CN101808623B - 包含11-脱氧-前列腺素化合物的药物组合物和使该化合物稳定化的方法 - Google Patents

包含11-脱氧-前列腺素化合物的药物组合物和使该化合物稳定化的方法 Download PDF

Info

Publication number
CN101808623B
CN101808623B CN2008800250368A CN200880025036A CN101808623B CN 101808623 B CN101808623 B CN 101808623B CN 2008800250368 A CN2008800250368 A CN 2008800250368A CN 200880025036 A CN200880025036 A CN 200880025036A CN 101808623 B CN101808623 B CN 101808623B
Authority
CN
China
Prior art keywords
fatty acid
deoxy
carbon atoms
composition
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2008800250368A
Other languages
English (en)
Chinese (zh)
Other versions
CN101808623A (zh
Inventor
原田康弘
川崎淳一
西村佳惠
上野隆司
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sucampo GmbH
Co Ltd R Tech Ueno
Original Assignee
Sucampo GmbH
Co Ltd R Tech Ueno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sucampo GmbH, Co Ltd R Tech Ueno filed Critical Sucampo GmbH
Publication of CN101808623A publication Critical patent/CN101808623A/zh
Application granted granted Critical
Publication of CN101808623B publication Critical patent/CN101808623B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2008800250368A 2007-07-19 2008-07-16 包含11-脱氧-前列腺素化合物的药物组合物和使该化合物稳定化的方法 Expired - Fee Related CN101808623B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92994807P 2007-07-19 2007-07-19
US60/929,948 2007-07-19
PCT/JP2008/063222 WO2009011449A2 (en) 2007-07-19 2008-07-16 Pharmaceutical composition comprising 11-deoxy-prostaglandin compound and method for stabilizing the compound

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2013102926965A Division CN103393618A (zh) 2007-07-19 2008-07-16 包含11-脱氧-前列腺素化合物的药物组合物和使该化合物稳定化的方法

Publications (2)

Publication Number Publication Date
CN101808623A CN101808623A (zh) 2010-08-18
CN101808623B true CN101808623B (zh) 2013-08-14

Family

ID=39720491

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2008800250368A Expired - Fee Related CN101808623B (zh) 2007-07-19 2008-07-16 包含11-脱氧-前列腺素化合物的药物组合物和使该化合物稳定化的方法
CN2013102926965A Pending CN103393618A (zh) 2007-07-19 2008-07-16 包含11-脱氧-前列腺素化合物的药物组合物和使该化合物稳定化的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2013102926965A Pending CN103393618A (zh) 2007-07-19 2008-07-16 包含11-脱氧-前列腺素化合物的药物组合物和使该化合物稳定化的方法

Country Status (14)

Country Link
US (2) US8969324B2 (enExample)
EP (2) EP2327398A3 (enExample)
JP (2) JP5390519B2 (enExample)
KR (1) KR101485212B1 (enExample)
CN (2) CN101808623B (enExample)
AU (1) AU2008276840B2 (enExample)
BR (1) BRPI0814115B8 (enExample)
CA (1) CA2691995C (enExample)
IL (1) IL203064B (enExample)
MX (1) MX339727B (enExample)
NZ (2) NZ595270A (enExample)
RU (3) RU2506072C2 (enExample)
TW (2) TWI446912B (enExample)
WO (1) WO2009011449A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101410097A (zh) * 2006-01-24 2009-04-15 株式会社·R-技术上野 软明胶胶囊制剂
CN107903173A (zh) * 2011-08-05 2018-04-13 苏坎波公司 治疗精神分裂症的方法
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
JP6580414B2 (ja) * 2015-08-07 2019-09-25 小林製薬株式会社 生薬末含有錠剤
US10716544B2 (en) 2015-10-08 2020-07-21 Zmk Medical Technologies Inc. System for 3D multi-parametric ultrasound imaging
CN108619107A (zh) * 2018-05-28 2018-10-09 青海制药厂有限公司 一种含鲁比前列酮的软胶囊及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE572839A (enExample) * 1958-02-12
JPS5350141A (en) * 1976-10-18 1978-05-08 Ono Pharmaceut Co Ltd Stabilization of prostaglandin and prostaglandin analogues
US4310543A (en) 1980-10-09 1982-01-12 Hoffmann-La Roche Inc. Prostaglandin compositions
US4301175A (en) * 1980-12-29 1981-11-17 The Upjohn Company E-Type prostaglandin compositions
US4431833A (en) * 1982-12-27 1984-02-14 American Cyanamid Company Prostaglandin and hydroxylated fatty acid ester formulations
KR920007569B1 (ko) * 1984-11-30 1992-09-07 쥬우가이 세이야꾸 가부시끼가이샤 프로스타글란딘 e 유도체의 안정한 제제의 제조방법
US5166174A (en) * 1987-01-28 1992-11-24 K.K. Ueno Seiyaku Oyo Kenkyujo Prostaglandins E and anti-ulcers containing same
US6183466B1 (en) * 1998-08-21 2001-02-06 Alza Corporation Dosage form comprising a capsule
EP1220849B1 (en) * 1999-10-15 2004-05-19 Sucampo AG Bicyclic compounds composition and method for stabilizing the same
ATE387191T1 (de) * 2002-04-25 2008-03-15 Banner Pharmacaps Inc Kaubare weichkapsel
FR2850275B1 (fr) * 2003-01-24 2005-04-08 Scherer Technologies Inc R P Capsules molles a macher contenant une substance active a gout masque
DE602004015507D1 (de) * 2004-02-17 2008-09-11 Symrise Gmbh & Co Kg Überzogene, sphärische, nahtlose, gefüllte kapseln
BRPI0607084A2 (pt) * 2005-01-27 2009-08-04 Sucampo Ag uso de um composto 11-desóxiprostaglandina, composição compreendendo o mesmo, e composto
TWI432201B (zh) 2005-03-04 2014-04-01 Sucampo Ag 11-去氧基-前列腺素化合物用於治療週邊血管疾病之用途
CN101410097A (zh) 2006-01-24 2009-04-15 株式会社·R-技术上野 软明胶胶囊制剂

Also Published As

Publication number Publication date
NZ583203A (en) 2011-10-28
WO2009011449A3 (en) 2010-04-29
MX339727B (es) 2016-06-06
CN101808623A (zh) 2010-08-18
WO2009011449A2 (en) 2009-01-22
RU2013135403A (ru) 2015-02-10
TWI552772B (zh) 2016-10-11
BRPI0814115A2 (pt) 2015-02-03
RU2651471C2 (ru) 2018-04-19
AU2008276840A1 (en) 2009-01-22
CA2691995C (en) 2016-04-26
JP5390519B2 (ja) 2014-01-15
EP2178516B1 (en) 2015-09-09
CN103393618A (zh) 2013-11-20
CA2691995A1 (en) 2009-01-22
US20150126609A1 (en) 2015-05-07
EP2327398A3 (en) 2014-05-21
TW201436824A (zh) 2014-10-01
EP2327398A2 (en) 2011-06-01
US8969324B2 (en) 2015-03-03
IL203064B (en) 2018-02-28
RU2010105847A (ru) 2011-08-27
US9254326B2 (en) 2016-02-09
KR20100053563A (ko) 2010-05-20
TW200911273A (en) 2009-03-16
MX2010000693A (es) 2010-06-01
BRPI0814115B8 (pt) 2021-05-25
KR101485212B1 (ko) 2015-01-22
TWI446912B (zh) 2014-08-01
EP2178516A2 (en) 2010-04-28
RU2018113296A (ru) 2019-10-14
AU2008276840B2 (en) 2013-10-03
US20090022787A1 (en) 2009-01-22
NZ595270A (en) 2013-04-26
JP2014001247A (ja) 2014-01-09
BRPI0814115B1 (pt) 2019-04-02
RU2506072C2 (ru) 2014-02-10
JP2010533707A (ja) 2010-10-28

Similar Documents

Publication Publication Date Title
KR101393944B1 (ko) 연질-젤라틴 캡슐 제형물
CN101808623B (zh) 包含11-脱氧-前列腺素化合物的药物组合物和使该化合物稳定化的方法
US8669284B2 (en) Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound
AU2013203903A1 (en) Pharmaceutical composition comprising 11-deoxy-prostaglandin compound and method for stabilizing the compound

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130814

Termination date: 20190716