CN101801373B - 具有抗糖尿病作用的药物组合物 - Google Patents

具有抗糖尿病作用的药物组合物 Download PDF

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Publication number
CN101801373B
CN101801373B CN2008801068127A CN200880106812A CN101801373B CN 101801373 B CN101801373 B CN 101801373B CN 2008801068127 A CN2008801068127 A CN 2008801068127A CN 200880106812 A CN200880106812 A CN 200880106812A CN 101801373 B CN101801373 B CN 101801373B
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CN
China
Prior art keywords
methyl
purposes
ethoxycarbonyl
hydroxyl
phenyl
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Expired - Fee Related
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CN2008801068127A
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English (en)
Chinese (zh)
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CN101801373A (zh
Inventor
A·V·杰明
V·A·马蒂亚诺夫
A·M·舒斯特尔
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ZAKRYTOE AKTSIONERNOE OBSCHESTVO "MASTERCLONE"
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ZAKRYTOE AKTSIONERNOE OBSCHESTVO "MASTERCLONE"
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Publication of CN101801373A publication Critical patent/CN101801373A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2008801068127A 2007-09-14 2008-05-22 具有抗糖尿病作用的药物组合物 Expired - Fee Related CN101801373B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2007134267/15A RU2361581C2 (ru) 2007-09-14 2007-09-14 Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний
RU2007134267 2007-09-14
PCT/RU2008/000320 WO2009035368A1 (en) 2007-09-14 2008-05-22 Antidiabetic pharmaceutical composition

Publications (2)

Publication Number Publication Date
CN101801373A CN101801373A (zh) 2010-08-11
CN101801373B true CN101801373B (zh) 2013-03-27

Family

ID=40452228

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801068127A Expired - Fee Related CN101801373B (zh) 2007-09-14 2008-05-22 具有抗糖尿病作用的药物组合物

Country Status (11)

Country Link
US (1) US8247407B2 (https=)
EP (1) EP2204173B1 (https=)
JP (1) JP2010539160A (https=)
KR (1) KR20100086981A (https=)
CN (1) CN101801373B (https=)
AU (1) AU2008297608A1 (https=)
BR (1) BRPI0815200A2 (https=)
CA (1) CA2699403A1 (https=)
MX (1) MX2010002754A (https=)
RU (1) RU2361581C2 (https=)
WO (1) WO2009035368A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2361581C2 (ru) 2007-09-14 2009-07-20 Закрытое Акционерное Общество "Мастерклон" Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний
RU2421219C1 (ru) * 2009-11-19 2011-06-20 Закрытое Акционерное Общество "Мастерклон" Ингибиторы протеинкиназы с

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005102320A1 (fr) * 2004-04-21 2005-11-03 Zakrytoe Aktsionernoe Obschestvo 'masterklon' Medicament pour traiter des infections virales
WO2007075102A1 (en) * 2005-12-28 2007-07-05 Zakrytoe Aktsionernoe Obschestvo 'masterklon' Medicinal agent for treating viral infections
WO2007136302A2 (en) * 2006-05-23 2007-11-29 Alla Chem, Llc Active substances, pharmaceutical composition and a method for the production and use thereof

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US3510491A (en) * 1967-02-02 1970-05-05 Sterling Drug Inc 4-(cyclicaminomethyl)-5-hydroxyindole-3-carboxylic acids and esters thereof
US4226829A (en) * 1978-10-04 1980-10-07 Andrew Mike Renewable vaporizer for air treatment and the like
US4889286A (en) * 1988-09-19 1989-12-26 Donald Spector Controllable air freshener unit
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
DE19753956A1 (de) * 1997-12-05 1999-06-17 Draeger Sicherheitstech Gmbh Duftpatrone
SE0104334D0 (sv) 2001-12-19 2001-12-19 Astrazeneca Ab Therapeutic agents
CN100457730C (zh) * 2002-08-29 2009-02-04 默克公司 具有抗糖尿病活性的吲哚化合物
AR041481A1 (es) 2002-10-07 2005-05-18 Hoffmann La Roche Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar
CA2502269C (en) 2002-10-18 2009-12-22 Merck & Co., Inc. Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
US20060233538A1 (en) * 2005-04-14 2006-10-19 Tollens Fernando R Energized systems and devices for delivering volatile materials
US20070176015A1 (en) * 2006-01-30 2007-08-02 The Procter & Gamble Company System for delivering volatile materials
US8329689B2 (en) 2006-05-23 2012-12-11 Alexandre Vasilievich Ivachtchenko Substituted indoles and a method for the production and use thereof
WO2008100977A2 (en) * 2007-02-14 2008-08-21 N.V. Organon Carbamates therapeutic release agents as amidase inhibitors
RU2344817C1 (ru) 2007-06-19 2009-01-27 Андрей Александрович Иващенко Замещенные эфиры 5-гидрокси-1н-индол-3-карбоновой кислоты, фармацевтическая композиция, способ их получения и применения
RU2361581C2 (ru) 2007-09-14 2009-07-20 Закрытое Акционерное Общество "Мастерклон" Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005102320A1 (fr) * 2004-04-21 2005-11-03 Zakrytoe Aktsionernoe Obschestvo 'masterklon' Medicament pour traiter des infections virales
WO2007075102A1 (en) * 2005-12-28 2007-07-05 Zakrytoe Aktsionernoe Obschestvo 'masterklon' Medicinal agent for treating viral infections
WO2007136302A2 (en) * 2006-05-23 2007-11-29 Alla Chem, Llc Active substances, pharmaceutical composition and a method for the production and use thereof

Non-Patent Citations (7)

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Title
ANlSlMOVA O S,et al."Study of metabolism of the antiviral drug arbidol by mass spectrometry, thin-layer and high-performance liquid chromatography".《Pharmaceutical Chemistry Journal》.1995,第29卷(第2期),第78-82页.
宋艳玲，等."N-取代-5-羟基-1H吲哚-3-羧酸酯类衍生物的合成".《中国新药杂志》.2004,第13卷(第4期),第335-337页.
宋艳玲,等."N-取代-5-羟基-1H吲哚-3-羧酸酯类衍生物的合成".《中国新药杂志》.2004,第13卷(第4期),第335-337页. *
王钝，等."6-溴-5-羟基吲哚-3-羧酸酯类衍生物的合成及其抗病毒活性".《中国药物化学杂志》.2003,第13卷(第4期),第200-204页.
王钝,等."6-溴-5-羟基吲哚-3-羧酸酯类衍生物的合成及其抗病毒活性".《中国药物化学杂志》.2003,第13卷(第4期),第200-204页. *
赵燕芳，等."5-羟基-1H-吲哚-3-羧酸乙酯类化合物的合成".《中国药物化学杂志》.2004,第14卷(第4期),第219-224页.
赵燕芳,等."5-羟基-1H-吲哚-3-羧酸乙酯类化合物的合成".《中国药物化学杂志》.2004,第14卷(第4期),第219-224页. *

Also Published As

Publication number Publication date
EP2204173A1 (en) 2010-07-07
CN101801373A (zh) 2010-08-11
AU2008297608A1 (en) 2009-03-19
BRPI0815200A2 (pt) 2015-03-31
RU2361581C2 (ru) 2009-07-20
EP2204173A4 (en) 2010-12-29
JP2010539160A (ja) 2010-12-16
US8247407B2 (en) 2012-08-21
CA2699403A1 (en) 2009-03-19
MX2010002754A (es) 2010-03-30
US20100168092A1 (en) 2010-07-01
EP2204173B1 (en) 2013-07-03
WO2009035368A1 (en) 2009-03-19
KR20100086981A (ko) 2010-08-02
RU2007134267A (ru) 2009-03-20

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