 2009-04-23 | Abbott Lab | Agentes anti-infecciosos y su uso |
| EP2307372B1 (en) | 2008-07-23 | 2012-04-25 | F. Hoffmann-La Roche AG | Heterocyclic antiviral compounds |
| CN102164909A (zh) | 2008-09-26 | 2011-08-24 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗hcv的吡啶或吡嗪衍生物 |
| KR20110074941A (ko) | 2008-10-30 | 2011-07-04 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 항바이러스 아릴피리돈 유도체 |
| CN102256968A (zh) | 2008-12-22 | 2011-11-23 | 弗·哈夫曼-拉罗切有限公司 | 杂环抗病毒化合物 |
| MX2011008641A (es) | 2009-03-06 | 2011-09-06 | Hoffmann La Roche | Compuestos heterociclicos antivirales. |
| NZ594923A (en) * | 2009-03-24 | 2013-11-29 | Abbott Lab | Process for preparing antiviral compound |
| JP2012524752A (ja) * | 2009-04-25 | 2012-10-18 | エフ．ホフマン−ラ ロシュ アーゲー | 複素環式抗ウイルス化合物 |
| AR077004A1 (es) | 2009-06-09 | 2011-07-27 | Hoffmann La Roche | Compuestos heterociclicos antivirales |
| MX2011012541A (es) | 2009-06-24 | 2012-08-03 | Hoffmann La Roche | Compuestos heterociclicos antivirales. |
| CA2768924A1 (en) | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| EA201200650A1 (ru) | 2009-10-30 | 2012-12-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Курсы комбинированного лечения вируса гепатита с, включающие bi201335, интерферон-альфа и рибавирин |
| CN102639504A (zh) * | 2009-11-21 | 2012-08-15 | 弗·哈夫曼-拉罗切有限公司 | 杂环抗病毒化合物 |
| PH12012501216A1 (en) * | 2009-12-18 | 2012-11-05 | Boehringer Ingelheim Int | Hcv combination therapy |
| US9216952B2 (en) | 2010-03-23 | 2015-12-22 | Abbvie Inc. | Process for preparing antiviral compound |
| ES2481411T3 (es) * | 2010-07-07 | 2014-07-30 | F. Hoffmann-La Roche Ag | Compuestos heterocíclicos antivíricos |
| SG187103A1 (en) | 2010-07-16 | 2013-02-28 | Abbvie Inc | Phosphine ligands for catalytic reactions |
| CA2805748A1 (en) | 2010-07-16 | 2012-01-19 | Shashank Shekhar | Process for preparing n-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| WO2012129099A1 (en) * | 2011-03-18 | 2012-09-27 | Abbott Laboratories | Formulations of phenyl uracil compounds |
| US8989328B2 (en) * | 2013-03-14 | 2015-03-24 | Qualcomm Incorporated | Systems and methods for serial communication |
| LT3043803T (lt) | 2013-09-11 | 2022-08-10 | Emory University | Nukleotidų ir nukleozidų kompozicijos ir jų panaudojimas |
| WO2015197028A1 (en) * | 2014-06-28 | 2015-12-30 | Sunshine Lake Pharma Co., Ltd. | Compounds as hepatitis c virus (hcv) inhibitors and uses thereof in medicine |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| CA3041331A1 (en) * | 2016-11-01 | 2018-05-11 | Merck Sharp & Dohme Corp. | Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors |
| CN111936498B (zh) | 2018-03-26 | 2024-04-16 | 诺华股份有限公司 | N-(3-(7H-吡咯并[2,3-d]嘧啶-4-基)苯基)苯甲酰胺衍生物 |
| CN110483496B (zh) * | 2019-07-17 | 2021-05-04 | 杭州市西溪医院 | 一类具有尿嘧啶-苯并噻唑结构衍生物、其制备方法及抗hcv药物的应用 |
| CN114424227B (zh) | 2019-09-16 | 2025-10-21 | 维萨国际服务协会 | 用于验证卡图像的系统、方法和计算机程序产品 |
| CN114521196A (zh) * | 2019-09-16 | 2022-05-20 | 诺华股份有限公司 | 双官能团降解剂及其使用方法 |
| EP3819006A1 (en) | 2019-11-05 | 2021-05-12 | Technische Universität Dresden | Compounds with thymine skeleton for use in medicine |
| CN111018910A (zh) * | 2019-12-05 | 2020-04-17 | 上海应用技术大学 | 一种铜催化合成含芳环α-羟基膦酸酯的方法 |
| CN111518036A (zh) * | 2020-04-29 | 2020-08-11 | 杭州勇诚睿生物科技有限公司 | 一种达沙布韦关键中间体的制备方法 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4239888A (en) * | 1974-11-04 | 1980-12-16 | Pfizer Inc. | 1-Phenyluracils |
| JPS60243017A (ja) * | 1984-05-16 | 1985-12-03 | Kyowa Hakko Kogyo Co Ltd | 抗けいれん組成物 |
| AU627906B2 (en) * | 1989-07-14 | 1992-09-03 | Nissan Chemical Industries Ltd. | Uracil derivatives and herbicides containing the same as active ingredient |
| US5084084A (en) * | 1989-07-14 | 1992-01-28 | Nissan Chemical Industries Ltd. | Uracil derivatives and herbicides containing the same as active ingredient |
| EP0442473B1 (en) * | 1990-02-15 | 1998-08-19 | Takeda Chemical Industries, Ltd. | Pyrimidinedione derivatives, their production and use |
| NL9001075A (https=) * | 1990-05-04 | 1991-12-02 | Duphar Int Res | |
| EP0489480A1 (en) * | 1990-12-05 | 1992-06-10 | Nissan Chemical Industries Ltd. | Uracil derivatives and herbicides containing the same as active ingredient |
| JPH05213755A (ja) | 1992-02-07 | 1993-08-24 | Nikko Kyodo Co Ltd | 肝臓障害治療薬 |
| DE19528305A1 (de) | 1995-08-02 | 1997-02-06 | Bayer Ag | Substituierte Phenyluracile |
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| CN101918369B (zh) | 2007-09-17 | 2016-02-24 | 艾伯维巴哈马有限公司 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
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2008
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105693626A (zh) * | 2007-09-17 | 2016-06-22 | 艾伯维巴哈马有限公司 | 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105294569A (zh) | 2016-02-03 |
| DK2203430T3 (da) | 2011-09-26 |
| WO2009039135A1 (en) | 2009-03-26 |
| EP2203430B1 (en) | 2011-06-15 |
| US8178548B2 (en) | 2012-05-15 |
| JP2010539188A (ja) | 2010-12-16 |
| ZA201002690B (en) | 2015-12-23 |
| JP5726527B2 (ja) | 2015-06-03 |
| HK1145839A1 (en) | 2011-05-06 |
| CN105693626A (zh) | 2016-06-22 |
| US20090176784A1 (en) | 2009-07-09 |
| CN101918369A (zh) | 2010-12-15 |
| US20120189580A1 (en) | 2012-07-26 |
| RU2542099C2 (ru) | 2015-02-20 |
| RU2010114826A (ru) | 2011-10-27 |
| US8986740B2 (en) | 2015-03-24 |
| CA2699989A1 (en) | 2009-03-26 |
| HRP20110632T1 (hr) | 2011-10-31 |
| PT2203430E (pt) | 2011-09-02 |
| MX2010002904A (es) | 2010-06-02 |
| EP2548873A1 (en) | 2013-01-23 |
| PL2203430T3 (pl) | 2011-12-30 |
| CA2699989C (en) | 2014-03-25 |
| EP2203430A1 (en) | 2010-07-07 |
| ATE512954T1 (de) | 2011-07-15 |
| EP2377854A1 (en) | 2011-10-19 |
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