CN101903047A - 生物分子的选择性放射性标记 - Google Patents
生物分子的选择性放射性标记 Download PDFInfo
- Publication number
- CN101903047A CN101903047A CN2008801216576A CN200880121657A CN101903047A CN 101903047 A CN101903047 A CN 101903047A CN 2008801216576 A CN2008801216576 A CN 2008801216576A CN 200880121657 A CN200880121657 A CN 200880121657A CN 101903047 A CN101903047 A CN 101903047A
- Authority
- CN
- China
- Prior art keywords
- group
- thiol
- bridging agent
- biomolecule
- azide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
时间 | %A | %B |
0 | 100 | 0 |
4 | 80 | 20 |
16 | 40 | 60 |
20 | 0 | 100 |
Claims (21)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/961,108 US8071718B2 (en) | 2004-12-22 | 2007-12-20 | Selective radiolabeling of biomolecules |
US11/961108 | 2007-12-20 | ||
PCT/EP2008/067413 WO2009080561A1 (en) | 2007-12-20 | 2008-12-12 | Selective radiolabeling of biomolecules |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101903047A true CN101903047A (zh) | 2010-12-01 |
CN101903047B CN101903047B (zh) | 2015-10-21 |
Family
ID=40510013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880121657.6A Active CN101903047B (zh) | 2007-12-20 | 2008-12-12 | 生物分子的选择性放射性标记 |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP2591808A3 (zh) |
JP (1) | JP5566905B2 (zh) |
KR (1) | KR101563758B1 (zh) |
CN (1) | CN101903047B (zh) |
AU (1) | AU2008340449B2 (zh) |
BR (1) | BRPI0821300A8 (zh) |
CA (1) | CA2705134C (zh) |
ES (1) | ES2662495T3 (zh) |
HK (1) | HK1151225A1 (zh) |
IL (1) | IL205392A (zh) |
MX (1) | MX2010006910A (zh) |
NZ (1) | NZ584900A (zh) |
RU (1) | RU2491958C2 (zh) |
WO (1) | WO2009080561A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201203793D0 (en) * | 2012-03-05 | 2012-04-18 | Ge Healthcare Ltd | Imaging neural activity |
US9839704B2 (en) | 2013-05-02 | 2017-12-12 | Duke University | Prosthetic compounds for labeling internalizing biomolecules |
GB201504755D0 (en) * | 2015-03-20 | 2015-05-06 | Isis Innovation | Fluorination process |
KR102230657B1 (ko) * | 2018-07-17 | 2021-03-23 | 한국원자력연구원 | 방사성 원소의 표지방법, 방사성 표지화합물 및 이를 포함하는 방사성 원소 표지 키트 |
EP4279502A1 (en) * | 2021-01-18 | 2023-11-22 | Ajinomoto Co., Inc. | Compound or salt thereof, and antibody obtained therefrom |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0428012D0 (en) * | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
JP4883640B2 (ja) * | 2005-05-26 | 2012-02-22 | 独立行政法人科学技術振興機構 | 新規糖固定化金属ナノ粒子およびこれを用いて糖−タンパク質相互作用を測定する方法、並びに糖−タンパク質相互作用体からタンパク質を回収する方法 |
US20070020620A1 (en) * | 2005-07-14 | 2007-01-25 | Finn M G | Compositions and methods for coupling a plurality of compounds to a scaffold |
WO2007080114A2 (en) * | 2006-01-11 | 2007-07-19 | Biotech Igg Ab | Macromolecule conjugate |
-
2008
- 2008-12-12 CN CN200880121657.6A patent/CN101903047B/zh active Active
- 2008-12-12 WO PCT/EP2008/067413 patent/WO2009080561A1/en active Application Filing
- 2008-12-12 JP JP2010538605A patent/JP5566905B2/ja active Active
- 2008-12-12 MX MX2010006910A patent/MX2010006910A/es active IP Right Grant
- 2008-12-12 AU AU2008340449A patent/AU2008340449B2/en not_active Ceased
- 2008-12-12 RU RU2010123475/04A patent/RU2491958C2/ru not_active IP Right Cessation
- 2008-12-12 BR BRPI0821300A patent/BRPI0821300A8/pt not_active IP Right Cessation
- 2008-12-12 ES ES08865548.5T patent/ES2662495T3/es active Active
- 2008-12-12 EP EP13154289.6A patent/EP2591808A3/en not_active Withdrawn
- 2008-12-12 KR KR1020107013550A patent/KR101563758B1/ko active IP Right Grant
- 2008-12-12 CA CA2705134A patent/CA2705134C/en not_active Expired - Fee Related
- 2008-12-12 NZ NZ584900A patent/NZ584900A/xx not_active IP Right Cessation
- 2008-12-12 EP EP08865548.5A patent/EP2231201B1/en active Active
-
2010
- 2010-04-28 IL IL205392A patent/IL205392A/en active IP Right Grant
-
2011
- 2011-05-27 HK HK11105295.8A patent/HK1151225A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU2008340449B2 (en) | 2014-05-22 |
RU2491958C2 (ru) | 2013-09-10 |
KR101563758B1 (ko) | 2015-10-27 |
JP5566905B2 (ja) | 2014-08-06 |
JP2011508194A (ja) | 2011-03-10 |
RU2010123475A (ru) | 2012-01-27 |
EP2591808A2 (en) | 2013-05-15 |
HK1151225A1 (zh) | 2012-01-27 |
IL205392A0 (en) | 2010-12-30 |
EP2231201A1 (en) | 2010-09-29 |
BRPI0821300A2 (pt) | 2015-06-16 |
CA2705134C (en) | 2018-05-08 |
AU2008340449A1 (en) | 2009-07-02 |
EP2231201B1 (en) | 2018-02-14 |
WO2009080561A1 (en) | 2009-07-02 |
EP2591808A3 (en) | 2014-06-25 |
KR20100098405A (ko) | 2010-09-06 |
CA2705134A1 (en) | 2009-07-02 |
BRPI0821300A8 (pt) | 2017-10-03 |
ES2662495T3 (es) | 2018-04-06 |
CN101903047B (zh) | 2015-10-21 |
IL205392A (en) | 2015-07-30 |
MX2010006910A (es) | 2010-10-25 |
NZ584900A (en) | 2012-09-28 |
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Effective date of registration: 20170214 Address after: American New York Patentee after: Ge Corp Patentee after: GE Healthcare Ltd. Address before: American New York Patentee before: Ge Corp Patentee before: Amersham Health AS |