CN101810829B

CN101810829B - Medicament for treating mastopathy

Info

Publication number: CN101810829B
Application number: CN2010101711799A
Authority: CN
Inventors: 林艳芳; 段立纲; 赵应红; 岩罕单; 廖瑞玲; 玉腊波; 谭志刚; 潘玉秀; 刀红英; 曾君; 王孝蓉; 肖丽香; 刀会仙; 陈亚梅; 刘志强; 邓群; 刘扬扬
Original assignee: XISHUANGBANNA INSTITUTE OF NATIONAL MEDICINE
Current assignee: XISHUANGBANNA INSTITUTE OF NATIONAL MEDICINE
Priority date: 2010-05-13
Filing date: 2010-05-13
Publication date: 2011-12-07
Anticipated expiration: 2030-05-13
Also published as: CN101810829A

Abstract

The invention relates to a medicament for treating mastopathy, which is prepared form the following medicinal materials in part by weight: 1 to 3 parts of Motherwort herb, 1 to 3 parts of lasianthus chinensis, 1 to 3 parts of zedoary, 1 to 3 parts of root of red-rooted salvia, 0.5 to 1 part of serrate glory-bower, 1 to 2 parts of rhizoma corydalis, 1 to 3 parts of cyperusrotundus, 1 to 3 parts of mongolian dandelion herb and 1 to 2 parts of mirabilite. The medicament adopts a formula consisting of a plurality of medicinal materials, and has the effects of activating blood and dissolving stasis, softening hardness to dissipate stagnation, and dispersing swelling and relieving pain so as to fulfill the aims of clearing fire and detoxifying, freeing vitality and activating blood, eliminating stasis and relieving pain, and dispersing swelling and dissipating stagnation when the medicinal materials are used together. The medicament is prepared into different formulations by applying modern technology for clinical use, and has obvious curative effect.

Description

The mastotic medicine of a kind of treatment

Technical field

The invention provides a kind of preparation technology who treats mastotic medicine and this medicine.

Background technology

In recent years because Inheritance, menstruation, fertility, ionizing radiation, dietary habit, life style, hormone, competitive pressure, Nervous and Mental Factors, factors such as environmental pollution cause cystic hyperplasia of breast: as urgency, chronic mastitis, the breast mass tumor, the gynecologic menstrual distending pain of the breast, stomachache, sickness rate such as breast lobule hyperplasia are the trend that rises year by year, age is rejuvenation more and more, according to statistics, 30 years old in 50 years old women crowd, the cyclomastopathy sickness rate is about 15%, the sickness rate of breast carcinoma accounts for 50% to 70% in the mammary gland special outpatient clinic, occupy the first place of women's malignant tumor, therefore, become the common important topic of paying close attention to of medical circle for the mastotic problem of preventing and treating.Regulating menstruation, blood circulation promoting and blood stasis dispelling, promoting QI to circulate and dispersing the agglomeration of the pathogens medicine are adopted in treatment by Chinese herbs, Chinese patent medicines such as cyclomastopathy ball commonly used, infantile eczema disappear, JIAWEI XIAOYAOWAN, but the most DeGrain of this class pharmaceutical composition, though what have also has certain therapeutic effect, but there is safe and reliable relatively poor problem in most of prescriptions, and what have also has than big toxic and side effects.

Summary of the invention

The objective of the invention is to propose a kind of drug effect height, cost is low, the course of treatment is short, the easy to use mastotic medicine of treatment, to solve the deficiencies in the prior art.

The mastotic medicine of this treatment that the present invention proposes, make by the medical material of following weight parts:

Herba Leonuri 1-3, Radix lasianthi chinensis 1-3, Rhizoma Curcumae 1-3, Radix Salviae Miltiorrhizae 1-3, Herba Clerodendri Serrati 0.5-1, Rhizoma Corydalis 1-2, Rhizoma Cyperi 1-3, Herba Taraxaci 1-3, Natrii Sulfas 1-2.

But Radix lasianthi chinensis and Herba Leonuri regulating qi and activating blood, inducing menstruation to relieve menalgia are principal agent in the prescription; Rhizoma Curcumae, Radix Salviae Miltiorrhizae, Herba Clerodendri Serrati, Rhizoma Corydalis and Rhizoma Cyperi have the merit of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, cure mainly stagnation of QI-blood and the breast mass that causes swells and ache, and help medicine to strengthen, promoting blood flow to regulate menstruation, and the merit of blood-activating analgetic is adjuvant; Herba Taraxaci and Natrii Sulfas have heat-clearing and toxic substances removing, hard masses softening and resolving, and the power of reducing swelling and alleviating pain helps the stronger effect of principal agent performance, is all adjuvant.Full side share, and brings into play blood circulation promoting and blood stasis dispelling jointly, hard masses softening and resolving, the effect of reducing swelling and alleviating pain and can treat the breast various diseases.

According to the needs of disease, also can add Herba Violae and Rhizoma Paridis on the basis of above-mentioned prescription, Herba Violae, Rhizoma Paridis are cool in nature, have powerful heat-clearing and toxic substances removing, and the function of reducing swelling and alleviating pain can strengthen our heat-clearing and toxic substances removing, the power of reducing swelling and alleviating pain and be used to cure mainly acute mastitis.

On the basis of above-mentioned two prescriptions, also can add Radix Bupleuri, Squama Manis, Os Draconis and Concha Ostreae, wherein Radix Bupleuri has depressed liver-energy dispersing and QI regulating, heat-clearing and toxic substances removing, during priming is directly gone into, last two dishes, Ruzhong, ambition and treat the function of cystic hyperplasia of breast, Squama Manis, Os Draconis and Concha Ostreae have very strong heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the power of hard masses softening and resolving, modern study proves that Squama Manis has antitumor and treats multiple inflammation, cancers such as breast carcinoma/tumor, cystic hyperplasia of breast.Therefore, the medicine of adding can strengthen we treatment and Breast Cancer Prevention/tumor /), disease such as cystic hyperplasia of breast.

The each side that several medical materials that the present invention adopts are formed, full side share, and brings into play blood circulation promoting and blood stasis dispelling jointly, hard masses softening and resolving, the curative effect of reducing swelling and alleviating pain, to reach the detoxifcation of relieving inflammation or internal heat, ventilation is invigorated blood circulation, blood-activating analgetic, the purpose of dispersing swelling and dissipating binds.Applicating modern times technology is developed into different dosage forms and is applied to clinically, receives significant curative effect.

This medicine has been finished corresponding research work according to the requirement of national drug administrative law hospital preparation registration, through clinical observation on the therapeutic effect and anxious poison test, do not find toxicity, curative effect is safe and reliable, and is evident in efficacy, has the good development prospect and the market competitiveness.

Treat through clinical observation on the therapeutic effect: acute mastitis 42 examples, produce effects 25 examples, effective 13 examples, invalid 4 examples, total effective rate is 90.4%; Gynecologic menstrual distending pain of the breast 188 examples, produce effects 101 examples, effective 73 examples, invalid 14 examples, total effective rate is 92.5%; Breast lobule hyperplasia 102 examples, produce effects 49 examples, effective 35 examples, invalid 18 examples, total effective rate is 82.3%.

The specific embodiment

Embodiment 1, the mastotic medicine of a kind of treatment, make by the medical material of following weight parts:

Step of preparation process is as follows:

1), get Herba Leonuri, Radix lasianthi chinensis, Rhizoma Curcumae, Radix Salviae Miltiorrhizae, Herba Clerodendri Serrati and Herba Taraxaci, add decocting in water and carry three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, gets extractum, and is standby;

2) get surplus medicine Rhizoma Corydalis, Rhizoma Cyperi and Natrii Sulfas pulverize separately, again to the fine powder of crossing 100 mesh sieves, mixing is standby;

3), with 1) step gained extractum and 2) step gained fine powder mixing, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves, made capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.

Embodiment 2, the mastotic medicine of a kind of treatment, make by the medical material of following weight parts:

Herba Leonuri 1-3, Radix lasianthi chinensis 1-3, Rhizoma Curcumae 1-3, Radix Salviae Miltiorrhizae 1-3, Herba Clerodendri Serrati 0.5-1, Rhizoma Corydalis 1-2, Rhizoma Cyperi 1-3, Herba Taraxaci 1-3, Herba Violae 1-3, Rhizoma Paridis 1-2, Natrii Sulfas 1-2.

The step of preparation process of decoction is as follows:

Get Herba Leonuri, Radix lasianthi chinensis, Rhizoma Curcumae, Radix Salviae Miltiorrhizae, Herba Clerodendri Serrati, Rhizoma Corydalis, Rhizoma Cyperi, Herba Taraxaci, Herba Violae, Rhizoma Paridis and Natrii Sulfas, heat boiled water to flooding medicine 10-15 centimetre, after soaking half an hour, decoct three times, for the first time, boiled 30 minutes, second and third time all adds boiled water to flat medicinal residues, respectively boiled 30 minutes, and merged three times decocting liquid.

Instructions of taking: decoction being taken warmly, obey 200ml, every day three times at every turn.

Also can make other dosage form in conjunction with the modern pharmaceutical technology, step of preparation process is as follows:

1), get Herba Leonuri, Radix lasianthi chinensis, Radix Salviae Miltiorrhizae, Herba Clerodendri Serrati, Herba Taraxaci, Herba Violae and Rhizoma Paridis, add decocting in water and carry three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, gets extractum, and is standby;

2) get surplus medicine Rhizoma Curcumae, Rhizoma Cyperi, Natrii Sulfas and Rhizoma Corydalis pulverize separately, again to the fine powder of crossing 100 mesh sieves, mixing is standby;

Embodiment 3, the mastotic medicine of a kind of treatment, make by the medical material of following weight parts:

Herba Leonuri 1-3, Radix lasianthi chinensis 1-3, Rhizoma Curcumae 1-3, Radix Salviae Miltiorrhizae 1-3, Herba Clerodendri Serrati 0.5-1, Rhizoma Corydalis 1-2, Rhizoma Cyperi 1-3, Herba Taraxaci 1-3, Herba Violae 1-3, Rhizoma Paridis 1-2, Natrii Sulfas 1-2, Squama Manis 1-3, Os Draconis 1-3, Concha Ostreae 1-3, Radix Bupleuri 1-1.5.

The step of preparation process of decoction is as follows:

Get Herba Leonuri, Radix lasianthi chinensis, Rhizoma Curcumae, Radix Salviae Miltiorrhizae, Herba Clerodendri Serrati, Rhizoma Corydalis, Rhizoma Cyperi, Herba Taraxaci, Herba Violae, Rhizoma Paridis, Natrii Sulfas, Squama Manis, Os Draconis, Concha Ostreae and Radix Bupleuri, heat boiled water to flooding medicine 10-15 centimetre, after soaking half an hour, decoct three times, for the first time, boiled 30 minutes, second and third time all adds boiled water to flat medicinal residues, respectively boiled 30 minutes, and merged three times decocting liquid.

1), get Herba Leonuri, Radix lasianthi chinensis, Rhizoma Curcumae, Radix Salviae Miltiorrhizae, Herba Clerodendri Serrati, Herba Taraxaci and Herba Violae, add decocting in water and carry three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, gets extractum, and is standby;

2) get surplus medicine Rhizoma Paridis, Rhizoma Cyperi, Natrii Sulfas and Rhizoma Corydalis pulverize separately, again to the fine powder of crossing 100 mesh sieves, mixing is standby;

Claims

1. treat mastotic medicine for one kind, it is characterized in that making by the medical material of following weight parts:

2. the preparation technology of treatment breast disease medicine according to claim 1 is characterized in that step is as follows:

Get Herba Leonuri, Radix lasianthi chinensis, Rhizoma Curcumae, Radix Salviae Miltiorrhizae, Herba Clerodendri Serrati, Rhizoma Corydalis, Rhizoma Cyperi, Herba Taraxaci, Herba Violae, Rhizoma Paridis and Natrii Sulfas, heat boiled water to flooding 10-15 centimeters of medicines, after soaking half an hour, decoct three times, for the first time, boiled 30 minutes, second and third time all adds boiled water to flat medicinal residues, respectively boiled 30 minutes, and merged three times decocting liquid.

3, the preparation technology of treatment breast disease medicine according to claim 1 is characterized in that step is as follows:

1), gets Herba Leonuri, Radix lasianthi chinensis, Radix Salviae Miltiorrhizae, Herba Clerodendri Serrati, Herba Taraxaci, Herba Violae and Rhizoma Paridis ,Add decocting in water and carry three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3 ~ 1.35, gets extractum, and is standby;