CN101821407B - 神经退行性疾病中的cd44剪接变体 - Google Patents

神经退行性疾病中的cd44剪接变体 Download PDF

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CN101821407B
CN101821407B CN2008801049431A CN200880104943A CN101821407B CN 101821407 B CN101821407 B CN 101821407B CN 2008801049431 A CN2008801049431 A CN 2008801049431A CN 200880104943 A CN200880104943 A CN 200880104943A CN 101821407 B CN101821407 B CN 101821407B
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disease
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CN101821407A (zh
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埃尔赫南·皮纳
莫什·劳顿
纳瓦·齐萨佩尔
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Neurim Pharmaceuticals 1991 Ltd
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette

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  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
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  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
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CN2008801049431A 2007-07-10 2008-07-10 神经退行性疾病中的cd44剪接变体 Active CN101821407B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92970607P 2007-07-10 2007-07-10
US60/929,706 2007-07-10
PCT/IB2008/052786 WO2009007934A2 (en) 2007-07-10 2008-07-10 Cd44 splice variants in neurodegenerative diseases

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CN101821407A CN101821407A (zh) 2010-09-01
CN101821407B true CN101821407B (zh) 2013-09-18

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US (2) US9018180B2 (enExample)
EP (1) EP2167692B1 (enExample)
JP (1) JP2010532989A (enExample)
KR (1) KR20100044793A (enExample)
CN (1) CN101821407B (enExample)
AU (1) AU2008273713B2 (enExample)
BR (1) BRPI0814685A2 (enExample)
CA (1) CA2692861A1 (enExample)
EA (1) EA201070108A1 (enExample)
ES (1) ES2423182T3 (enExample)
IL (1) IL203130A (enExample)
MX (1) MX2010000236A (enExample)
NZ (1) NZ582390A (enExample)
WO (1) WO2009007934A2 (enExample)
ZA (1) ZA201000083B (enExample)

Families Citing this family (10)

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JP5511680B2 (ja) 2007-12-19 2014-06-04 キャンサー・リサーチ・テクノロジー・リミテッド ピリド［２，３−ｂ］ピラジン−８−置換化合物及びその使用
NZ601085A (en) 2010-02-01 2015-04-24 Cancer Rec Tech Ltd 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
BR112013024323A2 (pt) * 2011-03-24 2017-06-13 Neurim Pharmaceuticals ( 1991 ) Ltd peptídeos neuroprotetores
US9399779B2 (en) * 2011-06-08 2016-07-26 The Corporation Of Mercer University Alternative splicing constructs and methods of use
CN104277092B (zh) * 2013-07-12 2017-10-31 天津医科大学 用于预防和/或治疗老年性痴呆的β片层阻断肽
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
US10400009B2 (en) 2014-09-04 2019-09-03 Tianjin Medical University β-sheet breaker peptide used for preventing and/or treating alzheimer's disease
CN107815438A (zh) * 2017-08-02 2018-03-20 清华大学 重组细胞、筛选l型钙通道调节剂的方法、试剂在制备药物中的用途和药物组合物
CN117377777A (zh) * 2021-05-11 2024-01-09 纽瑞姆制药（1991）有限公司 诊断和治疗具有2号染色体2:107,510,000-107,540,000基因座单核苷酸多态性受试者的方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2000075312A1 (en) * 1999-06-08 2000-12-14 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Cd44 splice variant associated with rheumatoid arthritis

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US5990299A (en) 1995-08-14 1999-11-23 Icn Pharmaceuticals, Inc. Control of CD44 gene expression for therapeutic use
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US6150162A (en) 1998-12-17 2000-11-21 Isis Pharmaceuticals Inc. Antisense modulation of CD44 expression
EP1309726B2 (en) 2000-03-30 2018-10-03 Whitehead Institute For Biomedical Research Rna sequence-specific mediators of rna interference
US20040259247A1 (en) * 2000-12-01 2004-12-23 Thomas Tuschl Rna interference mediating small rna molecules
JP2004537282A (ja) 2001-03-23 2004-12-16 エージーワイ セラピューティクス 脳腫瘍の処置及び可視化における生体分子標的の使用法
EP1386004A4 (en) * 2001-04-05 2005-02-16 Ribozyme Pharm Inc MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID
EP1401472A4 (en) 2001-05-25 2005-04-06 Univ Jefferson ALTERNATIVE SPLICE FORMS OF PROTEINS AS A BASIS FOR MULTIPLE THERAPEUTIC MODALITIES
US7833779B2 (en) * 2001-07-25 2010-11-16 Jivan Biologies Inc. Methods and systems for polynucleotide detection
WO2005030947A2 (en) 2003-09-30 2005-04-07 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of a sulfotransferase for neurodegenerative diseases
DE602006019582D1 (de) 2005-06-16 2011-02-24 Evotec Neurosciences Gmbh Adarb2 proteine als diagnostische und therapeutische targets für neurodegenerative erkrankungen

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2000075312A1 (en) * 1999-06-08 2000-12-14 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Cd44 splice variant associated with rheumatoid arthritis

Non-Patent Citations (1)

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Title
S O Suzuki 等.Differential expression of CD44 variants among meningioma subtypes.《Clinical Molecular Pathology》.1996,第49卷(第3期),M140-M146. *

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US9416166B2 (en) 2016-08-16
EP2167692A2 (en) 2010-03-31
NZ582390A (en) 2012-05-25
IL203130A (en) 2014-07-31
EA201070108A1 (ru) 2010-06-30
HK1145856A1 (en) 2011-05-06
US9018180B2 (en) 2015-04-28
CA2692861A1 (en) 2009-01-15
ES2423182T3 (es) 2013-09-18
JP2010532989A (ja) 2010-10-21
AU2008273713B2 (en) 2014-07-03
MX2010000236A (es) 2010-06-02
CN101821407A (zh) 2010-09-01
ZA201000083B (en) 2011-03-30
KR20100044793A (ko) 2010-04-30
WO2009007934A2 (en) 2009-01-15
EP2167692B1 (en) 2013-05-22
AU2008273713A1 (en) 2009-01-15
US20150266940A1 (en) 2015-09-24
WO2009007934A3 (en) 2009-05-07
US20110172286A1 (en) 2011-07-14
BRPI0814685A2 (pt) 2019-09-24

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