CN101843662B - Chinese medicinal composition for preventing and treating asthenopia - Google Patents
Chinese medicinal composition for preventing and treating asthenopia Download PDFInfo
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- CN101843662B CN101843662B CN2010101940783A CN201010194078A CN101843662B CN 101843662 B CN101843662 B CN 101843662B CN 2010101940783 A CN2010101940783 A CN 2010101940783A CN 201010194078 A CN201010194078 A CN 201010194078A CN 101843662 B CN101843662 B CN 101843662B
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Abstract
The invention relates to the field of Chinese medicine, and discloses a Chinese medicinal composition for preventing and treating asthenopia. The composition comprises wild chrysanthemums, red sage roots, pearls, borneol and menthol. The Chinese medicinal composition preferably comprises the following in part by weight: 450 to 490 parts of wild chrysanthemums, 280 to 310 parts of red sage roots, 33 to 39 parts of pearls, 5 to 9 parts of borneol and 5 to 9 parts of menthol. The invention also provides a wet application of the Chinese medicinal composition and a preparation method thereof. The Chinese medicinal composition has the advantages of dredging blocked capillaries and increasing supply of eye nutrition, along with easy absorption, quick response, good curative effect and good application prospects.
Description
Technical field
The present invention relates to tcm field, be specifically related to a kind of asthenopic Chinese medicine composition that prevents and treat.
Background technology
Asthenopia claims eyestrain's syndrome again, it is the syndrome that eye or the organic factor of whole body and Nervous and Mental Factors are interweaved, because eyeball is often in tension, extraocular muscles and ciliary muscle metabolism increase, cause the increase of metabolic waste and oxygen-derived free radicals, the eye microcirculation stops up, eye nutrition supply deficiency, thus cause asthenopic various symptom.
Asthenopia is an ophthalmology common disease, and patient's symptom is varied, can not be lasting as near work, and pain around eye and the eye socket, blurred vision, eyes are dry and astringent, severe patient headache, nauseating, dizzy such as shed tears.Its occurrence cause is common have following several:
(1) eyes local factor is as ametropia such as myopia, hypermetropia, astigmatism, adjusting factor, eye muscle factor, conjunctivitis, keratitis etc.;
(2) systemic factor is as neurasthenia, health overwork, hysteria or involutional women;
(3) environmental factors, not enough or strong excessively as illumination, distribution of light sources is inhomogeneous or glimpse, too small, the meticulous or instability of fixation object etc.
Because of the defective that existence has a big risk is corrected in operation, many both at home and abroad now by oral vitamin A, B
1, B
12, the inosine sheet, or drip with collyrium as lubricate, nutrition or guttae sulfacetamidi natrici come alleviating asthenopia.
But, oral vitamin A, B
1, B
12, the inosine sheet takes effect slowly, and because most collyrium in preparation process, for the performance and the long period of stablizing medicine are not polluted by external microbe, all add antiseptic or excipient.If using method is improper, these become branch directly to influence the tear composition of eyes, and a change eye table microenvironment is destroyed the eye list structure, and the close-connected epithelial cell of script is suffered damage, and exfoliation of corneal epithelium, damaged, rotten to the corn occurs.Not only can not relief of symptoms, and can increase the weight of the eyes sense of discomfort, can cause vicious cycle in the course of time.Severe patient generation corneal ulcer, even corneal solution, perforation cause losing one's sight.The patient lacks enough understandings to the use of collyrium in addition, and collyrium is used and abused to mistake, antibiotic collyrium especially, and the result causes again because of dripping the disease due to the usefulness collyrium.
Adopt the Chinese medicine determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs that curative effect is preferably arranged according to the whole body situation, as with feel dizzy, pale complexion, tired blood deficiency shower such as unable, can suitably use blood-nourishing drugs such as Radix Angelicae Sinensis, Colla Corii Asini, the Radix Paeoniae Alba; Dry and astringent, the photophobia of eye, frequent nictation, companion's soreness of the waist and knees, dizziness and tinnitus, dreaminess person are deficiency of both the liver and kidney, can oral prince wife's Ju Dihuang ball; Conjunctivitis, keratitis person are arranged, can suitably use clearing away heat and expelling wind medicines such as Flos Chrysanthemi, Radix Glycyrrhizae, Radix Platycodonis.But tcm product mostly is Orally taken product at present, and through first pass effect, onset is slow, uses defectives such as inconvenience.
Summary of the invention
The purpose of this invention is to provide and a kind ofly be suitable for topical, effect rapidly and the good Chinese medicine composition of therapeutic effect.
For realizing above purpose, the present invention adopts following technical scheme:
A kind ofly prevent and treat asthenopic Chinese medicine composition, comprise: Flos Chrysanthemi Indici, Radix Salviae Miltiorrhizae, Margarita, Borneolum Syntheticum, Mentholum.
Wherein Flos Chrysanthemi Indici is that monarch drug, Radix Salviae Miltiorrhizae are that ministerial drug, Margarita are adjuvant drug, and Borneolum Syntheticum, Mentholum are messenger drug.According to the record of Chinese medicine historical data, Flos Chrysanthemi Indici has diffusing wind heat clearing away, and suppressing the hyperactive liver makes eye bright, the effect of heat-clearing and toxic substances removing; But the Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, the removing heat from blood eliminating carbuncle.Margarita has the arresting convulsion of calming the nerves, the effect of the pin nebula that makes eye bright.The Borneolum Syntheticum refreshment of can having one's ideas straightened out, clearing away heat to alleviate pain.Mentholum has wind-dispelling heat-dissipating, the clear sharp head's effect.
Classic doctor's nationality record Flos Chrysanthemi Indici can dispelling wind warm, the refresh oneself.Flos Chrysanthemi Indici is in the existing application widely of clinical ophthalmology at present, safety and stability, be used for the treatment of by antibacterial as compounding wild chrysanthemum membrane agent and cause mucosa or the keratopathy that causes with the herpes simplex types 1 viral infection, the anterior chamber that Flos Chrysanthemi Indici treatment keratopathy causes collects pus, hordeolum, iridocyclitis, pink eye disease etc.
Effects such as the progress of Flos Chrysanthemi Indici chemical constituent and pharmacological action and Flos Chrysanthemi Indici shows, Flos Chrysanthemi Indici has antimicrobial, antiinflammatory and immunomodulating, anti-platelet aggregation, protect the liver.
Radix Salviae Miltiorrhizae (Salvia miltiorrhiza-Bunge) is a conventional Chinese medicine, has blood circulation promoting and blood stasis dispelling, active blood stasis dispelling, and tranquilizing by nourishing the heart, the detoxifcation removing heat from blood, the evacuation of pus granulation promoting, reducing swelling and alleviating pain is treated effects such as skin ulcer dysentery relieving.The diterpenoid tanshinone compounds has anti-inflammation, effects such as coronary dilating, anti-platelet aggregation.TANSHINONES A sodium sulfonate injection by TANSHINONES A preparation can increase the coronary vasodilator flow, is used for the treatment of coronary heart disease, myocardial infarction etc.
Recently liposoluble constituent and the water soluble ingredient of finding Radix Salviae Miltiorrhizae can both be well to free radical resisting and lipid peroxide.Can suppress xanthine one oxidase system generation superoxide anion (O to some extent as danshensu and protocatechualdehyde
2-.), significantly stop hydrogen peroxide (H
2O
2) due to mouse red blood cell haemolysis and malonaldehyde (MDA) form, Sal A wherein, Sal B, the activity of Sal C and Ros A is stronger.Sal A gives the protective effect of oxygen injury may be relevant with its oxygen radical removing activity to myocardial ischemia/again.The diterpenoid tanshinone compounds is to O
2-.Inhibitory action is arranged.
Radix Salviae Miltiorrhizae can improve hemorheological property, improves erythrocyte deformability and reconcile the viscosity of blood, improves each internal organs microcirculation disturbance of whole body, helps the correction of severe complications such as the rehabilitation of body tissue and adult respiratory distress syndrome.
Asthenopia patient eyeball is often in tension, because extraocular muscles and ciliary muscle metabolism increase, causes the increase of metabolic waste and oxygen-derived free radicals, and the eye microcirculation stops up, and the eye nutrition supply is not gone up, and causes asthenopia.
The present application people finds that Flos Chrysanthemi Indici anti-platelet aggregation action intensity is 2.3 times of Radix Salviae Miltiorrhizae, but does not suppress mutually with the effect of Radix Salviae Miltiorrhizae, unite and use Flos Chrysanthemi Indici and Radix Salviae Miltiorrhizae, strengthen the effect of the anti-platelet aggregation of product, the blood capillary that mediation is stopped up strengthens the supply of eye nutrition.
The present invention has selected for use Borneolum Syntheticum and Mentholum to unite use, further promotes the absorption of various medicines, reaches better therapeutic.
As preferably, Chinese medicine composition of the present invention comprises in weight portion: Flos Chrysanthemi Indici 450-490 part, Radix Salviae Miltiorrhizae 280-310 part, Margarita 33-39 part, Borneolum Syntheticum 5-9 part, Mentholum 5-9 part.
Preferred, Chinese medicine composition of the present invention comprises in weight portion: Flos Chrysanthemi Indici 460-485 part, Radix Salviae Miltiorrhizae 290-300 part, Margarita 35-38 part, Borneolum Syntheticum 6-8 part, Mentholum 6-8 part.
Preferred, Chinese medicine composition of the present invention comprises in weight portion: Flos Chrysanthemi Indici 470-483 part, Radix Salviae Miltiorrhizae 295-300 part, Margarita 35-37 part, Borneolum Syntheticum 7-8 part, Mentholum 7-8 part.
Most preferred Chinese medicine composition of the present invention comprises in weight portion: 481 parts of Flos Chrysanthemi Indicis, 300 parts of Radix Salviae Miltiorrhizaes, 36 parts of Margaritas, 7 parts of Borneolum Syntheticums, 7 parts of Mentholums.
Those skilled in the art can adopt conventional method, Chinese medicine composition of the present invention are added that conventional adjuvant makes the regular dosage form of ophthalmology, as eye drop, gel, ointment, tablet, water preparation, granule etc.
The present invention also provides the Wet-dressing agent that comprises above-mentioned Chinese medicine composition.
In the specific embodiment, the present invention specifically provides a kind of preparation method of preventing and treating asthenopic Chinese medicine composition Wet-dressing agent, comprises following steps:
Step 1: Flos Chrysanthemi Indici, Radix Salviae Miltiorrhizae, Margarita, Borneolum Syntheticum, Mentholum are decocted with water, cross leaching filtrate, the simmer down to thick paste;
Step 2: after getting thick paste and adding ethanol precipitation, reclaim ethanol, be sub-packed in after the cold preservation in the non-woven fabrics carrier to there not being the alcohol flavor.
As preferably, step 1 is specially: get Flos Chrysanthemi Indici 450-490 part, Radix Salviae Miltiorrhizae 280-310 part, Margarita 33-39 part, Borneolum Syntheticum 5-9 part, Mentholum 5-9 part and decoct with water 2 times, merge decoction liquor and filter, get the thick paste that filtrate is concentrated into relative density 1.20.
Preferred, step 1 is specially: get 481 parts of Flos Chrysanthemi Indicis, 300 parts of Radix Salviae Miltiorrhizaes, 36 parts of Margaritas, 7 parts of Borneolum Syntheticums, Mentholum and decoct with water 2 times for 7 parts, merge decoction liquor and filter, get the thick paste that filtrate is concentrated into relative density 1.20.
As preferably, step 2 is specially: get thick paste and add 65% ethanol precipitation after 24 hours, reclaim ethanol to there not being the alcohol flavor, cold preservation 12 hours is sub-packed in the non-woven fabrics carrier.
Percutaneous dosing is a kind of medication that medicine passes through skin absorbs, and medicinal application is passed horny layer after on the skin, diffuses through skin, is absorbed by blood capillary to enter body circulation process, is called percutaneous and absorbs or Transdermal absorption.The most frequently used dosage form that percutaneous absorbs is patch (dermalpstch).Percutaneous dosing has following characteristics:
(1) can avoid liver first-pass effect that oral administration produces and in the gastrointestinal degraded, individual variation is little.
(2) can keep constant optimum blood medicine concentration or physiological effect, reduce side effect.
(3) prolong effective acting time, reduce the medication number of times.
(4) easy to use, interruption of the administration at any time, remove drug-supplying system after, blood drug level descends, and is particularly suitable for the patient of baby, old man or unsuitable oral administration.
Wet-dressing agent of the present invention is a kind of mode of new percutaneous dosing, and adopting safe and reliable spun-laced nonwoven fabric is carrier, and Flos Chrysanthemi Indici, Radix Salviae Miltiorrhizae, Margarita, Borneolum Syntheticum, Mentholum are decocted with water, and crosses leaching filtrate, the simmer down to thick paste; After getting thick paste and adding ethanol precipitation, reclaim ethanol, be sub-packed in after the cold preservation in the non-woven fabrics carrier and form Wet-dressing agent to there not being the alcohol flavor, topical, effect rapidly, toxic and side effects is few.
The present invention also provides the using method of described Wet-dressing agent, promptly closes eyes, and Wet-dressing agent of the present invention is affixed on eye, keeps every day 2-3 time 15-20 minute.
Chinese medicine composition of the present invention is a pure Chinese medicinal preparation, has no side effect, and easily absorbs, and effect prepares simple rapidly.
The specific embodiment:
The invention discloses a kind of asthenopic Chinese medicine composition that prevents and treat, those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are regarded as being included in the present invention.Product of the present invention and application are described by preferred embodiment, the related personnel obviously can change or suitably change and combination methods and applications as herein described in not breaking away from content of the present invention, spirit and scope, realizes and use the technology of the present invention.
Below in conjunction with embodiment, further explain the present invention:
Embodiment 1: prepare Chinese medicine composition of the present invention
Prescription: Flos Chrysanthemi Indici 450-490 part, Radix Salviae Miltiorrhizae 280-310 part, Margarita 33-39 part, Borneolum Syntheticum 5-9 part, Mentholum 5-9 part.
Embodiment 2: prepare Chinese medicine composition of the present invention
Flos Chrysanthemi Indici 460-485 part, Radix Salviae Miltiorrhizae 290-300 part, Margarita 35-38 part, Borneolum Syntheticum 6-8 part, Mentholum 6-8 part.
Embodiment 3: prepare Chinese medicine composition of the present invention
481 parts of Flos Chrysanthemi Indicis, 300 parts of Radix Salviae Miltiorrhizaes, 36 parts of Margaritas, 7 parts of Borneolum Syntheticums, 7 parts of Mentholums.
Embodiment 4: the Wet-dressing agent for preparing Chinese medicine composition of the present invention
Step 1: by each recipe quantity of embodiment 1-3 Flos Chrysanthemi Indici, Radix Salviae Miltiorrhizae, Margarita, Borneolum Syntheticum, Mentholum are decocted with water 2 times, cross leaching filtrate, the simmer down to relative density is 1.2 thick paste;
Step 2: get thick paste and add 65% ethanol precipitation after 24 hours, reclaim ethanol to there not being the alcohol flavor, cold preservation was sub-packed in the non-woven fabrics carrier after 12 hours, was Wet-dressing agent of the present invention.
Embodiment 5: the observation of curative effect of Wet-dressing agent of the present invention
Case 1: white collar Xiao Zhang, 25 years old, the male, IT engineer, main suit's asthenopia can not be alleviated for a long time, occurs headache when serious, feels sick, and influences work.The eye general inspection is not found obviously unusual.With with the described Chinese medicine composition of embodiment of the invention 1-4 with reference to the described methods preparation of embodiment 5 Wet-dressing agent be affixed on eye, kept 15-20 minute, every day 2-3 time, observe after 20 days and ignore fatigue symptom, promptly sleepy, the photophobia of eye, ache, shed tears, foreign body sensation, dry and astringent, the ophthalmospasm of eye, illustrate that Wet-dressing agent of the present invention is respond well.
Embodiment 6: the observation of curative effect of Wet-dressing agent of the present invention
Asthenopic clinical diagnosis standard:
1), visual disorder: blurred vision when mainly showing close eye, diplopia, word is capable overlapping, literal jumps and to walk about.
2), eye symptom: sleepy, the photophobia of eye, ache, shed tears, foreign body sensation, eye are dry and astringent, ophthalmospasm etc., the symptom grade scale is as follows:
Therapeutic Method
Enjoin the patient to lie low, close eyes, with the described Chinese medicine composition of embodiment of the invention 1-3 with reference to embodiment 4 described methods preparations Wet-dressing agent spread on eye, kept 20 minutes, each 2 paste every day 3 times, each treatment finishes rest 2-3 minute a little, and 20 days is a course of treatment.Check and write down before the treatment 1 day first, treatment 10 days, 20 days improvement situations that observe the symptoms respectively of treatment respectively, and the result is recorded faithfully.
Evaluation methodology
Observe that visual disorder, eye are sleepy, photophobia, ache, shed tears, 7 indexs such as foreign body sensation, eye are dry and astringent, ophthalmospasm, according to symptom light, in, weight standard and observed and recorded result, carry out statistical appraisal.
Evaluation criterion
Recovery from illness: transference cure or basic the disappearance, symptom integral reduces more than 90%;
Produce effects: symptom is obviously improved, and symptom integral reduces 60%-89%;
Effectively: symptom all take a favorable turn, and symptom integral reduces 30%-59%;
Invalid: symptom does not all have obvious improvement, even increase the weight of, symptom integral reduces below 30%.
Clinical effectiveness is analyzed
Asthenopia patient 30 examples are observed in this experiment altogether, recovery from illness 1 example (3.33%) after 20 days, and produce effects 23 (76.67%), effective 6 (20.00%), invalid 0, total effective rate (100%).
The transference cure rate is ophthalmospasm from high to low successively, shed tears, photophobia, ache, eye is sleepy, foreign body sensation, dry and astringent, the visual disorder of eye.
More than the Wet-dressing agent treatment asthenopia of test explanation Chinese medicine composition of the present invention is respond well, has potential applicability in clinical practice widely.
The above only is a preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
- One kind the prevention and treat asthenopic Chinese medicine composition, it is characterized in that, make by following bulk drugs: Flos Chrysanthemi Indici 450-490 part, Radix Salviae Miltiorrhizae 280-310 part, Margarita 33-39 part, Borneolum Syntheticum 5-9 part, Mentholum 5-9 part.
- 2. Chinese medicine composition according to claim 1 is characterized in that, is made by following bulk drugs: Flos Chrysanthemi Indici 460-485 part, Radix Salviae Miltiorrhizae 290-300 part, Margarita 35-38 part, Borneolum Syntheticum 6-8 part, Mentholum 6-8 part.
- 3. Chinese medicine composition according to claim 1 is characterized in that, is made by following bulk drugs: Flos Chrysanthemi Indici 470-483 part, Radix Salviae Miltiorrhizae 295-300 part, Margarita 35-37 part, Borneolum Syntheticum 7-8 part, Mentholum 7-8 part.
- 4. Chinese medicine composition according to claim 1 is characterized in that, is made by following bulk drugs: 481 parts of Flos Chrysanthemi Indicis, 300 parts of Radix Salviae Miltiorrhizaes, 36 parts of Margaritas, 7 parts of Borneolum Syntheticums, 7 parts of Mentholums.
- 5. the Wet-dressing agent that comprises each described Chinese medicine composition of claim 1-4.
- 6. a prevention and treat the preparation method of asthenopic Chinese medicine composition Wet-dressing agent comprises following steps:Step 1: Flos Chrysanthemi Indici 450-490 part, Radix Salviae Miltiorrhizae 280-310 part, Margarita 33-39 part, Borneolum Syntheticum 5-9 part, Mentholum 5-9 part are decocted with water, cross leaching filtrate, the simmer down to thick paste;Step 2: after getting thick paste and adding ethanol precipitation, reclaim ethanol, be sub-packed in after the cold preservation in the non-woven fabrics carrier to there not being the alcohol flavor.
- 7. preparation method according to claim 6, it is characterized in that, described step 1 is: get Flos Chrysanthemi Indici 450-490 part, Radix Salviae Miltiorrhizae 280-310 part, Margarita 33-39 part, Borneolum Syntheticum 5-9 part, Mentholum 5-9 part and decoct with water 2 times, merge decoction liquor and filter, get the thick paste that filtrate is concentrated into relative density 1.20.
- 8. preparation method according to claim 6, it is characterized in that, described step 1 is: get 481 parts of Flos Chrysanthemi Indicis, 300 parts of Radix Salviae Miltiorrhizaes, 36 parts of Margaritas, 7 parts of Borneolum Syntheticums, Mentholum and decoct with water 2 times for 7 parts, merge decoction liquor and filter, get the thick paste that filtrate is concentrated into relative density 1.20.
- 9. according to each described preparation method of claim 6-8, it is characterized in that described step 2 is: get thick paste and add 65% ethanol precipitation after 24 hours, reclaim ethanol to there not being the alcohol flavor, cold preservation 12 hours is sub-packed in the non-woven fabrics carrier.
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|---|---|---|---|
| CN2010101940783A CN101843662B (en) | 2010-05-28 | 2010-05-28 | Chinese medicinal composition for preventing and treating asthenopia |
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| CN2010101940783A CN101843662B (en) | 2010-05-28 | 2010-05-28 | Chinese medicinal composition for preventing and treating asthenopia |
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| CN104740644B (en) * | 2013-07-03 | 2017-11-24 | 郑州市新视明科技工程有限公司 | Promote eye Wet-dressing agent skin compliance and the preparation method of ingredient draws composition |
| CN104274383B (en) * | 2013-07-03 | 2017-11-24 | 郑州市新视明科技工程有限公司 | Promote the skin compliance of eye Wet-dressing agent and the composition of active ingredient draws |
| CN103933124B (en) * | 2014-03-27 | 2016-06-15 | 陕西新视明医药生物科技有限公司 | The Chinese herb medicine eye paste of a kind of remitting vision fatigue and preparation technology thereof |
| CN104306430B (en) * | 2014-10-29 | 2015-10-28 | 东莞市达庆医疗器械有限公司 | Cold treatment dressing of a kind of medical bio eye and preparation method thereof |
| CN104644754B (en) * | 2015-03-05 | 2018-09-28 | 北京明士达生物科技有限责任公司 | It is a kind of alleviate visual fatigue Chinese medicine preparation and its application |
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| CN108567910A (en) * | 2017-03-13 | 2018-09-25 | 陕西新视明医药生物科技有限公司 | The Chinese medicine composition of eye strain is alleviated in a kind of external application |
| CN107582771A (en) * | 2017-07-19 | 2018-01-16 | 长春源健医疗技术有限公司 | Stick eyelid alleviation visual fatigue sticks preparation and preparation method thereof |
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| CN109125375B (en) * | 2018-08-23 | 2021-04-30 | 刘汉珍 | Preparation method of Chuzhou chrysanthemum eye patch liquid for protecting eyes and improving eyesight |
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