MX2010006910A - Radioetiquetado selectivo de biomoleculas. - Google Patents
Radioetiquetado selectivo de biomoleculas.Info
- Publication number
- MX2010006910A MX2010006910A MX2010006910A MX2010006910A MX2010006910A MX 2010006910 A MX2010006910 A MX 2010006910A MX 2010006910 A MX2010006910 A MX 2010006910A MX 2010006910 A MX2010006910 A MX 2010006910A MX 2010006910 A MX2010006910 A MX 2010006910A
- Authority
- MX
- Mexico
- Prior art keywords
- reactive
- linker
- alkyne
- thiol
- biomolecules
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Se proporcionan en la presente métodos para introducir átomo de flúor sobre una biomolécula que comprenden: (I) proporcionar un enlazador comprendiendo un extremo tiol-reactivo y un extremo azido/alquino-reactivo; (II) hacer reaccionar el extremo tiol-reactivo del enlazador con una biomolécula comprendiendo al menos un grupo tiol o un derivado reactivo del mismo; y (iii) hacer reaccionar subsecuentemente el extremo azido/alquino-reactiv o del enlazador con una azida o alquino substituido con flúor, respectivamente. También se proporcionan composiciones y método de síntesis de enlazadores bifuncionales y bioconjugados así como agentes de radio-diagnóstico comprendiendo biomoléculas etiquetadas con flúor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/961,108 US8071718B2 (en) | 2004-12-22 | 2007-12-20 | Selective radiolabeling of biomolecules |
PCT/EP2008/067413 WO2009080561A1 (en) | 2007-12-20 | 2008-12-12 | Selective radiolabeling of biomolecules |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010006910A true MX2010006910A (es) | 2010-10-25 |
Family
ID=40510013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010006910A MX2010006910A (es) | 2007-12-20 | 2008-12-12 | Radioetiquetado selectivo de biomoleculas. |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP2231201B1 (es) |
JP (1) | JP5566905B2 (es) |
KR (1) | KR101563758B1 (es) |
CN (1) | CN101903047B (es) |
AU (1) | AU2008340449B2 (es) |
BR (1) | BRPI0821300A8 (es) |
CA (1) | CA2705134C (es) |
ES (1) | ES2662495T3 (es) |
HK (1) | HK1151225A1 (es) |
IL (1) | IL205392A (es) |
MX (1) | MX2010006910A (es) |
NZ (1) | NZ584900A (es) |
RU (1) | RU2491958C2 (es) |
WO (1) | WO2009080561A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201203793D0 (en) * | 2012-03-05 | 2012-04-18 | Ge Healthcare Ltd | Imaging neural activity |
US9839704B2 (en) | 2013-05-02 | 2017-12-12 | Duke University | Prosthetic compounds for labeling internalizing biomolecules |
GB201504755D0 (en) * | 2015-03-20 | 2015-05-06 | Isis Innovation | Fluorination process |
KR102230657B1 (ko) * | 2018-07-17 | 2021-03-23 | 한국원자력연구원 | 방사성 원소의 표지방법, 방사성 표지화합물 및 이를 포함하는 방사성 원소 표지 키트 |
WO2022154127A1 (ja) * | 2021-01-18 | 2022-07-21 | 味の素株式会社 | 化合物またはその塩、およびそれらにより得られる抗体 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0428012D0 (en) | 2004-12-22 | 2005-01-26 | Hammersmith Imanet Ltd | Radiolabelling methods |
JP4883640B2 (ja) * | 2005-05-26 | 2012-02-22 | 独立行政法人科学技術振興機構 | 新規糖固定化金属ナノ粒子およびこれを用いて糖−タンパク質相互作用を測定する方法、並びに糖−タンパク質相互作用体からタンパク質を回収する方法 |
US20070020620A1 (en) * | 2005-07-14 | 2007-01-25 | Finn M G | Compositions and methods for coupling a plurality of compounds to a scaffold |
WO2007080114A2 (en) * | 2006-01-11 | 2007-07-19 | Biotech Igg Ab | Macromolecule conjugate |
-
2008
- 2008-12-12 EP EP08865548.5A patent/EP2231201B1/en active Active
- 2008-12-12 CA CA2705134A patent/CA2705134C/en not_active Expired - Fee Related
- 2008-12-12 KR KR1020107013550A patent/KR101563758B1/ko active IP Right Grant
- 2008-12-12 EP EP13154289.6A patent/EP2591808A3/en not_active Withdrawn
- 2008-12-12 RU RU2010123475/04A patent/RU2491958C2/ru not_active IP Right Cessation
- 2008-12-12 MX MX2010006910A patent/MX2010006910A/es active IP Right Grant
- 2008-12-12 NZ NZ584900A patent/NZ584900A/xx not_active IP Right Cessation
- 2008-12-12 AU AU2008340449A patent/AU2008340449B2/en not_active Ceased
- 2008-12-12 ES ES08865548.5T patent/ES2662495T3/es active Active
- 2008-12-12 CN CN200880121657.6A patent/CN101903047B/zh active Active
- 2008-12-12 WO PCT/EP2008/067413 patent/WO2009080561A1/en active Application Filing
- 2008-12-12 BR BRPI0821300A patent/BRPI0821300A8/pt not_active IP Right Cessation
- 2008-12-12 JP JP2010538605A patent/JP5566905B2/ja active Active
-
2010
- 2010-04-28 IL IL205392A patent/IL205392A/en active IP Right Grant
-
2011
- 2011-05-27 HK HK11105295.8A patent/HK1151225A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2705134C (en) | 2018-05-08 |
CN101903047A (zh) | 2010-12-01 |
EP2591808A3 (en) | 2014-06-25 |
ES2662495T3 (es) | 2018-04-06 |
AU2008340449A1 (en) | 2009-07-02 |
AU2008340449B2 (en) | 2014-05-22 |
BRPI0821300A8 (pt) | 2017-10-03 |
BRPI0821300A2 (pt) | 2015-06-16 |
CN101903047B (zh) | 2015-10-21 |
KR20100098405A (ko) | 2010-09-06 |
JP5566905B2 (ja) | 2014-08-06 |
EP2231201A1 (en) | 2010-09-29 |
RU2491958C2 (ru) | 2013-09-10 |
CA2705134A1 (en) | 2009-07-02 |
IL205392A (en) | 2015-07-30 |
WO2009080561A1 (en) | 2009-07-02 |
HK1151225A1 (zh) | 2012-01-27 |
KR101563758B1 (ko) | 2015-10-27 |
JP2011508194A (ja) | 2011-03-10 |
EP2591808A2 (en) | 2013-05-15 |
RU2010123475A (ru) | 2012-01-27 |
IL205392A0 (en) | 2010-12-30 |
EP2231201B1 (en) | 2018-02-14 |
NZ584900A (en) | 2012-09-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2009007290A (es) | Compuestos agonistas del receptor de la proteina 1 similar al glucagon. | |
MX2010006910A (es) | Radioetiquetado selectivo de biomoleculas. | |
WO2009129311A3 (en) | Somatostatin receptor 2 antagonists | |
CY1117731T1 (el) | Διαμορφωτες μεταφορεων κασετας δεσμευσης ατρ | |
CY1116953T1 (el) | Παραγωγα πυριδυλιου ως διαμορφωτες cftr | |
ZA200801564B (en) | Process for preparaing maytansinoid antibody conjugates | |
CR20130418A (es) | Anticuerpos contra la angiopoyetina 2 humana (divisional exp. 2011-0321) | |
MXPA06001225A (es) | Metodos de tratamiento de enfermedad cardiovascular usando una molecula soluble de ctla4. | |
WO2009100194A3 (en) | Camptothecin-binding moiety conjugates | |
WO2010045598A3 (en) | Psma binding ligand-linker conjugates and methods for using | |
NO20061845L (no) | Fenyl-piperazinderivater som modulatorer for muskarine reseptorer | |
CY1114922T1 (el) | Κυτταροτοξικοι παραγοντες οι οποιοι περιλαμβανουν νεα παραγωγα τομαϋμυκινης και τη θεραπευτικη τους χρηση | |
MX2009008211A (es) | Agentes que capturan celulas que presentan antigenos mediante un receptor de asialoglicoproteina de celula dendritica (dc-asgpr). | |
MX2010005830A (es) | Conjugado de anticuerpo monoclonal anti-b7h4 - farmaco y metodos de uso del mismo. | |
JO2778B1 (en) | Certain vehicles, installations and methods | |
CY1115078T1 (el) | Παραγωγα πυραζολοαμινοπυριδινης χρησιμα ως αναστολεις της κινασης | |
WO2009002947A3 (en) | Compounds and peptides that bind the trail receptor | |
MX2011009220A (es) | Anticuerpos completamente humanos especificos para la molecula de adhesion celular 1. | |
WO2009132081A3 (en) | Monoclonal antibody-based targeting of folate receptors | |
WO2009113814A3 (ko) | 간암 진단용 단백질성 마커 | |
MA30042B1 (fr) | Composes calcilytiques | |
TW200800986A (en) | Tetrahydroquinolines, synthesis thereof, and intermediates thereto | |
TW200738713A (en) | Diazepinoquinolines, synthesis thereof, and intermediates thereto | |
WO2006075139A3 (en) | Novel process for the preparation of substituted indoles | |
NO20074277L (no) | Kinnolinforbindelser og anvendelse derav som lever X reseptor modulatorer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |