CN101903039B - 用于溶栓的新型患者亚群 - Google Patents
用于溶栓的新型患者亚群 Download PDFInfo
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- CN101903039B CN101903039B CN200880112073.2A CN200880112073A CN101903039B CN 101903039 B CN101903039 B CN 101903039B CN 200880112073 A CN200880112073 A CN 200880112073A CN 101903039 B CN101903039 B CN 101903039B
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- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Description
安慰剂 | 90μg/kg | 125μg/kg | 总计 | |
NIHSS(中位数) | 9.0 | 9.0 | 9.0 | 9.0 |
年龄(中位数)[yrs] | 73.0 | 71.0 | 73.5 | - |
男性[%] | 58.7 | 47.4 | 43.9 | 50.0 |
女性[%] | 41.3 | 52.6 | 56.1 | 50.0 |
BL TIMI 0-1[%] | 27.0 | 25.9 | 35.5 | 29.6 |
BL TIMI 2-3[%] | 73.0 | 74.1 | 64.5 | 70.4 |
Claims (7)
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EP07020401.1 | 2007-10-18 | ||
EP07020401A EP2050462A1 (en) | 2007-10-18 | 2007-10-18 | Improved treatment of stroke patients |
EP07022867 | 2007-11-26 | ||
EP07022867.1 | 2007-11-26 | ||
EP08017954.2 | 2008-10-15 | ||
EP08017954 | 2008-10-15 | ||
PCT/EP2008/008871 WO2009049914A2 (en) | 2007-10-18 | 2008-10-20 | Novel patient subgroups for thrombolysis |
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CN101903039A CN101903039A (zh) | 2010-12-01 |
CN101903039B true CN101903039B (zh) | 2014-04-02 |
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LT (1) | LT2211898T (zh) |
MX (1) | MX2010004157A (zh) |
MY (1) | MY159200A (zh) |
NZ (1) | NZ584640A (zh) |
PL (1) | PL2211898T3 (zh) |
PT (1) | PT2211898T (zh) |
RS (1) | RS55590B1 (zh) |
SI (1) | SI2211898T1 (zh) |
TW (1) | TWI482628B (zh) |
WO (1) | WO2009049914A2 (zh) |
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DE10153601A1 (de) * | 2001-11-02 | 2003-05-22 | Paion Gmbh | DSPA zur Behandlung von Schlaganfall |
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US20060135425A1 (en) * | 2003-05-02 | 2006-06-22 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
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US4766075A (en) * | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
US5244806A (en) * | 1985-08-26 | 1993-09-14 | Eli Lilly And Company | DNA encoding novel tissue plasminogen activator derivatives having kringles 1 and 2 deleted, vectors and host cells |
IL87276A (en) * | 1987-08-03 | 1995-07-31 | Fujisawa Pharmaceutical Co | Analog of a tissue plasminogen activator containing the Pringle 2 and protease regions only, DNA encoding it, processes for its preparation, and pharmaceutical preparations containing it |
US5094953A (en) * | 1988-03-21 | 1992-03-10 | Genentech, Inc. | Human tissue plasminogen activator variants |
IE69054B1 (en) * | 1988-07-20 | 1996-08-07 | Schering Ag | Vampire bat salivary plasminogen activators |
US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
DE3903581A1 (de) * | 1989-02-07 | 1990-08-16 | Boehringer Mannheim Gmbh | Gewebs-plasminogenaktivator-derivat |
US5676947A (en) * | 1989-02-07 | 1997-10-14 | Boehringer Manneheim Gmbh | Method for treating thromboembolic conditions using thrombolytically active proteins |
US6008019A (en) * | 1989-02-13 | 1999-12-28 | Schering Aktiengesellschaft | Plasminogen activator from saliva of the vampire bat |
US5891664A (en) * | 1989-04-07 | 1999-04-06 | Cancerforskningsfondet Af 1989 | Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR) |
US5326700A (en) * | 1990-11-06 | 1994-07-05 | Eli Lilly And Company | DNA sequences encoding t-PA derivatives with cleavable sites |
ES2082465T3 (es) * | 1991-04-16 | 1996-03-16 | Boehringer Mannheim Gmbh | Unidad farmaceutica de envasado que contiene activadores de plasminogeno para la administracion multiple de bolos. |
US5595736A (en) * | 1991-04-22 | 1997-01-21 | Eli Lilly And Company | Compounds and methods for treatment of thromboembolic disorders |
DE59307091D1 (de) * | 1992-12-04 | 1997-09-11 | Schering Ag | Thrombininhibitor aus speichel von protostomiern |
US5510330A (en) * | 1994-03-25 | 1996-04-23 | Boehringer Mannheim Gmbh | Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof. |
GB9412131D0 (en) * | 1994-06-17 | 1994-08-10 | British Bio Technology | Thrombolytic composition |
US5827832A (en) * | 1995-03-06 | 1998-10-27 | Interneuron Pharmaceuticals, Inc. | Method of protecting brain tissue from cerebral infarction subsequent to ischemia |
US5786187A (en) * | 1995-09-21 | 1998-07-28 | The Research Foundation Of State University Of New York | Method for reducing neuronal degeneration associated with seizure |
US5945432A (en) * | 1995-12-22 | 1999-08-31 | The University Of Vermont And State Agricultural College | Thrombolytic agents and thienopyridine derivatives in acute stroke |
US20020081294A1 (en) * | 1996-01-23 | 2002-06-27 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-CD18 antibody in stroke |
US5731186A (en) * | 1996-02-05 | 1998-03-24 | Schering Aktiengesellschaft | Method for the production of rDSPA α1 |
US6354999B1 (en) * | 2000-01-14 | 2002-03-12 | Florence Medical Ltd. | System and method for detecting, localizing, and characterizing occlusions and aneurysms in a vessel |
GB0025473D0 (en) * | 2000-10-17 | 2000-11-29 | Pfizer Ltd | Pharmaceutical combinations |
DE10153601A1 (de) * | 2001-11-02 | 2003-05-22 | Paion Gmbh | DSPA zur Behandlung von Schlaganfall |
US20080057050A1 (en) * | 2003-05-02 | 2008-03-06 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
KR20060015721A (ko) * | 2003-05-05 | 2006-02-20 | 파이온 도이치란트 게엠베하 | 신경보호제로서의 글루타메이트 수용체 길항제 |
US20050085478A1 (en) * | 2003-08-22 | 2005-04-21 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a low-molecular-weight heparin for the treatment of central nervous system damage |
BRPI0615266A2 (pt) * | 2005-08-25 | 2011-05-17 | Biogen Idec Inc | polipeptìdeos nogo receptor e fragmentos de polipeptìdeo e usos destes |
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