CN101810807A - Chinese medicinal liquor for treating rheumatoid arthritis and preparation method thereof - Google Patents
Chinese medicinal liquor for treating rheumatoid arthritis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to Chinese medicinal liquor for treating rheumatoid arthritis and a preparation method thereof. The Chinese medicinal liquor comprises the following raw materials: eucalyptusglobulus labill (eucalyptus globulus fruit) in a formulation of decoction pieces, ovientvine, cissus assamica, white paeony root, tangerine peel, papaya, largehead atractylodes rhizome, white liquor and the like. The Chinese medicinal liquor has the advantages of mild medicinal properties, small toxic and side effects, less using amount, simple administration, quick response, good effect, short course of treatment, compact formula, short cure time, 70 percent of cure rate and 99.1 percent of total effective rate, and has the effects of warming channel, expelling cold and dehumidifying, activating blood, expelling stasis and freeing network vessels, tonifying spleen and stomach, tonifying middle-Jiao and qi, regulating unusual immunologic function of the organism, resisting inflammation, relieving pain and treating both sympotoms and root causes. The preparation method not only meets the traditional Chinese medicine process, but also is in accordance with modern pharmacology research results, has the advantages of simple equipment, energy saving, water saving, low product cost and no pollution, and solves the problems that patients with the rheumatoid arthritis have to take medicaments for a long time.
Description
Technical field
The present invention relates to a kind of oral Chinese medicine medicated wine that is used for the treatment of atrophic arthritis.
Background technology
Rheumatoid arthritis is a kind of rheumatism.It is to be the systemic autoimmune disease of feature with the articular synovitis.Synovitis is outbreak repeatedly lastingly, the destruction that can cause intraarticular cartilage and bone, joint function disturbance, deformity even deformity.Modal clinical manifestation is the pain in joints such as hands, wrist, elbow, foot, knee joint, ankle, shoulder and temporo jaw, swelling, hydrops.
Show that according to World Health Organization's updated statistics rheumatoid arthritis is at average about 1% (0.3%-2.1%) of the prevalence in the world.Sickness rate increases with age growth, the 40-50 frequently-occurring disease of being everlasting, and China is many with northeast, North China.About 80% patient's age of onset is many in 20-45 year with person between twenty and fifty, and men and women's ratio is 1: 2-4.Rheumatoid arthritis becomes the killer of serious threat human health.
The cause of disease of rheumatoid arthritis is fully clear and definite as yet, and big multi-expert thinks that rheumatoid arthritis pathogenic factor and factors such as environment, antibacterial, virus, heredity, gonadal hormone and the neural mental status are closely related.Comparatively slow when rheumatoid arthritis is just sent out, have earlier several thoughtful some months lassitude and weak, lose weight, prodrome such as anorexia, low grade fever and numb hand and foot twinge.A certain arthralgia, stiff takes place subsequently, after, arthroncus day by day increases the weight of, may one, two joint involvement, migration often during beginning.Develop into the symmetry polyarthritis later on, the normal articulations digitorum manus from distal limbs of getting involved in joint involves other joint later on again.The regular incidence of the interphalangeal joint of nearside is the enlargement of shuttle shape; Secondly be joints such as the palm refers to, toe, knee joint, elbow, ankle, shoulder and hip.And companion's daystart ankylosis, muscular soreness, the stiff phenomenon in the movable back of appropriateness can alleviate.Along with pathological development, irregular heating can be arranged, significantly anemia.The pathological changes joint becomes stiff and lopsided at last, and knee joint, elbow, finger, wrist all are fixed on bends the position.Point the metacarpophalangeal joint of being everlasting and become subluxation laterally, form distinctive ulnar side deflection deformity, far-end articulations digitorum manus flexing, the proximal interphalangeal joint hyperextension is goose-neck deformity, and this moment, patient's daily life all needed the people to assist.About 10%-30% patient is at the knuckle position in joint, and is prominent as the olecranon of upper limb, and subcutaneous nodule appears in wrist and following 's ankle etc., and is hard as rubber, is called rheumatoid nodules.This tuberosity is difficult for being absorbed, and its appearance often points out disease to be in serious operational phase.The therapeutic purposes of rheumatoid arthritis mainly are in order to alleviate the inflammation reflection in joint, to suppress pathological development and irreversible bone destruction, protecting the function of joint and muscle as much as possible and reach the state of an illness and alleviate fully clinically at present.The Therapeutic Principle of rheumatoid arthritis is following four aspects: the one, the early treatment: in case be diagnosed as rheumatoid arthritis, should use pathological changes to alleviate the property antirheumatic as early as possible, and the time control rheumatoid arthritis pathological changes progress; The 2nd, get and share medicine: most patient needs two or more slow-acting drugs to unite use; The 3rd, the therapeutic scheme of individuation: because each patient's clinical manifestation, severity extent reaches the differences such as reflection to medicine, answers " cutting the garment according to the figure ", and being necessary for patient provides curative effect preferably not have the individualized treatment scheme of obvious adverse reaction.The 4th, functional exercise: the main purpose for the treatment of rheumatoid arthritis is the function in protection joint, and therefore, the function of joint activity is also very important in treatment.At present the scheme selected easily of patient be active stage earlier with Western medicine onset efficiently, regulate control with Chinese medicine to the catabasis, in a word, the western medical treatment primary disease is based on the antagonism therapy, the Chinese traditional treatment primary disease is to regulate the control therapy.Have his own strong points, but all exist not enough.
One, the present situation of western modern medicine treatment rheumatoid arthritis: based on the antagonism therapy.
1, in the arthritis active stage, and when getting involved with organs such as the heart, lung, eye and nervous system, earlier alleviate arthralgia swelling rapidly with fugitive hormone (low dose of glucocorticoid), or alleviate organ and get involved, take the antirheumatic (methotrexate, leflunomide, chloroquine etc.) that improves the state of an illness simultaneously.Because the hormone therapy rheumatoid arthritis can cause osteoporosis, so will control use.
2, in the catabasis, nonsteroidal antiinflammatory drug and the antirheumatic use in conjunction of improving the state of an illness.Nonsteroidal antiinflammatory drug is by suppressing the Cycloxygenase activity, reduce prostaglandin synthetic and have antiinflammatory, pain relieving, bring down a fever, the detumescence effect.Because nonsteroidal antiinflammatory drug makes the synthetic minimizing of prostaglandin, thus the corresponding untoward reaction of appearance, as gastrointestinal side effect (feel sick, vomit, suffer from abdominal pain, suffer from diarrhoea, be off one's feed, digestive tract ulcer, hemorrhage, perforation etc.); Kidney untoward reaction (the renal perfusion amount reduces, and occurs that Shui Na Retention stays, hyperkalemia, hematuria, albuminuria, interstitial nephritis, severe patient generation renal necrosis); Peripheral blood cells reduces, blood coagulation disorders, aplastic anemia, liver function injury etc.The antirheumatic that improves the state of an illness plays a role slowly (1-6 month), and bad toxic reaction is also arranged simultaneously.As methotrexate, leflunomide etc. can cause toxic reactions such as gastrointestinal disease, stomatitis, dermatitis, bone marrow depression.
There is a following shortcoming difficult problem (this is one of product of the present invention difficult problem that will solve) when 3, to sum up finding the western medicine rheumatoid arthritis.
Produce effects is slow during 1. without hormone.
Produce effects is fast when 2. using hormone, but bigger with untoward reaction for a long time, and is difficult for removing and stops the burden that also increases the weight of the pathological changes joint because of osteoporosis that has.
3. untoward reaction is serious, causes pathological changes such as intestinal, stomach, kidney, liver, blood system, central nervous system.
4. various in style, early, middle and late phase medication changes greatly wayward use.
Two, Chinese medicine is to the rheumatoid arthritis treatment situation: theory of Chinese medical science thinks that rheumatoid arthritis is the damp and hot numbness resistance of a wind and cold channels, due to the multiple abscess joint, is the common rule of treatment of primary disease so collateral dredging is declared numbness.New for sick wind dispelling, cold expelling, dehumidifying, heat clearing away, prolonged illness is with liver and kidney tonifying, and benefiting QI and nourishing blood be earlier, double simultaneously with reduce phlegm, removing blood stasis.Always with qi and blood circulation, the Wei Fuchang of battalion, beniol profit in Lip river be purpose, and concrete determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs is tied mutually for 1. cold-damp again, and channels numbness hinders to be demonstrate,proved:
Symptom and performance: joint and muscle cold type of pain are weighing, and sore spot is more fixing, and morning is stiff, and obviously arthralgia is violent, even the joint incapable of flexing and extending is met cold painful play, hotly subtract slightly, light red tongue is fat, Tai Bai or greasy, stringy pulse or heavy tight.
Method of treatment: dispelling cold by warming the meridian, removing obstruction in the collateral to relieve pain.The medicinal Aconiti Decoction plus-minus in side.Arthroncus, wet Sheng person adds WUJISAN; The stasis of blood person that stagnates is arranged, drink and add Olibanum, Myrrha, Semen Persicae, Flos Carthami, Squama Manis with promoting blood circulation to remove obstruction in the collateral;
2. damp-heat accumulation, channels numbness resistance card:
Symptom and performance: the redness and swelling of joints burning pain, cool easypro slightly, joint motion is limited, morning, deadlock was thirsty or do not like drink yearningly, yellowish urine, it is not well to defecate, the patient has heating concurrently more, red tongue, yellow and greasy fur, slippery and rapid pulse.Method of treatment: removing damp-heat, a surname's numbness collateral dredging.Side medicinal a surname's numbness Tonga subtracts.Heat very adds Gypsum Fibrosum, Radix Rehmanniae with clearing away heat pathogen; It is wet with tonneau water that wet Sheng person adds Rhizoma Smilacis Glabrae, Fructus Chaenomelis, Caulis Akebiae, holds concurrently with heat clearing away; The patient adds Scorpio, Pheretima, the Radix Paeoniae Alba and picks collateral dredging, relieving spasm to stop pain to search; Joint stuffiness adds Fructus Chaenomelis, Herba Lycopodii with soothing the channels and quicking the network vessels.
3. phlegm and blood stasis, channels numbness group card:
Symptom and performance: the arthralgia distortion, limitation of activity, pain in fixed position, the stupid fiber crops of limbs, the juxtra-articular skin is purple dark, or amyotrophy is arranged, darkish complexion, or subcutaneous nodule is arranged, dimly red tongue or ecchymosis, petechiae, white and thin fur, stringy and hesitant pulse.Method of treatment: activating blood and removing stasis, eleminating phlegm and freeing channels.The medicinal Traditional Chinese medicine decoction for treating-ache and expelling atagnate in side closes the XIAOHUOLUO DAN plus-minus.The pain play adds Olibanum, Rhizoma Corydalis, Eupolyphaga Seu Steleophaga; Swelling obviously adds Rhizoma Curcumae, and Hirudo, Herba Lycopi, Scolopendra are picked collateral dredging, activating blood and eliminatng dampness to search; The darkish complexion person can share Radix Et Rhizoma Rhei ZHECHONG ball.
4. deficiency of qi and blood, channels cervical carcinoma with cachexia card
Symptom and performance: emaciated physique, joint deformity, joint is ached, the time heavy when light, when bending and stretching for very, lustreless complexion, heart beating is losed heart, fatigue and asthenia, spontaneous perspiration, anorexia and loose stool, light red tongue, white and thin fur, the little or soft-weak pulse of thready pulse.Method of treatment: benefiting qi and nourishing blood, collateral dredging a surname numbness.Side's medicinal Astragalis Ramulus Cinnamomi five thing soup close medicinal piece of shiquan dabu Tonga and subtract.Cold partially person adds Radix Aconiti Lateralis Preparata, and partial heat person is with Radix Gentianae Macrophyllae, and the weight in wet base loose stool goes Radix Rehmanniae to add Semen Coicis, Rhizoma Atractylodis with invigorating spleen to remove dampness; The low and deep person of the stasis of blood adds Scorpio, Scolopendra, Eupolyphaga Seu Steleophaga and picks collateral dredging, blood circulation promoting and blood stasis dispelling to search.
5. Liver and kidney is with sick deficiency syndrome of both YIN and YANG.
Symptom and performance: joint deformity, emaciated physique, amyotrophy, acute pain in the joints, stiff and limitation of activity, spasm of muscles and vessels.The few China of companion's pale white complexion, soreness of the waist and knees is unable, coldness of the body with chills, cardiopalmus is breathed hard; Or hectic fever night sweat, continuing low grade fever, the red tongue tongue is white, deep-thready pulse or count accurately.Method of treatment: nourishing the liver and kidney, removing obstruction in the collateral to relieve pain.The medicinal Radix Angelicae Pubescentis et Herba Taxilli Decoction plus-minus in side.Deficiency of YIN person sees tinnitus, insomnia, night sweat dysphoria with smothery sensation partially, and flushed cheeks adds Bolus as a Kidney-Yin-Tonic and controls it; Yang deficiency person sees aversion to cold and cold limbs partially, hands and feet being not warm, and the joint cold type of pain adds Yougui Wan, the kidney-Yang-Reinforcing Bolus and controls it.
Because concrete clinically damp and hot four heresies of patient with rheumatoid arthritis wind and cold mix, disease is mixed and disorderly, common patient's active stage and catabasis alternately occur, cause the clinicist to be difficult to accurate determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs medication, this cause treatment by Chinese herbs should disease the time produce effects slow, regulate the disease controlling instability, heavy when light during the state of an illness, outbreak repeatedly, effective percentage is not high.Single medicinal material treatment rheumatoid arthritis, generally with Radix Tripterygii Wilfordii, toxic herb decoction pieces such as Semen Strychni, Radix Aconiti, Radix Aconiti Kusnezoffii are main, though it is evident in efficacy, have toxic and side effects significantly again simultaneously, cause the patient to be difficult to accept.
Comprehensively above-mentioned, Chinese medicine decoction treatment rheumatoid arthritis exists produce effects slow clinically at present, and the disease controlling instability is heavy when light when causing the state of an illness, repeatedly an outbreak and the low difficult problem of effective percentage.(this be the product of the present invention difficult problem that will solve two).Single medicinal material exists toxic and side effects big when treating this disease, the difficult problem that the patient is difficult to accept (this be the product of the present invention difficult problem that will solve three).In order to solve the above Three Difficult Issues that exist in the treatment rheumatoid arthritis process, product of the present invention provides a kind of Chinese medicine medicated wine.Acute active stage patient is oral on request, and four days to ten days, red and swollen heat pain disappeared rapidly; Chronic alleviation phase patient takes three-six months posterior joint pain, swelling, stiff, deformity etc. and all disappears, laboratory indexes is normal, and X line film making shows that bone destruction has and improve or do not have development, and following up a case by regular visits in 1 year after the drug withdrawal does not have recurrence, toxic and side effects is very low simultaneously, and the patient is acceptant.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Therapeutic Principle's (dispelling cold by warming the meridian that had both met traditional Chinese traditional treatment rheumatoid arthritis, dehumidifying, promoting blood circulation to remove obstruction in the collateral removing blood stasis, invigorating the spleen and regulating the stomach invigorating the spleen and replenishing QI), (for example Eucalyptus globules Fruits is that Eucalyptus globules Fruits solution has the body immune system of transfer function, anti-inflammatory and analgesic effect according to the modern pharmacological research newest fruits again simultaneously; Caulis Sinomenii extract-sinomenine hydrochloride can suppress synovium of joint emiocytosis inflammatory mediator, recovers synovial cell's form; Radix Paeoniae Alba extract-Radix Paeoniae Alba total glucosides can the reaction of ameliorate osteoarthritis disease, eliminates swelling, reduces synovial tissue's inflammatory cell infiltration, protection cartilaginous tissue damage or the like) the Chinese medicine medicated wine and the manufacture method of treatment rheumatoid arthritis.Really solved six hang-ups that exist in the present western medicine rheumatoid arthritis process clinically: the one, produce effects is slow during without hormone, and the 2nd, untoward reaction is serious; The 3rd, though make produce effects fast with hormone, bigger with untoward reaction for a long time, and be difficult for removing and stop the burden that also increases the weight of the pathological changes joint because of osteoporosis that has; The 4th, medicine for treatment is various in style, and early, middle and late phase medication changes greatly wayward use; The 5th, Chinese medicinal formulae kind complexity mixes owing to wind and cold is damp and hot when dialectical and causes opinion to be controlled being difficult to accurately, and it is slow produce effects to occur, regulates the disease controlling instability, and is heavy when light during the state of an illness, outbreak repeatedly, and effective percentage is not high; The 6th, some single medicinal material (as Radix Tripterygii Wilfordii, Semen Strychni, Radix Aconiti, Radix Aconiti Kusnezoffii etc.) decoction pieces, though it is evident in efficacy, toxic and side effects is very big.
In order to solve above six hang-ups, the present invention treats the Chinese medicine medicated wine and the manufacture method of rheumatoid arthritis and promptly arises at the historic moment.With tcm and herbal slice Eucalyptus globules Fruits (Eucalyptus globules Fruits), Caulis Sinomenii, ANTONGTENG, caragana, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Fructus Chaenomelis, the Rhizoma Atractylodis Macrocephalae, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Olibanum, Myrrha, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Pheretima, the Radix Astragali, Radix Codonopsis, Chinese liquor is raw material, adopts modern Chinese medicine extraction process and traditional traditional Chinese medical science technology to combine and processes.According to executing the principle of controlling about up-to-date modern pharmacological research achievement and traditional differential diagnosis in tcm of treatment rheumatoid arthritis at present, the different state of an illness need flexible prescription therapeutic.
The property of medicine of the used Chinese medicine of the present invention and modern pharmacological research achievement are as follows: Eucalyptus globules Fruits (being Eucalyptus globules Fruits): be China's tradition Chinese herbal medicine among the people, it is the fruit of Myrtaceae eucalyptus plant Eucalyptus globulus Labill, Eucalyptus globulus Labill has another name called cajaput, grey willow, bead Eucalyptus, Herba Tephrosiae purpureae eucalyptus globulus, mostly be cultivation, be distributed in provinces and regions such as Fujian, Guangdong, Guangxi, Yunnan, Guizhou, Sichuan.But the Eucalyptus globulus Labill all herbal medicine, the clinical fruits of using more.The Eucalyptus globulus Labill fruit medicine is commonly called as " Eucalyptus globules Fruits ", and mildly bitter flavor, property are flat, has except that wind, damp eliminating, analgesic, detoxifcation, parasite killing, effect such as antipruritic; Modern pharmacological research achievement: Eucalyptus globules Fruits solution treatment rheumatoid arthritis with remarkable effect.The conclusion in " Eucalyptus globules Fruits chemical constituent and pharmacological research progress " (Jilin, the Jilin 132013) of " Jilin medicine institute journal ": the pharmacological action of Eucalyptus globules Fruits has: analgesic and anti-inflammatory effects, antibacterial action, immunoregulation effect, antitumor action etc.
" medical Leader " 2009 08 phases conclusion Eucalyptus globules Fruits extract has remarkable therapeutical effect to rat assist agent arthritis.For its clinical treatment rheumatoid arthritis provides experimental basis.
Caulis Sinomenii: have another name called Caulis Sinomenii, Sinomenium acutum, bitter in the mouth, suffering, property is flat, returns liver, spleen channel, has expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, the effect of diuresis.The effect of modern pharmacological research achievement-Caulis Sinomenii extract (sinomenine) treatment rheumatoid arthritis may can suppress the synovial cell with it and secrete inflammatory mediator, and it is relevant to recover synovial cell's form.Have effects such as analgesia, antiinflammatory, swelling diuretic, immunomodulating clinically.
ANTONGTENG: lightly seasoned, little puckery, property is flat.Return liver, stomach warp, have wind-expelling pain-stopping, relaxing muscles and tendons and activating QI and blood in the collateral, dial the pus detumescence, function.Be used for traumatic injury, sprain fracture, Fengshi Guanjie pain, the carbuncle skin ulcer swells and ache.Modern pharmacological research result-ANTONGTENG decocting thing has resistant function to rat assist agent arthritis, and this has easing pain and diminishing inflammation, detumescence during for the treatment of ANTONGTENG clinically rheumatoid joint, and experimental basis is provided.
The Radix Paeoniae Alba: bitter in the mouth acid, cold nature.Go into liver, spleen channel.Has the suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, the function of astringing YIN to stop sweating.The modern pharmacological research result: Radix Paeoniae Alba extract-Radix Paeoniae Alba total glucosides treatment rheumatoid arthritis has specially good effect; pharmacological research proof Radix Paeoniae Alba total glucosides can ameliorate osteoarthritis disease react; eliminate swelling, reduce synovial tissue's inflammatory cell infiltration, damage has the certain protection effect to cartilaginous tissue.
Pericarpium Citri Reticulatae: bitter in the mouth suffering, warm in nature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.It is that Hesperidin can be regulated the unusual immunologic function of body that modern pharmacological research result-Pericarpium Citri Reticulatae extract (Hesperidin) treatment rheumatoid arthritis has the reason of produce effects, can keep the cytokine network balance.
Fructus Chaenomelis: sour in the mouth, warm in nature, return liver, spleen channel.Has suppressing the hyperactive liver and easing the stomach, the function of damp eliminating Shujin.Be used for the arthralgia chiefly caused by damp pathogen contracture, soreness of waist and knee joint, the convulsion of vomiting and diarrhoea, articular instability, beriberi swelling etc.It is that glucosides of Fructus Chaenomelis can be regulated body's immunity that modern pharmacological research result-Fructus Chaenomelis extract (glucosides of Fructus Chaenomelis) treatment rheumatoid arthritis has the reason of produce effects.
The Rhizoma Atractylodis Macrocephalae: bitter but sweet flavor, warm in nature, go into spleen, stomach warp, have invigorating the spleen and benefiting QI, dampness diuretic, the function that hidroschesis is antiabortive.
Caragana: bitter, hot, property is put down.Return the lung spleen channel.Has the lung heat clearing strengthening the spleen, the function of blood circulation and channel invigorating.Be used for deficient consumptive disease heat, cough, rheumatic arthritis, traumatic injury.Modern experimental pharmacology studies have shown that it is that caragana has antiinflammatory action and immunologic function regulating action that caragana water decoction treatment rheumatoid arthritis has the reason of good result.
Olibanum: hot, bitter, warm.GUIXIN, liver, spleen channel.Has promoting blood circulation and stopping pain, the function of detumescence and promoting granulation.Be used for epigastric pain, dysmenorrhea, amenorrhea, injury from falling down, carbuncle pain.
Myrrha: bitter, flat.GUIXIN, liver, spleen channel.Has promoting blood circulation and stopping pain, the function of detumescence and promoting granulation.Be used for pain due to blood stasis, amenorrhea, ulcer sores, diabrosis is not closed up for a long time.
Radix Angelicae Sinensis: sweet, hot, warm.Return liver, heart spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the function of loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, menoxenia, amenorrhea, dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine, constipation, rheumatic arthralgia, ulcer sores, injury from falling down.
Radix Salviae Miltiorrhizae: bitter, be slightly cold.GUIXIN, Liver Channel.Has stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the function of the relieving restlessness that clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea.Caking gathers in the abdomen, breast ventral spine pain, and pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia, cards such as angina pectoris.
Pheretima: salty, cold.Return liver, spleen, urinary bladder channel.Have heat clearing away, arresting convulsion, collateral dredging is relievingd asthma, the diuretic function.Be used for unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, diseases such as oliguria edema.
Radix Codonopsis: sweet in the mouth, property are put down.Go into spleen, lung meridian.Has invigorating the spleen and replenishing QI, the function of spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard.
The Radix Astragali: sweet in the mouth, slightly warm in nature.Go into lung, spleen channel.Has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the function of expelling pus and promoting granulation.Be used for the weak anorexia and loose stool of the deficiency of vital energy, sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, spontaneous sweating due to deficiency of QI, edema, carbuncle is difficult bursts, and bursts for a long time and does not hold back blood deficiency dull yellowish colored skin etc.Modern experimental pharmacology studies have shown that advantages such as Radix Astragali total extract treatment rheumatoid arthritis is effective in cure good, rapid-action, and untoward reaction is few, be since Radix Astragali total extract (Radix Astragali general glycoside) to rat assist agent arthritis, Wheat Protein.
JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata): dyspepsia and intestinal stasis relieving, invigorating the spleen and stomach.
Chinese liquor: sweet suffering is hot greatly, the energy promoting blood circulation, and cold expelling, row medicine gesture, the abnormal smells from the patient sweet-smelling is special.So medicated wine is applicable to the treatment anemofrigid-damp arthralgia, and expelling wind and activating blood circulation is arranged, the effect of eliminating stasis to stop pain.The chemical constituent of Chinese liquor is made up of the second alcohol and water, and ethanol is the commonly used main extraction solvent in the modern Chinese medicine extracting technology.Ethanol is can be by regulating concentration of ethanol, optionally some effective ingredient or effective site in the lixiviate medical material as the great advantage of extraction solvent.General ethanol content is suitable for alkaloid and glycoside in the lixiviate Chinese crude drug when 50%-70%.And the various glycosides that prepared slices of Chinese crude drugs Eucalyptus globules Fruits, Caulis Sinomenii, ANTONGTENG, the Radix Paeoniae Alba, Fructus Chaenomelis, Pericarpium Citri Reticulatae, the Radix Astragali etc. contain itself are treated the effective ingredient of rheumatoid arthritis just.So product of the present invention just manufactures medicated wine.
During the treatment rheumatoid arthritis, the rule of treatment of the traditional Chinese medical science is: new sick collateral dredging a surname numbness is main, is aided with expelling wind and cold, removes damp and clearing heat; Prolonged illness collateral dredging a surname numbness is main, is aided with liver and kidney tonifying, and benefiting QI and nourishing blood reduces phlegm, removing blood stasis.The modern doctor trained in Western medicine pharmacology rule of treatment is: regulate body abnormal immune function, and analgesia, antiinflammatory, detumescence, protection intraarticular cartilaginous tissue is injury-free.Here Eucalyptus globules Fruits (Eucalyptus globules Fruits) is a monarch drug, evil-wind expelling and dampness removing, heat clearing away collateral dredging, and its extract eases pain again simultaneously, and body abnormal immune function is regulated in detumescence, antiinflammatory; Caulis Sinomenii, ANTONGTENG is a ministerial drug, share auxiliary Eucalyptus globules Fruits evil-wind expelling and dampness removing, collateral dredging Shujin, its extract are strengthened detumescence, analgesia, antiinflammatory, adjusting body abnormal immune function again; Caragana lung heat clearing strengthening the spleen, blood circulation and channel invigorating can improve the ankylosis symptom, strengthens antiinflammatory action and immunoregulation effect simultaneously again; Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen dampness can guide the joint blood circulation, and its extract continues to strengthen the adjusting body's immunity; The Fructus Chaenomelis suppressing the hyperactive liver and easing the stomach, the damp eliminating Shujin is beneficial to and improves the arthralgia chiefly caused by damp pathogen contracture, articular instability, its extract also can be regulated body's immunity; The Rhizoma Atractylodis Macrocephalae, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), invigorating the spleen and benefiting QI, blending taste; The Radix Paeoniae Alba suppressing the hyperactive liver that nourishes blood, menstruction regulating and pain relieving, its extract can anti-inflammation detumescences, and the protection cartilaginous tissue is injury-free; Olibanum, Myrrha, promoting blood circulation and stopping pain, detumescence and promoting granulation; Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Pheretima are share to strengthen and loose except that the blood stasis effect; The Radix Astragali, Radix Codonopsis share invigorating the spleen and replenishing QI, and the spleen invigorating lung benefiting can improve the sick deficiency of vital energy for a long time, emaciated physique.Chinese liquor is used to extract Eucalyptus globules Fruits as solvent, Caulis Sinomenii, Pericarpium Citri Reticulatae, the effective ingredient in the prepared slices of Chinese crude drugs such as the Radix Paeoniae Alba, the effect that has the capable medicine gesture of blood circulation and channel invigorating cold expelling again simultaneously.
These crude drug are filled a prescription flexibly, and unique lixiviate manufacturing to improve curative effect, is specifically asked for an interview
The specific embodiment.
The manufacture method of product of the present invention:
The concrete prescription of embodiment by the different state of an illness.
1. the preparation of Chinese medicine medicated wine
A, the choosing of raw material Chinese medicine is equipped with: drink sheet type Chinese crude drug Eucalyptus globules Fruits (Eucalyptus globules Fruits) 160-180 gram, Caulis Sinomenii 60-80 gram, ANTONGTENG 50-70 gram, Radix Paeoniae Alba 50-70 gram, Pericarpium Citri Reticulatae 30-50 gram, Fructus Chaenomelis 30-50 gram, Rhizoma Atractylodis Macrocephalae 30-50 gram, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) (Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus) each 30-50 gram, caragana 50-70 gram, Olibanum 30-50 gram, Myrrha 30-50 gram, Radix Angelicae Sinensis 30-50 gram, Radix Salviae Miltiorrhizae 30-50 gram, Pheretima 30-50 gram, Radix Astragali 30-50 gram, Radix Codonopsis 30-50 gram, more than the Massa Medicata Fermentata of 18 flavors in JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) all the other 17 distinguish the flavor of be ground into rough segmentation (" Chinese pharmacopoeia 2005 editions) and add Massa Medicata Fermentata then after, insert in the stainless steel storage tank jointly, add pure grain 60 degree Chinese liquor 10000 grams-13000 grams, airtight dipping;
B, every day stir 1-2 time, stir weekly after the week 1 time, flood altogether 30, get supernatant, and the squeezing medicinal residues merge press liquor and supernatant, add 500g brown sugar again, stirring and dissolving, and the sealing back is static more than at least 15 days, and Kaifeng back filtering promptly gets medicated wine.
2. the preparation of product,
promptly get among the 1B medicated wine under the state that stirs by the 500ml/ bottle, divide in the vial of packing into airtight preserve product.
The usage of product of the present invention, consumption explanation: usage: oral; Consumption a: 10ml, 2 times on the 1st.
The major advantage of product of the present invention is as follows:
1. kind is single, and is easy to use.
2. scope of medication is wide, can be used for the treatment of early, middle and late each phase of rheumatoid arthritis.
3. has certain etiological treatment effect.
4. produce effects is fast, and disease controlling is stable.
5. toxic and side effects is little.
6. it is fine to regulate the unusual effect of body's immunity.
7. shorten relatively the course of treatment, recurrence rate after healing is very low, is beneficial to drug withdrawal as early as possible.
8. solved the difficult problem that patient with rheumatoid arthritis is taken medicine for a long time.
The specific embodiment
1. drink sheet type Chinese crude drug Eucalyptus globules Fruits (Eucalyptus globules Fruits) 160-180 gram, Caulis Sinomenii 60-80 gram, ANTONGTENG 50-70 gram, Radix Paeoniae Alba 50-70 gram, Pericarpium Citri Reticulatae 30-50 gram, Fructus Chaenomelis 30-50 gram, Rhizoma Atractylodis Macrocephalae 30-50 gram, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) (Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus) each 30-50 gram, caragana 50-70 gram, Radix Astragali 30-50 gram, Radix Codonopsis 30-50 gram manufactures product and usage by manufacture method of the present invention, consumption uses: be applicable to emaciated physique, joint deformity, amyotrophy, arthralgia with restlessness, ankylosis, limitation of activity, soreness of the waist and knees is unable, the treatment of the patient with rheumatoid arthritis of shortness of breath and palpitation.
2. drink sheet type Chinese crude drug Eucalyptus globules Fruits (Eucalyptus globules Fruits) 160-180 gram, Caulis Sinomenii 60-80 gram, ANTONGTENG 50-70 gram, Radix Paeoniae Alba 50-70 gram, Pericarpium Citri Reticulatae 30-50 gram, Fructus Chaenomelis 30-50 gram, Rhizoma Atractylodis Macrocephalae 30-50 gram, Pericarpium Citri Reticulatae 30-50 gram, Fructus Chaenomelis 30-50 gram, Rhizoma Atractylodis Macrocephalae 30-50 gram, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) (Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus) each 30-50 gram, caragana 50-70 gram, Radix Angelicae Sinensis 30-50 gram, Radix Salviae Miltiorrhizae 30-50 gram, Pheretima 30-50 gram, manufacture product and usage by manufacture method of the present invention, consumption uses: be applicable to arthralgia and distortion, muscle twinge when movable, pain in fixed position, bend and stretch limited, skin follows the string, that presses is hard slightly, the skin purple is dim, darkish complexion, dimly red tongue, or ecchymosis arranged, the treatment of the patient with rheumatoid arthritis of petechia.
3. drink sheet type Chinese crude drug Eucalyptus globules Fruits (Eucalyptus globules Fruits) 160-180 gram, Caulis Sinomenii 60-80 gram, ANTONGTENG 50-70 gram, Radix Paeoniae Alba 50-70 gram, Pericarpium Citri Reticulatae 30-50 gram, Fructus Chaenomelis 30-50 gram, Rhizoma Atractylodis Macrocephalae 30-50 gram, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) (Fructus Crataegi, Massa Medicata Fermentata, Fructus Hordei Germinatus) each 30-50 gram, caragana 50-70 gram, Olibanum 30-50 gram, Myrrha 30-50 gram, Radix Angelicae Sinensis 30-50 gram, Radix Salviae Miltiorrhizae 30-50 gram, Pheretima 30-50 gram, Radix Astragali 30-50 gram, Radix Codonopsis 30-50 gram, manufacture product and usage by manufacture method of the present invention, consumption uses: be applicable to that whole body arthralgia is violent, morning is obviously stiff, joint motion is limited, swelling, heating, the treatment of the patient with rheumatoid arthritis of aversion to wind.
Experiment, data, effect and explanation:
The disease that product of the present invention is treated belongs to common frdquently encountered disease, so have extensive representativeness, test of cure patient 120 examples, wherein male 52 examples, women 68 examples; The course of disease 6 months-28 years, average 3.8 years.Early stage 34 examples, mid-terms 60 example, late periods 26 example.Be in 42 examples that have of active stage among this 120 routine patient, be in paracmastic 78 examples.
Routine patient of active stages 26, owing to use product of the present invention, pain obviously alleviates in the time of 7-10 days, the stiff time in morning begins to shorten, and arthroncus alleviates, and deadlock, pain, arthroncus are obviously alleviated morning during by 30 days-45 days, relative western medicine, obviously shorten the course of treatment, and expense saves about 60%; Early stage 34 routine patients owing to use product of the present invention, begin produce effects in the time of 5-7 days, 15 days-20 days, arthroncus disappeared, and pain obviously alleviates, and cure in 45 days-60 days, and relative Western medicine is more obvious reducing by half than the course of treatment, and expense saves 60%.Late periods 26, routine patient was owing to use product of the present invention, and amyotrophy begins to alleviate in the time of 30 days-40 days, and body is gradually rich, the muscle veinclearing is apparent to be loosened, and stiff the beginning alleviated, and all diseases are clearly better in the time of 60 days-80 days, western medicine obviously shortens 1/3 the course of treatment relatively, and expense saves about 60%; In a word, whole 120 routine patient treatment results: cure (symptom all disappears, and the functional activity recovery is normal, ESR, anti-" O ", RF check normal) 84 examples, drug withdrawal observation state of an illness half a year does not have recurrence; Produce effects (cardinal symptom disappears, and function of joint is recovered substantially, can participate in normal work) 21 examples; Take a turn for the better (arthralgia and stiff alleviating, but laboratory indexes does not have change, disease relapse after the drug withdrawal) 14 examples; Invalid (treat continuously more than 1 month, the state of an illness does not have improvement) 1 example; Cure rate 70%, total effective rate 99.1%.
Claims (3)
1. Chinese medicine medicated wine for the treatment of rheumatoid arthritis, it is characterized in that: by decoction pieces type Chinese crude drug Eucalyptus globules Fruits is Eucalyptus globules Fruits 160-180 gram, Caulis Sinomenii 60-80 gram, ANTONGTENG 50-70 gram, Radix Paeoniae Alba 50-70 gram, Pericarpium Citri Reticulatae 30-50 gram, Fructus Chaenomelis 30-50 gram, Rhizoma Atractylodis Macrocephalae 30-50 gram, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) is promptly: Fructus Crataegi, god goes, each 30-50 gram of Fructus Hordei Germinatus, caragana 50-70 gram, 60 degree brewing grains white spirits, 10000 grams-13000 grams are principal agent, optional Olibanum 30-50 gram, Myrrha 30-50 gram, Radix Angelicae Sinensis 30-50 gram, Radix Salviae Miltiorrhizae 30-50 gram, Pheretima 30-50 gram, Radix Astragali 30-50 gram, Radix Codonopsis 30-50 gram, zero kind is accessory drugs all extremely.
2. the manufacture method of the Chinese medicine medicated wine of treatment rheumatoid arthritis according to claim 1 is characterized in that: by the concrete prescription of embodiment of the different state of an illness,
(1) preparation of Chinese medicine medicated wine
A, the choosing of raw material Chinese medicine is equipped with: drinking sheet type Chinese crude drug Eucalyptus globules Fruits is Eucalyptus globules Fruits 160-180 gram, Caulis Sinomenii 60-80 gram, ANTONGTENG 50-70 gram, Radix Paeoniae Alba 50-70 gram, Pericarpium Citri Reticulatae 30-50 gram, Fructus Chaenomelis 30-50 gram, Rhizoma Atractylodis Macrocephalae 30-50 gram, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) is a Fructus Crataegi, Massa Medicata Fermentata, each 30-50 gram of Fructus Hordei Germinatus, caragana 50-70 gram, Olibanum 30-50 gram, Myrrha 30-50 gram, Radix Angelicae Sinensis 30-50 gram, Radix Salviae Miltiorrhizae 30-50 gram, Pheretima 30-50 gram, Radix Astragali 30-50 gram, Radix Codonopsis 30-50 gram, more than the Massa Medicata Fermentata of 18 flavors in JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) all the other 17 distinguish the flavor of and be ground into rough segmentation and meet " Chinese pharmacopoeia 2005 editions, after adding Massa Medicata Fermentata then, insert in the stainless steel storage tank jointly, add pure grain 60 degree Chinese liquor 10000 grams-13000 grams, airtight dipping;
B, every day stir 1-2 time, stir weekly after the week 1 time, flood altogether 30, get supernatant, and the squeezing medicinal residues merge press liquor and supernatant, add 500g brown sugar again, stirring and dissolving, and the sealing back is static more than at least 15 days, and Kaifeng back filtering promptly gets medicated wine;
(2) preparation of product
promptly get among (1) B medicated wine under the state that stirs by the 500ml/ bottle, divide in the vial of packing into airtight preserve product.
3. the purposes of the Chinese medicine medicated wine of treatment rheumatoid arthritis according to claim 1 and 2, it is characterized in that: the Chinese medicine medicated wine that is used for the production for treating rheumatoid arthritis, consumption is by the ordinary production demand, Chinese medicine medicated wine as the treatment rheumatoid arthritis, usage: oral, consumption a: 10ml, 2 times on the one.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188553A (en) * | 2011-05-06 | 2011-09-21 | 周荣华 | Medicinal wine for oral and external administration and manufacturing method thereof |
| CN105969600A (en) * | 2016-03-03 | 2016-09-28 | 亳州市益众堂保健食品有限公司 | Rheumatism healthcare liquor and preparing method thereof |
| CN115990234A (en) * | 2022-12-09 | 2023-04-21 | 湖南省中医药研究院 | Traditional Chinese medicine composition for treating bone cancer pain by combining traditional Chinese medicine and packaging decoction and preparation method thereof |
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| CN1327841A (en) * | 2001-05-04 | 2001-12-26 | 刘玉福 | Medicine for treating rheumatoid arthritis |
| CN101406646A (en) * | 2008-11-26 | 2009-04-15 | 路敦祥 | Chinese medicinal liquor for treating arthritis |
| CN101579503A (en) * | 2009-06-29 | 2009-11-18 | 王敬恩 | Traditional Chinese medicine for treating rheumatism |
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| CN1327841A (en) * | 2001-05-04 | 2001-12-26 | 刘玉福 | Medicine for treating rheumatoid arthritis |
| CN101406646A (en) * | 2008-11-26 | 2009-04-15 | 路敦祥 | Chinese medicinal liquor for treating arthritis |
| CN101579503A (en) * | 2009-06-29 | 2009-11-18 | 王敬恩 | Traditional Chinese medicine for treating rheumatism |
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| 《四川中医》 20011231 覃小兰，等 运动神经元病的中医治疗进展 17-19 1-2 第19卷, 第5期 2 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188553A (en) * | 2011-05-06 | 2011-09-21 | 周荣华 | Medicinal wine for oral and external administration and manufacturing method thereof |
| CN102188553B (en) * | 2011-05-06 | 2012-11-07 | 周荣华 | Medicinal wine for oral and external administration and manufacturing method thereof |
| CN105969600A (en) * | 2016-03-03 | 2016-09-28 | 亳州市益众堂保健食品有限公司 | Rheumatism healthcare liquor and preparing method thereof |
| CN115990234A (en) * | 2022-12-09 | 2023-04-21 | 湖南省中医药研究院 | Traditional Chinese medicine composition for treating bone cancer pain by combining traditional Chinese medicine and packaging decoction and preparation method thereof |
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| CN101810807B (en) | 2012-02-08 |
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