CN101870674A - 改进的瑞巴派特中间体的制备方法 - Google Patents
改进的瑞巴派特中间体的制备方法 Download PDFInfo
- Publication number
- CN101870674A CN101870674A CN200910022114A CN200910022114A CN101870674A CN 101870674 A CN101870674 A CN 101870674A CN 200910022114 A CN200910022114 A CN 200910022114A CN 200910022114 A CN200910022114 A CN 200910022114A CN 101870674 A CN101870674 A CN 101870674A
- Authority
- CN
- China
- Prior art keywords
- rebamipide
- dmf
- yield
- naoh
- add
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- ALLWOAVDORUJLA-UHFFFAOYSA-N Rebamipida Chemical compound C=1C(=O)NC2=CC=CC=C2C=1CC(C(=O)O)NC(=O)C1=CC=C(Cl)C=C1 ALLWOAVDORUJLA-UHFFFAOYSA-N 0.000 title claims abstract description 10
- 229950004535 rebamipide Drugs 0.000 title claims abstract description 8
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 30
- 230000035484 reaction time Effects 0.000 claims abstract description 4
- 239000000543 intermediate Substances 0.000 claims description 27
- 238000009833 condensation Methods 0.000 claims description 3
- 230000005494 condensation Effects 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 238000006482 condensation reaction Methods 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 description 8
- 239000000047 product Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012065 filter cake Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000005457 ice water Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- -1 sodium alkoxide Chemical class 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 229950002342 bisfentidine Drugs 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
- 229960002986 dinoprostone Drugs 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- FXJAOWANXXJWGJ-UHFFFAOYSA-N n-[4-(2-methyl-1h-imidazol-5-yl)phenyl]-n'-propan-2-ylmethanimidamide Chemical compound C1=CC(NC=NC(C)C)=CC=C1C1=CN=C(C)N1 FXJAOWANXXJWGJ-UHFFFAOYSA-N 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 239000000612 proton pump inhibitor Substances 0.000 description 1
- 229940126409 proton pump inhibitor Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009100221145A CN101870674B (zh) | 2009-04-21 | 2009-04-21 | 改进的瑞巴派特中间体的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009100221145A CN101870674B (zh) | 2009-04-21 | 2009-04-21 | 改进的瑞巴派特中间体的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101870674A true CN101870674A (zh) | 2010-10-27 |
CN101870674B CN101870674B (zh) | 2012-04-18 |
Family
ID=42995777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009100221145A Expired - Fee Related CN101870674B (zh) | 2009-04-21 | 2009-04-21 | 改进的瑞巴派特中间体的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101870674B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110426463A (zh) * | 2019-07-08 | 2019-11-08 | 苏州天马药业有限公司 | 一种对氯苯甲酰氨基丙二酸二乙酯样品中有关物质的检测方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4578381A (en) * | 1982-07-05 | 1986-03-25 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
CN100537541C (zh) * | 2004-12-01 | 2009-09-09 | 大塚制药株式会社 | 制备瑞巴派特的改进的方法 |
-
2009
- 2009-04-21 CN CN2009100221145A patent/CN101870674B/zh not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110426463A (zh) * | 2019-07-08 | 2019-11-08 | 苏州天马药业有限公司 | 一种对氯苯甲酰氨基丙二酸二乙酯样品中有关物质的检测方法 |
CN110426463B (zh) * | 2019-07-08 | 2022-03-04 | 苏州正济药业有限公司 | 一种对氯苯甲酰氨基丙二酸二乙酯样品中有关物质的检测方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101870674B (zh) | 2012-04-18 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHAANXI DASHENG PHARMACEUTICAL TECH CO., LTD. Free format text: FORMER OWNER: SHAANXI DASHENG CHEMICAL TECHNOLOGY CO., LTD. Effective date: 20121203 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20121203 Address after: Mojiezuo Plaza No. 2 710075 Shaanxi high tech Zone in Xi'an City, Feng Hui Nan Lu Patentee after: SHAANXI DASHENG PHARMACEUTICAL TECHNOLOGY CO., LTD. Address before: Mojiezuo Plaza No. 2 710075 Shaanxi province high tech Zone of Xi'an Fenghui Road No. 906 Patentee before: Shaanxi Dasheng Chemical Technology Co., Ltd. |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Improved preparation method of rebamipide intermediate Effective date of registration: 20130723 Granted publication date: 20120418 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: SHAANXI DASHENG PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2013990000487 |
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PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20140819 Granted publication date: 20120418 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: SHAANXI DASHENG PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2013990000487 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Improved preparation method of rebamipide intermediate Effective date of registration: 20140820 Granted publication date: 20120418 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: SHAANXI DASHENG PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2014990000675 |
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PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20150811 Granted publication date: 20120418 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: SHAANXI DASHENG PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2014990000675 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Improved preparation method of rebamipide intermediate Effective date of registration: 20150818 Granted publication date: 20120418 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: SHAANXI DASHENG PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2015990000694 |
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PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20160825 Granted publication date: 20120418 Pledgee: Xi'an innovation financing Company limited by guarantee Pledgor: SHAANXI DASHENG PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2015990000694 |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120418 Termination date: 20180421 |