CN101874857A - Liver-protecting white spirit for resisting alcoholic liver injury and production process thereof - Google Patents
Liver-protecting white spirit for resisting alcoholic liver injury and production process thereof Download PDFInfo
- Publication number
- CN101874857A CN101874857A CN 201010196987 CN201010196987A CN101874857A CN 101874857 A CN101874857 A CN 101874857A CN 201010196987 CN201010196987 CN 201010196987 CN 201010196987 A CN201010196987 A CN 201010196987A CN 101874857 A CN101874857 A CN 101874857A
- Authority
- CN
- China
- Prior art keywords
- liver
- extract
- white spirit
- protecting
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The invention discloses a liver-protecting white spirit for resisting an alcoholic liver injury and a production process thereof. The white spirit is produced by the following steps of: heating the medicine food dual-purpose traditional Chinese medicinal raw materials: 1-100g of kudzu-vine root, 1-100g of medlar, 1-100g of hawthorn and 5-100g of pawpaw, to 30-90 DEG C respectively with alcohol of which the volume percent content is 30-95% and the weight is 5-15 times of the weight of the medicinal materials; carrying out reflux extraction for 1-3 hours to obtain the extract of each medicine; and then dissolving the extracts in Xiaoqu white spirit, decoloring and filtering. The invention requires that the contents of puerarin, wolfberry polysaccharide, betaine and oleanolic acid in the white spirit is not lower than 10-250mg/L, 10-250mg/L, 10-1000mg/L and 0.1-1.0mg/L respectively. Shown by the result of an acute toxicity experiment, the liver-protecting white spirit has very low acute toxicity and high safety; and shown by the result of a pharmacodynamics experiment, the liver-protecting white spirit has the action of resisting the alcoholic liver injury and has obvious effect on reducing the liver injury on the basis of pathological sections and antioxidation index analysis.
Description
(1) technical field: the present invention relates to a kind of Chinese liquor and production technology thereof, specifically is a kind of liver-protecting white spirit and production technology thereof of resisting alcoholic hepatic injury.
(2) prior art: a hundred flowers blossom for China white wine, and as food, its cardinal principle of the formation of Chinese liquor is utilized the Cereals starch materials, forms through blending and tasting after saccharifying unstrained spirits bacterium, the fermented distilled wine base that forms, the aging; But, formed the exclusive culture of Chinese distilled spirit because the difference of its fermentation raw material, the alcoholic fermented product starter and fermentation form and fermentation time etc. has also brought up the different of Chinese liquor odor type.The colony of drinking of today comprises courtesy drink colony, reason hobby drink colony, irrational hobby drink colony, custom drink colony, the colony of drinking of steeping in wine, and the infringement greatly of excessively being addicted to drink undoubtedly is healthy, especially causes alcoholic liver injury; Through to experiment mice 0.2ml/10g filling by volume stomach, to behind the 31d its liver morphological indexes is detected continuously, find that its normal hepatocytes leaflet structure destroys or disappearance, the hepatocyte arrangement disorder, hepatocellular degeneration mostly is the steatosis (see figure 2) greatly; Illustrate that it is undisputable fact that excessive drinking causes damage to liver.For avoiding excessive drinking that liver is caused damage, the correlational study personnel of liquor industry study with regard to the problem that how to alleviate hepatic injury when drinking as much as possible, and the liver-protecting white spirit that has Chinese medicine soak solution such as adding Radix Glycyrrhizae, Fructus Lycii, Fructus Mori, Radix Puerariae in wine appears on the market.Yet Ministry of Public Health has sent about restriction in calendar year 2001 be the notice (defend method prison [2001] No. 188) of raw material production health food with Radix Glycyrrhizae and products thereof, point out in the notice: " banning use of wild Radix Glycyrrhizae and products thereof as the health food composition ".
Because the main component of Radix Glycyrrhizae is a glycyrrhizin, the glycyrrhizin hydrolyzable becomes enoxolone.The chemical constitution of enoxolone and effect all are similar to adrenocortical hormone.Taking hormone for a long time can cause elevation of the blood pressure, and long-term indiscriminate clothes Radix Glycyrrhizae also can produce phenomenons such as anasarca, blood na concn increase.Secular edema has increased the weight of the burden of heart and blood vessel, adds the infringement of sodium at high concentration ion pair blood vessel wall, finally causes hypertension to take place.Therefore, above-mentioned so-called liver-protecting white spirit is short-lived beyond doubt, does not have vitality.
Under above-mentioned background, our company is devoted to the research of liver-protecting white spirit always, adopt the medical material of the medicine-food two-purpose of Ministry of Public Health approval to test, go through pharmacology prescription many times, and by the biological extraction technology, extract the hepatoprotective active component, reach the repetition test research of several years through the relevant expert, confirm not have toxic and side effects through independent trials, and the functional component that dissolves in does not only influence the style of traditional liquor, remedied Chinese liquor thin defective on style simultaneously, for China liquor industry develops the leading effect of playing to safety, healthy direction.
(3) summary of the invention: purpose of the present invention just provides a kind of active component that adds hepatoprotective in existing Chinese liquor, and the wine body is sweet clean refreshing, the liver-protecting white spirit and the production technology thereof of the resisting alcoholic hepatic injury of unique style.
The liver-protecting white spirit of resisting alcoholic hepatic injury of the present invention, medicinal and edible Chinese medicine raw material Radix Puerariae 1-100g, Fructus Lycii 1-100g, Fructus Crataegi 1-100g, Fructus Chaenomelis 5-100g by following dosage are respectively that 30%-95%, medical material weight 5-15 ethanol doubly is heated to 30 ℃-90 ℃ with the volumn concentration, reflux, extract, 3 times, each 1-3 hour, merge extractive liquid,, reclaim ethanol, get the extract of each medicine; Extract is dissolved in the distilled liquor, decolouring is filtered, promptly again; Require the content of puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid in the Chinese liquor to be not less than 10-250mg/L, 10-250mg/L, 10-1000mg/L and 0.1-1.0mg/L respectively.
Prepare the production technology of the liver-protecting white spirit of above-mentioned resisting alcoholic hepatic injury, comprise the steps:
(1) be respectively that 30%-95%, medical material weight 5-15 ethanol doubly is heated to 50 ℃-90 ℃ with the volumn concentration with Radix Puerariae, Fructus Lycii, Fructus Crataegi, Fructus Chaenomelis, reflux, extract, 3 times, each 1-3 hour, merge extractive liquid, reclaimed ethanol, gets the extract of each medicine;
(2) detect puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid content corresponding in each medicament extract respectively, calculate the extract amount that should add;
(3) extract is dissolved in the distilled liquor according to quantity, decolouring is filtered, promptly.
It is raw material that prescription of the present invention is selected Radix Puerariae, Fructus Lycii, Fructus Crataegi, the Fructus Chaenomelis of the medicine-food two-purpose of Ministry of Public Health regulation for use, according to monarch, the minister of the traditional Chinese medical science, the formulation principle of helping, making, through Traditional Chinese Medicine experts several medicament composing prescription, in conjunction with the toxicology of modern Chinese medicine and the technological achievement of Ergonomy research, reach the repetition test research of several years and determine through the pharmacy expert.Fructus Chaenomelis suppressing the hyperactive liver Shujin, stomach function regulating removing dampness in the side; The Fructus Lycii liver and kidney tonifying, both compatibilities are used for the nourishing the liver suppressing the hyperactive liver; The Fructus Crataegi blood circulation promoting and blood stasis dispelling, the circulation of qi promoting of reducing phlegm is unfolded irritability; The Radix Puerariae relieving restlessness is quenched one's thirst, the dry property of mediation Chinese liquor.Make full side's nourishing the liver suppressing the hyperactive liver soothing the liver, to play the effect of protecting and nourishing liver.
The present invention has abandoned traditional medical material and has soaked the method for extracting its effective ingredient on technology, the employing effective ingredient is difficult for destroyed and extracts solvent reflux technology completely, especially each single medical material is separately extracted, again extract separately is dissolved in the distilled liquor, functional component content is higher, extraction process is simple, has reduced production cost, easier formation industrial-scale production.
Used distilled liquor among the present invention, the Sorghum vulgare Pers. of taking advantage of of going up north to the east of being is a raw material, with the GUANYINTU song is saccharifying ferment, adopt the saccharifying of solid-state unstrained spirits bacterium, the little bent wine base of delicate fragrance type that fermentation, distillation are produced was stored 1 year through pithos, colluded to transfer through combination to design that to have delicate fragrance pure, the wine body is sweet clean refreshing, the distilled liquor of unique style.
After testing; contain puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid among the present invention; show through pharmacology and pharmacodynamic study; puerarin in the Radix Puerariae helps ethanol catabolism in vivo; thereby alcoholic intoxication has improved Agifutol activity level in the liver cytoplasm simultaneously, helps the performance of body detoxification ability; the protection hepatocyte avoids the infringement of free radical, electrophilic compound and poisonous substance, thereby can alleviate the toxicity of ethanol to liver.Puerarin then is a kind of active monomer component in the total flavones, all has preventing drunkenness, controls drunk and effect such as antagonism alcoholic liver injury etc.
Lycium barbarum polysaccharide in the Fructus Lycii can suppress liver cell pigment gene and protein expression; reduce serum alanine aminotransferase ALT, aspartate amino transferase AST, gamma-glutamyl based transferase γ-GT content; improve glutathion peroxidase GSH-PX, superoxide dismutase SOD activity; increase reduced glutathion GSH content; reducing malonaldehyde MDA produces; rat liver fat lesion due to obvious improvement and the prevention ethanol. lycium barbarum polysaccharide can be prevented and treated the rat alcoholic fatty liver effectively by alleviating lipid peroxidation.
The betanin that contains in the Fructus Crataegi can prevent the vitamin A deficiency that caused by ethanol, can obviously improve liver biochemistry and pathological change, transaminase lowering, significantly improve steatosis, gangrenous inflammation, use betanin and can improve hepatic fibrosis, betanin has abundant pharmacological action, and safe toxic and side effects is few.Abroad be widely used among the treatment of hyperhomocysteinemiainjury, hepatic disease etc., determined curative effect acts on original.
The oleanolic acid that contains in the MUZHUA to the protective effect of liver mainly owing to its antioxidation, antiinflammatory action and to the influence of drug metabolism enzyme; oleanolic acid can promote liver cell regeneration; the necrotic area is repaired rapidly; the vigor of hepatic tissue recovery normally the alleviating alanine (AI T) of degeneration necrosis is descended; make the liver tissues inflammatory habituation; gamma globulin descends in the blood, thereby suppresses hair jelly fibril hypertrophy, makes liver cirrhosis be difficult to form.Oleanolic acid is not only effective in cure to general hepatitis, alcoholic liver injury, treatment to viral hepatitis also has curative effect preferably, by the effect experiment confirm, feeds this prescription liver-protecting white spirit through irritating, its mouse liver pathomorphology is all obviously improved, and the hepatic tissue anti-oxidation function strengthens.
Liver-protecting white spirit of the present invention shows through the acute toxicity testing result, and (after 0.244g crude drug/ml), maximum volume 20ml/kg per os irritated the stomach mice, the mice body weight is stable to be increased, and does not have dead the generation with Chinese medicine Cmax in the Chinese liquor.This dosage is equivalent to the adult and drinks the daily recommended amounts of liver-protecting white spirit of the present invention (2440 times of 0.002g crude drug/kg), the Chinese medicine ingredients acute toxicity of prompting Chinese liquor of the present invention is extremely low, safe.
Pharmacodynamic experiment situation of the present invention is as follows: experimental design divides six groups of mouse stomaches to contrast: normal saline matched group, model control group (distilled liquor that does not add Chinese medicine ingredients), liver-protecting white spirit of the present invention, according to the amount of the middle pharmaceutically active ingredient that adds divide little, in, big, super large dosage group, successive administration 31d.Behind the 30d administration 1h, detect animal prologue behavior (climbing the lattice number and the number of times of standing); Behind the 31d administration 1h, the sacrificed by decapitation animal, get hepatic tissue, measure malonaldehyde (MDA) content in the liver plasma membrane (P9), the middle superoxide dismutase (SOD) of liver cytoplasm (S9), catalase (Cat) and glutathion peroxidase (GSH-Px) activity simultaneously.
Experimental result shows that after the distilled liquor of model control group (seeing Fig. 2, Fig. 7, Fig. 8) mice through not adding Chinese medicine ingredients irritated stomach processing 31d, remarkable steatosis took place hepatocyte, and MDA content obviously increases simultaneously, and SOD, Cat and GSH-Px activity then reduce.Compare with model control group, liver-protecting white spirit of the present invention is little, in, big, super large dosage group mouse liver cell film MDA content obviously reduces (P＜0.05; P＜0.01), active (P＜0.05 that raises of SOD, CAT and GSH-Px; P＜0.01) (sees Fig. 3, Fig. 4, Fig. 5, Fig. 6, Fig. 7, Fig. 8); The histopathology aspect, four dosage of liver-protecting white spirit of the present invention all can improve hepatocellular denaturation degrees.More than the variation tendency of each index in female and buck, do not have significant difference.The result of study prompting, from the antioxidation index analysis of liver function, liver plasma membrane MDA, GSH-Px all are positive, and show that the Chinese medicine ingredients of liver-protecting white spirit of the present invention has the effect of resisting alcoholic hepatic injury, and its mechanism of action is relevant with the raising hepatic antioxidative function.
It is remarkable to think that from pathological section and antioxidation index analysis this Chinese liquor reduces the effect of hepatic injury.
Puerarin among the present invention, lycium barbarum polysaccharide, betanin and oleanolic acid content detect by the JP/JSGF130-2003 standard that our company formulates; Also can use the method for putting down in writing on Chinese Pharmacopoeia or other documents to detect.
(4) description of drawings
Fig. 1 is the murine liver tissue HE dyeing hepatic tissue section figure of blank group;
Fig. 2 is the murine liver tissue HE dyeing hepatic tissue section figure of model control group;
Fig. 3 is small dose group (the murine liver tissue HE dyeing hepatic tissue section figure of 0.02g crude drug/kg) of liver-protecting white spirit;
Fig. 4 is middle dosage group (the murine liver tissue HE dyeing hepatic tissue section figure of 0.04g crude drug/kg) of liver-protecting white spirit;
Fig. 5 is heavy dose group (the murine liver tissue HE dyeing hepatic tissue section figure of 0.08g crude drug/kg) of liver-protecting white spirit;
Fig. 6 is super large dosage group (the murine liver tissue HE dyeing hepatic tissue section figure of 0.2g crude drug/kg) of liver-protecting white spirit;
Fig. 7 is the influence of liver-protecting white spirit to mouse liver cell film malonaldehyde (MDA) content;
Fig. 8 is that liver-protecting white spirit is to the active influence of murine liver tissue catalase (Cat);
(5) specific embodiment:
Embodiment 1
(1) with Radix Puerariae 1g, Fructus Lycii 1g, Fructus Crataegi 1g, Fructus Chaenomelis 5g respectively with volumn concentration be 30%, 5 times of ethanol of medical material weight are heated to 50 ℃, reflux, extract, 3 times, each 1 hour, merge 3 times extracting solution, reclaim ethanol, the extract of each medicine;
(2) detect puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid content corresponding in each medicament extract respectively, go out the extract amount that should add according to the cubage that requires in the end-product;
(3) extract is added in the distilled liquor according to quantity, decolouring is filtered, promptly.The content that detects puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid in the finished product is not less than 10-250mg/L, 10-250mg/L, 10-1000mg/L and 0.1-1.0mg/L respectively.
Used distilled liquor can directly be bought on market.
Embodiment 2
(1) with Radix Puerariae 100g, Fructus Lycii 100g, Fructus Crataegi 100g, Fructus Chaenomelis 100g respectively with volumn concentration be 95%, 8 times of ethanol of medical material weight are heated to 90 ℃, reflux, extract, 3 times, each 3 hours, merge 3 times extracting solution, reclaim ethanol, the extract of each medicine;
(2) detect puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid content corresponding in each medicament extract respectively, calculate the extract amount that should add;
(3) extract is added in the distilled liquor according to quantity, decolouring is filtered, promptly.The content that detects puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid in the finished product is not less than 10-250mg/L, 10-250mg/L, 10-1000mg/L and 0.1-1.0mg/L respectively.
Used distilled liquor can directly be bought on market.
Embodiment 3
(1) with Radix Puerariae 50g, Fructus Lycii 50g, Fructus Crataegi 50g, Fructus Chaenomelis 50g respectively with volumn concentration be 50%, 12 times of ethanol of medical material weight are heated to 70 ℃, reflux, extract, 3 times, each 2 hours, reclaim ethanol, the extract of each medicine;
(2) detect puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid content corresponding in each medicament extract respectively, calculate the extract amount that should add;
(3) extracting solution is dissolved in according to quantity to distilled liquor, decolouring is filtered, promptly.The content that detects puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid in the finished product is not less than 10-250mg/L, 10-250mg/L, 10-1000mg/L and 0.1-1.0mg/L respectively.Used distilled liquor can directly be bought on market.
Embodiment 4
(1) with Radix Puerariae 80g, Fructus Lycii 80g, Fructus Crataegi 80g, Fructus Chaenomelis 80g respectively with volumn concentration be 75%, 15 times of ethanol of medical material weight are heated to 80 ℃, reflux, extract, 3 times, each 1.5 hours, reclaim ethanol, the extract of each medicine;
(2) detect puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid content corresponding in each medicament extract respectively, calculate the extract amount that should add;
(3) extract is dissolved in according to quantity to distilled liquor, decolouring is filtered, promptly.The content that detects puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid in the finished product is not less than 10-250mg/L, 10-250mg/L, 10-1000mg/L and 0.1-1.0mg/L respectively.
Used distilled liquor can directly be bought on market.
Claims (2)
1. the liver-protecting white spirit of resisting alcoholic hepatic injury, it is characterized in that medicinal and edible Chinese medicine raw material Radix Puerariae 1-100g, Fructus Lycii 1-100g, Fructus Crataegi 1-100g, Fructus Chaenomelis 5-100g by following dosage are respectively that 30%-95%, medical material weight 5-15 ethanol doubly is heated to 30 ℃-90 ℃ with the volumn concentration, reflux, extract, 3 times, each 1-3 hour, merge extractive liquid,, reclaim ethanol, get the extract of each medicine; Extract is dissolved in the distilled liquor, decolouring is filtered, promptly again; Require the content of puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid in the Chinese liquor to be not less than 10-250mg/L, 10-250mg/L, 10-1000mg/L and 0.1-1.0mg/L respectively.
2. the production technology of the liver-protecting white spirit of resisting alcoholic hepatic injury as claimed in claim 1 is characterized in that comprising the steps:
(1) be respectively that 30%-95%, medical material weight 5-15 ethanol doubly is heated to 50 ℃-90 ℃ with the volumn concentration with Radix Puerariae, Fructus Lycii, Fructus Crataegi, Fructus Chaenomelis, reflux, extract, 3 times, each 1-3 hour, merge extractive liquid, reclaimed ethanol, gets the extract of each medicine;
(2) detect puerarin, lycium barbarum polysaccharide, betanin and oleanolic acid content corresponding in each medicament extract respectively, calculate the extract amount that should add;
(3) extract is dissolved in the distilled liquor according to quantity, decolouring is filtered, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101969870A CN101874857B (en) | 2010-05-28 | 2010-05-28 | Liver-protecting white spirit for resisting alcoholic liver injury and production process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101969870A CN101874857B (en) | 2010-05-28 | 2010-05-28 | Liver-protecting white spirit for resisting alcoholic liver injury and production process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101874857A true CN101874857A (en) | 2010-11-03 |
| CN101874857B CN101874857B (en) | 2012-01-04 |
Family
ID=43017602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101969870A Active CN101874857B (en) | 2010-05-28 | 2010-05-28 | Liver-protecting white spirit for resisting alcoholic liver injury and production process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101874857B (en) |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225120A (en) * | 2011-06-16 | 2011-10-26 | 安徽安科生物工程（集团）股份有限公司 | Medicine for treating fatty liver and preparation method thereof |
| CN102552537A (en) * | 2011-12-19 | 2012-07-11 | 东乌珠穆沁旗悦艺生物科技有限责任公司 | Chinese medicinal composition for treating qi and blood loss |
| CN104630009A (en) * | 2015-02-23 | 2015-05-20 | 酒口袋（上海）投资控股有限公司 | Liver protecting liquor resisting alcoholic liver damage and preparation method thereof |
| CN105524810A (en) * | 2016-02-03 | 2016-04-27 | 哈尔滨御防酒业有限公司 | Betaine wine and production method thereof |
| CN105524811A (en) * | 2016-02-03 | 2016-04-27 | 哈尔滨御防酒业有限公司 | Oleanolic acid wine and production method thereof |
| CN105907573A (en) * | 2016-05-28 | 2016-08-31 | 怀宁县望春花绿化工程有限公司 | Magnolia biondii nutrient health-care yellow wine and preparation method thereof |
| CN107057903A (en) * | 2017-05-11 | 2017-08-18 | 劲牌有限公司 | It is a kind of to improve grape wine of comfort level and preparation method thereof after drink |
| CN107509907A (en) * | 2017-10-18 | 2017-12-26 | 山西琪尔康翅果生物制品有限公司 | A kind of solid beverage with preventing alcoholic liver injury |
| CN108014324A (en) * | 2017-10-24 | 2018-05-11 | 中国科学院兰州化学物理研究所 | A kind of health care preparation for having effects that to protect alcoholic liver injury |
| CN108690775A (en) * | 2017-04-10 | 2018-10-23 | 李杨 | The production method of health care white wine and health care white wine and usage thereof |
| CN108753517A (en) * | 2018-05-22 | 2018-11-06 | 山东双陵春生物科技股份有限公司 | A kind of pueraria lobata wine with liver protective function and its manufacture craft |
| CN108795683A (en) * | 2018-06-25 | 2018-11-13 | 沈周平 | A kind of fruit vinegar formula |
| CN109022222A (en) * | 2018-09-28 | 2018-12-18 | 侯军 | A kind of jasmine fragrance protect liver health preserving wine and preparation method thereof |
| CN109628265A (en) * | 2019-01-09 | 2019-04-16 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | A kind of liver-protection health-care molecule wine and preparation method thereof containing general flavone |
| CN110184163A (en) * | 2019-07-12 | 2019-08-30 | 劲牌有限公司 | A kind of preparation method with the kudzuvine root wine for reducing hepatic injury function |
| CN114712425A (en) * | 2022-04-20 | 2022-07-08 | 庄玉坤 | Liver-protecting wine |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088830A (en) * | 1993-06-09 | 1994-07-06 | 鲁学智 | Sober-up nutrition granules and processing technology thereof |
| CN1120454A (en) * | 1995-09-06 | 1996-04-17 | 杭州娃哈哈集团公司 | Beverage for sobering up and removing nicotine |
| CN1491686A (en) * | 2003-08-21 | 2004-04-28 | 何昌义 | Chinese medicine preparation for sobering up and liver protection and its preparing method |
| CN1799620A (en) * | 2005-08-17 | 2006-07-12 | 王林祥 | Healthcare wine and its preparation method |
| CN1995317A (en) * | 2006-12-20 | 2007-07-11 | 赵广涛 | Preparation method of medlar fruit vinegar and medlar fruit vinegar drink |
-
2010
- 2010-05-28 CN CN2010101969870A patent/CN101874857B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088830A (en) * | 1993-06-09 | 1994-07-06 | 鲁学智 | Sober-up nutrition granules and processing technology thereof |
| CN1120454A (en) * | 1995-09-06 | 1996-04-17 | 杭州娃哈哈集团公司 | Beverage for sobering up and removing nicotine |
| CN1491686A (en) * | 2003-08-21 | 2004-04-28 | 何昌义 | Chinese medicine preparation for sobering up and liver protection and its preparing method |
| CN1799620A (en) * | 2005-08-17 | 2006-07-12 | 王林祥 | Healthcare wine and its preparation method |
| CN1995317A (en) * | 2006-12-20 | 2007-07-11 | 赵广涛 | Preparation method of medlar fruit vinegar and medlar fruit vinegar drink |
Non-Patent Citations (3)
| Title |
|---|
| 《中国初级卫生保健》 20030315 任建社等 脂肪肝的中医治疗概况 第17卷, 第03期 2 * |
| 《新中医》 20080105 冯丽娟等 脂肪肝中医药治疗研究进展 第40卷, 第01期 2 * |
| 《辽宁中医杂志》 20071218 李有田等 中西药联用治疗酒精肝病疗效观察 第34卷, 第12期 2 * |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225120A (en) * | 2011-06-16 | 2011-10-26 | 安徽安科生物工程（集团）股份有限公司 | Medicine for treating fatty liver and preparation method thereof |
| CN102552537A (en) * | 2011-12-19 | 2012-07-11 | 东乌珠穆沁旗悦艺生物科技有限责任公司 | Chinese medicinal composition for treating qi and blood loss |
| CN102552537B (en) * | 2011-12-19 | 2013-12-11 | 东乌珠穆沁旗悦艺生物科技有限责任公司 | Chinese medicinal composition for treating qi and blood loss |
| CN104630009A (en) * | 2015-02-23 | 2015-05-20 | 酒口袋（上海）投资控股有限公司 | Liver protecting liquor resisting alcoholic liver damage and preparation method thereof |
| CN104630009B (en) * | 2015-02-23 | 2016-06-08 | 酒口袋（上海）投资控股有限公司 | Liver-protecting white spirit of resisting alcoholic hepatic injury and preparation method thereof |
| CN105524810A (en) * | 2016-02-03 | 2016-04-27 | 哈尔滨御防酒业有限公司 | Betaine wine and production method thereof |
| CN105524811A (en) * | 2016-02-03 | 2016-04-27 | 哈尔滨御防酒业有限公司 | Oleanolic acid wine and production method thereof |
| CN105907573A (en) * | 2016-05-28 | 2016-08-31 | 怀宁县望春花绿化工程有限公司 | Magnolia biondii nutrient health-care yellow wine and preparation method thereof |
| CN108690775A (en) * | 2017-04-10 | 2018-10-23 | 李杨 | The production method of health care white wine and health care white wine and usage thereof |
| CN108690775B (en) * | 2017-04-10 | 2021-06-01 | 李杨 | Production method of health-preserving and health-care white spirit, health-preserving and health-care white spirit and use method thereof |
| CN107057903A (en) * | 2017-05-11 | 2017-08-18 | 劲牌有限公司 | It is a kind of to improve grape wine of comfort level and preparation method thereof after drink |
| CN107509907A (en) * | 2017-10-18 | 2017-12-26 | 山西琪尔康翅果生物制品有限公司 | A kind of solid beverage with preventing alcoholic liver injury |
| CN108014324A (en) * | 2017-10-24 | 2018-05-11 | 中国科学院兰州化学物理研究所 | A kind of health care preparation for having effects that to protect alcoholic liver injury |
| CN108753517A (en) * | 2018-05-22 | 2018-11-06 | 山东双陵春生物科技股份有限公司 | A kind of pueraria lobata wine with liver protective function and its manufacture craft |
| CN108795683A (en) * | 2018-06-25 | 2018-11-13 | 沈周平 | A kind of fruit vinegar formula |
| CN109022222A (en) * | 2018-09-28 | 2018-12-18 | 侯军 | A kind of jasmine fragrance protect liver health preserving wine and preparation method thereof |
| CN109628265A (en) * | 2019-01-09 | 2019-04-16 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | A kind of liver-protection health-care molecule wine and preparation method thereof containing general flavone |
| CN110184163A (en) * | 2019-07-12 | 2019-08-30 | 劲牌有限公司 | A kind of preparation method with the kudzuvine root wine for reducing hepatic injury function |
| CN114712425A (en) * | 2022-04-20 | 2022-07-08 | 庄玉坤 | Liver-protecting wine |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101874857B (en) | 2012-01-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101874857B (en) | Liver-protecting white spirit for resisting alcoholic liver injury and production process thereof | |
| CN102188513A (en) | Medical composition with auxiliary protection function for chemical liver damage | |
| CN104383315A (en) | Chinese herbal medicinal composition for protecting liver and sobering and drink containing Chinese herbal medicinal composition | |
| CN107951935A (en) | A kind of pueraria lobata hoveniae semoveniae semen broken wall composition and its preparation method and application | |
| CN102178885A (en) | Medicinal composition for sobering | |
| CN104208581A (en) | Schisandra chinensis health care oral liquid capable of preventing alcoholic liver and preparation method thereof | |
| CN110777042A (en) | SOD (superoxide dismutase) white spirit with liver nourishing and health care effects and preparation method and packaging structure thereof | |
| CN107158152A (en) | A kind of traditional Chinese medicine health care product composition | |
| CN103933487A (en) | Compound traditional Chinese medicament for treating depression | |
| CN106822622A (en) | A kind of relieving alcoholism and protecting liver Orally administered composition and preparation method thereof | |
| CN104474135A (en) | Pharmaceutical composition with auxiliary protection function of treating chemical liver injury | |
| CN107019136A (en) | A kind of solid beverage with effect of lowering blood sugar and preparation method thereof | |
| Kim | Antidiabetic and antioxidative effects of Lycii fructus in streptozotocin-induced diabetic rats | |
| CN103860628B (en) | A kind of Dealcoholic sobering-up Chinese patent medicine preparation and preparation method thereof | |
| CN110973625A (en) | Liver-protecting and sobering-up composition based on fructus cannabis and preparation method and application thereof | |
| CN106176830A (en) | Effects of Extracts of Grifola frondosa on Active and its preparation method and application | |
| CN103181431B (en) | Liver-nourishing health protection tea and preparation method | |
| CN106727902B (en) | Cordyceps sinensis-containing traditional Chinese medicine composition for dispelling effects of alcohol and protecting liver and application thereof | |
| CN108714164A (en) | The purposes of Folium Forsythia black tea extract | |
| CN102462740B (en) | Pharmaceutical composition for relieving alcoholism and protecting liver and preparation method thereof | |
| CN108030010B (en) | Diaphragma juglandis instant powder and preparation method thereof | |
| CN107951984A (en) | Preparation method of kidney-tonifying yang-strengthening health wine | |
| CN104585469B (en) | A kind of chewing gum to alcoholic liver injury with protective effect and preparation method thereof | |
| CN1742825A (en) | Medicine preparation for preventing and treating allergic rhinitis and compliance rhinitis | |
| KR20180079920A (en) | Composition for preventing, improving or treating hepatic fibrosis or liver cirrhosis comprising Cuscuta Semen extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |