CN101879142B - 马度米星铵预混剂的制备方法 - Google Patents
马度米星铵预混剂的制备方法 Download PDFInfo
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- CN101879142B CN101879142B CN2010101982201A CN201010198220A CN101879142B CN 101879142 B CN101879142 B CN 101879142B CN 2010101982201 A CN2010101982201 A CN 2010101982201A CN 201010198220 A CN201010198220 A CN 201010198220A CN 101879142 B CN101879142 B CN 101879142B
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- Prior art keywords
- maduramicin
- drying
- ammonium
- fermentation liquid
- fermentation
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- BXHCJLRTXPHUGH-UHFFFAOYSA-N 2-oxo-1h-pyridine-4-carboxylic acid Chemical compound OC(=O)C=1C=CNC(=O)C=1 BXHCJLRTXPHUGH-UHFFFAOYSA-N 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 238000000855 fermentation Methods 0.000 claims abstract description 44
- 230000004151 fermentation Effects 0.000 claims abstract description 44
- 238000001035 drying Methods 0.000 claims abstract description 32
- 229950006915 maduramicin Drugs 0.000 claims abstract description 26
- 239000012065 filter cake Substances 0.000 claims abstract description 19
- 238000002156 mixing Methods 0.000 claims abstract description 16
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000003825 pressing Methods 0.000 claims abstract description 12
- 229910021529 ammonia Inorganic materials 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 7
- 238000005550 wet granulation Methods 0.000 claims abstract description 7
- 239000008187 granular material Substances 0.000 claims abstract description 6
- 241001052560 Thallis Species 0.000 claims abstract description 5
- 238000012216 screening Methods 0.000 claims abstract description 5
- RWVUEZAROXKXRT-VQLSFVLHSA-N maduramicin Chemical compound O1[C@@H](C)[C@H](OC)[C@@H](OC)C[C@H]1O[C@@H]1[C@H]([C@@]2(C)O[C@H](CC2)[C@@]2(C)O[C@]3(O[C@@H]([C@H](C)[C@@H](O)C3)[C@@H](C)[C@H]3[C@@H]([C@@H](OC)[C@H](C)[C@@](O)(CC(O)=O)O3)OC)CC2)O[C@@H]([C@@H]2[C@H](C[C@@H](C)[C@@](C)(O)O2)C)C1 RWVUEZAROXKXRT-VQLSFVLHSA-N 0.000 claims abstract 8
- 239000000047 product Substances 0.000 claims description 36
- 239000007788 liquid Substances 0.000 claims description 28
- 239000000843 powder Substances 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- 241000894006 Bacteria Species 0.000 claims description 6
- 239000011230 binding agent Substances 0.000 claims description 6
- 239000004615 ingredient Substances 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 5
- 229910021536 Zeolite Inorganic materials 0.000 claims description 5
- PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 claims description 5
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 5
- 238000005453 pelletization Methods 0.000 claims description 5
- 239000002002 slurry Substances 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 238000012546 transfer Methods 0.000 claims description 5
- 239000010457 zeolite Substances 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 230000003321 amplification Effects 0.000 claims description 4
- 230000005587 bubbling Effects 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- 235000010216 calcium carbonate Nutrition 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 239000006052 feed supplement Substances 0.000 claims description 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 238000002255 vaccination Methods 0.000 claims description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 229920000881 Modified starch Polymers 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 11
- 239000003960 organic solvent Substances 0.000 abstract description 8
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000005576 amination reaction Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000007908 dry granulation Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000000227 grinding Methods 0.000 abstract 1
- 239000012452 mother liquor Substances 0.000 abstract 1
- 238000007670 refining Methods 0.000 abstract 1
- WQGJEAMPBSZCIF-HKSLRPGUSA-N Maduramicin Chemical compound N.O1[C@@H](C)[C@H](OC)[C@@H](OC)C[C@H]1O[C@@H]1[C@H]([C@@]2(C)O[C@H](CC2)[C@@]2(C)O[C@]3(O[C@@H]([C@H](C)[C@@H](O)C3)[C@@H](C)[C@H]3[C@@H]([C@@H](OC)[C@H](C)[C@@](O)(CC(O)=O)O3)OC)CC2)O[C@@H]([C@@H]2[C@H](C[C@@H](C)[C@@](C)(O)O2)C)C1 WQGJEAMPBSZCIF-HKSLRPGUSA-N 0.000 description 20
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 230000003115 biocidal effect Effects 0.000 description 4
- 239000010413 mother solution Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000003495 Coccidiosis Diseases 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 206010023076 Isosporiasis Diseases 0.000 description 2
- 230000001165 anti-coccidial effect Effects 0.000 description 2
- 235000019445 benzyl alcohol Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000000273 veterinary drug Substances 0.000 description 2
- ZSZFUDFOPOMEET-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]acetonitrile Chemical compound C1=CC(Cl)=CC=C1C(C#N)C1=C(Cl)C=C(N2C(NC(=O)C=N2)=O)C=C1Cl ZSZFUDFOPOMEET-UHFFFAOYSA-N 0.000 description 1
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 description 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000223924 Eimeria Species 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 229960000248 diclazuril Drugs 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229960002418 ivermectin Drugs 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (5)
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CN2010101982201A CN101879142B (zh) | 2010-06-11 | 2010-06-11 | 马度米星铵预混剂的制备方法 |
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CN2010101982201A CN101879142B (zh) | 2010-06-11 | 2010-06-11 | 马度米星铵预混剂的制备方法 |
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CN101879142A CN101879142A (zh) | 2010-11-10 |
CN101879142B true CN101879142B (zh) | 2011-09-07 |
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Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102331405A (zh) * | 2011-05-30 | 2012-01-25 | 濮阳泓天威药业有限公司 | 马度米星发酵液效价的检测方法 |
CN102759255B (zh) * | 2012-07-26 | 2014-09-24 | 浙江佐力药业股份有限公司 | 连续式自动化真菌发酵后处理工艺 |
CN103230582A (zh) * | 2013-04-17 | 2013-08-07 | 南京工业大学 | 一种持久霉素预混剂的制备方法 |
CN103479658A (zh) * | 2013-10-09 | 2014-01-01 | 郑州福源动物药业有限公司 | 一种马度米星铵尼卡巴嗪预混剂及其制备方法 |
CN104351483A (zh) * | 2014-11-13 | 2015-02-18 | 河北圣雪大成制药有限责任公司 | 一种全发酵土霉素钙颗粒剂的制备方法 |
CN112426431A (zh) * | 2020-11-19 | 2021-03-02 | 濮阳泓天威药业有限公司 | 一种复方马度米星铵预混剂及其制备方法 |
CN112791052A (zh) * | 2021-01-21 | 2021-05-14 | 南京农业大学 | 一种马度米星铵结构脂质载体及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0290792A2 (en) * | 1987-05-12 | 1988-11-17 | American Cyanamid Company | Method for the preparation of feed premix in compositions of maduramicin |
CN1129100A (zh) * | 1995-02-16 | 1996-08-21 | 姜正才 | 马杜霉素(铵)液体剂 |
CN1460485A (zh) * | 2003-03-27 | 2003-12-10 | 中牧实业股份有限公司 | 制造兽药马杜霉素铵、伊维菌素或地克珠利预混剂的新工艺 |
-
2010
- 2010-06-11 CN CN2010101982201A patent/CN101879142B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0290792A2 (en) * | 1987-05-12 | 1988-11-17 | American Cyanamid Company | Method for the preparation of feed premix in compositions of maduramicin |
CN1129100A (zh) * | 1995-02-16 | 1996-08-21 | 姜正才 | 马杜霉素(铵)液体剂 |
CN1460485A (zh) * | 2003-03-27 | 2003-12-10 | 中牧实业股份有限公司 | 制造兽药马杜霉素铵、伊维菌素或地克珠利预混剂的新工艺 |
Non-Patent Citations (1)
Title |
---|
赵子刚.Actinomadura yumaensis发酵生产马杜霉素的研究.《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》.2004,(第4期),B016-239. * |
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Denomination of invention: Preparation of madomicin ammonium premix Effective date of registration: 20210308 Granted publication date: 20110907 Pledgee: Puyang branch of Bank of Zhengzhou Co.,Ltd. Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2021980001498 |
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Denomination of invention: Preparation of madumicin ammonium premix Effective date of registration: 20220608 Granted publication date: 20110907 Pledgee: Postal Savings Bank of China Limited by Share Ltd. Puyang branch Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2022980007339 |
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Denomination of invention: Preparation method of Madumicin ammonium premix Effective date of registration: 20230517 Granted publication date: 20110907 Pledgee: Postal Savings Bank of China Limited by Share Ltd. Puyang branch Pledgor: PUYANG HOTWAY PHARMACEUTICALS Co.,Ltd. Registration number: Y2023980040671 |
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