ES2423182T3 - Variantes de unión CD44 en las enfermedades neurodegenerativas - Google Patents
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- C07—ORGANIC CHEMISTRY
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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| US92970607P | 2007-07-10 | 2007-07-10 | |
| US929706P | 2007-07-10 | ||
| PCT/IB2008/052786 WO2009007934A2 (en) | 2007-07-10 | 2008-07-10 | Cd44 splice variants in neurodegenerative diseases |
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| ES2423182T3 true ES2423182T3 (es) | 2013-09-18 |
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| BRPI0821227A2 (pt) | 2007-12-19 | 2015-06-16 | Cancer Rec Tech Ltd | Composto, composição farmacêutica, método para preparar a mesma, uso de um composto, método para tratar uma doença ou distúrbio, para inibir função de raf e para inibir proliferação celular, inibir progressão do ciclo celular, promover apoptose, ou uma combinação de um ou mais dos mesmos |
| EP2531502B1 (en) | 2010-02-01 | 2014-04-02 | Cancer Research Technology Limited | 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy |
| JP5960793B2 (ja) | 2011-03-24 | 2016-08-02 | ニューリム ファーマシューティカルズ（１９９１）リミテッド | 神経保護ペプチド |
| US9399779B2 (en) * | 2011-06-08 | 2016-07-26 | The Corporation Of Mercer University | Alternative splicing constructs and methods of use |
| CN104277092B (zh) * | 2013-07-12 | 2017-10-31 | 天津医科大学 | 用于预防和/或治疗老年性痴呆的β片层阻断肽 |
| GB201320729D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| GB201320732D0 (en) | 2013-11-25 | 2014-01-08 | Cancer Rec Tech Ltd | Methods of chemical synthesis |
| US10400009B2 (en) | 2014-09-04 | 2019-09-03 | Tianjin Medical University | β-sheet breaker peptide used for preventing and/or treating alzheimer's disease |
| CN107815438A (zh) * | 2017-08-02 | 2018-03-20 | 清华大学 | 重组细胞、筛选l型钙通道调节剂的方法、试剂在制备药物中的用途和药物组合物 |
| MX2023013420A (es) | 2021-05-11 | 2023-12-06 | Neurim Pharmaceuticals 1991 Ltd | Metodo para diagnosticar y tratar sujetos que tienen polimorfismos de un solo nucleotido en el cromosoma 2, locus 2:107,510,000-107,540,000. |
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| US5990299A (en) * | 1995-08-14 | 1999-11-23 | Icn Pharmaceuticals, Inc. | Control of CD44 gene expression for therapeutic use |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| US6150162A (en) | 1998-12-17 | 2000-11-21 | Isis Pharmaceuticals Inc. | Antisense modulation of CD44 expression |
| IL133647A0 (en) * | 1999-06-08 | 2001-04-30 | Yissum Res Dev Co | Novel cd44 variant |
| US20070026394A1 (en) * | 2000-02-11 | 2007-02-01 | Lawrence Blatt | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies |
| EP1309726B2 (en) | 2000-03-30 | 2018-10-03 | Whitehead Institute For Biomedical Research | Rna sequence-specific mediators of rna interference |
| RU2322500C2 (ru) * | 2000-12-01 | 2008-04-20 | Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. | Малые молекулы рнк, опосредующие интерференцию рнк |
| CA2439630A1 (en) | 2001-03-23 | 2002-10-03 | Agy Therapeutics | Use of biomolecular targets in the treatment and visualization of brain tumors |
| CN1511040A (zh) | 2001-05-25 | 2004-07-07 | ����˹���ѷ��ѧ | 作为多种治疗模式基础的蛋白质的选择性剪接形式 |
| US7833779B2 (en) * | 2001-07-25 | 2010-11-16 | Jivan Biologies Inc. | Methods and systems for polynucleotide detection |
| EP1670943B1 (en) * | 2003-09-30 | 2013-11-13 | Evotec International GmbH | Diagnostic and therapeutic use of a sulfotransferase for alzheimer's disease |
| ATE495269T1 (de) * | 2005-06-16 | 2011-01-15 | Evotec Neurosciences Gmbh | Adarb2 proteine als diagnostische und therapeutische targets für neurodegenerative erkrankungen |
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| WO2009007934A3 (en) | 2009-05-07 |
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| US9416166B2 (en) | 2016-08-16 |
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| EP2167692A2 (en) | 2010-03-31 |
| KR20100044793A (ko) | 2010-04-30 |
| NZ582390A (en) | 2012-05-25 |
| JP2010532989A (ja) | 2010-10-21 |
| US20110172286A1 (en) | 2011-07-14 |
| CN101821407A (zh) | 2010-09-01 |
| AU2008273713A1 (en) | 2009-01-15 |
| CN101821407B (zh) | 2013-09-18 |
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