CN107519338A - A kind of Chinese medicine composition of external application protection eyesight - Google Patents
A kind of Chinese medicine composition of external application protection eyesight Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition of external application protection eyesight, the bulk drug of the Chinese medicine composition includes：Menthol, storax, styrax, borneol, grass-leaved sweetflag, the red sage root, Radix Angelicae Sinensis, chrysanthemum indicum, mother-of-pearl, borax, cassia seed, the shell of seaear, calamine, peppermint, earthworm, radix glycyrrhizae, Rui Ren.The Chinese medicine composition to alleviate visual fatigue caused by ophthalmospasm, shed tears, photophobia, symptom of aching have significant curative effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of external application protection eyesight, belong to Chinese medicine health-care field.
Background technology
Kopiopia is a kind of ophthalmology common disease, the eye caused by it is dry, eye is puckery, eye it is sour it is swollen, regarding thing
Fuzzy even visual impairment directly affects the work and life of people.Kopiopia is mainly due to people
Watch computer or television screen attentively for a long time, number of winks, which is reduced, causes tears Secretion to reduce,
The neck that people caused by the intense stimulus eyes of fluorescent screen, can be caused is flashed simultaneously, shoulder, first-class position go out
Existing pain, can also trigger various illness in eye.
People are alleviated and treatment eye strain solves usually through dripping eyedrop, but direct contact angle
The mode of film may cause groups of people not tolerate due to the stimulation component in medicament for the eyes, or even produce stimulation.
Massage method can also alleviate eye strain, but can only typically play the effect of respite.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition of external application protection eyesight, the original of said composition
Material medicine includes：Menthol, storax, styrax, borneol, grass-leaved sweetflag, the red sage root, Radix Angelicae Sinensis, chrysanthemum indicum,
Mother-of-pearl, borax, cassia seed, the shell of seaear, calamine, peppermint, earthworm, radix glycyrrhizae, Rui Ren.
In some embodiments, the bulk drug composition of the Chinese medicine composition is：The weight of menthol 0.5~4
Measure part, the parts by weight of storax 2~10, the parts by weight of styrax 1~12, the parts by weight of borneol 6~30, stone Chang
The parts by weight of Pu 6~30, the parts by weight of the red sage root 6~30, the parts by weight of Radix Angelicae Sinensis 2.5~25, the weight of chrysanthemum indicum 2.5~25
Measure part, the parts by weight of mother-of-pearl 2~20, the parts by weight of borax 1~15, the parts by weight of cassia seed 1~15, Shi Jue
Bright 1~12 parts by weight, the parts by weight of calamine 1~12, the parts by weight of peppermint 1~12, the weight of earthworm 1~12
Part, the parts by weight of radix glycyrrhizae 1~12, the parts by weight of Rui Ren 1~10.
Preferably, the bulk drug composition of the Chinese medicine composition is：The parts by weight of menthol 0.8~3, Su He
Fragrant 2~15 parts by weight, the parts by weight of styrax 1.5~10, the parts by weight of borneol 8~25, grass-leaved sweetflag 8~25
Parts by weight, the parts by weight of the red sage root 8~25, the parts by weight of Radix Angelicae Sinensis 3~20, the parts by weight of chrysanthemum indicum 3~20, pearl
Female 2~15 parts by weight, the parts by weight of borax 1.5~12, the parts by weight of cassia seed 1.5~12, the shell of seaear 1.5~10
Parts by weight, the parts by weight of calamine 1.5~10, the parts by weight of peppermint 1.5~10, the parts by weight of earthworm 1.5~10,
The parts by weight of radix glycyrrhizae 1.5~10, the parts by weight of Rui Ren 1.5~7；
It is further preferred that the bulk drug composition of the Chinese medicine composition is：The parts by weight of menthol 1~2.2,
The parts by weight of storax 3~12, the parts by weight of styrax 2~8, the parts by weight of borneol 10~22, grass-leaved sweetflag 10~22
Parts by weight, the parts by weight of the red sage root 10~22, the parts by weight of Radix Angelicae Sinensis 5~18, the parts by weight of chrysanthemum indicum 5~18, treasure
The parts by weight of pearl oyster 3~12, the parts by weight of borax 2~10, the parts by weight of cassia seed 2~10, the weight of the shell of seaear 2~8
Measure part, the parts by weight of calamine 2~8, the parts by weight of peppermint 2~8, the parts by weight of earthworm 2~8, radix glycyrrhizae 2~8
Parts by weight, the parts by weight of Rui Ren 1.8~6；
It is further preferred that the bulk drug composition of the Chinese medicine composition is：The weight of menthol 1.3~1.8
Part, the parts by weight of storax 5~10, the parts by weight of styrax 3~7, the parts by weight of borneol 12~18, grass-leaved sweetflag
12~18 parts by weight, the parts by weight of the red sage root 12~18, the parts by weight of Radix Angelicae Sinensis 7~14, the weight of chrysanthemum indicum 7~14
Part, the parts by weight of mother-of-pearl 5~10, the parts by weight of borax 3~9, the parts by weight of cassia seed 3~9, the shell of seaear 3~7
Parts by weight, the parts by weight of calamine 3~7, the parts by weight of peppermint 3~7, the parts by weight of earthworm 3~7, radix glycyrrhizae 3~7
Parts by weight, the parts by weight of Rui Ren 2~5；
Still more preferably, the bulk drug composition of the Chinese medicine composition is：The parts by weight of menthol 1.5,
The parts by weight of storax 8, the parts by weight of styrax 5, the parts by weight of borneol 15, the parts by weight of grass-leaved sweetflag 15,
The parts by weight of the red sage root 15, the parts by weight of Radix Angelicae Sinensis 10, the parts by weight of chrysanthemum indicum 10, the parts by weight of mother-of-pearl 8, boron
The parts by weight of sand 6, the parts by weight of cassia seed 6, the parts by weight of the shell of seaear 5, the parts by weight of calamine 5, peppermint 5
Parts by weight, the parts by weight of earthworm 5, the parts by weight of radix glycyrrhizae 5, the parts by weight of Rui Ren 3；
Or, the parts by weight of menthol 1.6, the parts by weight of storax 6, the parts by weight of styrax 6, borneol 13
Parts by weight, the parts by weight of grass-leaved sweetflag 16, the parts by weight of the red sage root 13, the parts by weight of Radix Angelicae Sinensis 13, the weight of chrysanthemum indicum 8
Measure part, the parts by weight of mother-of-pearl 9, the parts by weight of borax 4, the parts by weight of cassia seed 8, the weight of the shell of seaear 4
Part, the parts by weight of calamine 6, the parts by weight of peppermint 4, the parts by weight of earthworm 6, the parts by weight of radix glycyrrhizae 4, Rui
The parts by weight of benevolence 4；
Or, the parts by weight of menthol 1.4, the parts by weight of storax 9, the parts by weight of styrax 4, borneol 16
Parts by weight, the parts by weight of grass-leaved sweetflag 13, the parts by weight of the red sage root 16, the parts by weight of Radix Angelicae Sinensis 8, the weight of chrysanthemum indicum 12
Measure part, the parts by weight of mother-of-pearl 6, the parts by weight of borax 8, the parts by weight of cassia seed 4, the weight of the shell of seaear 6
Part, the parts by weight of calamine 4, the parts by weight of peppermint 6, the parts by weight of earthworm 4, the parts by weight of radix glycyrrhizae 6, Rui
The parts by weight of benevolence 2.5.
In some embodiments, the grass-leaved sweetflag in the bulk drug, the red sage root, Radix Angelicae Sinensis, chrysanthemum indicum, certainly
Pine torch, radix glycyrrhizae, Rui Ren, can also extract or active components in addition to being fed intake in the form of crude drug
Form is fed intake, such as Flos Chrysanthemi Indici extract, Salvia root P.E, and the extract or active component are
Each crude drug extracts according to a conventional method to be prepared, and the general extraction methods include decocting extraction, ultrasound
Extraction, seepage pressure effects, Soakage extraction, refluxing extraction, water extract-alcohol precipitation etc., Extraction solvent include water or
40~80% ethanol solutions.
In some embodiments, routinely external preparation is made in preparation process to the Chinese medicine composition；Institute
Stating external preparation includes liquid preparation, ophthalmically acceptable semisolid preparation, ophthalmically acceptable solid pharmaceutical preparation；It is further described
External preparation include be easy to ultrasonic atomizatio be administered preparation (liquid formulation or solid formulation), ocular inserts,
Gel for eye, Eye ointments, ophthalmically acceptable cream, ophthalmically acceptable liposome, ophthalmically acceptable microparticle formulation, stick preparation
Deng.
To enable formulation of the present invention to realize, need to be added when preparing these formulations pharmaceutically acceptable
Additive, such as buffer, isotonic agent, preservative, cosolvent, pH adjusting agent, tackifier, chelating
Agent etc..In above-mentioned additive, PB, borate buffer, lemon can be used as buffer
Lemon hydrochlorate buffer, tartarate buffer, acetate buffer, amino acid etc.；As isotonic agent example
Such as D-sorbite, glucose, the polyalcohol such as mannitol carbohydrate, glycerine, polyethylene glycol, propane diols
Salts such as class, sodium chloride etc.；It can use benzalkonium chloride, benzethonium chloride, glucose pickling must as preservative
Thailand, methyl p-hydroxybenzoate, thiomersalate, methaform etc.；As cosolvent such as ring
The surfaces such as the water soluble polymer such as dextrin class and its derivative, polyvinylpyrrolidone, polyoxyethylene sorbitan monoleate
Activating agent etc.；As tackifier such as hydroxyethyl cellulose, hydroxypropyl cellulose, methylcellulose, hydroxyl
Propyl methocel, carboxymethyl cellulose and its salt etc.；As chelating agent such as edetate sodium, citric acid
Sodium, condensed phosphoric acid sodium etc..
Embodiment
Embodiment 1
Menthol 1.5g, storax 8g, styrax 5g, borneol 15g, grass-leaved sweetflag 15g, red sage root 15g,
Radix Angelicae Sinensis 10g, chrysanthemum indicum 10g, mother-of-pearl 8g, borax 6g, cassia seed 6g, shell of seaear 5g, stove are sweet
Stone 5g, peppermint 5g, earthworm 5g, radix glycyrrhizae 5g, Rui Ren 3g；
Preparation method：After each bulk drug is crushed, it is well mixed, is packaged in made of chemical fabric in cyclic bags.
Application method：The Chinese medicine composition health care ring is externally applied to around eye socket (can be with CN
" double mists regard medicine Vacuum Pressure Swing instrument for eye disease " disclosed in 2339193Y utility model patents is common
Use, the Chinese medicine composition health care ring is put into " double mists regard medicine Vacuum Pressure Swing instrument for eye disease " picture frame
It is interior), patient closes eyes, Chinese medicine composition health care ring is worn in eye, retains more than 20 minutes.
Embodiment 2
Menthol 1.6g, storax 6g, styrax 6g, borneol 13g, grass-leaved sweetflag 16g, red sage root 13g,
Radix Angelicae Sinensis 13g, chrysanthemum indicum 8g, mother-of-pearl 9g, borax 4g, cassia seed 8g, shell of seaear 4g, calamine
6g, peppermint 4g, earthworm 6g, radix glycyrrhizae 4g, Rui Ren 4g；
Preparation method：After each bulk drug is crushed, it is well mixed, is packaged in made of chemical fabric in cyclic bags.
Application method：With embodiment 1.
Embodiment 3
Menthol 1.4g, storax 9g, styrax 4g, borneol 16g, grass-leaved sweetflag 13g, red sage root 16g,
Radix Angelicae Sinensis 8g, chrysanthemum indicum 12g, mother-of-pearl 6g, borax 8g, cassia seed 4g, shell of seaear 6g, calamine
4g, peppermint 6g, earthworm 4g, radix glycyrrhizae 6g, Rui Ren 2.5g；
Preparation method：After each bulk drug is crushed, it is well mixed, is packaged in made of chemical fabric in cyclic bags.
Application method：With embodiment 1.
Embodiment 4
Menthol 1.3g, storax 10g, styrax 3g, borneol 18g, grass-leaved sweetflag 12g, red sage root 18g,
Radix Angelicae Sinensis 7g, chrysanthemum indicum 14g, mother-of-pearl 5g, borax 9g, cassia seed 3g, shell of seaear 7g, calamine
3g, peppermint 7g, earthworm 3g, radix glycyrrhizae 7g, Rui Ren 2g；
Preparation method：Grass-leaved sweetflag, the red sage root, Radix Angelicae Sinensis, chrysanthemum indicum, cassia seed, radix glycyrrhizae, Rui Ren is taken to add decocting
Boil, filter, merge extract solution, be dried under reduced pressure to obtain extract medicinal extract, it is standby；Mixed with other raw materials
Crush, be packaged in made of chemical fabric in cyclic bags after even.
Application method：With embodiment 1.
Embodiment 5
Menthol 1.8g, storax 5g, styrax 7g, borneol 12g, grass-leaved sweetflag 18g, red sage root 12g,
Radix Angelicae Sinensis 14g, chrysanthemum indicum 7g, mother-of-pearl 10g, borax 3g, cassia seed 9g, shell of seaear 3g, stove are sweet
Stone 7g, peppermint 3g, earthworm 7g, radix glycyrrhizae 3g, Rui Ren 5g；
Preparation method：Grass-leaved sweetflag, the red sage root, Radix Angelicae Sinensis, chrysanthemum indicum, cassia seed, radix glycyrrhizae, Rui Ren is taken to add 50%
Alcohol reflux extracts, and merges extract solution, filtration, filtrate concentration, 15min is centrifuged with 3000r/min,
Supernatant is taken, is concentrated, is dried, is crushed after being mixed with other raw materials, is packaged in ring made of chemical fabric
In shape bag.
Application method：With embodiment 1.
Embodiment 6
Menthol 2.2g, storax 3g, styrax 8g, borneol 10g, grass-leaved sweetflag 22g, red sage root 10g,
Radix Angelicae Sinensis 18g, chrysanthemum indicum 5g, mother-of-pearl 12g, borax 2g, cassia seed 10g, shell of seaear 2g, stove are sweet
Stone 8g, peppermint 2g, earthworm 8g, radix glycyrrhizae 2g, Rui Ren 6g；
Preparation method：Grass-leaved sweetflag, the red sage root, Radix Angelicae Sinensis, chrysanthemum indicum, cassia seed, radix glycyrrhizae, Rui Ren is taken to add 60% second
Alcohol reflux extracts, and filtration, merges extract solution, is dried under reduced pressure to obtain extract medicinal extract, is mixed with other raw materials
After crush, be packaged in made of chemical fabric in cyclic bags.
Application method：With embodiment 1.
Embodiment 7
Menthol 1g, storax 12g, styrax 2g, borneol 22g, grass-leaved sweetflag 10g, red sage root 22g,
Radix Angelicae Sinensis 5g, chrysanthemum indicum 18g, mother-of-pearl 3g, borax 10g, cassia seed 2g, shell of seaear 8g, stove are sweet
Stone 2g, peppermint 8g, earthworm 2g, radix glycyrrhizae 8g, Rui Ren 1.8g；
Preparation method：Grass-leaved sweetflag, the red sage root, Radix Angelicae Sinensis, chrysanthemum indicum, cassia seed, radix glycyrrhizae, Rui Ren is taken to add water to cook,
Filtration, merge extract solution, be dried under reduced pressure to obtain extract medicinal extract, mixed with other raw materials, add normal
Externally used paste is made in rule auxiliary material.
Embodiment 8
Menthol 3g, storax 2g, styrax 10g, borneol 8g, grass-leaved sweetflag 25g, red sage root 8g,
Radix Angelicae Sinensis 20g, chrysanthemum indicum 3g, mother-of-pearl 15g, borax 1.5g, cassia seed 12g, shell of seaear 1.5g,
Calamine 10g, peppermint 1.5g, earthworm 10g, radix glycyrrhizae 1.5g, Rui Ren 7g；
Preparation method：Grass-leaved sweetflag, the red sage root, Radix Angelicae Sinensis, chrysanthemum indicum, cassia seed, radix glycyrrhizae, Rui Ren is taken to add water to cook,
Filtration, merge extract solution, be dried under reduced pressure to obtain extract medicinal extract, mixed with other raw materials, add normal
External use plaster is made in rule auxiliary material.
Embodiment 9
Menthol 0.8g, storax 15g, styrax 1.5g, borneol 25g, grass-leaved sweetflag 8g, red sage root 25g,
Radix Angelicae Sinensis 3g, chrysanthemum indicum 20g, mother-of-pearl 2g, borax 12g, cassia seed 1.5g, shell of seaear 10g, stove
Sweet stone 1.5g, peppermint 10g, earthworm 1.5g, radix glycyrrhizae 10g, Rui Ren 1.5g；Preparation method and application method are same
Embodiment 1.
Embodiment 10
Menthol 0.5g, storax 10g, styrax 1g, borneol 15g, grass-leaved sweetflag 6g, red sage root 16g,
Radix Angelicae Sinensis 2.5g, chrysanthemum indicum 25g, mother-of-pearl 2g, borax 15g, cassia seed 1g, shell of seaear 12g, stove
Sweet stone 1g, peppermint 12g, earthworm 1g, radix glycyrrhizae 10g, Rui Ren 1g；Preparation method and the same embodiment of application method
1。
Embodiment 11
Menthol 4g, storax 2g, styrax 12g, borneol 6g, grass-leaved sweetflag 30g, red sage root 6g,
Radix Angelicae Sinensis 25g, chrysanthemum indicum 2.5g, mother-of-pearl 20g, borax 1g, cassia seed 15g, shell of seaear 1g, stove
Sweet stone 12g, peppermint 1g, earthworm 12g, radix glycyrrhizae 1g, Rui Ren 10g；Preparation method and application method are the same as implementation
Example 1.
Embodiment 12
Menthol 1.5g, storax 8g, styrax 5g, borneol 15g, Rhizoma Acori Graminei extract 15g, pellet
Conopsea extraction 15g, angelica extract 10g, Flos Chrysanthemi Indici extract 10g, mother-of-pearl 8g, borax 6g,
Cassia seed extract 6g, shell of seaear 5g, calamine 5g, peppermint 5g, earthworm 5g, licorice
5g, Rui Ren extract 3g；
After each bulk drug is crushed, it is well mixed, is packaged in made of chemical fabric in cyclic bags.
Wherein, each extract is respectively the water extract of each bulk drug.
Embodiment 13
Menthol 1.6g, storax 6g, styrax 6g, borneol 13g, Rhizoma Acori Graminei extract 16g, pellet
Conopsea extraction 13g, angelica extract 13g, Flos Chrysanthemi Indici extract 8g, mother-of-pearl 9g, borax 4g, certainly
Pine torch extract 8g, shell of seaear 4g, calamine 6g, peppermint 4g, earthworm 6g, licorice 4g,
Rui Ren extracts 4g；
After each bulk drug is crushed, it is well mixed, is packaged in made of chemical fabric in cyclic bags；
Wherein, each extract is respectively 70% ethanol extract of each bulk drug.
Embodiment 14
Menthol 1.4g, storax 9g, styrax 4g, borneol 16g, Rhizoma Acori Graminei extract 13g, pellet
Conopsea extraction 16g, angelica extract 8g, Flos Chrysanthemi Indici extract 12g, mother-of-pearl 6g, borax 8g, certainly
Pine torch extract 4g, shell of seaear 6g, calamine 4g, peppermint 6g, earthworm 4g, licorice 6g,
Rui Ren extracts 2.5g；
After each bulk drug is crushed, it is well mixed, is packaged in made of chemical fabric in cyclic bags；
Wherein, each extract is respectively that to add ethanol to alcohol content after the extraction of each bulk drug water be 50%
Take the extract obtained after ethanol filtering and concentrating.
Embodiment 15
Menthol 1.3g, storax 10g, styrax 3g, borneol 18g, Rhizoma Acori Graminei extract 12g,
Salvia root P.E 18g, angelica extract 7g, Flos Chrysanthemi Indici extract 14g, mother-of-pearl 5g, borax 9g,
Cassia seed extract 3g, shell of seaear 7g, calamine 3g, peppermint 7g, earthworm 3g, licorice
7g, Rui Ren extract 2g；
Each extract is respectively the water extract of each bulk drug；
After each bulk drug is crushed, it is well mixed, is packaged in made of chemical fabric in cyclic bags.
Embodiment 16
Menthol 1.8g, storax 5g, styrax 7g, borneol 12g, Rhizoma Acori Graminei extract 18g, pellet
Conopsea extraction 12g, angelica extract 14g, Flos Chrysanthemi Indici extract 7g, mother-of-pearl 10g, borax 3g,
Cassia seed extract 9g, shell of seaear 3g, calamine 7g, peppermint 3g, earthworm 7g, licorice
3g, Rui Ren extract 5g；
Wherein, each extract is respectively 90% ethanol extract of each bulk drug.
After each bulk drug is crushed, it is well mixed, is packaged in made of chemical fabric in cyclic bags.
Comparative examples
Borneol 15g, grass-leaved sweetflag 15g, red sage root 15g, Radix Angelicae Sinensis 10g, chrysanthemum indicum 10g, mother-of-pearl 8g,
Shell of seaear 8g, peppermint 5g, earthworm 5g, radix glycyrrhizae 5g, Rui Ren 8g, Ligusticum wallichii 8g, illiteracy flower 12g, radix scutellariae
6g, golden cypress 6g, fruit of Chinese wolfberry 6g, safflower 6g；
Preparation method and application method are the same as embodiment 1.
Effect experimental examples 1
72 people at age 18-65 year are selected, clinical general information is shown in Table 1, is stranded with vision disorder, eye
Tired, photophobia, ache, shed tears, entering in the crowd of visual fatigue symptom such as foreign body sensation, the dry and astringent, ophthalmospasm of eye
Row continues to use the Chinese traditional medicine composition composition powders in 30 days.Because the 18-65 year Gao Fa Nian Ling section for visual fatigue,
There is relatively good compliance.
1 72 visual fatigue patient clinical general information of table
72 patient's stochastic averaginas are divided into 2 groups, a group echo is experimental group (using embodiment 1
Prescription), another group echo is control group (using placebo), experimental group and control group patient clinical one
As data be shown in Table 2.
The experimental group of table 2 and control group visual fatigue patient clinical general information
The Chinese medicine composition health care ring is worn in eye by the application method of embodiment 1, is retained more than 20 minutes,
3 times a day, 30 days as one therapeutic course.Testing site is recorded respectively：One day first before treatment, treat
The improvement situation that 15 (± 1) days, 30 (± 2) days for the treatment of observe the symptoms with sign respectively, and result is remembered
Record, it is efficient with healing+effective+effective case load statistics, judge clinical improvementses result.
Improve the evaluation criterion for alleviating visual fatigue：
Recovery from illness：Symptom disappears or basic disappearance, symptom integral reduce more than 90%；
It is effective：Symptom is obviously improved, and symptom integral reduces 60%-89%；
Effectively：Symptom take a favorable turn, and symptom integral reduces 30%-59%；
It is invalid：Symptom is not improved, even aggravating, symptom integral reduces 30%.
With recovery from illness+effective+effective case load statistics total effective rate.
Evaluation method：
The improvement of symptom is alleviated and passes through clinical test, observation, photophobia, aches, sheds tears, ophthalmospasm etc.
4 indexs, each treatment is made it is light, in, the quantitative criteria of weight, carry out statistical evaluation, Specific amounts
Change standard is shown in " visual fatigue symptom weight hierarchical table " (table 3).
The visual fatigue symptom weight hierarchical table of table 3
| 0 point | 2 points (light) | 4 points (in) | 6 points of (weight)s | |
| Photophobia | Nothing | Photophobia eye to be narrowed | Photophobia narrows eye | Photophobia dare not open eyes |
| Ache | Nothing | Ache indistinctly | Persistently ache | Ache unbearably |
| Shed tears | Nothing | Shed tears less | Shed tears obvious | Shed tears more than |
| Ophthalmospasm | Nothing | Occasionally there is eyelid bounce | Continue eyelid bounce | Serious bounce can not open |
Calculation formula：【Integrated before (being integrated before treatment after integration-treatment)/treatment】* 100%
Statistical processing methods and evaluation method
1st, statistical method
Analyzed using EXCEL.Descriptive statistical analysis, technical indicator are described with frequency table, percentage；
Measuring index is described with mean, standard deviation.
Before and after treatment and experimental group and control group comparative analysis, quantitative data meet normal distribution pairing
T is examined, and does not meet normal distribution Wilcoxon signed rank sum tests, using P≤0.05 as there is statistics
Learn meaning.
2nd, evaluation method
Observation photophobia, ache, shed tears, 4 indexs such as ophthalmospasm, according to symptom it is light, in, weight
Change standard and observe and record result, carry out statistical appraisal.
Clinical test results
1 efficacy evaluation result, is shown in Table 4
The function of table 4 improves efficacy evaluation analysis
| Group | Number of cases | Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate |
| Experimental group | 36 | 3(8.33) | 27(75) | 6(16.67) | 0(0) | 100% |
| Control group | 36 | 0(0) | 3(8.33) | 13(36.11) | 20(55.56) | 44.44% |
2 experimental groups and the pretherapy and post-treatment t check analyses of control group, the results are shown in Table 5.
The experimental group of table 5 and the analysis of control group total mark
From result above it can be found that the experimental group and control group that are randomly assigned each symptom before being treated
There was no significant difference；Experimental group and there is significant difference to a group photograph symptom integral after the treatment；Prove this hair
The significant effect that bright Chinese prescription alleviates 4 kinds of visual fatigue symptoms is better than placebo, has to kopiopia aobvious
The therapeutic effect of work.
The t check analyses of 3 experimental groups and each symptom of control group, the results are shown in Table 6.
The t check analyses of the experimental group of table 6 and each symptom of control group
The distribution situation of experimental group and each symptom of control group is divided and ruled before treating, disappeared after treatment with each symptom
Rate carries out t check analyses, the results are shown in Table 7：
The distribution situation t check analyses of the experimental group of table 7 and each symptom of control group
| T Stat | P | |
| Before treatment | 0 | 1 |
| After treatment | -5.478 | 0.0021 |
| Disappearance rate | 17.223 | 0.0009 |
From result above it can be found that the experimental group and control group that are randomly assigned each symptom before being treated
There was no significant difference；(including disappearance rate) experimental group and there is significant difference to a group photograph after the treatment；Card
The significant effect that bright prescription alleviates 4 kinds of visual fatigue symptoms is better than placebo.
3 symptom analysis, the results are shown in Table 8：
Each symptom t check analyses after the experimental group of table 8 and control group treatment
| Symptom | T Stat | P |
| Ophthalmospasm | -1.269 | 0.021 |
| Shed tears | -1.332 | 0.019 |
| Photophobia | -1.160 | 0.025 |
| Ache | -1.834 | 0.031 |
Experimental group and control group are subjected to t check analyses to each symptom after treatment respectively, are as a result eye convulsion
Contraction, shed tears, photophobia, four indexs such as ache have significant difference；Prove prescription of the present invention for this
The remission effect of four kinds of visual fatigues is superior to placebo.
Effect experimental examples 2
60 people at age 18-65 year are selected, clinical general information is shown in Table 9, is stranded with vision disorder, eye
Tired, photophobia, ache, shed tears, entering in the crowd of visual fatigue symptom such as foreign body sensation, the dry and astringent, ophthalmospasm of eye
Row continues to use the Chinese medicine composition in 30 days.Because the 18-65 year Gao Fa Nian Ling section for visual fatigue, have
Relatively good compliance.
9 60 visual fatigue patient clinical general information of table
60 patient's stochastic averaginas are divided into 2 groups, a group echo is experimental group (using embodiment 1
Prescription), another group echo is the control group prescription of comparative examples (use), experimental group and control group
Patient clinical general information is shown in Table 10.
10 experimental group of table, 30 visual fatigue patient clinical general information
The prescription of embodiment 1 and comparative examples is prepared into health care ring and worn by the application method of embodiment 1
In eye, retain more than 20 minutes, 3 times a day, 30 days as one therapeutic course.Record and test respectively
Point：One day first before treatment, 15 (± 1) days for the treatment of, treat 30 (± 2) days and observe the symptoms respectively and body
The improvement situation of sign, and result is recorded, it is efficient with healing+effective+effective case load statistics, sentence
Determine clinical improvementses result.
Improve the evaluation criterion for alleviating visual fatigue, evaluation method, calculation formula, statistical processing methods and comment
Valency method is the same as effect experimental examples 1.
Clinical test results
1 efficacy evaluation result, is shown in Table 11
The function of table 11 improves efficacy evaluation analysis
| Group | Number of cases | Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate |
| Experimental group | 30 | 2(6.67) | 25(83.33) | 3(10.00) | 0(0) | 100% |
| Control group | 30 | 1(3.33) | 22(73.33) | 7(23.34) | 0(0) | 100% |
2 experimental groups and the pretherapy and post-treatment t check analyses of control group, the results are shown in Table 12.
The experimental group of table 12 and the analysis of control group total mark
Analyzed compared with pre-treatment using paired t-test after experimental group and control group treatment, p value is respectively less than
0.05, show that two kinds of prescriptions are effective for more than treatment four kinds of symptoms.
The t check analyses of 2 experimental groups and each symptom of control group, the results are shown in Table 13.
The t check analyses of the experimental group of table 13 and each symptom of control group
The distribution situation of experimental group and each symptom of control group is divided and ruled before treating, disappeared after treatment with each symptom
Rate carries out t check analyses, the results are shown in Table 14：
The distribution situation t check analyses of the experimental group of table 14 and each symptom of control group
| T Stat | P | |
| Before treatment | 0 | 1 |
| After treatment | -8.467 | 0.0033 |
| Disappearance rate | 14.216 | 0.0007 |
From result above it can be found that the experimental group and control group that are randomly assigned each symptom before being treated
There was no significant difference；(including disappearance rate) experimental group and there is significant difference to a group photograph after the treatment；Card
Bright prescription of the present invention alleviates the significant effect of 4 kinds of visual fatigue symptoms better than control prescription.
3 symptom analysis, the results are shown in Table 15：
Each symptom t check analyses after the experimental group of table 15 and control group treatment
| Symptom | T Stat | P |
| Ophthalmospasm | -2.124 | 0.042 |
| Shed tears | -2.386 | 0.021 |
| Photophobia | -2.283 | 0.030 |
| Ache | -2.189 | 0.037 |
Experimental group and control group are subjected to t check analyses to each symptom after treatment respectively, are as a result eye convulsion
Contraction, shed tears, photophobia, four indexs such as ache have significant difference；Prove prescription of the present invention for this
The remission effect of four kinds of visual fatigues is superior to compare prescription.
Claims (10)
1. a kind of Chinese medicine composition of external application protection eyesight, it is characterised in that the bulk drug of the Chinese medicine composition includes：Menthol, storax, styrax, borneol, grass-leaved sweetflag, the red sage root, Radix Angelicae Sinensis, chrysanthemum indicum, mother-of-pearl, borax, cassia seed, the shell of seaear, calamine, peppermint, earthworm, radix glycyrrhizae, Rui Ren.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that the bulk drug of the Chinese medicine composition, which forms, is：The parts by weight of menthol 0.5~4, the parts by weight of storax 2~10, the parts by weight of styrax 1~12, the parts by weight of borneol 6~30, the parts by weight of grass-leaved sweetflag 6~30, the parts by weight of the red sage root 6~30, the parts by weight of Radix Angelicae Sinensis 2.5~25, the parts by weight of chrysanthemum indicum 2.5~25, the parts by weight of mother-of-pearl 2~20, the parts by weight of borax 1~15, the parts by weight of cassia seed 1~15, the parts by weight of the shell of seaear 1~12, the parts by weight of calamine 1~12, the parts by weight of peppermint 1~12, the parts by weight of earthworm 1~12, the parts by weight of radix glycyrrhizae 1~12, the parts by weight of Rui Ren 1~10.
3. Chinese medicine composition as claimed in claim 1, it is characterised in that the bulk drug of the Chinese medicine composition, which forms, is：The parts by weight of menthol 0.8~3, the parts by weight of storax 2~15, the parts by weight of styrax 1.5~10, the parts by weight of borneol 8~25, the parts by weight of grass-leaved sweetflag 8~25, the parts by weight of the red sage root 8~25, the parts by weight of Radix Angelicae Sinensis 3~20, the parts by weight of chrysanthemum indicum 3~20, the parts by weight of mother-of-pearl 2~15, the parts by weight of borax 1.5~12, the parts by weight of cassia seed 1.5~12, the parts by weight of the shell of seaear 1.5~10, the parts by weight of calamine 1.5~10, the parts by weight of peppermint 1.5~10, the parts by weight of earthworm 1.5~10, the parts by weight of radix glycyrrhizae 1.5~10, the parts by weight of Rui Ren 1.5~7.
4. Chinese medicine composition as claimed in claim 1, it is characterised in that the bulk drug of the Chinese medicine composition, which forms, is：The parts by weight of menthol 1~2.2, the parts by weight of storax 3~12, the parts by weight of styrax 2~8, the parts by weight of borneol 10~22, the parts by weight of grass-leaved sweetflag 10~22, the parts by weight of the red sage root 10~22, the parts by weight of Radix Angelicae Sinensis 5~18, the parts by weight of chrysanthemum indicum 5~18, the parts by weight of mother-of-pearl 3~12, the parts by weight of borax 2~10, the parts by weight of cassia seed 2~10, the parts by weight of the shell of seaear 2~8, the parts by weight of calamine 2~8, the parts by weight of peppermint 2~8, the parts by weight of earthworm 2~8, the parts by weight of radix glycyrrhizae 2~8, the parts by weight of Rui Ren 1.8~6.
5. Chinese medicine composition as claimed in claim 1, it is characterised in that the bulk drug of the Chinese medicine composition, which forms, is：The parts by weight of menthol 1.5, the parts by weight of storax 8, the parts by weight of styrax 5, the parts by weight of borneol 15, the parts by weight of grass-leaved sweetflag 15, the parts by weight of the red sage root 15, the parts by weight of Radix Angelicae Sinensis 10, the parts by weight of chrysanthemum indicum 10, the parts by weight of mother-of-pearl 8, the parts by weight of borax 6, the parts by weight of cassia seed 6, the parts by weight of the shell of seaear 5, the parts by weight of calamine 5, the parts by weight of peppermint 5, the parts by weight of earthworm 5, the parts by weight of radix glycyrrhizae 5, the parts by weight of Rui Ren 3；
Or, the parts by weight of menthol 1.6, the parts by weight of storax 6, the parts by weight of styrax 6, the parts by weight of borneol 13, the parts by weight of grass-leaved sweetflag 16, the parts by weight of the red sage root 13, the parts by weight of Radix Angelicae Sinensis 13, the parts by weight of chrysanthemum indicum 8, the parts by weight of mother-of-pearl 9, the parts by weight of borax 4, the parts by weight of cassia seed 8, the parts by weight of the shell of seaear 4, the parts by weight of calamine 6, the parts by weight of peppermint 4, the parts by weight of earthworm 6, the parts by weight of radix glycyrrhizae 4, the parts by weight of Rui Ren 4；
Or, the parts by weight of menthol 1.4, the parts by weight of storax 9, the parts by weight of styrax 4, the parts by weight of borneol 16, the parts by weight of grass-leaved sweetflag 13, the parts by weight of the red sage root 16, the parts by weight of Radix Angelicae Sinensis 8, the parts by weight of chrysanthemum indicum 12, the parts by weight of mother-of-pearl 6, the parts by weight of borax 8, the parts by weight of cassia seed 4, the parts by weight of the shell of seaear 6, the parts by weight of calamine 4, the parts by weight of peppermint 6, the parts by weight of earthworm 4, the parts by weight of radix glycyrrhizae 6, the parts by weight of Rui Ren 2.5.
6. the Chinese medicine composition as described in any one of Claims 1 to 5, characterized in that, routinely preparation process is prepared into the preparation of ultrasonic atomizatio administration, ocular inserts, gel for eye, Eye ointments, ophthalmically acceptable cream, ophthalmically acceptable liposome, ophthalmically acceptable microparticle formulation or sticks preparation the Chinese medicine composition.
7. the Chinese medicine composition as described in any one of Claims 1 to 5, it is characterised in that grass-leaved sweetflag, the red sage root, Radix Angelicae Sinensis, chrysanthemum indicum, cassia seed, radix glycyrrhizae, Rui Ren in the bulk drug are fed intake in the form of crude drug or fed intake in the form of extract or active component.
8. Chinese medicine composition as claimed in claim 7, it is characterized in that, the extract or active component are extracted and are prepared according to a conventional method for each crude drug, the general extraction methods, which include decoction extraction, ultrasonic extraction, seepage pressure effects, Soakage extraction, refluxing extraction or water extract-alcohol precipitation, Extraction solvent, includes water or 40~80% ethanol solutions.
9. the Chinese medicine composition as described in any one of Claims 1 to 5 is preparing the application in alleviating visual fatigue medicine.
10. application as claimed in claim 9, it is characterised in that the Chinese medicine composition prepare alleviate ophthalmospasm caused by visual fatigue, shed tears, photophobia, ache symptom medicine in application.
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