CN101810709A - Medicament for treating rheumatism - Google Patents

Abstract

The invention provides a medicament for treating rheumatism, which is prepared from the following medicinal materials in part by weight: 3.6 parts of fissistigma polyanthum, 1.6 parts of cassia twig, 1 part of gambir plant, 1 part of sappan wood, 2.4 parts of common clubmoss herb, 1.2 parts of crisped tinospora stem and 3.2 parts of mappianthus iodoies. The medicament is used for treating cold and hot rheumatalgia, limp and numb swollerpain or red and swollen heat pain of body joints, muscles and bones, and has the effects of dispelling wind and activating blood, and freeing impediment and relieving pain. The medicament is prepared by applying new industrial research of modern pharmacy according to the compatibility principle of Dai medicament. The medicament is prepared into powder, capsules, tablets and granules by combing the modern pharmaceutical technology, has the traditional characteristics of Dai medicine and the characteristics of modern preparations. The clinical curative effect observation and acute toxicity test research prove that the medicament has the advantages of no toxic or side response, and safe and reliable curative effects.

Description

The rheumatismal medicine of a kind of treatment

Technical field

The present invention relates to a kind of is the preparation technology that main component is used for the treatment of rheumatismal medicine and this medicine thereof with Dai Nationality's medicine.

Background technology

Rheumatism is common clinical, frequently-occurring disease, and motherland's traditional medicine is referred to as " arthromyodynia ", is because exopathogen invasion and attack human body impatency meridians such as wind, cold, wet, heat, due to QI-blood circulation is smooth.With muscles and bones, muscle, joint ache, the disease of main performances such as numb, joint stuffiness or arthroncus.According to statistics, global rheumatic osteopathia patient is about 400,000,000, is a class illness the hugest in the medical domain.Account for 18% of population Chinese rheumatism, rheumatoid arthritis, ankylosing spondylitis, gout, femur head necrosis patient, its sickness rate is up to 27%.5,600 ten thousand severe cases are wherein arranged.The rheumatisant is tormented by this pertinacious disease more, can not get effective treatment, and majority is controlled repeatly and do not healed, so that have that sb.'s illness took a turn for the worse and paralysis even dead, according to the health ministry investigation statistics, annual because of rheumatism, rheumatoid, osteopathia, directly or indirectly death toll reaches 1,500,000 people approximately.For this class treatment of diseases, up to the present, the medicine with significant curative effect is not seen more report as yet.Therefore, searching treatment rheumatism, rheumatoid, osteoarthritis have reality and profound significance from traditional national medicine.The area that the Dai nationality lives, since geographical environment, the particularity of weather conditions, and the sickness rate of this class disease is not less than national level.The people of the Dai nationality sum up the experience and the square medicine that have accumulated this class disease of a large amount of treatments in secular life and medical practice.

Summary of the invention

The objective of the invention is to propose a kind of drug effect height, cost is low, the course of treatment is short, the easy to use rheumatismal medicine of treatment, to solve the deficiencies in the prior art.

The rheumatismal medicine of this treatment that the present invention proposes, make by the medical material of following weight parts:

Caulis Fissistigmatis 3.6, Ramulus Cinnamomi 1.6, Ramulus Uncariae Cum Uncis 1, Lignum Sappan 1, Herba Lycopodii 2.4, green bag rattan 1.2, Caulis Mappianthi Iodoidis 3.2.

Caulis Fissistigmatis, Ramulus Cinnamomi, Lignum Sappan have Wind-expelling, blood circulation-promoting in the prescription, and the merit of the logical pain relieving of temperature is principal agent, has expelling wind and activating blood circulation, and the function of numbness relieving and pain relieving has embodied the characteristic of the doctor of the Dai Nationality " remove wind and invigorate blood circulation earlier, the blood sector-style is from going out ".The Dai nationality's medical science thinks, rheumatismal generation with cold, hot blast is evil in close relations, rheumatism is divided into two big classes: cold wind damp disease, hot blast damp disease, and clinically also often as seen cold and heat add assorted rheumatism, therefore, must cold and heat and control.It is cold to join Herba Lycopodii, Ramulus Uncariae Cum Uncis, green bag rattan, Caulis Mappianthi Iodoidis in this prescription, existing heat-clearing and toxic substances removing, reducing swelling and alleviating pain, expelling wind and activating blood circulation effect, can suppress the hot of principal agent again, full side share, and cold and heat match, and its characteristics are, expelling wind and activating blood circulation, the logical pain relieving of temperature and not hot, clearing heat, releasing toxin, removing swelling pain relieving and cold is so be suitable for treating various rheumatism.

On the basis of above-mentioned prescription one, also can add wild pepper daughter root, pith of Cassia siamea, TONGXUEXIANG and Flos Carthami medicine according to the state of an illness and form prescription two, strengthened heat clearing and blood circulation promoting, remove wind analgesic function and be longer than treatment rheumatism relatively thermogravimetric, that stop in the blood stasis.

On the basis of prescription one, two, also can add Rhizoma Curcumae Longae, Tetrastigma planicaule, Radix et Rhizoma Rhei Franzenbachii formation prescription three, more strengthened heat-clearing and toxic substances removing, promoting blood circulation and detumescence removes the effect of wind analgesic, and to being that the treatment of conditions of main clinical manifestation has significant curative effect with red and swollen heat pain or spasm severe pain in the rheumatism.

The present invention is used for the treatment of cold and hot rheumatalgia, and the medicine of limbs joint, muscle, the tingle distending pain of muscles and bones or red and swollen heat pain has expelling wind and activating blood circulation, the function of numbness relieving and pain relieving; Be after from the rheumatismal numerous prescriptions of Dai Nationality's treatment treatment, screening, using the modern pharmaceutical new industrial research according to the combination principle of Dai Nationality's medicine gets, modern formulations such as powder, capsule, tablet and granule have been developed in conjunction with the modern pharmaceutical technology, make it both have a Dai Nationality medicine traditional characteristics, modern preparation characteristic is arranged again; According to the requirement of national drug administrative law hospital preparation registration, finished corresponding research work, prove through clinical observation on the therapeutic effect and anxious malicious experimental study, do not find toxicity, curative effect is safe and reliable, and is evident in efficacy, has the good development prospect and the market competitiveness.158 routine rheumatisants have been carried out observation of curative effect, and total effective rate is 91%.Wherein: rheumatism pyretic arthralgia 67 examples, produce effects 47 examples, effective 13 examples, invalid 7 examples, total effective rate is 89.5%; Anemofrigid-damp arthralgia 81 examples, produce effects 68 examples, effective 15 examples, invalid 6 examples, total effective rate is 92.5%.

The specific embodiment

Embodiment 1, the rheumatismal medicine of a kind of treatment, make by the medical material of following weight parts:

Caulis Fissistigmatis 3.6, Ramulus Cinnamomi 1.6, Ramulus Uncariae Cum Uncis 1, Lignum Sappan 1, Herba Lycopodii 2.4, green bag rattan 1.2, Caulis Mappianthi Iodoidis 3.2.

Adopt the modern pharmaceutical technology to make various dosage forms by above-mentioned prescription, step of preparation process is as follows:

1., get Caulis Fissistigmatis, Ramulus Uncariae Cum Uncis, Lignum Sappan and Herba Lycopodii and add decocting in water and carry three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merges three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, must extractum, standby;

2., again get the fine powder that Caulis Mappianthi Iodoidis, Ramulus Cinnamomi and green bag rattan pulverize separately became 100 mesh sieves, mixing is standby;

3., with step 1. the extractum of gained add 2. mixing in the fine powder of step, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves, made capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.

Embodiment 2, the rheumatismal medicine of a kind of treatment, make by the medical material of following weight parts:

Caulis Fissistigmatis 3.6, Ramulus Cinnamomi 1.6, TONGXUEXIANG 3, Lignum Sappan 1, Flos Carthami 1, Ramulus Uncariae Cum Uncis 1, wild pepper daughter root 1.5, Herba Lycopodii 2.4, Caulis Mappianthi Iodoidis 3.2, green bag rattan 1.2, pith of Cassia siamea 1.5.

The decoction step of preparation process of medicine is as follows:

Get Caulis Fissistigmatis, Ramulus Cinnamomi, TONGXUEXIANG, Lignum Sappan, Flos Carthami, Ramulus Uncariae Cum Uncis, wild pepper daughter root, Herba Lycopodii, Caulis Mappianthi Iodoidis, green bag rattan and pith of Cassia siamea, heat boiled water to flooding about 10 centimeters of medicines, after soaking half an hour, decoct three times, boiled 10-15 minute for the first time, second and third time all adds boiled water to flat medicinal residues, respectively boils 5-10 minute, merges three times decocting liquid.

Instructions of taking: decoction being taken warmly, obey 200ml, every day three times at every turn.

Adopt the modern pharmaceutical technology also to can be made into various dosage forms by above-mentioned prescription, step of preparation process is as follows:

Get Caulis Fissistigmatis, TONGXUEXIANG, Lignum Sappan, Ramulus Uncariae Cum Uncis, wild pepper daughter root, Herba Lycopodii and pith of Cassia siamea and add decocting in water and carry three times 1., earlier, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, gets extractum, and is standby;

2., again get surplus medicine Caulis Mappianthi Iodoidis, Ramulus Cinnamomi, green bag rattan and Flos Carthami, pulverize separately became the fine powder of 100 mesh sieves, and mixing is standby;

3., with step 1. the extractum of gained add 2. mixing in the fine powder of step, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves,, made capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization.

Embodiment 3, the rheumatismal medicine of a kind of treatment, make by the medical material of following weight parts:

Caulis Fissistigmatis 3.6, Ramulus Cinnamomi 1.6, TONGXUEXIANG 3, Rhizoma Curcumae Longae 2, Lignum Sappan 1, Flos Carthami 1, Tetrastigma planicaule 3, Herba Lycopodii 2.4, Ramulus Uncariae Cum Uncis 1, wild pepper daughter root 1.5, pith of Cassia siamea 1.5, green bag rattan 1.2, Caulis Mappianthi Iodoidis 3.2, Radix et Rhizoma Rhei Franzenbachii 1.

The decoction step of preparation process of medicine is as follows:

Get Caulis Fissistigmatis, Ramulus Cinnamomi, TONGXUEXIANG, Rhizoma Curcumae Longae, Lignum Sappan, Flos Carthami, Tetrastigma planicaule, Herba Lycopodii, Ramulus Uncariae Cum Uncis, wild pepper daughter root, pith of Cassia siamea, green bag rattan, Caulis Mappianthi Iodoidis and Radix et Rhizoma Rhei Franzenbachii, heat boiled water to flooding medical material 10-12 centimetre, after soaking half an hour, decoct three times, for the first time, boiled 10-15 minute, second and third time all adds boiled water to flat medicinal residues, respectively boiled 5-10 minute, and merged three times decocting liquid.

Instructions of taking: decoction being taken warmly, obey 200ml, every day three times at every turn.

Adopt the modern pharmaceutical technology also to can be made into various dosage forms by above-mentioned prescription, step of preparation process is as follows:

1., get Caulis Fissistigmatis, TONGXUEXIANG, Lignum Sappan, Flos Carthami, Tetrastigma planicaule, Herba Lycopodii, Ramulus Uncariae Cum Uncis, wild pepper daughter root and pith of Cassia siamea earlier, adding decocting in water carries three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, gets extractum, and is standby;

2., again get surplus medicine Caulis Mappianthi Iodoidis, Ramulus Cinnamomi, green bag rattan, Radix et Rhizoma Rhei Franzenbachii became 100 mesh sieves with the Rhizoma Curcumae Longae pulverize separately fine powder, mixing is standby;

3., with step 1. the extractum of gained add 2. mixing in the fine powder of step, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves, made capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.

Claims (8)

1. treat rheumatismal medicine for one kind, it is characterized in that making by the medical material of following weight parts:

Caulis Fissistigmatis 3.6, Ramulus Cinnamomi 1.6, Ramulus Uncariae Cum Uncis 1, Lignum Sappan 1, Herba Lycopodii 2.4, green bag rattan 1.2, Caulis Mappianthi Iodoidis 3.2.

2. a kind of preparation technology who treats rheumatismal medicine according to claim 1 is characterized in that step is as follows:

1., get Caulis Fissistigmatis, Ramulus Uncariae Cum Uncis, Lignum Sappan and Herba Lycopodii and add decocting in water and carry three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merges three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, must extractum, standby;

2., again get the fine powder that Caulis Mappianthi Iodoidis, Ramulus Cinnamomi and green bag rattan pulverize separately became 100 mesh sieves, mixing is standby;

3., with step 1. the extractum of gained add 2. mixing in the fine powder of step, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves, made capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.

3. treat rheumatismal medicine for one kind, it is characterized in that making by the medical material of following weight parts:

Caulis Fissistigmatis 3.6, Ramulus Cinnamomi 1.6, TONGXUEXIANG 3, Lignum Sappan 1, Flos Carthami 1, Ramulus Uncariae Cum Uncis 1, wild pepper daughter root 1.5, Herba Lycopodii 2.4, Caulis Mappianthi Iodoidis 3.2, green bag rattan 1.2, pith of Cassia siamea 1.5.

4. a kind of preparation technology who treats rheumatismal medicine according to claim 3 is characterized in that step is as follows:

Get Caulis Fissistigmatis, Ramulus Cinnamomi, TONGXUEXIANG, Lignum Sappan, Flos Carthami, Ramulus Uncariae Cum Uncis, wild pepper daughter root, Herba Lycopodii, Caulis Mappianthi Iodoidis, green bag rattan and pith of Cassia siamea, heat boiled water to flooding about 10 centimeters of medicines, after soaking half an hour, decoct three times, boiled 10-15 minute for the first time, second and third time all adds boiled water to flat medicinal residues, respectively boils 5-10 minute, merges three times decocting liquid.

5. a kind of preparation technology who treats rheumatismal medicine according to claim 3 is characterized in that step is as follows:

Get Caulis Fissistigmatis, TONGXUEXIANG, Lignum Sappan, Ramulus Uncariae Cum Uncis, wild pepper daughter root, Herba Lycopodii and pith of Cassia siamea and add decocting in water and carry three times 1., earlier, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, gets extractum, and is standby;

2., again get surplus medicine Caulis Mappianthi Iodoidis, Ramulus Cinnamomi, green bag rattan and Flos Carthami, pulverize separately became the fine powder of 100 mesh sieves, and mixing is standby;

3., with step 1. the extractum of gained add 2. mixing in the fine powder of step, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves,, made capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization.

6. treat rheumatismal medicine for one kind, it is characterized in that making by the medical material of following weight parts:

Caulis Fissistigmatis 3.6, Ramulus Cinnamomi 1.6, TONGXUEXIANG 3, Rhizoma Curcumae Longae 2, Lignum Sappan 1, Flos Carthami 1, Tetrastigma planicaule 3, Herba Lycopodii 2.4, Ramulus Uncariae Cum Uncis 1, wild pepper daughter root 1.5, pith of Cassia siamea 1.5, green bag rattan 1.2, Caulis Mappianthi Iodoidis 3.2, Radix et Rhizoma Rhei Franzenbachii 1.

7. a kind of preparation technology who treats rheumatismal medicine according to claim 6 is characterized in that step is as follows:

Get Caulis Fissistigmatis, Ramulus Cinnamomi, TONGXUEXIANG, Rhizoma Curcumae Longae, Lignum Sappan, Flos Carthami, Tetrastigma planicaule, Herba Lycopodii, Ramulus Uncariae Cum Uncis, wild pepper daughter root, pith of Cassia siamea, green bag rattan, Caulis Mappianthi Iodoidis and Radix et Rhizoma Rhei Franzenbachii, heat boiled water to flooding medical material 10-12 centimetre, after soaking half an hour, decoct three times, for the first time, boiled 10-15 minute, second and third time all adds boiled water to flat medicinal residues, respectively boiled 5-10 minute, and merged three times decocting liquid.

8. a kind of preparation technology who treats rheumatismal medicine according to claim 6 is characterized in that step is as follows:

1., get Caulis Fissistigmatis, TONGXUEXIANG, Lignum Sappan, Flos Carthami, Tetrastigma planicaule, Herba Lycopodii, Ramulus Uncariae Cum Uncis, wild pepper daughter root and pith of Cassia siamea earlier, adding decocting in water carries three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merge three times filtrate, filter, filtrate is concentrated into relative density 1.3～1.35, gets extractum, and is standby;

2., again get surplus medicine Caulis Mappianthi Iodoidis, Ramulus Cinnamomi, green bag rattan, Radix et Rhizoma Rhei Franzenbachii became 100 mesh sieves with the Rhizoma Curcumae Longae pulverize separately fine powder, mixing is standby;

3., with step 1. the extractum of gained add 2. mixing in the fine powder of step, in 60 ℃ ± 5 ℃ temperature after the drying, pulverized 100 mesh sieves, made capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.