CN101896502A - 抗人TNFα单抗、分子进化及其应用 - Google Patents
抗人TNFα单抗、分子进化及其应用 Download PDFInfo
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- CN101896502A CN101896502A CN2009800005464A CN200980000546A CN101896502A CN 101896502 A CN101896502 A CN 101896502A CN 2009800005464 A CN2009800005464 A CN 2009800005464A CN 200980000546 A CN200980000546 A CN 200980000546A CN 101896502 A CN101896502 A CN 101896502A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Description
Claims (8)
- 权利要求1. 一种抗人 TNFa抗体, 其特征在于, 其轻链氨基酸序列包含 SEQ ID NO: 8, 重链氨基酸 序列包含 SEQ ID NO: 9或 SEQ ID NO: 10。
- 2. 如权利要求 1所述抗人 TNFa抗体, 其特征在于, 所述抗人 TNFa抗体的重链的全长氨基 酸序列为 SEQ ID NO: 16或 SEQ ID NO: 18。
- 3. 一种多核苷酸, 其特征在于, 该多核苷酸编码权利要求 1所述抗人 TNFa抗体的轻链。
- 4. 如权利要求 3所述多核苷酸, 其特征在于, 所述多核苷酸的序列包括 SEQ ID N0: 5。
- 5. 一种多核苷酸, 其特征在于, 该多核苷酸编码权利要求 1所述抗人 TNFa抗体的全长重 链。
- 6. 如权利要求 5所述多核苷酸, 其特征在于, 所述多核苷酸的序列包括 SEQ ID NO: 15或 SEQ ID NO: 17。
- 7. 如权利要求 1所述抗人 TNFa抗体的 Fab抗体。
- 8. 权利要求 1或权利要求 2所述抗人 TNFa抗体, 或权利要求 7所述抗人 TNFa抗体的 Fab 抗体在制备治疗与 TNFa相关的炎症的药物上的应用。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2009/070938 WO2010105446A1 (zh) | 2009-03-20 | 2009-03-20 | 抗人肿瘤坏死因子受体α单抗及其应用 |
Publications (2)
Publication Number | Publication Date |
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CN101896502A true CN101896502A (zh) | 2010-11-24 |
CN101896502B CN101896502B (zh) | 2012-10-17 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2009800005464A Expired - Fee Related CN101896502B (zh) | 2009-03-20 | 2009-03-20 | 抗人TNFα单抗、分子进化及其应用 |
Country Status (4)
Country | Link |
---|---|
US (1) | US8354108B2 (zh) |
EP (1) | EP2409992B1 (zh) |
CN (1) | CN101896502B (zh) |
WO (1) | WO2010105446A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114591432A (zh) * | 2022-03-25 | 2022-06-07 | 南京融捷康生物科技有限公司 | 抗TNFα的单域抗体及其用途 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012041018A1 (zh) | 2010-09-30 | 2012-04-05 | 成都康弘生物科技有限公司 | 抗TNFα的人源化抗体及其抗原结合片段Fab和用途 |
CN103773770A (zh) * | 2012-10-18 | 2014-05-07 | 高峰 | 一种可分泌的绿色荧光蛋白及其在重组蛋白高产表达细胞株筛选方面的应用 |
EP3823994A4 (en) * | 2018-07-19 | 2022-04-20 | Ab Studio Inc. | NOVEL INTERNALIZING ANTIBODY SCREENING SYSTEMS AND THEIR USES |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
DE60333228D1 (de) | 2002-12-02 | 2010-08-12 | Amgen Fremont Inc | Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen |
CN100393748C (zh) * | 2003-11-06 | 2008-06-11 | 上海中信国健药业有限公司 | 全人源肿瘤坏死因子抗体,其制备方法以及药物组合物 |
CN100436580C (zh) * | 2003-11-13 | 2008-11-26 | 中国人民解放军第四军医大学 | 高中和活性抗肿瘤坏死因子单克隆抗体的可变区基因及其制备 |
KR100772800B1 (ko) * | 2003-11-17 | 2007-11-01 | 주식회사유한양행 | 인간 종양괴사인자 α를 인식하는 단일클론항체의가변영역 및 이를 코딩하는 유전자 |
US20060024308A1 (en) * | 2004-07-06 | 2006-02-02 | Roberto Crea | High affinity anti-TNF-alpha antibodies and method |
ES2359567T3 (es) * | 2004-12-29 | 2011-05-24 | Yuhan Corporation | Anticuerpo humanizado específico para el factor de necrosis tumoral-alfa. |
WO2008141511A1 (fr) * | 2007-05-22 | 2008-11-27 | Human Antibodomics (Shanghai) Inc. | ANTICORPS MONOCLONAL HUMAIN ANTI-TNFα ET SON UTILISATION |
-
2009
- 2009-03-20 CN CN2009800005464A patent/CN101896502B/zh not_active Expired - Fee Related
- 2009-03-20 EP EP09841729.8A patent/EP2409992B1/en not_active Not-in-force
- 2009-03-20 WO PCT/CN2009/070938 patent/WO2010105446A1/zh active Application Filing
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2011
- 2011-01-18 US US13/008,015 patent/US8354108B2/en not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114591432A (zh) * | 2022-03-25 | 2022-06-07 | 南京融捷康生物科技有限公司 | 抗TNFα的单域抗体及其用途 |
CN114591432B (zh) * | 2022-03-25 | 2023-10-31 | 南京融捷康生物科技有限公司 | 抗TNFα的单域抗体及其用途 |
Also Published As
Publication number | Publication date |
---|---|
EP2409992A1 (en) | 2012-01-25 |
CN101896502B (zh) | 2012-10-17 |
EP2409992A4 (en) | 2012-08-08 |
EP2409992B1 (en) | 2017-10-25 |
US8354108B2 (en) | 2013-01-15 |
US20110182906A1 (en) | 2011-07-28 |
WO2010105446A1 (zh) | 2010-09-23 |
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