CN101811979A - 注射级土霉素生产工艺 - Google Patents
注射级土霉素生产工艺 Download PDFInfo
- Publication number
- CN101811979A CN101811979A CN 201010175027 CN201010175027A CN101811979A CN 101811979 A CN101811979 A CN 101811979A CN 201010175027 CN201010175027 CN 201010175027 CN 201010175027 A CN201010175027 A CN 201010175027A CN 101811979 A CN101811979 A CN 101811979A
- Authority
- CN
- China
- Prior art keywords
- terramycin
- grade
- purified water
- injection
- technology
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KIPLYOUQVMMOHB-MXWBXKMOSA-L [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O Chemical compound [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O KIPLYOUQVMMOHB-MXWBXKMOSA-L 0.000 title claims abstract description 34
- 229940063650 terramycin Drugs 0.000 title claims abstract description 34
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000008213 purified water Substances 0.000 claims abstract description 21
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 20
- 238000001914 filtration Methods 0.000 claims abstract description 11
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 10
- XOGGUFAVLNCTRS-UHFFFAOYSA-N tetrapotassium;iron(2+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] XOGGUFAVLNCTRS-UHFFFAOYSA-N 0.000 claims abstract description 10
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims abstract description 10
- 229960001763 zinc sulfate Drugs 0.000 claims abstract description 10
- 229910000368 zinc sulfate Inorganic materials 0.000 claims abstract description 10
- 235000011114 ammonium hydroxide Nutrition 0.000 claims abstract description 6
- 238000002425 crystallisation Methods 0.000 claims abstract description 6
- 230000008025 crystallization Effects 0.000 claims abstract description 6
- 239000012046 mixed solvent Substances 0.000 claims abstract description 6
- 238000005406 washing Methods 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 3
- 239000000047 product Substances 0.000 claims description 12
- 239000012982 microporous membrane Substances 0.000 claims description 7
- 239000004677 Nylon Substances 0.000 claims description 5
- 239000013078 crystal Substances 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000012065 filter cake Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 229920001778 nylon Polymers 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 4
- 239000004744 fabric Substances 0.000 claims description 2
- 239000012535 impurity Substances 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- 238000002835 absorbance Methods 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000001291 vacuum drying Methods 0.000 abstract 1
- 238000012262 fermentative production Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101750276A CN101811979B (zh) | 2010-04-29 | 2010-04-29 | 注射级土霉素生产工艺 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101750276A CN101811979B (zh) | 2010-04-29 | 2010-04-29 | 注射级土霉素生产工艺 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101811979A true CN101811979A (zh) | 2010-08-25 |
| CN101811979B CN101811979B (zh) | 2012-10-31 |
Family
ID=42619367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101750276A Active CN101811979B (zh) | 2010-04-29 | 2010-04-29 | 注射级土霉素生产工艺 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101811979B (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102320990A (zh) * | 2011-07-07 | 2012-01-18 | 赤峰制药股份有限公司 | 从盐酸土霉素废液中回收土霉素的方法 |
| CN103896798A (zh) * | 2014-01-14 | 2014-07-02 | 李学强 | 一种四环素提纯工艺 |
| CN106380422A (zh) * | 2016-08-29 | 2017-02-08 | 河北健民淀粉糖业有限公司 | 一种从土霉素发酵液中提取低磷含量土霉素成品的方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090268A (zh) * | 1993-11-12 | 1994-08-03 | 清华大学 | 盐酸土霉素生产新工艺 |
| CN1094484C (zh) * | 1999-09-09 | 2002-11-20 | 石家庄市华曙联合制药厂 | 土霉素纯化方法 |
-
2010
- 2010-04-29 CN CN2010101750276A patent/CN101811979B/zh active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090268A (zh) * | 1993-11-12 | 1994-08-03 | 清华大学 | 盐酸土霉素生产新工艺 |
| CN1094484C (zh) * | 1999-09-09 | 2002-11-20 | 石家庄市华曙联合制药厂 | 土霉素纯化方法 |
Non-Patent Citations (1)
| Title |
|---|
| 《中国抗生素杂志》 20001031 李十中等 "高纯度土霉素碱生产工艺研究(Ⅰ)" 第344-345，394页 1-4 第25卷, 第5期 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102320990A (zh) * | 2011-07-07 | 2012-01-18 | 赤峰制药股份有限公司 | 从盐酸土霉素废液中回收土霉素的方法 |
| CN102320990B (zh) * | 2011-07-07 | 2013-07-17 | 赤峰制药股份有限公司 | 从盐酸土霉素废液中回收土霉素的方法 |
| CN103896798A (zh) * | 2014-01-14 | 2014-07-02 | 李学强 | 一种四环素提纯工艺 |
| CN106380422A (zh) * | 2016-08-29 | 2017-02-08 | 河北健民淀粉糖业有限公司 | 一种从土霉素发酵液中提取低磷含量土霉素成品的方法 |
| CN106380422B (zh) * | 2016-08-29 | 2018-04-03 | 河北健民淀粉糖业有限公司 | 一种从土霉素发酵液中提取低磷含量土霉素成品的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101811979B (zh) | 2012-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Technology for producing injection-grade terramycin Effective date of registration: 20191218 Granted publication date: 20121031 Pledgee: Hongmiaozi Credit Union, Hongshan rural credit cooperative association, Chifeng City Pledgor: CHIFENG PHARMACEUTICAL Co.,Ltd. Registration number: Y2019150000024 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20200320 Granted publication date: 20121031 Pledgee: Hongmiaozi Credit Union, Hongshan rural credit cooperative association, Chifeng City Pledgor: CHIFENG PHARMACEUTICAL Co.,Ltd. Registration number: Y2019150000024 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Technology for producing injection-grade terramycin Effective date of registration: 20200322 Granted publication date: 20121031 Pledgee: Agricultural Bank of China Limited Chifeng Baima sub branch Pledgor: CHIFENG PHARMACEUTICAL Co.,Ltd. Registration number: Y2020150000008 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210222 Granted publication date: 20121031 Pledgee: Agricultural Bank of China Limited Chifeng Baima sub branch Pledgor: CHIFENG PHARMACEUTICAL Co.,Ltd. Registration number: Y2020150000008 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Production process of injection grade oxytetracycline Effective date of registration: 20210223 Granted publication date: 20121031 Pledgee: Agricultural Bank of China Limited Chifeng Baima sub branch Pledgor: CHIFENG PHARMACEUTICAL Co.,Ltd. Registration number: Y2021150000018 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20121031 Pledgee: Agricultural Bank of China Limited Chifeng Baima sub branch Pledgor: CHIFENG PHARMACEUTICAL Co.,Ltd. Registration number: Y2021150000018 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Injection grade oxytetracycline production process Granted publication date: 20121031 Pledgee: Agricultural Bank of China Limited Chifeng Baima sub branch Pledgor: CHIFENG PHARMACEUTICAL Co.,Ltd. Registration number: Y2024150000003 |