JP2014001247A - 11−デオキシ−プロスタグランジン化合物を含む医薬組成物およびその安定化方法 - Google Patents
11−デオキシ−プロスタグランジン化合物を含む医薬組成物およびその安定化方法 Download PDFInfo
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- JP2014001247A JP2014001247A JP2013211759A JP2013211759A JP2014001247A JP 2014001247 A JP2014001247 A JP 2014001247A JP 2013211759 A JP2013211759 A JP 2013211759A JP 2013211759 A JP2013211759 A JP 2013211759A JP 2014001247 A JP2014001247 A JP 2014001247A
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- linear
- branched
- deoxy
- alkyl
- hydroxy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
Description
Aは、−CH3、−CH2OH、−COCH2OH、−COOHまたはそれらの官能性誘導体;
R1は非置換またはハロゲン、低級アルキル、ヒドロキシ、オキソ、アリールまたは複素環で置換された、二価の飽和または不飽和の低〜中級の脂肪族炭化水素(脂肪族炭化水素における少なくとも1個の炭素原子は酸素、窒素または硫黄によって置換されていてもよい);
R0は非置換またはハロゲン、オキソ、ヒドロキシ、低級アルキル、低級アルコキシ、低級アルカノイルオキシ、シクロ(低級)アルキル、シクロ(低級)アルキルオキシ、アリール、アリールオキシ、複素環または複素環オキシで置換された、飽和または不飽和の低〜中級の脂肪族炭化水素残基;低級アルコキシ;低級アルカノイルオキシ;シクロ(低級)アルキル;シクロ(低級)アルキルオキシ;アリール;アリールオキシ;複素環;複素環オキシである(脂肪族炭化水素における少なくとも1個の炭素原子は酸素、窒素または硫黄によって置換されていてもよい)]。
Bは、単結合、−CH2−CH2−、−CH=CH−、−C≡C−、−CH2−CH2−CH2−、−CH=CH−CH2−、−CH2−CH=CH−、−C≡C−CH2−または−CH2−C≡C−;
Zは、
Raは、非置換またはハロゲン、オキソ、ヒドロキシ、低級アルキル、低級アルコキシ、低級アルカノイルオキシ、シクロ(低級)アルキル、シクロ(低級)アルキルオキシ、アリール、アリールオキシ、複素環または複素環オキシで置換された、飽和または不飽和の低〜中級脂肪族炭化水素残基;低級アルコキシ;低級アルカノイルオキシ;シクロ(低級)アルキル;シクロ(低級)アルキルオキシ;アリール;アリールオキシ;複素環基;複素環オキシ基(脂肪族炭化水素における少なくとも1個の炭素原子は酸素、窒素または硫黄によって置換されていてもよい)
L、N、A、およびR1は前記定義と同一]。
「アリールオキシ」の語は、式ArO−(ここで、Arは上記のようなアリール基)で示される基を意味する。
Aの「官能性誘導体」の語は、塩(好ましくは、医薬上許容し得る塩)、エーテル、エステルおよびアミド類を含む。
−CH2−CH2−CH2−CH2−CH2−CH2−、
−CH2−CH=CH−CH2−CH2−CH2−、
−CH2−CH2−CH2−CH2−CH=CH−、
−CH2−C≡C−CH2−CH2−CH2−、
−CH2−CH2−CH2−CH2−CH(CH3)−CH2−、
−CH2−CH2−CH2−CH2−O−CH2−、
−CH2−CH=CH−CH2−O−CH2−、
−CH2−C≡C−CH2−O−CH2−、
−CH2−CH2−CH2−CH2−CH2−CH2−CH2−、
−CH2−CH=CH−CH2−CH2−CH2−CH2−、
−CH2−CH2−CH2−CH2−CH2−CH=CH−、
−CH2−C≡C−CH2−CH2−CH2−CH2−、
−CH2−CH2−CH2−CH2−CH2−CH(CH3)−CH2−、
−CH2−CH2−CH2−CH2−CH2−CH2−CH2−CH2−、
−CH2−CH=CH−CH2−CH2−CH2−CH2−CH2−、
−CH2−CH2−CH2−CH2−CH2−CH2−CH=CH−、
−CH2−C≡C−CH2−CH2−CH2−CH2−CH2−、
−CH2−CH2−CH2−CH2−CH2−CH2−CH(CH3)−CH2−、
など。
化合物1:11−デオキシ−13,14−ジヒドロ−15−ケト−16,16−ジフルオロ−PGE1
化合物の量の測定は以下の通りに行った。約0.2gの試料を正確に2mLの内部標準溶液と混合し、次いで表1に示す溶解剤と混合して5mLの試料溶液を得た。約5mgの標準品の化合物1の重量を精密に量り、アセトニトリルを加えて、正確に50mL溶液とした。この液1mLを正確に量り、正確に4mLの内部標準溶液を加え、次いで溶解剤を加えて10mLの標準溶液を得た。
高速液体クロマトグラフィー分析条件:
カラム:内径約5mm、長さ約25cmのステンレス管に5μmの高速液体クロマトグラフ用オクタデシルシリル化シリカゲルを充てん
移動相:高速液体クロマトグラフ用アセトニトリルおよび過塩素酸緩衝液混液
温度:35℃
検出器:分光蛍光検出器
化合物1:11−デオキシ−13,14−ジヒドロ−15−ケト−16,16−ジフルオロ−PGE1を用いた。
適量の水とトウモロコシデンプン由来糖アルコール液(ゼラチンに対して60重量%)を撹拌しながら加温し、次いで100重量%のゼラチン液を加えてゼラチン溶液を得る。化合物1を中鎖脂肪酸トリグリセリド(米国局方(USP/NF)品)に溶かして、120μg/g濃度の内容液を調製する。調製したゼラチン液と内容液を軟カプセル形成充てん機に供し、上記内容液を封入後、適度な硬度となるまで乾燥させ、軟ゼラチンカプセル製品とする。
上記製剤例で製造された軟ゼラチンカプセルは40℃にて6ヶ月間または55℃にて1ヶ月間保管された。カプセル20個をとり、適当量の精製水を加えてカプセルを膨潤させた後、液体クロマトグラフ用酢酸エチル10mLを加えてカプセルを切り開き内容液を取り出した。表示量に従い、化合物100μg当り内部標準液1.0mLを正確に加えて、さらに1mL当り化合物が10μgとなるように液体クロマトグラフ用酢酸エチルを加えて、試料溶液とした。
高速液体クロマトグラフィー分析条件
カラム:内径約5mm、長さ約25cmのステンレス管に5μmの高速液体クロマトグラフ用オクタデシルシリル化シリカゲルを充てん
移動相:高速液体クロマトグラフ用アセトニトリル:高速液体クロマトグラフ用メタノール:酢酸アンモニウム混液(0.05mol/L)
温度:35℃
検出器:分光蛍光検出器
Claims (10)
- 可塑剤としてポリオールおよび/または糖アルコールを含有する軟ゼラチン皮膜、および該皮膜内に含まれる、下記式(II)
LおよびNは水素、ヒドロキシ、ハロゲン、直鎖または分岐鎖アルキル、ヒドロキシ(直鎖または分岐鎖のC1〜6)アルキル、直鎖または分岐鎖のC1〜6アルカノイルオキシまたはオキソであり、ここで、5員環は随意により少なくとも1つの二重結合を有していてもよく;
Aは、−CH3、−CH2OH、−COCH2OH、−COOHまたはそれらの医薬上許容される塩、エステル、エーテルもしくはアミドであり;
Bは、単結合、−CH2−CH2−、−CH=CH−、−C≡C−、−CH2−CH2−CH2−、−CH=CH−CH2−、−CH2−CH=CH−、−C≡C−CH2−または−CH2−C≡C−;
Zは、=O;
R1は非置換またはハロゲン、直鎖または分岐鎖のC1〜6アルキル、ヒドロキシ、オキソ、アリールまたは複素環基で置換された、二価の飽和または不飽和の直鎖または分岐鎖のC1〜14脂肪族炭化水素であり、脂肪族炭化水素における少なくとも1つの炭素原子は随意により酸素、窒素または硫黄によって置換されていてもよく;
Raは、非置換またはハロゲン、オキソ、ヒドロキシ、直鎖または分岐鎖のC1〜6アルキル、直鎖または分岐鎖のC1〜6アルコキシ、直鎖または分岐鎖のC1〜6アルカノイルオキシ、シクロ(C3〜6)アルキル、シクロ(C3〜6)アルキルオキシ、アリール、アリールオキシ、複素環または複素環オキシで置換された、飽和または不飽和の直鎖または分岐鎖のC1〜14脂肪族炭化水素残基;直鎖または分岐鎖のC1〜6アルコキシ;直鎖または分岐鎖のC1〜6アルカノイルオキシ;シクロ(C3〜6)アルキル;シクロ(C3〜6)アルキルオキシ;アリール;アリールオキシ;複素環基;複素環オキシ基(脂肪族炭化水素における少なくとも1個の炭素原子は酸素、窒素または硫黄によって置換されていてもよい)]
により表される11−デオキシ−プロスタグランジン化合物および医薬上許容し得る媒体を含む医薬組成物、を含む軟ゼラチンカプセル製剤。 - Lがヒドロキシまたはオキソであり、Nが水素である、請求項1記載の製剤。
- Aが−COOHまたはその医薬上許容される塩、エステル、もしくはアミドである、請求項1または2記載の製剤。
- Bが−CH2−CH2−である、請求項1〜3のいずれかに記載の製剤。
- R1が、非置換の、二価の飽和または不飽和の直鎖のC1〜10脂肪族炭化水素である、請求項1〜4のいずれかに記載の製剤。
- 可塑剤が糖アルコールである、請求項1〜6のいずれかに記載の製剤。
- 糖アルコールがトウモロコシデンプン由来糖アルコール液である、請求項7に記載の製剤。
- 医薬上許容し得る媒体が脂肪酸エステルである、請求項1〜8のいずれかに記載の製剤。
- 脂肪酸エステルが、炭素原子数6〜24の脂肪酸と、炭素原子数1〜6の一価アルコール、グリセリンおよびプロピレングリコールからなる群から選択されるアルコールとから得られる脂肪酸エステルである、請求項9記載の製剤。
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