CN101883843B - 破坏过氧化物酶体生物合成因子蛋白(pex)以改变含油真核生物中多不饱和脂肪酸和总脂质含量 - Google Patents

破坏过氧化物酶体生物合成因子蛋白(pex)以改变含油真核生物中多不饱和脂肪酸和总脂质含量 Download PDF

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CN101883843B
CN101883843B CN200880118917.4A CN200880118917A CN101883843B CN 101883843 B CN101883843 B CN 101883843B CN 200880118917 A CN200880118917 A CN 200880118917A CN 101883843 B CN101883843 B CN 101883843B
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gene
acid
strain
fatty acid
desaturase
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Chinese (zh)
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CN101883843A (zh
Inventor
Z·薛
Q·Q·朱
N·S·亚达夫
P·L·夏普
S-P·洪
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EIDP Inc
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EI Du Pont de Nemours and Co
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN200880118917.4A 2007-10-03 2008-10-03 破坏过氧化物酶体生物合成因子蛋白(pex)以改变含油真核生物中多不饱和脂肪酸和总脂质含量 Expired - Fee Related CN101883843B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97717407P 2007-10-03 2007-10-03
US60/977174 2007-10-03
PCT/US2008/078671 WO2009046248A1 (en) 2007-10-03 2008-10-03 Peroxisome biogenesis factor protein (pex) disruptions for altering the content of polyunsaturated fatty acids and the total lipid content in oleaginous eukaryotic organisms

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CN101883843A CN101883843A (zh) 2010-11-10
CN101883843B true CN101883843B (zh) 2016-03-02

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CN200880118917.4A Expired - Fee Related CN101883843B (zh) 2007-10-03 2008-10-03 破坏过氧化物酶体生物合成因子蛋白(pex)以改变含油真核生物中多不饱和脂肪酸和总脂质含量

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EP (1) EP2198005B1 (https=)
JP (1) JP5658034B2 (https=)
CN (1) CN101883843B (https=)
CA (1) CA2701130A1 (https=)
DK (1) DK2198005T3 (https=)
WO (1) WO2009046248A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009335903B2 (en) * 2008-12-18 2016-04-14 E. I. Du Pont De Nemours And Company Reducing byproduction of malonates in a fermentation process
WO2010147907A1 (en) 2009-06-16 2010-12-23 E. I. Du Pont De Nemours And Company High eicosapentaenoic acid oils from improved optimized strains of yarrowia lipolytica
CA2763424C (en) 2009-06-16 2018-06-12 E.I. Du Pont De Nemours And Company Improvement of long chain omega-3 and omega-6 polyunsaturated fatty acid biosynthesis by expression of acyl-coa lysophospholipid acyltransferases
EP2475679B1 (en) * 2009-06-16 2016-02-10 E. I. du Pont de Nemours and Company Improved optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production
AU2012285806B2 (en) * 2011-07-21 2017-09-14 Dsm Ip Assets B.V. Fatty acid compositions
EP3230446A4 (en) * 2014-12-10 2018-09-05 Novogy, Inc. Oleic acid production in yeast
CN104911192A (zh) * 2015-04-27 2015-09-16 海南大学 拟南芥抗逆相关基因AtPED2及其制备方法和应用
WO2025207802A1 (en) * 2024-03-27 2025-10-02 Nutrition & Biosciences USA 4, Inc. Recombinant microbial strains comprising reduced beta-oxidation phenotypes and methods thereof
CN118726155A (zh) * 2024-06-26 2024-10-01 微康益生菌(苏州)股份有限公司 一种防治真菌性阴道炎的植物乳植杆菌Lp769及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214491B2 (en) * 2003-05-07 2007-05-08 E. I. Du Pont De Nemours And Company Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
US7267976B2 (en) * 2003-07-02 2007-09-11 E.I. Du Pont De Nemours And Company Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts
US7659120B2 (en) * 2003-11-12 2010-02-09 E. I. Du Pont De Nemours And Company Δ 15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast
US7504259B2 (en) * 2003-11-12 2009-03-17 E. I. Du Pont De Nemours And Company Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast
US7550286B2 (en) * 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
US7273746B2 (en) * 2004-11-04 2007-09-25 E.I. Dupont De Nemours And Company Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
AU2006316610B2 (en) * 2005-11-23 2012-06-14 E. I. Du Pont De Nemours And Company Delta-9 elongases and their use in making polyunsaturated fatty acids

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Gary A. Eitzen,at el.Enlarged Peroxisomes Are Present in Oleic Acid–grown.<<The Journal of Cell Biology>>.1997,第137卷(第6期),1265-1278. *
崔凯，丁霄霖.苏子油多不饱和脂肪酸尿素富集研究.《中国油脂》.1996,(第06期), *
王显伦等.活性豆粉复合改良剂对面粉品质影响研究.《粮食与饲料工业》.2005,(第09期), *

Also Published As

Publication number Publication date
EP2198005A1 (en) 2010-06-23
WO2009046248A1 (en) 2009-04-09
JP2010539985A (ja) 2010-12-24
EP2198005B1 (en) 2014-05-07
JP5658034B2 (ja) 2015-01-21
CA2701130A1 (en) 2009-04-09
DK2198005T3 (da) 2014-07-21
CN101883843A (zh) 2010-11-10

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