CN111329915B

CN111329915B - Composition for relieving asthenopia of old people and hydrophilic gel thereof

Info

Publication number: CN111329915B
Application number: CN202010088321.7A
Authority: CN
Inventors: 赵永国; 汪弼晔; 金家骅; 王为安; 戴高飞; 孙建红; 王文娟; 吴琴琴
Original assignee: Shanghai Zhonghua Pharmaceutical Nantong Co ltd
Current assignee: Shanghai Zhonghua Pharmaceutical Nantong Co ltd
Priority date: 2020-02-12
Filing date: 2020-02-12
Publication date: 2022-01-11
Anticipated expiration: 2040-02-12
Also published as: CN111329915A

Abstract

The invention provides a traditional Chinese medicine composition for relieving asthenopia of old people and a hydrophilic gel thereof, wherein the traditional Chinese medicine composition comprises wild chrysanthemum flower, red sage root, phellodendron bark, coptis root, mint, cassia seed, honeysuckle flower and motherwort.

Description

Composition for relieving asthenopia of old people and hydrophilic gel thereof

Technical Field

The invention relates to a traditional Chinese medicine composition for relieving ophthalmic diseases, in particular to a traditional Chinese medicine composition for relieving asthenopia of old people and hydrophilic gel thereof.

Background

Asthenopia is a common ophthalmological disease, and is a group of syndromes of abnormal visual operation, nausea, dizziness and reaction retardation of patients with severe asthenopia due to the fact that various causes cause that human eyes can bear loads exceeding the visual function of the human eyes when viewing objects, and the symptoms of dry eyes, pain around eye sockets, blurred vision, easy lacrimation, incapability of performing short-distance work for a long time and the like occur after the eyes are used.

The number of asthenopia of the elderly is increasing with the increasing age. Some people have hyperopia or astigmatism, and clear vision can be obtained by adjustment in young age, but with the increase of age, the adjustment force is reduced, and the symptoms of blurred vision and asthenopia can appear; the secretion of tears of the elderly and the capability of the tears to lubricate the cornea of the eye change along with the increase of the age, and dry eye symptoms occur due to the influence of the decline of the function of meibomian glands and the like; the presbyopia patient does not have enough adjusting power when seeing the near object, so that the phenomena of blurring, handwriting deficiency, eye soreness, eye pain and the like occur when seeing the near object; cervical spondylosis, neurasthenia, or the like, or the patients with high mental stress, menopause, and the like can induce asthenopia; with the improvement of the culture level of the old people, some relatively family old people like watching news, pursuing dramas, playing games and the like on a computer, and the video terminal is used for too long time, so that the video terminal syndrome is caused. Therefore, how to relieve the visual fatigue of the elderly is a big problem that the contemporary medical workers must pay attention to and solve.

Modern medicine considers that the cause of visual fatigue is complex, and is a disease caused by the combined action of the self organ and the psychological health and other reasons. Asthenopia can be caused by eye factors such as ametropia of crystalline lens, damage of eyeball muscle, inflammation of eyes, weakened adjusting and polymerizing ability, and the like, and can also be caused by external environmental factors such as too weak or too strong light, uncertain light source flicker, bad use of a visual display terminal, and the like. Since most asthenopia patients are caused by abnormal eye accommodation function, improvement of eye accommodation function is an essential problem to be solved for such patients. In clinic, adenosine disodium triphosphate and diazepam drugs are used in the aspect of treating asthenopia, but are not suitable for long-term use. The eye drop such as taurine eye drop can act on ciliary muscle, improve eye regulation function by enhancing ciliary muscle function and increasing ciliary muscle blood flow, and relieve asthenopia. The artificial tears are a substitute made by simulating the components of human tears, for example, sodium hyaluronate eye drops can prevent conjunctiva from drying and eyes from being dry and have the function of moistening eyes, but in order to keep the sterility of the medicine and prolong the effective period of the medicine, preservatives such as benzalkonium bromide and the like are generally added into the eye drops, and the eye drops can cause the damage of normal tear film and the damage of corneal epithelial cells after long-term use, thereby not only not playing the role of relieving asthenopia, but also causing the damage to eyes.

Compared with the mode of 'external treatment of the external patient' in western medicine, the principle of the traditional Chinese medicine treatment is 'internal and external concurrent treatment'. The theory of traditional Chinese medicine considers that: eyes are liver orifices, tears are liver fluid, liver stores blood and mainly dredges and releases, heart blood is sufficient, eyes have spirit; spleen qi is vigorous, eyes are bright, so visual fatigue is liver fatigue, high myopia and maculopathy become liver and kidney deficiency; senile cataract is due to liver-kidney yin deficiency; asthenopia due to ametropia is liver yin deficiency. In the theory of traditional Chinese medicine, the occurrence of asthenopia is mainly eye-orifice malnutrition caused by liver and kidney deficiency, spleen deficiency and weak qi, heart and blood deficiency, liver depression and qi stagnation and the like. Therefore, the traditional Chinese medicine treatment mainly adopts the traditional Chinese medicines for nourishing essence and blood, clearing liver and improving vision, and dispelling wind and dredging orifices.

The pasting therapy is one of the traditional Chinese medicine external treatment methods, and originates from the application of fresh medicines, and more than 70 external preparations are contained in 283 prescriptions recorded in the Kam-Jordan-Temmit 'prescription for fifty two diseases'. The traditional Chinese medicine for treating eye diseases adopts a pasting therapy, but is not suitable to be prepared into an oral preparation, for example, the external application method for treating eye diseases by pounding, grinding or grinding the medicines into concentrated juice and applying the concentrated juice to eyes is adopted in Yinhai Jingwei, examining Yao letter and surgical orthodox.

The applicant searches the prior art, finds that the patent number is CN107596030A, and the invention is named as a traditional Chinese medicine composition of an eye mask, which is prepared from honeysuckle, radix sophorae flavescentis, cassia seed, coptis chinensis, climbing groundsel herb, mulberry leaf, safflower, menthol, wild chrysanthemum flower, salvia miltiorrhiza, phellodendron, pearl powder, tree peony bark, longan aril, mulberry, borneol, angelica sinensis, aloe, almond, bear gall and the like as raw materials. However, the composition has a complex formula, the raw materials are crushed, mixed into a medicine and then filled into a waist-shaped cloth bag made of cotton cloth to form an eyeshade, and the eyeshade is used during rest or sleep, namely, the raw materials are only crushed, the utilization rate of the active ingredients of the raw materials is low, the absorption rate of a human body to the medicine is low, the exertion of the medicine effect is hindered, and a large amount of waste of the raw materials is caused during use; moreover, for the elderly, the use process is complicated, the use is inconvenient and the effect is slow.

The existing eye patches contain chemical drugs with few side effects, and although the effect is quick, the situation of relapse in a short period is common. Based on the traditional Chinese medicine theory, the patent aims to provide a traditional Chinese medicine composition which can be prepared into a traditional Chinese medicine eye patch for relieving visual fatigue. Compared with the prior art, the traditional Chinese medicine composition used in the patent is simple in composition, and only wild chrysanthemum flower, salvia miltiorrhiza, golden cypress, coptis chinensis, mint, semen cassiae, honeysuckle and motherwort are used; the pharmacological experiment result shows that the invention has better effect of relieving asthenopia. The invention extracts the volatile components in the traditional Chinese medicine composition and prepares the volatile components into the gel patch, which is not only beneficial to the penetration of the medicine in eye tissues, the acceleration of local blood circulation, the increase of oxygen supply of the tissues around the eyes, the rapid taking away of local metabolites, the improvement of eye fatigue and other symptoms such as periorbital pain and the like, but also enables a user to close eyes and nourish the mind during the use process, and enables the eyes to have sufficient rest. Compared with the prior art, the traditional Chinese medicine composition has better curative effect, less stimulation to skin, more suitability for application therapy and high effect taking speed, and the medicine for activating the channels and collaterals is added on the basis of relieving the asthenopia, so that the symptoms of asthenopia, eye soreness and the like of the old can be more effectively relieved.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition which is simple in composition and has the effect of relieving the asthenopia of the old. The invention also provides a local external gel preparation which comprises the traditional Chinese medicine composition.

The traditional Chinese medicine composition for relieving asthenopia comprises 10 parts of wild chrysanthemum flower, 3 parts of salvia miltiorrhiza, 3 parts of golden cypress, 3 parts of coptis chinensis, 10 parts of mint, 10 parts of semen cassiae, 10 parts of honeysuckle and 8 parts of motherwort.

In some embodiments, the topical preparation is a gel, wherein the adjuvants for preparing the gel are carbomer, poloxamer, glycerin, sodium hydroxide, tween 80, menthol, borneol and EDTA-2 Na.

Drawings

FIG. 1 shows the effect of aromatic water on the contraction of smooth muscle of small intestine

FIG. 2 shows the effect of aromatic water on the contraction of smooth muscle of small intestine

Detailed Description

Example 1: preparation of volatile components of Chinese medicinal composition

Weighing 5.003g of wild chrysanthemum flower, 1.516g of salvia miltiorrhiza, 1.508g of phellodendron, 1.518g of coptis chinensis, 5.000g of mint, 5.005g of cassia seed, 5.004g of honeysuckle and 4.002g of motherwort, placing the materials in a round-bottom flask, adding distilled water with the mass 8 times that of the medicinal materials, heating for 4 hours, obtaining aromatic water by using a volatile oil extractor, collecting the aromatic water, sealing, cooling to room temperature, and refrigerating for later use.

Example 2: gel for relieving asthenopia

Weighing wild chrysanthemum flower, salvia miltiorrhiza, golden cypress, coptis chinensis, mint, cassia seed, honeysuckle and motherwort according to the prescription amount, putting the materials into a volatile oil extractor, adding distilled water with the mass being 8 times of that of the materials, soaking for 30min, and decocting for 4 h. Collecting aromatic water through a side tube of a volatile oil extractor, sealing, cooling to room temperature, and refrigerating for later use; then collecting water decoction in the round-bottom flask, and filtering the water decoction by using gauze. Adding 0.02% EDTA-2Na into the water decoction, heating in water bath at 90 deg.C, and concentrating to obtain dry extract. Weighing and dispersing 0.85 part of carbomer 940 and 0.2 part of poloxamer 188 in 100mL of distilled water, adding a proper amount of NaOH after complete swelling to adjust the pH value of the polymer solution to be neutral, adding 8mL of glycerol, and uniformly mixing to obtain a gel matrix; weighing 10 parts of the matrix, mixing the matrix with a proper amount of dry extract, and fully stirring; adding 2mL of aromatic water containing 0.4 part of Tween 80; weighing 0.01 part of menthol and 0.12 part of borneol, mixing and grinding (a small amount of ethanol can be added), and grinding until the gel matrix is added to the gel matrix to ensure that the gel matrix does not have foreign body sensation.

The traditional Chinese medicine composition can be prepared into gel, eye patches, eye masks and the like.

Example 3: inhibition of smooth muscle contraction

The effect of the formula is judged by the influence of the aromatic water of the traditional Chinese medicine composition on the contraction of smooth muscle. The reason why the small intestine smooth muscle was used instead of the ciliary muscle in this experiment was that: ciliary muscle is a smooth muscle, and the activity of the ciliary muscle belongs to neurogenic, is not myogenic, has no or few spontaneous activities, and is difficult to peel; secondly, the small intestine smooth muscle is a myogenic smooth muscle, although the section of the isolated intestine loses the innervation of external nerves, the intramural plexus still exists, and the contraction characteristic of the smooth muscle and the function of the intestinal wall plexus can be still maintained under proper conditions. Chua navigation Bo et al use rabbit small intestine smooth muscle to discuss the action mechanism of eyesight improving and eyesight improving No. I, and the result shows that the medicine can reduce the contraction amplitude and frequency of normal smooth muscle obviously, so as to relieve ciliary muscle spasm, correct and regulate myopia, relieve asthenopia and raise eyesight. Therefore, the small intestine smooth muscle is selected as a carrier for the research to evaluate the efficacy of the aromatic water, and the influence of the aromatic water extracted from the traditional Chinese medicine composition on the contraction activity of the smooth muscle can be evaluated, so that whether the ciliary muscle spasm can be relieved or not can be deduced, and the asthenopia can be relieved.

The prescription group is as follows: 5.003g of wild chrysanthemum flower, 1.516g of salvia miltiorrhiza, 1.508g of phellodendron, 1.518g of coptis chinensis, 5.000g of mint, 5.005g of cassia seed, 5.004g of honeysuckle flower and 4.002g of motherwort.

Control group: 5.008g of wild chrysanthemum flower, 1.512g of salvia miltiorrhiza, 1.500g of phellodendron, 1.512g of coptis chinensis, 5.010g of cassia seed and 5.000g of honeysuckle flower.

Weighing wild chrysanthemum flower, salvia miltiorrhiza, golden cypress, coptis chinensis, mint, cassia seed, honeysuckle and motherwort according to the prescription amount, placing the wild chrysanthemum flower, the salvia miltiorrhiza, the golden cypress, the golden thread, the mint, the cassia seed, the honeysuckle and the motherwort in a round-bottom flask, adding distilled water which is 8 times of the mass of the medicinal materials, heating for 4 hours, obtaining aromatic water by using a volatile oil extractor, collecting the aromatic water, sealing, cooling to room temperature, and refrigerating for later use. The control group obtained aromatic water in the same manner.

Preparing appropriate amount of Coriolis solution, and warm-bathing at 37 deg.C. A healthy rabbit is fasted for 24 hours before an experiment, water is not limited, the rabbit is killed, the rabbit is subjected to laparotomy, a section of small intestine with the length of 3-4cm is taken out near duodenum, the small intestine is placed in a beaker containing Coriolis solution at the temperature of 37 ℃, after the content of the small intestine is washed away by the Coriolis solution, mesentery is cut off, an intestine section with the length of 1.5-2.0cm is cut off from an intestinal canal, the intestine section is fixed in a smooth muscle perfusion muscle groove, the upper end of the intestine section is connected with a tension sensor, and air bubbles are introduced. After stabilizing for 20min, adding 1mL of aromatic water in sequence, accumulating for 5 times, and keeping the interval time of 1min every time, so that the Coriolis solution finally contains 5mL of aromatic water, and recording the activity curve of smooth muscles of intestine. The results of the experiment are shown in table 1.

TABLE 1 Effect of medicinal aromatic Water on Small intestine smooth muscle tone: (

n＝3)

Note: p <0.05 compared to normal group

The aromatic water extracted from the traditional Chinese medicine composition is subjected to a small intestine smooth muscle contraction experiment, and as can be seen from figure 1, after 1mL of the aromatic water extracted by the prescription is added into the rabbit small intestine which contracts normally, the contraction amplitude and frequency of the small intestine smooth muscle can be obviously weakened, and the tension state of the smooth muscle can be relieved. While the control group (figure 2) needs 2mL of aromatic water to begin to reduce the contraction amplitude and frequency of the smooth muscles of the small intestine, and the effect is weak. The aromatic water extracted from the composition can significantly reduce the contraction amplitude and frequency of smooth muscle in normal state. In a word, the aromatic water extracted by the formula can relieve ciliary muscle spasm to a certain extent, and improve the symptoms of asthenopia, blurred vision, eye soreness and the like of the old.

Claims

1. A traditional Chinese medicine composition for relieving asthenopia of the elderly is characterized in that the traditional Chinese medicine composition comprises the raw medicines of 10 parts by weight of wild chrysanthemum flower, 3 parts by weight of salvia miltiorrhiza, 3 parts by weight of phellodendron, 3 parts by weight of coptis chinensis, 10 parts by weight of mint, 10 parts by weight of cassia seed, 10 parts by weight of honeysuckle flower and 8 parts by weight of motherwort; the preparation method of the traditional Chinese medicine composition comprises the following steps: weighing wild chrysanthemum flower, salvia miltiorrhiza, golden cypress, coptis chinensis, mint, cassia seed, honeysuckle and motherwort according to the prescription amount, placing the wild chrysanthemum flower, the salvia miltiorrhiza, the golden cypress, the golden thread, the mint, the cassia seed, the honeysuckle and the motherwort in a volatile oil extractor, adding distilled water which is 8 times of the mass of the medicinal materials, and heating and extracting aromatic water in the volatile oil extractor to obtain the traditional Chinese medicine composition for relieving the asthenopia.

2. A traditional Chinese medicine composition preparation for relieving asthenopia of the old, which is characterized by comprising the traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition preparation is a gel.

3. The preparation method of the traditional Chinese medicine composition preparation according to claim 2, which is characterized by comprising the following steps:

(1) weighing wild chrysanthemum flower, salvia miltiorrhiza, golden cypress, coptis chinensis, mint, cassia seed, honeysuckle and motherwort according to the prescription amount, putting the wild chrysanthemum flower, the salvia miltiorrhiza, the golden cypress, the golden thread, the mint, the cassia seed, the honeysuckle and the motherwort into a volatile oil extractor device, adding distilled water which is 8 times of the mass of the medicinal materials, and collecting aromatic water through the volatile oil extractor;

(2) filtering the water decoction, heating and concentrating to obtain dry extract;

(3) weighing a proper amount of carbomer 940 and poloxamer 188, dispersing in distilled water, adjusting the pH value to be neutral after complete swelling, adding glycerol, and uniformly mixing to obtain a gel matrix;

(4) mixing the above matrix with appropriate amount of dry extract, stirring, adding obtained aromatic water, and grinding to remove foreign body sensation.

4. The use of the Chinese medicinal composition of claim 1 in the preparation of a medicament for relieving asthenopia.