CN101808990B - 作为趋化因子受体活性调节剂的哌啶衍生物 - Google Patents
作为趋化因子受体活性调节剂的哌啶衍生物 Download PDFInfo
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- CN101808990B CN101808990B CN200880108518XA CN200880108518A CN101808990B CN 101808990 B CN101808990 B CN 101808990B CN 200880108518X A CN200880108518X A CN 200880108518XA CN 200880108518 A CN200880108518 A CN 200880108518A CN 101808990 B CN101808990 B CN 101808990B
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- alkyl
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- heteroaryl
- cycloalkyl
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- 0 C[C@](CC1)*1NC Chemical compound C[C@](CC1)*1NC 0.000 description 11
- CVKGBEGKZIIWRA-UHFFFAOYSA-N C(C1)CC2=C1CCCC2 Chemical compound C(C1)CC2=C1CCCC2 CVKGBEGKZIIWRA-UHFFFAOYSA-N 0.000 description 1
- ALDYFKCYVAOMJY-UHFFFAOYSA-N C1C=C(C=CC=C2)C2=NC1 Chemical compound C1C=C(C=CC=C2)C2=NC1 ALDYFKCYVAOMJY-UHFFFAOYSA-N 0.000 description 1
- HRCMXYXVAWHBTH-UHFFFAOYSA-N C1Oc(cccc2)c2N1 Chemical compound C1Oc(cccc2)c2N1 HRCMXYXVAWHBTH-UHFFFAOYSA-N 0.000 description 1
- NGRGUSRTFHLYCF-UHFFFAOYSA-N C1c(cccc2)c2OCNC1 Chemical compound C1c(cccc2)c2OCNC1 NGRGUSRTFHLYCF-UHFFFAOYSA-N 0.000 description 1
- APJZRQDIBAHVPS-SBRXJDRESA-N CC(C([C@@](CC1)(C(C)(C)CN1C([C@@H](COCC1)[C@@H]1NC(c1ccccc1)=O)=O)O)C=C1)C=C1Cl Chemical compound CC(C([C@@](CC1)(C(C)(C)CN1C([C@@H](COCC1)[C@@H]1NC(c1ccccc1)=O)=O)O)C=C1)C=C1Cl APJZRQDIBAHVPS-SBRXJDRESA-N 0.000 description 1
- PMOLUOITLCQFBE-GLDPYIMESA-N CC(C)(C)OC(N[C@H](CCC1)[C@H]1C(N(CC1)CC(C)(C)[C@]1(c(cc1)ccc1Cl)O)=O)=O Chemical compound CC(C)(C)OC(N[C@H](CCC1)[C@H]1C(N(CC1)CC(C)(C)[C@]1(c(cc1)ccc1Cl)O)=O)=O PMOLUOITLCQFBE-GLDPYIMESA-N 0.000 description 1
- OBJNISRXJLCLMM-ZYMBUAEHSA-N CC(C)(CN(CC1)C([C@@H](CCC2)[C@@H]2NC(O/C(/C=C)=C/C=C\C)=O)=O)[C@]1(c(cc1)ccc1Cl)O Chemical compound CC(C)(CN(CC1)C([C@@H](CCC2)[C@@H]2NC(O/C(/C=C)=C/C=C\C)=O)=O)[C@]1(c(cc1)ccc1Cl)O OBJNISRXJLCLMM-ZYMBUAEHSA-N 0.000 description 1
- XAOMFFUMQSSGFE-KQDQWFAOSA-N CC(C)(CN(CC1)C([C@@H](CCC2)[C@@H]2NC(c2cc(-c3n[n](COCc4ccccc4)nn3)ccc2)=O)=O)[C@]1(c(cc1)ccc1Cl)O Chemical compound CC(C)(CN(CC1)C([C@@H](CCC2)[C@@H]2NC(c2cc(-c3n[n](COCc4ccccc4)nn3)ccc2)=O)=O)[C@]1(c(cc1)ccc1Cl)O XAOMFFUMQSSGFE-KQDQWFAOSA-N 0.000 description 1
- SMAMJBBSFSOBCD-OBTVHEKISA-N CC(C)(CN(CC1)C([C@@H](CCCC2)[C@@H]2NC(Oc2ccccc2)=O)=O)[C@]1(C(CC1)=CC=C1Cl)O Chemical compound CC(C)(CN(CC1)C([C@@H](CCCC2)[C@@H]2NC(Oc2ccccc2)=O)=O)[C@]1(C(CC1)=CC=C1Cl)O SMAMJBBSFSOBCD-OBTVHEKISA-N 0.000 description 1
- KQKFNIVNRRMMHA-UHFFFAOYSA-N CCCC[Sn](CCCC)(CCCC)c1n[n](COCc2ccccc2)nn1 Chemical compound CCCC[Sn](CCCC)(CCCC)c1n[n](COCc2ccccc2)nn1 KQKFNIVNRRMMHA-UHFFFAOYSA-N 0.000 description 1
- CJWQBLCGSMIQJV-UHFFFAOYSA-N COC(c1cc(-c2cc(C(O)=O)ccc2)ccc1)=O Chemical compound COC(c1cc(-c2cc(C(O)=O)ccc2)ccc1)=O CJWQBLCGSMIQJV-UHFFFAOYSA-N 0.000 description 1
- YOMSLCVVZDGKNG-UHFFFAOYSA-N COC(c1cc(-c2ccccc2)cc(C(O)=O)c1)=O Chemical compound COC(c1cc(-c2ccccc2)cc(C(O)=O)c1)=O YOMSLCVVZDGKNG-UHFFFAOYSA-N 0.000 description 1
- AOYYJCSJRGKARE-GJEMNUMLSA-N C[C@H](CC(C1)C(N[C@H](CCCC2)[C@H]2C(N(CC2)CC(C)(C)[C@]2(c(cc2)ccc2Cl)O)=O)=O)[C@H]1O Chemical compound C[C@H](CC(C1)C(N[C@H](CCCC2)[C@H]2C(N(CC2)CC(C)(C)[C@]2(c(cc2)ccc2Cl)O)=O)=O)[C@H]1O AOYYJCSJRGKARE-GJEMNUMLSA-N 0.000 description 1
- IODHTKAGEQWXOT-UHFFFAOYSA-N Cc(cc1)cc2c1NC(C1)C1=C2 Chemical compound Cc(cc1)cc2c1NC(C1)C1=C2 IODHTKAGEQWXOT-UHFFFAOYSA-N 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N O=C1Oc(cccc2)c2C=C1 Chemical compound O=C1Oc(cccc2)c2C=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- NPAXFZBGZWAVIF-NVGWPGHNSA-N O[C@H](CC(C1)C(O)=O)[C@H]1O Chemical compound O[C@H](CC(C1)C(O)=O)[C@H]1O NPAXFZBGZWAVIF-NVGWPGHNSA-N 0.000 description 1
- IOJUPLGTWVMSFF-UHFFFAOYSA-N c1nc(cccc2)c2[s]1 Chemical compound c1nc(cccc2)c2[s]1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95147807P | 2007-07-24 | 2007-07-24 | |
| US60/951,478 | 2007-07-24 | ||
| US8152908P | 2008-07-17 | 2008-07-17 | |
| US61/081,529 | 2008-07-17 | ||
| PCT/US2008/070804 WO2009015166A1 (en) | 2007-07-24 | 2008-07-23 | Piperidine derivatives as modulators of chemokine receptor activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101808990A CN101808990A (zh) | 2010-08-18 |
| CN101808990B true CN101808990B (zh) | 2012-09-05 |
Family
ID=39817116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880108518XA Expired - Fee Related CN101808990B (zh) | 2007-07-24 | 2008-07-23 | 作为趋化因子受体活性调节剂的哌啶衍生物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8536198B2 (OSRAM) |
| EP (1) | EP2173714B9 (OSRAM) |
| JP (1) | JP5292400B2 (OSRAM) |
| CN (1) | CN101808990B (OSRAM) |
| WO (1) | WO2009015166A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI433838B (zh) * | 2008-06-25 | 2014-04-11 | 必治妥美雅史谷比公司 | 作為趨化因子受體活性調節劑之六氫吡啶衍生物 |
| WO2011009021A1 (en) | 2009-07-16 | 2011-01-20 | Abbott Laboratories | Processes for the synthesis of (2s, 3ar, 7as)-octahydro-1h-indole carboxylic acid as an intermediate for trandolapril |
| US8410139B2 (en) | 2009-10-07 | 2013-04-02 | Bristol-Myers Squibb Company | Prodrugs of a piperidinyl derivative as modulators of chemokine receptor activity |
| CN102648193A (zh) | 2009-10-07 | 2012-08-22 | 百时美施贵宝公司 | 作为趋化因子受体活性调节剂的螺环化合物 |
| US8642622B2 (en) | 2010-06-16 | 2014-02-04 | Bristol-Myers Squibb Company | Piperidinyl compound as a modulator of chemokine receptor activity |
| GB201318222D0 (en) * | 2013-10-15 | 2013-11-27 | Takeda Pharmaceutical | Novel compounds |
| EP3852879A1 (en) | 2018-09-21 | 2021-07-28 | Pfizer Inc. | N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamides useful as ccr6 inhibitors |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000051609A1 (en) * | 1999-03-02 | 2000-09-08 | Merck & Co., Inc. | 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity |
| CN1867336A (zh) * | 2002-06-12 | 2006-11-22 | 凯莫森特里克斯股份有限公司 | 1－芳基－4－取代的哌嗪衍生物用作ccr1拮抗剂以治疗炎症和免疫疾病 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6429213B1 (en) | 1998-06-17 | 2002-08-06 | Bristol Myers Squibb Pharma Co | Cyclic hydroxamic acids as metalloproteinase inhibitors |
| US6638950B2 (en) * | 2000-06-21 | 2003-10-28 | Bristol-Myers Squibb Pharma Company | Piperidine amides as modulators of chemokine receptor activity |
| US6627629B2 (en) * | 2000-06-30 | 2003-09-30 | Bristol-Myers Squibb Pharma | N-ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity |
| SE0202133D0 (sv) * | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
| GEP20094844B (en) | 2004-06-28 | 2009-11-25 | Incyte Corp | 3-aminocyclopentane carboxamides as modulators of chemokine receptors |
| WO2006004684A2 (en) | 2004-06-28 | 2006-01-12 | Incyte Corporation | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| GB0525957D0 (en) * | 2005-12-21 | 2006-02-01 | Astrazeneca Ab | Methods |
| US7615556B2 (en) | 2006-01-27 | 2009-11-10 | Bristol-Myers Squibb Company | Piperazinyl derivatives as modulators of chemokine receptor activity |
| US7601844B2 (en) * | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
-
2008
- 2008-07-23 EP EP08796435.9A patent/EP2173714B9/en not_active Not-in-force
- 2008-07-23 JP JP2010518342A patent/JP5292400B2/ja not_active Expired - Fee Related
- 2008-07-23 WO PCT/US2008/070804 patent/WO2009015166A1/en not_active Ceased
- 2008-07-23 CN CN200880108518XA patent/CN101808990B/zh not_active Expired - Fee Related
- 2008-07-23 US US12/670,025 patent/US8536198B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000051609A1 (en) * | 1999-03-02 | 2000-09-08 | Merck & Co., Inc. | 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity |
| CN1867336A (zh) * | 2002-06-12 | 2006-11-22 | 凯莫森特里克斯股份有限公司 | 1－芳基－4－取代的哌嗪衍生物用作ccr1拮抗剂以治疗炎症和免疫疾病 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5292400B2 (ja) | 2013-09-18 |
| EP2173714B1 (en) | 2012-12-26 |
| CN101808990A (zh) | 2010-08-18 |
| JP2010534670A (ja) | 2010-11-11 |
| WO2009015166A1 (en) | 2009-01-29 |
| EP2173714A1 (en) | 2010-04-14 |
| US20100222366A1 (en) | 2010-09-02 |
| US8536198B2 (en) | 2013-09-17 |
| EP2173714B9 (en) | 2013-04-10 |
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