CN101820879B - 具有柔性侧链的抗疟用化合物 - Google Patents

具有柔性侧链的抗疟用化合物 Download PDF

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Publication number
CN101820879B
CN101820879B CN2008801106805A CN200880110680A CN101820879B CN 101820879 B CN101820879 B CN 101820879B CN 2008801106805 A CN2008801106805 A CN 2008801106805A CN 200880110680 A CN200880110680 A CN 200880110680A CN 101820879 B CN101820879 B CN 101820879B
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China
Prior art keywords
ethyl
diamino
propoxy
pyrimidine
compound
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Chinese (zh)
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CN101820879A (zh
Inventor
B·塔恩卓普
Y·育他翁
T·威莱梵
P·基特纳萨布
C·童潘昌
S·甘宗翁拜杉
D·马楚斯
L·维维斯
J·尤瓦尼亚玛
S·扎曼
W·扎曼
S·B·卡蒂亚
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NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT BUREAU
Medicines for Malaria Venture
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Medicines for Malaria Venture
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2008801106805A 2007-10-08 2008-10-08 具有柔性侧链的抗疟用化合物 Active CN101820879B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97837507P 2007-10-08 2007-10-08
US60/978,375 2007-10-08
PCT/US2008/079210 WO2009048957A1 (en) 2007-10-08 2008-10-08 Antimalarial compounds with flexible side-chains

Publications (2)

Publication Number Publication Date
CN101820879A CN101820879A (zh) 2010-09-01
CN101820879B true CN101820879B (zh) 2013-01-02

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CN2008801106805A Active CN101820879B (zh) 2007-10-08 2008-10-08 具有柔性侧链的抗疟用化合物

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US (1) US8530491B2 (cg-RX-API-DMAC10.html)
EP (2) EP3546452A1 (cg-RX-API-DMAC10.html)
JP (1) JP5603775B2 (cg-RX-API-DMAC10.html)
KR (1) KR101578949B1 (cg-RX-API-DMAC10.html)
CN (1) CN101820879B (cg-RX-API-DMAC10.html)
AU (1) AU2008310898B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0818618B8 (cg-RX-API-DMAC10.html)
CA (1) CA2700880C (cg-RX-API-DMAC10.html)
CY (1) CY1121598T1 (cg-RX-API-DMAC10.html)
DK (1) DK2194985T3 (cg-RX-API-DMAC10.html)
ES (1) ES2727015T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20190589T1 (cg-RX-API-DMAC10.html)
HU (1) HUE044398T2 (cg-RX-API-DMAC10.html)
LT (1) LT2194985T (cg-RX-API-DMAC10.html)
MX (1) MX2010003739A (cg-RX-API-DMAC10.html)
PL (1) PL2194985T3 (cg-RX-API-DMAC10.html)
PT (1) PT2194985T (cg-RX-API-DMAC10.html)
RU (1) RU2485107C2 (cg-RX-API-DMAC10.html)
SI (1) SI2194985T1 (cg-RX-API-DMAC10.html)
TR (1) TR201904913T4 (cg-RX-API-DMAC10.html)
UA (1) UA105759C2 (cg-RX-API-DMAC10.html)
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Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
US9611503B2 (en) 2011-02-09 2017-04-04 National Science And Technology Development Agency Escherichia coli cell line with thyA knockout and folA knockout
WO2012121682A2 (en) * 2011-03-10 2012-09-13 National Science And Technology Development Agency Anti-folate antimalarials with dual-binding modes and their preparation
US10011842B2 (en) 2013-09-30 2018-07-03 National Science And Technology Development Agency Escherichia coli cell line with thyA knockout, folA knockout, and one or both of folP knockout, and folK knockout
CN104593406A (zh) * 2015-01-08 2015-05-06 山西医科大学 pIRES/TgDHFR-TS真核表达重组质粒及其构建和应用
US11028072B2 (en) 2015-09-23 2021-06-08 National Science And Technology Development Agency 2,4-diamino-6-ethylpyrimidine derivatives with antimalarial activities against Plasmodium falciparum
CN106083742A (zh) * 2016-05-31 2016-11-09 广东工业大学 一种2,4‑二胺基喹唑啉衍生物及其制备方法和应用
WO2021155748A1 (en) * 2020-02-04 2021-08-12 Tsinghua University Inhibitors of malarial and plasmodium falciparum hexose transporter and uses thereof
CN112961106A (zh) * 2021-03-13 2021-06-15 德州学院 一种4-羟基-6氯喹啉合成新工艺
EP4438596A1 (en) * 2023-03-28 2024-10-02 Université de Lille Diaminopyrimidine derivatives as hdac and dhfr dual-targeting inhibitors and use thereof in preventing and treating malaria
WO2025053796A1 (en) * 2023-09-04 2025-03-13 National Science And Technology Development Agency Hybrid molecules between pyrimidine derivatives and idasanutlin
CN117025299A (zh) * 2023-09-07 2023-11-10 中国烟草总公司郑州烟草研究院 一种烟用豆香香基模块、香精和卷烟
CN117263804A (zh) * 2023-09-07 2023-12-22 中国烟草总公司郑州烟草研究院 邻羟基苯丙酸酯及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4033962A (en) * 1975-06-26 1977-07-05 Hoffman-La Roche Inc. 2,4-Diamino-pyrimidine derivatives and processes
US4232023A (en) * 1977-07-11 1980-11-04 Dick Pierre R G Novel soluble derivatives of 2,4-diamino pyrimidine
US20040180913A1 (en) * 2003-03-13 2004-09-16 National Science And Technology Development Agency Antimalarial pyrimidine derivatives and methods of making and using them

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1546937A (en) * 1976-07-29 1979-05-31 Beecham Group Ltd 2,4-diaminopyrimidine derivatives
OA07362A (fr) 1980-10-27 1984-06-30 May & Baker Ltd Dérivés de la pyrimidine, leur procédé de préparation et les compositions les contenant.
GB2086386B (en) 1980-10-27 1984-01-18 May & Baker Ltd Pyrimidine derivatives
US5322858A (en) 1992-02-14 1994-06-21 Jacobus Pharmaceutical Co. Inc. N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines
RU95113597A (ru) * 1992-12-02 1997-06-10 ФМК Корпорейшн (US) Инсектицидная композиция, способы борьбы с насекомыми
KR20020008197A (ko) * 1999-05-24 2002-01-29 가와무라 요시부미 항-Ｆａｓ 항체를 함유하는 의약 조성물
IT1317826B1 (it) * 2000-02-11 2003-07-15 Dompe Spa Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4033962A (en) * 1975-06-26 1977-07-05 Hoffman-La Roche Inc. 2,4-Diamino-pyrimidine derivatives and processes
US4232023A (en) * 1977-07-11 1980-11-04 Dick Pierre R G Novel soluble derivatives of 2,4-diamino pyrimidine
US20040180913A1 (en) * 2003-03-13 2004-09-16 National Science And Technology Development Agency Antimalarial pyrimidine derivatives and methods of making and using them

Also Published As

Publication number Publication date
EP2194985B1 (en) 2019-02-20
JP5603775B2 (ja) 2014-10-08
CY1121598T1 (el) 2020-07-31
WO2009048957A8 (en) 2010-04-22
MX2010003739A (es) 2010-04-21
PT2194985T (pt) 2019-05-30
TR201904913T4 (tr) 2019-05-21
KR101578949B1 (ko) 2015-12-18
EP2194985A1 (en) 2010-06-16
AU2008310898B2 (en) 2014-05-08
PL2194985T3 (pl) 2019-12-31
UA105759C2 (uk) 2014-06-25
DK2194985T3 (da) 2019-05-20
JP2010540666A (ja) 2010-12-24
CA2700880A1 (en) 2009-04-16
EP2194985A4 (en) 2012-01-25
CA2700880C (en) 2016-03-08
RU2485107C2 (ru) 2013-06-20
SI2194985T1 (sl) 2019-04-30
EP3546452A1 (en) 2019-10-02
RU2010117193A (ru) 2011-11-20
WO2009048957A1 (en) 2009-04-16
HRP20190589T1 (hr) 2019-05-31
US20090099220A1 (en) 2009-04-16
US8530491B2 (en) 2013-09-10
ES2727015T3 (es) 2019-10-11
BRPI0818618A2 (pt) 2015-08-04
KR20100094459A (ko) 2010-08-26
AU2008310898A1 (en) 2009-04-16
BRPI0818618B1 (pt) 2020-03-03
HUE044398T2 (hu) 2019-10-28
BRPI0818618B8 (pt) 2023-04-25
LT2194985T (lt) 2019-04-10
CN101820879A (zh) 2010-09-01

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Address after: Geneva, Switzerland

Patentee after: MMV MEDICINES FOR MALARIA VENTURE

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Patentee before: MEDICINES FOR MALARIA VENTURE

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Patentee after: National Science and Technology Development Bureau

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