CN101902912A - 杀真菌杂环胺 - Google Patents

杀真菌杂环胺 Download PDF

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Publication number
CN101902912A
CN101902912A CN2008801217475A CN200880121747A CN101902912A CN 101902912 A CN101902912 A CN 101902912A CN 2008801217475 A CN2008801217475 A CN 2008801217475A CN 200880121747 A CN200880121747 A CN 200880121747A CN 101902912 A CN101902912 A CN 101902912A
Authority
CN
China
Prior art keywords
alkyl
amino
carbonyl
cycloalkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2008801217475A
Other languages
English (en)
Chinese (zh)
Inventor
Y·陈
P·L·夏普
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of CN101902912A publication Critical patent/CN101902912A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/66—1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2008801217475A 2007-11-06 2008-11-05 杀真菌杂环胺 Pending CN101902912A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US212907P 2007-11-06 2007-11-06
US61/002129 2007-11-06
PCT/US2008/082398 WO2009061761A2 (en) 2007-11-06 2008-11-05 Fungicidal heterocyclic amines

Publications (1)

Publication Number Publication Date
CN101902912A true CN101902912A (zh) 2010-12-01

Family

ID=40521581

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801217475A Pending CN101902912A (zh) 2007-11-06 2008-11-05 杀真菌杂环胺

Country Status (9)

Country Link
US (2) US8026359B2 (https=)
EP (1) EP2205086B1 (https=)
JP (1) JP2011503006A (https=)
KR (1) KR20100088150A (https=)
CN (1) CN101902912A (https=)
AU (1) AU2008324833A1 (https=)
BR (1) BRPI0817135A2 (https=)
MX (1) MX2010005033A (https=)
WO (1) WO2009061761A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112645927A (zh) * 2014-04-09 2021-04-13 基因泰克公司 用于制备药物的方法
CN119841771A (zh) * 2025-01-08 2025-04-18 华中农业大学 一种猪链球菌丝氨酸蛋白激酶抑制剂的筛选方法及其应用

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012101065A2 (en) * 2011-01-28 2012-08-02 Novartis Ag Pyrimidine biaryl amine compounds and their uses
CN103635472B (zh) 2011-02-28 2018-01-12 阵列生物制药公司 丝氨酸/苏氨酸激酶抑制剂
JP6097289B2 (ja) 2011-08-04 2017-03-15 アレイ バイオファーマ、インコーポレイテッド セリン／スレオニンキナーゼインヒビターとしてのキナゾリン化合物
HUE053994T2 (hu) 2012-03-01 2021-08-30 Array Biopharma Inc Szerin/treonin kináz inhibitorok
JP6378171B2 (ja) 2012-04-24 2018-08-22 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ｄｎａ−ｐｋ阻害剤
AR092253A1 (es) 2012-08-27 2015-04-08 Array Biopharma Inc Inhibidores de serina/treonina cinasa
SI3527563T1 (sl) 2013-03-12 2022-01-31 Vertex Pharmaceuticals Incorporated Inhibitorji DNA-PK
RU2675270C2 (ru) 2013-10-17 2018-12-18 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы и содержащие их фармацевтические композиции
CN105431424B (zh) * 2013-12-18 2019-09-06 出光兴产株式会社 化合物、有机电致发光元件用材料、油墨组合物、有机电致发光元件、电子机器及制造方法
RU2758669C2 (ru) 2016-09-27 2021-11-01 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с применением сочетания днк-поражающих агентов и ингибиторов днк-пк
CA3189027A1 (en) 2020-07-11 2022-01-20 Pfizer Inc. Antiviral heteroaryl ketone derivatives
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025220A1 (en) * 1999-10-07 2001-04-12 Amgen Inc. Triazine kinase inhibitors
CN1446048A (zh) * 2000-06-08 2003-10-01 辛甄塔合股公司 N－苯基－4－(4－吡啶基)－2－嘧啶胺衍生物
US20040043388A1 (en) * 2001-03-02 2004-03-04 Come Jon H. Three hybrid assay system
CN1582285A (zh) * 2001-11-01 2005-02-16 詹森药业有限公司 用作糖原合酶激酶3β抑制剂(GSK3抑制剂)的杂芳胺化合物
WO2005033095A1 (en) * 2003-10-03 2005-04-14 Dow Agrosciences Llc Fungicidal 4-(2-aminopyridin-4-yl)-n-phenyl-1,3,5-triazin-2-amine derivatives
CN1764380A (zh) * 2003-03-28 2006-04-26 辛根塔参与股份公司 作为植物保护剂的n－苯基－[(4－吡啶基)－吖嗪基]－胺衍生物
CN1798734A (zh) * 2003-04-04 2006-07-05 Irm责任有限公司 作为蛋白激酶抑制剂的新化合物和组合物
CN101039920A (zh) * 2004-10-15 2007-09-19 安万特药物公司 作为前列腺素d2受体拮抗剂的2,6－取代的－4－单取代的氨基嘧啶

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050014753A1 (en) * 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
KR20100020454A (ko) * 2007-06-08 2010-02-22 바이엘 크롭사이언스 소시에떼아노님 살진균제 헤테로사이클릴-피리미디닐-아미노 유도체

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025220A1 (en) * 1999-10-07 2001-04-12 Amgen Inc. Triazine kinase inhibitors
CN1446048A (zh) * 2000-06-08 2003-10-01 辛甄塔合股公司 N－苯基－4－(4－吡啶基)－2－嘧啶胺衍生物
US20040043388A1 (en) * 2001-03-02 2004-03-04 Come Jon H. Three hybrid assay system
CN1582285A (zh) * 2001-11-01 2005-02-16 詹森药业有限公司 用作糖原合酶激酶3β抑制剂(GSK3抑制剂)的杂芳胺化合物
CN1764380A (zh) * 2003-03-28 2006-04-26 辛根塔参与股份公司 作为植物保护剂的n－苯基－[(4－吡啶基)－吖嗪基]－胺衍生物
CN1798734A (zh) * 2003-04-04 2006-07-05 Irm责任有限公司 作为蛋白激酶抑制剂的新化合物和组合物
WO2005033095A1 (en) * 2003-10-03 2005-04-14 Dow Agrosciences Llc Fungicidal 4-(2-aminopyridin-4-yl)-n-phenyl-1,3,5-triazin-2-amine derivatives
CN101039920A (zh) * 2004-10-15 2007-09-19 安万特药物公司 作为前列腺素d2受体拮抗剂的2,6－取代的－4－单取代的氨基嘧啶

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112645927A (zh) * 2014-04-09 2021-04-13 基因泰克公司 用于制备药物的方法
CN119841771A (zh) * 2025-01-08 2025-04-18 华中农业大学 一种猪链球菌丝氨酸蛋白激酶抑制剂的筛选方法及其应用

Also Published As

Publication number Publication date
US20100267729A1 (en) 2010-10-21
KR20100088150A (ko) 2010-08-06
US8026359B2 (en) 2011-09-27
JP2011503006A (ja) 2011-01-27
EP2205086A2 (en) 2010-07-14
US20110301123A1 (en) 2011-12-08
MX2010005033A (es) 2010-05-27
BRPI0817135A2 (pt) 2014-10-07
WO2009061761A2 (en) 2009-05-14
AU2008324833A1 (en) 2009-05-14
WO2009061761A3 (en) 2009-06-25
EP2205086B1 (en) 2013-08-14

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20101201