CN101820947A - 用电场治疗寄生物 - Google Patents

用电场治疗寄生物 Download PDF

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Publication number
CN101820947A
CN101820947A CN200880111479A CN200880111479A CN101820947A CN 101820947 A CN101820947 A CN 101820947A CN 200880111479 A CN200880111479 A CN 200880111479A CN 200880111479 A CN200880111479 A CN 200880111479A CN 101820947 A CN101820947 A CN 101820947A
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electric field
electrodes
field
insulated
cells
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CN200880111479A
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Chinese (zh)
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Y·帕尔蒂
M·吉拉第
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Novocure Ltd USA
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Novocure Ltd USA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Electrotherapy Devices (AREA)
  • Radiation-Therapy Devices (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
CN200880111479A 2007-08-14 2008-08-13 用电场治疗寄生物 Pending CN101820947A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95571907P 2007-08-14 2007-08-14
US60/955719 2007-08-14
PCT/IB2008/002134 WO2009022225A1 (en) 2007-08-14 2008-08-13 Treating parasites with electric fields

Publications (1)

Publication Number Publication Date
CN101820947A true CN101820947A (zh) 2010-09-01

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Family Applications (1)

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CN200880111479A Pending CN101820947A (zh) 2007-08-14 2008-08-13 用电场治疗寄生物

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US (1) US7890183B2 (https=)
EP (1) EP2183024B1 (https=)
JP (1) JP5485153B2 (https=)
CN (1) CN101820947A (https=)
CA (1) CA2696352C (https=)
DK (1) DK2183024T3 (https=)
ES (1) ES2739384T3 (https=)
PT (1) PT2183024T (https=)
WO (1) WO2009022225A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113908430A (zh) * 2018-08-23 2022-01-11 诺沃库勒有限责任公司 使用交变电场来提高血脑屏障的通透性
CN114269274A (zh) * 2020-07-16 2022-04-01 株式会社电界 基于吸收能量的电场癌治疗计划系统及方法

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8447395B2 (en) * 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US7890183B2 (en) 2000-02-17 2011-02-15 Novocure Ltd. Treating parasites with electric fields
US8175698B2 (en) * 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
JP5280600B2 (ja) 2000-02-17 2013-09-04 パルティ、ヨーラム 分裂中の細胞を破壊するための方法および装置
DE10260149A1 (de) * 2002-12-20 2004-07-01 BSH Bosch und Siemens Hausgeräte GmbH Vorrichtung zur Bestimmung des Leitwertes von Wäsche, Wäschetrockner und Verfahren zur Verhinderung von Schichtbildung auf Elektroden
CA2563817C (en) 2004-04-23 2018-07-10 Yoram Palti Treating a tumor or the like with electric fields at different frequencies
ES2344215T3 (es) * 2004-12-07 2010-08-20 Standen Ltd. Electrodos para aplicar un campo electrico in vivo durante un dilatado periodo de tiempo.
CN101321555B (zh) * 2005-10-03 2020-12-08 诺沃库勒有限责任公司 优化电场特征以增加电场在增殖细胞上的效果
US8019414B2 (en) * 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
WO2008063338A2 (en) * 2006-10-18 2008-05-29 Buckeye Pharmaceuticals, Llc Chemical compound delivery device and method
US8465533B2 (en) * 2007-03-06 2013-06-18 Novocure Limited Treating cancer using electromagnetic fields in combination with photodynamic therapy
US8992593B2 (en) * 2007-12-26 2015-03-31 Cook Medical Technologies Llc Apparatus and methods for deployment of a modular stent-graft system
US8684901B1 (en) 2010-11-22 2014-04-01 Jacob Zabara Electromagnetic radiation treatment for cancer and pathological genetic regulations
US9233257B1 (en) 2010-11-22 2016-01-12 Jacob Zabara Electromagnetic radiation treatment
US9031701B2 (en) 2011-02-15 2015-05-12 Hemosonics Llc Characterization of blood hemostasis and oxygen transport parameters
EP2522389A3 (en) * 2011-05-13 2014-08-27 Sergio Lara Pereira Monteiro Animal and plant cell electric stimulator with randomized spatial distribution of electrodes for both current injection and for electric field shaping
US9486625B2 (en) 2011-08-08 2016-11-08 Medamp Electronics, Llc Method for treating benign prostate hyperplasia
JP2014522714A (ja) 2011-08-08 2014-09-08 ルース，リチャード，ビー． 癌を処置する為の方法及び装置
DE102012015482A1 (de) * 2012-08-07 2014-02-13 Cinogy Gmbh Elektrodenanordnung für ein behindertes Plasma
DE102012025052A1 (de) * 2012-12-20 2014-06-26 Fresenius Medical Care Deutschland Gmbh Hämodiafiltrationsverfahren
US9655669B2 (en) 2013-05-06 2017-05-23 Novocure Limited Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US20190117963A1 (en) * 2014-07-25 2019-04-25 Loyalty Based Innovations, LLC Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields
US9726647B2 (en) 2015-03-17 2017-08-08 Hemosonics, Llc Determining mechanical properties via ultrasound-induced resonance
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
US20180001075A1 (en) 2016-06-30 2018-01-04 Novocure Limited Arrays for Longitudinal Delivery of TTFields to a Body
EP3546020B1 (en) 2016-11-24 2024-01-03 Public University Corporation Yokohama City University Cancer treatment apparatus
EP3571503B1 (en) 2017-01-19 2026-04-15 Novocure GmbH System for viewing cell cultures under a microscope whilst applying ttfields
US11364390B2 (en) * 2017-02-07 2022-06-21 Santi Tofani Apparatus for treating pathological cells
US12403306B2 (en) 2017-10-23 2025-09-02 Cardiac Pacemakers, Inc. Electric field shaping leads for treatment of cancer
US11338135B2 (en) 2017-10-23 2022-05-24 Cardiac Pacemakers, Inc. Medical devices for cancer therapy with electric field shaping elements
US10953209B2 (en) 2018-03-28 2021-03-23 Board Of Regents Of The University Of Texas System Treating tumors using TTFields combined with a PARP inhibitor
US11298422B2 (en) 2018-04-09 2022-04-12 Novocure Gmbh Treating tumors with TTFields and an aurora kinase inhibitor
WO2019197999A1 (en) 2018-04-10 2019-10-17 Zeev Bomzon Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times
KR102870236B1 (ko) 2018-07-03 2025-10-14 에드윈 창 세포막 투과성을 향상시키기 위한 교류 전기장 사용
US11179322B2 (en) 2018-07-10 2021-11-23 Novocure Gmbh Methods and compositions for treating tumors with TTFields and sorafenib
BR112020025692A2 (pt) 2018-07-10 2021-03-16 Novocure Gmbh Inibição de infecção viral usando campos elétricos alternados
EP3967361A1 (en) 2018-07-18 2022-03-16 Novocure GmbH Using power loss density and related measures to quantify the dose of tumor treating fields
US11160977B2 (en) 2018-09-04 2021-11-02 Novocure Gmbh Delivering tumor treating fields (TTFields) to the infratentorial brain
EP3846894B8 (en) 2018-09-07 2025-06-18 Novocure GmbH Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells
US11986647B2 (en) 2018-09-07 2024-05-21 Novocure Gmbh Treating autoinflammatory and mitochondrial diseases using an alternating electric field
PL3984590T3 (pl) 2018-10-15 2023-05-02 Novocure Gmbh Wytwarzanie pól leczących guzy (pól elektrycznych do leczenia nowotworów ttfields) o wysokiej równomierności w całym mózgu
CN112955208B (zh) * 2018-10-25 2024-11-22 诺沃库勒有限责任公司 向受试者的脊柱解剖结构递送交变电场(例如，ttfields)的方法
EP3880299B1 (en) 2018-11-13 2025-09-24 The Methodist Hospital Device for oncomagnetic treatment
CN113015553B (zh) 2018-11-19 2025-01-14 诺沃库勒有限责任公司 用于递送具有选择性可寻址子元件的肿瘤治疗场（TTField）的阵列
BR112021004336A2 (pt) 2018-11-29 2021-08-17 Novocure Gmbh matrizes de transdutor com flexibilidade melhorada para entregar ttfields (campos de tratamento de tumor)
EP3968279B1 (en) 2019-01-08 2025-01-01 Novocure GmbH Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields)
JP2022519782A (ja) 2019-02-07 2022-03-24 ヴィヴェーク・ケー・シャルマ 交番極性磁場によってがん細胞を治療するシステム、および方法
US11027143B2 (en) 2020-02-06 2021-06-08 Vivek K. Sharma System and methods for treating cancer cells with alternating polarity magnetic fields
US11344740B2 (en) 2019-02-07 2022-05-31 Asha Medical, Inc. System and methods for treating cancer cells with alternating polarity magnetic fields
US11554262B2 (en) 2019-02-26 2023-01-17 Novocure Gmbh Determining a frequency for TTFields treatment based on an electrical characteristic of targeted cancer cells
EP4491214B1 (en) 2019-02-27 2026-01-21 Novocure GmbH Delivering tumor treating fields (ttfields) using implantable transducer arrays
FR3093645B1 (fr) * 2019-03-15 2021-04-02 Univ Montpellier Puce microfluidique pour attirer et détruire un élément biologique spécifique
JP7419391B2 (ja) 2019-03-29 2024-01-22 ノボキュア ゲーエムベーハー ＰＴＧＥＲ３阻害剤によりＴＴＦｉｅｌｄｓ－耐性がん細胞におけるＴＴＦｉｅｌｄｓに対する感受性を回復させるための方法
ES2940749T3 (es) 2019-04-17 2023-05-11 Novocure Gmbh Carga de datos desde un sistema aislado sin comprometer el aislamiento
EP3958954B1 (en) 2019-04-22 2024-04-24 Boston Scientific Scimed Inc. Electrical stimulation devices for cancer treatment
CN113766949B (zh) 2019-04-22 2025-04-08 波士顿科学国际有限公司 用于施用电刺激以治疗癌症的系统
EP4480526A3 (en) 2019-04-22 2025-03-12 Boston Scientific Scimed, Inc. Combination electrical and chemotherapeutic treatment of cancer
US11850422B2 (en) 2019-04-23 2023-12-26 Boston Scientific Scimed, Inc. Electrodes for electrical stimulation to treat cancer
CN113766950A (zh) 2019-04-23 2021-12-07 波士顿科学国际有限公司 带有热治疗或热监测的电刺激
WO2020219517A2 (en) 2019-04-23 2020-10-29 Boston Scientific Scimed, Inc. Electrical stimulation for cancer treatment with internal and external electrodes
CN121314073A (zh) 2019-07-31 2026-01-13 诺沃库勒有限责任公司 经由埋入颅骨植入物中的电极施加肿瘤治疗场（TTField）
WO2021024170A1 (en) 2019-08-05 2021-02-11 Voloshin Sela Tali Increasing cancer cells' sensitivity to tumor treating fields (ttfields) by inhibiting il11 activity
CN114364433A (zh) 2019-08-30 2022-04-15 诺沃库勒有限责任公司 向颈部输送肿瘤治疗场（TTFields）
CN114786763A (zh) * 2019-12-11 2022-07-22 诺沃库勒有限责任公司 更改交变电场的电阻抗的合成物和方法
CN121695416A (zh) 2019-12-31 2026-03-20 诺沃库勒有限责任公司 具有可单独访问的电极元件和温度传感器的用于传递肿瘤治疗场（tt场）的阵列
CN121314067A (zh) 2019-12-31 2026-01-13 诺沃库勒有限责任公司 防止幅度调整和信道切换期间的尖峰的高电压、高效率正弦波生成器
US12121739B2 (en) 2019-12-31 2024-10-22 Novocure Gmbh Methods, systems, and apparatuses for managing temperatures induced by alternating fields
US11883655B2 (en) 2020-02-24 2024-01-30 Boston Scientific Scimed, Inc. Systems and methods for treatment of pancreatic cancer
US20210299440A1 (en) 2020-03-30 2021-09-30 Novocure Gmbh Intravenous / Intra-Spinal / Intra-Cavity / Intraventricular Delivery of TTFields (Tumor Treating Fields) for Treating Cancer and Metastases
BR112022021484A2 (pt) 2020-04-24 2022-12-13 Novocure Gmbh Uso de campos elétricos alternados para aumentar a permeabilidade da barreira hematoencefálica
TWI889816B (zh) 2020-05-06 2025-07-11 瑞士商諾沃庫勒有限責任公司 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法
EP4168108A4 (en) 2020-06-19 2024-07-17 The Methodist Hospital dba Houston Methodist Hospital METHOD AND APPARATUS FOR ONCOMAGNETIC TREATMENT
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
EP4223364B1 (en) 2020-09-25 2024-04-24 Novocure GmbH Varying the metallization area on individual electrode elements in a tumor treating fields system to maximize current without overheating
DE102021102884A1 (de) * 2021-02-08 2022-08-11 Elea Vertriebs- Und Vermarktungsgesellschaft Mbh Verfahren zum Paralysieren von Parasiten in Nahrung, insbesondere in einem Lebens- oder Futtermittel und damit hergestelltes Lebensmittel mit paralysierten Parasiten
US12397151B2 (en) 2021-02-17 2025-08-26 Novocure Gmbh Arrays for delivering tumor treating fields (TTFields) with sets of electrode elements having individually adjustable active areas
US12440680B2 (en) 2021-03-12 2025-10-14 Novocure Gmbh Methods of treating disease by skewing macrophage phenotype with alternating electric fields
US12589255B2 (en) * 2021-03-23 2026-03-31 Novocure Gmbh Methods and apparatuses for detecting and responding to changes in a subject
EP4284489B1 (en) 2021-03-31 2025-07-16 Novocure Gmbh Impedance tomography using electrodes of a tumor treating fields (ttfields) system
EP4359065A4 (en) 2021-06-22 2025-03-19 LifeBridge Innovations, PBC Device and method for improving electrical field therapy for reducing solid tumors
WO2023275749A1 (en) 2021-06-30 2023-01-05 Novocure Gmbh Using capacitors to regulate current in transducer arrays for applying tumor treating fields (ttfields)
WO2023275804A1 (en) * 2021-06-30 2023-01-05 Novocure Gmbh Using alternating electric fields at different frequencies to increase the permeability of the blood brain barrier and also to provide other benefits
KR20240027063A (ko) * 2021-06-30 2024-02-29 노보큐어 게엠베하 교류 전기장, 체크포인트 억제제 및 병용 화학요법으로 암을 치료하는 방법
CN113663215B (zh) * 2021-10-22 2022-01-21 杭州维纳安可医疗科技有限责任公司 电场发生装置及其控制方法、计算机可读存储介质
US20230173265A1 (en) * 2021-12-10 2023-06-08 Novocure Gmbh Garment providing a biasing force on a transducer array
MX2024006036A (es) 2021-12-14 2024-06-05 Novocure Gmbh Desplazamiento de matriz de transductores para reducir la irritacion cutanea.
TW202333820A (zh) 2021-12-29 2023-09-01 瑞士商諾沃庫勒有限責任公司 在使用交流電場治療受試者時藉由使用較大陰極和較小陽極來降低電知覺
JP2024545019A (ja) 2021-12-30 2024-12-05 ノボキュア ゲーエムベーハー 腫瘍治療フィールド（ｔｔｆｉｅｌｄ）を使用した治療のためのパラメータ値の選択
JP7710117B2 (ja) 2022-03-30 2025-07-17 ノボキュア ゲーエムベーハー トランスデューサアレイをペアリングすることによる交流電場を用いた被験者の治療および電気感覚の軽減
EP4460361B1 (en) 2022-03-30 2025-03-19 Novocure GmbH Using interleaved cooling periods to increase the peak intensity of tumor treating fields
US12420113B2 (en) 2022-04-01 2025-09-23 The Board Of Regents Of The University Of Texas System Methods and apparatus for applying tumor treating fields combined with personalized ultra-fractionated stereotactic adaptive radiotherapy
CN120417962A (zh) * 2022-12-28 2025-08-01 诺沃库勒有限责任公司 具有集成肿瘤治疗电场电压发生器的可穿戴服装
US12268863B2 (en) 2023-02-06 2025-04-08 Novocure Gmbh Shiftable transducer array with anisotropic material layer
CN116020054B (zh) * 2023-02-24 2023-12-08 北京微脊医疗科技有限公司 植入式电场治疗装置
US12465759B2 (en) 2023-03-14 2025-11-11 Boris Kriman Electrostatic therapeutic device
WO2025068924A1 (en) * 2023-09-29 2025-04-03 Novocure Gmbh Using staggered changes in amplitude and frequency to ameliorate electrosensation during treatment with alternating electric fields

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060167499A1 (en) * 2000-02-17 2006-07-27 Standen Ltd Treating a tumor or the like with electric fields at different orientations
US20070184020A1 (en) * 2004-06-09 2007-08-09 Jochen Kalbe Combination of radio waves with pharmacologically active substances

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR446660A (fr) 1911-09-02 1912-12-12 Gottlieb Schuettel Dispositif pour métiers continus à anneaux pour monter les curseurs sur les anneaux
BE794566A (fr) 1972-01-28 1973-07-26 Esb Inc Regenerateur et stimulateur bioelectrochimique et procedes d'application in vivo d'energie electrique a des cellules et des tissus.
US3991770A (en) 1974-01-24 1976-11-16 Leveen Harry H Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation
US4016886A (en) 1974-11-26 1977-04-12 The United States Of America As Represented By The United States Energy Research And Development Administration Method for localizing heating in tumor tissue
US4121592A (en) 1975-08-04 1978-10-24 Critical Systems, Inc. Apparatus for heating tissue
DE2907013A1 (de) 1978-02-24 1979-08-30 American Med Syst Verfahren und vorrichtung zum beguenstigen der heilung von verletzten knochenknorpeln und geweben im gesichtsbereich
DE2813068A1 (de) 1978-03-25 1979-10-04 Philips Patentverwaltung Verfahren und vorrichtung zur ermittlung von inneren koerperstrukturen
GB2043453A (en) 1979-02-22 1980-10-08 Electrochem Tech Corp Improvements in or relating to an electrode
US4472506A (en) 1981-01-13 1984-09-18 Liburdy Robert P Method for determining cell membrane dielectric breakdown
US4467809A (en) 1982-09-17 1984-08-28 Biolectron, Inc. Method for non-invasive electrical stimulation of epiphyseal plate growth
US4622952A (en) 1983-01-13 1986-11-18 Gordon Robert T Cancer treatment method
CA1244889A (en) 1983-01-24 1988-11-15 Kureha Chemical Ind Co Ltd HYPERTHERMIA DEVICE
DE3323415C2 (de) 1983-06-29 1985-04-25 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verwendung eines Verfahrens und einer Vorrichtung zur Bestimmung von Zellinhaltstoffe sezernierenden Zellen
SE455920B (sv) 1986-01-29 1988-08-22 Hans Wiksell Anordning for hypertermibehandling av tumorer
US4923814A (en) 1986-05-09 1990-05-08 Electropore, Inc. High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
CN86103803B (zh) 1986-06-05 1987-11-18 北京信息工程学院 静电场治疗装置
US4822470A (en) 1987-10-09 1989-04-18 Baylor College Of Medicine Method of and apparatus for cell poration and cell fusion using radiofrequency electrical pulses
US4936303A (en) 1987-11-20 1990-06-26 Ultrathermics Ultrasonic heating apparatus and method
JPH0629196B2 (ja) 1987-12-01 1994-04-20 甲子郎 梅村 超音波による腫瘍治療用生理作用増強剤
US5389069A (en) 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
FR2627987B3 (fr) 1988-03-04 1990-02-02 Indiba Sa Appareil electronique pour la therapie medicale et cosmetique
US5158071A (en) 1988-07-01 1992-10-27 Hitachi, Ltd. Ultrasonic apparatus for therapeutical use
GB8904998D0 (en) 1989-03-04 1989-04-19 Matthews Tony Anaesthetising apparatus
US5099756A (en) 1989-06-01 1992-03-31 Harry H. Leveen Radio frequency thermotherapy
US5441746A (en) 1989-12-22 1995-08-15 Molecular Bioquest, Inc. Electromagnetic wave absorbing, surface modified magnetic particles for use in medical applications, and their method of production
US5236410A (en) 1990-08-02 1993-08-17 Ferrotherm International, Inc. Tumor treatment method
AU1672492A (en) 1991-05-03 1992-12-21 University Technologies International Inc. Biofilm reduction method
US5441532A (en) 1991-06-26 1995-08-15 Massachusetts Institute Of Technology Adaptive focusing and nulling hyperthermia annular and monopole phased array applicators
US5468223A (en) 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
US5386837A (en) 1993-02-01 1995-02-07 Mmtc, Inc. Method for enhancing delivery of chemotherapy employing high-frequency force fields
FR2703253B1 (fr) 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
IL108775A (en) 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
US5704355A (en) 1994-07-01 1998-01-06 Bridges; Jack E. Non-invasive system for breast cancer detection
WO1997004830A1 (en) 1995-07-28 1997-02-13 Gray James R Use of a polarizing field to modify the efficacy of a bioactive agent
US5606971A (en) 1995-11-13 1997-03-04 Artann Corporation, A Nj Corp. Method and device for shear wave elasticity imaging
US5718246A (en) 1996-01-03 1998-02-17 Preferential, Inc. Preferential induction of electrically mediated cell death from applied pulses
US5984882A (en) 1996-08-19 1999-11-16 Angiosonics Inc. Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy
US5869326A (en) 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6043066A (en) 1997-09-04 2000-03-28 Mangano; Joseph A. Cell separation using electric fields
US6027488A (en) 1998-06-03 2000-02-22 Genetronics, Inc. Flow-through electroporation system for ex vivo gene therapy
US5976092A (en) 1998-06-15 1999-11-02 Chinn; Douglas O. Combination stereotactic surgical guide and ultrasonic probe
US6319901B1 (en) 1998-10-15 2001-11-20 Ichor Medical Systems, Inc. Methods for prolonging cell membrane permeability
CA2364098C (en) 1999-03-09 2010-11-16 Thermage, Inc. Apparatus and method for treatment of tissue
US6678558B1 (en) 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US6366808B1 (en) 2000-03-13 2002-04-02 Edward A. Schroeppel Implantable device and method for the electrical treatment of cancer
US6853864B2 (en) 2000-02-02 2005-02-08 Catholic University Of America, The Use of electromagnetic fields in cancer and other therapies
US7890183B2 (en) 2000-02-17 2011-02-15 Novocure Ltd. Treating parasites with electric fields
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
US7016725B2 (en) 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7089054B2 (en) 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
JP5280600B2 (ja) 2000-02-17 2013-09-04 パルティ、ヨーラム 分裂中の細胞を破壊するための方法および装置
US7136699B2 (en) 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US7146210B2 (en) 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
US6546290B1 (en) 2000-04-12 2003-04-08 Roamitron Holding S.A. Method and apparatus for electromedical therapy
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US8986944B2 (en) * 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
CA2563817C (en) 2004-04-23 2018-07-10 Yoram Palti Treating a tumor or the like with electric fields at different frequencies
ES2344215T3 (es) 2004-12-07 2010-08-20 Standen Ltd. Electrodos para aplicar un campo electrico in vivo durante un dilatado periodo de tiempo.
US20060282122A1 (en) 2005-06-08 2006-12-14 Yoram Palti Treating cancer with electric fields that are guided to desired locations within a body
CN101321555B (zh) 2005-10-03 2020-12-08 诺沃库勒有限责任公司 优化电场特征以增加电场在增殖细胞上的效果
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
US8465533B2 (en) 2007-03-06 2013-06-18 Novocure Limited Treating cancer using electromagnetic fields in combination with photodynamic therapy
US8715203B2 (en) 2007-09-17 2014-05-06 Novocure Limited Composite electrode

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060167499A1 (en) * 2000-02-17 2006-07-27 Standen Ltd Treating a tumor or the like with electric fields at different orientations
US20070184020A1 (en) * 2004-06-09 2007-08-09 Jochen Kalbe Combination of radio waves with pharmacologically active substances

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113908430A (zh) * 2018-08-23 2022-01-11 诺沃库勒有限责任公司 使用交变电场来提高血脑屏障的通透性
CN113908431A (zh) * 2018-08-23 2022-01-11 诺沃库勒有限责任公司 使用交变电场来提高血脑屏障的通透性
CN114269274A (zh) * 2020-07-16 2022-04-01 株式会社电界 基于吸收能量的电场癌治疗计划系统及方法

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