CN101755845B - Bactericide composition containing flutolanil - Google Patents
Bactericide composition containing flutolanil Download PDFInfo
- Publication number
- CN101755845B CN101755845B CN2009102239938A CN200910223993A CN101755845B CN 101755845 B CN101755845 B CN 101755845B CN 2009102239938 A CN2009102239938 A CN 2009102239938A CN 200910223993 A CN200910223993 A CN 200910223993A CN 101755845 B CN101755845 B CN 101755845B
- Authority
- CN
- China
- Prior art keywords
- flutolanil
- concentration
- test
- agent
- spore
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- PTCGDEVVHUXTMP-UHFFFAOYSA-N flutolanil Chemical compound CC(C)OC1=CC=CC(NC(=O)C=2C(=CC=CC=2)C(F)(F)F)=C1 PTCGDEVVHUXTMP-UHFFFAOYSA-N 0.000 title claims abstract description 82
- 239000005786 Flutolanil Substances 0.000 title claims abstract description 81
- 239000000203 mixture Substances 0.000 title claims abstract description 57
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 43
- 239000003899 bactericide agent Substances 0.000 title abstract description 30
- 235000007164 Oryza sativa Nutrition 0.000 claims description 40
- 235000009566 rice Nutrition 0.000 claims description 40
- 201000010099 disease Diseases 0.000 claims description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- 239000000843 powder Substances 0.000 claims description 13
- 238000009736 wetting Methods 0.000 claims description 11
- 239000000375 suspending agent Substances 0.000 claims description 9
- 239000000839 emulsion Substances 0.000 claims description 8
- 239000004530 micro-emulsion Substances 0.000 claims description 8
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 abstract description 29
- DQJCHOQLCLEDLL-UHFFFAOYSA-N tricyclazole Chemical compound CC1=CC=CC2=C1N1C=NN=C1S2 DQJCHOQLCLEDLL-UHFFFAOYSA-N 0.000 abstract description 18
- 229930182764 Polyoxin Natural products 0.000 abstract description 16
- TWFZGCMQGLPBSX-UHFFFAOYSA-N carbendazim Chemical compound C1=CC=C2NC(NC(=O)OC)=NC2=C1 TWFZGCMQGLPBSX-UHFFFAOYSA-N 0.000 abstract description 16
- YEBIHIICWDDQOL-YBHNRIQQSA-N polyoxin Polymers O[C@@H]1[C@H](O)[C@@H](C(C=O)N)O[C@H]1N1C(=O)NC(=O)C(C(O)=O)=C1 YEBIHIICWDDQOL-YBHNRIQQSA-N 0.000 abstract description 16
- UFHLMYOGRXOCSL-UHFFFAOYSA-N isoprothiolane Chemical compound CC(C)OC(=O)C(C(=O)OC(C)C)=C1SCCS1 UFHLMYOGRXOCSL-UHFFFAOYSA-N 0.000 abstract description 14
- 239000004480 active ingredient Substances 0.000 abstract description 5
- 229960002447 thiram Drugs 0.000 abstract description 3
- KUAZQDVKQLNFPE-UHFFFAOYSA-N thiram Chemical compound CN(C)C(=S)SSC(=S)N(C)C KUAZQDVKQLNFPE-UHFFFAOYSA-N 0.000 abstract description 3
- IUOKJNROJISWRO-UHFFFAOYSA-N N-(2-cyano-3-methylbutan-2-yl)-2-(2,4-dichlorophenoxy)propanamide Chemical compound CC(C)C(C)(C#N)NC(=O)C(C)OC1=CC=C(Cl)C=C1Cl IUOKJNROJISWRO-UHFFFAOYSA-N 0.000 abstract description 2
- 239000005843 Thiram Substances 0.000 abstract description 2
- VMFXMTJCTSYHCF-HHQUSWFZSA-N [(2r,3r,4s,5r)-5-(hexylamino)-4-hydroxy-2-(hydroxymethyl)-6-[(7-hydroxy-4-oxo-1,3a,5,6,7,7a-hexahydroimidazo[4,5-c]pyridin-2-yl)amino]oxan-3-yl] carbamate Chemical compound CCCCCCN[C@@H]1[C@H](O)[C@@H](OC(N)=O)[C@@H](CO)OC1\N=C\1NC(C(=O)NCC2O)C2N/1 VMFXMTJCTSYHCF-HHQUSWFZSA-N 0.000 abstract description 2
- FCOAHACKGGIURQ-UHFFFAOYSA-N iprobenfos Chemical compound CC(C)OP(=O)(OC(C)C)SCC1=CC=CC=C1 FCOAHACKGGIURQ-UHFFFAOYSA-N 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 60
- 238000012360 testing method Methods 0.000 description 45
- 241000894006 Bacteria Species 0.000 description 44
- 241000209094 Oryza Species 0.000 description 40
- 239000003795 chemical substances by application Substances 0.000 description 38
- 238000000034 method Methods 0.000 description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 31
- 238000011835 investigation Methods 0.000 description 28
- 231100000419 toxicity Toxicity 0.000 description 23
- 230000001988 toxicity Effects 0.000 description 23
- 230000003993 interaction Effects 0.000 description 22
- 230000004763 spore germination Effects 0.000 description 22
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 21
- 150000001408 amides Chemical class 0.000 description 17
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 16
- 239000006013 carbendazim Substances 0.000 description 15
- JNPZQRQPIHJYNM-UHFFFAOYSA-N carbendazim Chemical compound C1=C[CH]C2=NC(NC(=O)OC)=NC2=C1 JNPZQRQPIHJYNM-UHFFFAOYSA-N 0.000 description 15
- 230000005764 inhibitory process Effects 0.000 description 15
- 238000002360 preparation method Methods 0.000 description 15
- 235000014347 soups Nutrition 0.000 description 15
- 230000001954 sterilising effect Effects 0.000 description 15
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 14
- 235000010603 pastilles Nutrition 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- 229940079593 drug Drugs 0.000 description 13
- 239000003921 oil Substances 0.000 description 13
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 238000012545 processing Methods 0.000 description 12
- 230000009471 action Effects 0.000 description 11
- 230000008485 antagonism Effects 0.000 description 11
- 238000004166 bioassay Methods 0.000 description 11
- 238000013461 design Methods 0.000 description 11
- 238000011156 evaluation Methods 0.000 description 11
- 230000000855 fungicidal effect Effects 0.000 description 11
- 238000000611 regression analysis Methods 0.000 description 11
- 238000010998 test method Methods 0.000 description 11
- 239000000417 fungicide Substances 0.000 description 10
- 244000052769 pathogen Species 0.000 description 10
- 230000001717 pathogenic effect Effects 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 239000003995 emulsifying agent Substances 0.000 description 8
- 239000000575 pesticide Substances 0.000 description 8
- 238000004659 sterilization and disinfection Methods 0.000 description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 7
- 241000233866 Fungi Species 0.000 description 7
- 241000813090 Rhizoctonia solani Species 0.000 description 7
- 230000009036 growth inhibition Effects 0.000 description 7
- -1 polyoxypropylene Polymers 0.000 description 7
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 7
- 241000196324 Embryophyta Species 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 241001344131 Magnaporthe grisea Species 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 239000008367 deionised water Substances 0.000 description 6
- 229910021641 deionized water Inorganic materials 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 241001272567 Hominoidea Species 0.000 description 5
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 5
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 5
- 239000007859 condensation product Substances 0.000 description 5
- 238000009313 farming Methods 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 5
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 239000003905 agrochemical Substances 0.000 description 4
- 230000002528 anti-freeze Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 238000011081 inoculation Methods 0.000 description 4
- 231100000053 low toxicity Toxicity 0.000 description 4
- 230000010534 mechanism of action Effects 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 206010039509 Scab Diseases 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000000440 bentonite Substances 0.000 description 3
- 229910000278 bentonite Inorganic materials 0.000 description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000009833 condensation Methods 0.000 description 3
- 230000005494 condensation Effects 0.000 description 3
- 238000002242 deionisation method Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000003673 groundwater Substances 0.000 description 3
- 239000010440 gypsum Substances 0.000 description 3
- 229910052602 gypsum Inorganic materials 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 description 3
- 235000011152 sodium sulphate Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000001082 somatic cell Anatomy 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- QPUYECUOLPXSFR-UHFFFAOYSA-N 1-methylnaphthalene Chemical compound C1=CC=C2C(C)=CC=CC2=C1 QPUYECUOLPXSFR-UHFFFAOYSA-N 0.000 description 2
- ZITVKGIRQCDOSX-UHFFFAOYSA-N 1h-cyclopropa[a]naphthalene Chemical compound C1=CC=CC2=C3CC3=CC=C21 ZITVKGIRQCDOSX-UHFFFAOYSA-N 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 241000209140 Triticum Species 0.000 description 2
- 235000021307 Triticum Nutrition 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- 239000002518 antifoaming agent Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- 239000007957 coemulsifier Substances 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000006184 cosolvent Substances 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- XUZHLZDRCCUWEV-UHFFFAOYSA-N formaldehyde;methyl naphthalene-1-sulfonate Chemical compound O=C.C1=CC=C2C(S(=O)(=O)OC)=CC=CC2=C1 XUZHLZDRCCUWEV-UHFFFAOYSA-N 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- HJOVHMDZYOCNQW-UHFFFAOYSA-N isophorone Chemical compound CC1=CC(=O)CC(C)(C)C1 HJOVHMDZYOCNQW-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000028070 sporulation Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- RQJQQSAYDFANNM-UHFFFAOYSA-N 2,3-dibutylnaphthalene-1-sulfonic acid;formaldehyde Chemical compound O=C.C1=CC=C2C(S(O)(=O)=O)=C(CCCC)C(CCCC)=CC2=C1 RQJQQSAYDFANNM-UHFFFAOYSA-N 0.000 description 1
- JECYNCQXXKQDJN-UHFFFAOYSA-N 2-(2-methylhexan-2-yloxymethyl)oxirane Chemical compound CCCCC(C)(C)OCC1CO1 JECYNCQXXKQDJN-UHFFFAOYSA-N 0.000 description 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
- QQZOPKMRPOGIEB-UHFFFAOYSA-N 2-Oxohexane Chemical compound CCCCC(C)=O QQZOPKMRPOGIEB-UHFFFAOYSA-N 0.000 description 1
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
- WODGMMJHSAKKNF-UHFFFAOYSA-N 2-methylnaphthalene-1-sulfonic acid Chemical compound C1=CC=CC2=C(S(O)(=O)=O)C(C)=CC=C21 WODGMMJHSAKKNF-UHFFFAOYSA-N 0.000 description 1
- UQPLZHUFLPDORW-UHFFFAOYSA-N 2-phenylphenol;sodium Chemical compound [Na].OC1=CC=CC=C1C1=CC=CC=C1 UQPLZHUFLPDORW-UHFFFAOYSA-N 0.000 description 1
- PMZBHPUNQNKBOA-UHFFFAOYSA-N 5-methylbenzene-1,3-dicarboxylic acid Chemical compound CC1=CC(C(O)=O)=CC(C(O)=O)=C1 PMZBHPUNQNKBOA-UHFFFAOYSA-N 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- TWLXYPCDAWOZEO-UHFFFAOYSA-N C1(=CC=CC2=CC=CC=C12)C=O.CC1=C(C2=CC=CC=C2C=C1)S(=O)(=O)O Chemical compound C1(=CC=CC2=CC=CC=C12)C=O.CC1=C(C2=CC=CC=C2C=C1)S(=O)(=O)O TWLXYPCDAWOZEO-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229940124186 Dehydrogenase inhibitor Drugs 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000001293 FEMA 3089 Substances 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- BOLQUPOXTWHXIX-UHFFFAOYSA-N OC1=CC=CC=C1.C=1C=CC=CC=1C=C(C=1C=CC=CC=1)C1=CC=CC=C1 Chemical compound OC1=CC=CC=C1.C=1C=CC=CC=1C=C(C=1C=CC=CC=1)C1=CC=CC=C1 BOLQUPOXTWHXIX-UHFFFAOYSA-N 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000006004 Quartz sand Substances 0.000 description 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
- 239000004113 Sepiolite Substances 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 241001655322 Streptomycetales Species 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 240000006677 Vicia faba Species 0.000 description 1
- 235000010749 Vicia faba Nutrition 0.000 description 1
- 235000002098 Vicia faba var. major Nutrition 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000004996 alkyl benzenes Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000003931 anilides Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 239000000987 azo dye Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229920005551 calcium lignosulfonate Polymers 0.000 description 1
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- XFMJUIKWKVJNDY-UHFFFAOYSA-N diethoxyphosphorylsulfanylmethylbenzene Chemical compound CCOP(=O)(OCC)SCC1=CC=CC=C1 XFMJUIKWKVJNDY-UHFFFAOYSA-N 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- QRVSDVDFJFKYKA-UHFFFAOYSA-N dipropan-2-yl propanedioate Chemical compound CC(C)OC(=O)CC(=O)OC(C)C QRVSDVDFJFKYKA-UHFFFAOYSA-N 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 125000001924 fatty-acyl group Chemical group 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- PKJZYOFPPJHDRW-UHFFFAOYSA-N formaldehyde;sulfuric acid Chemical compound O=C.OS(O)(=O)=O PKJZYOFPPJHDRW-UHFFFAOYSA-N 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000003630 growth substance Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000001023 inorganic pigment Substances 0.000 description 1
- DCYOBGZUOMKFPA-UHFFFAOYSA-N iron(2+);iron(3+);octadecacyanide Chemical compound [Fe+2].[Fe+2].[Fe+2].[Fe+3].[Fe+3].[Fe+3].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] DCYOBGZUOMKFPA-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- PVTHJAPFENJVNC-MHRBZPPQSA-N kasugamycin Chemical compound N[C@H]1C[C@H](NC(=N)C(O)=O)[C@@H](C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O PVTHJAPFENJVNC-MHRBZPPQSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical class COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000001069 nematicidal effect Effects 0.000 description 1
- 239000005645 nematicide Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
- 229940080818 propionamide Drugs 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 230000003161 proteinsynthetic effect Effects 0.000 description 1
- 229960003351 prussian blue Drugs 0.000 description 1
- 239000013225 prussian blue Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 229910052624 sepiolite Inorganic materials 0.000 description 1
- 235000019355 sepiolite Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000003516 soil conditioner Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 238000009333 weeding Methods 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a synergistic bactericide composition, in particular to a synergistic bactericide composition which comprises flutolanil and any one of bactericidal active ingredients selected from the group consisting of tricyclazole, carbendazin, iprobenfos, isoprothiolane, fenoxanil, thiram, kasugamicin, polyoxin, zhongshengmycin, wuyiencin and jinggangmycin.
Description
Technical field
The present invention relates to a kind of Synergistic bactericidal composition, particularly relate to a kind of flutolanil and Synergistic bactericidal composition that is selected from arbitrary fungicide active ingredient of tricyclazole, carbendazim, IBP, Isoprothiolane, rice blast acid amides, tmtd, kasugarnycin, polyoxin, middle living rhzomorph, Wuyiencin and jinggangmeisu of comprising.
Background technology
Flutolanil (flutolanil), chemical name be 3 '-isopropoxy-2-(trifluoromethyl) benzanilide, belong to the anilide bactericide; Its mechanism of action be in the respiratory electron transport chain as the succinate dehydrogenase inhibitor, suppress the synthetic of aspartate and glutamate, be a kind of have protect and the systemic fungicide of therapeutic activity; Hinder the growth of bacterium on the infected body and penetrate; Causing the disappearance of mycelia, is the new medicament of preventing and treating rice sheath blight disease, and drug effect is long; To rice safety, prevent and treat rice sheath blight disease and can make paddy rice improve ripening rate.
Tricyclazole (tricyclazole), chemical name are the 5-methyl isophthalic acid, 2; (3,4-b) benzothiazole is a kind of stronger protectiveness triazole bactericidal agent of interior absorption that has to the 4-triazol; Its mechanism of action mainly is the formation that suppresses spore germination and adhere to spore; Thereby stop germ to invade and reduce the generation of magnaporthe grisea spore, can absorbed, and be transported to each one of rice strain by rice root, stem, leaf rapidly.Tricyclazole antiscour power is strong, and the spray medicine is met the rain medicine that need not fill spray after one hour.
Carbendazim (carbendazim), chemical name are N-(2-benzimidazolyl) methyl carbamate, belong to benzimidazole, and high-efficiency low-toxicity is effective to sac fungi and imperfect fungus, and is invalid to oomycetes and bacterial disease, has protection and therapeutic action.The mechanism of action is the formation of imitative hammer body in the mitosis of disturbing bacterium, thereby influences cell division.
IBP (iprobenfos), chemical name are O, O-diisopropyl-S-benzyl thiolophosphate, and promptly different third kitazine belongs to organophosphorus fungicide.Main interference cell membrane permeability stops some lipophilic chitin precursor through cytoplasma membrane, and chitinous biosynthesis block is hindered, and cell wall can not be grown, and suppresses the normal development of thalline.
Isoprothiolane (isoprothiolane), chemical name are 1, and 3-dithiolane-2-subunit Diisopropyl malonate belongs to the organosulfureous fungicide of efficient, low toxicity, low-residual, has treatment and protective effect, and rice blast is had special efficacy.Rice plant accumulates on leaf texture after absorbing medicament, concentrates on cob and branch stalk especially, invades thereby suppress germ, hinders the germ lipid-metabolism, suppresses the germ growth, plays prevention and treatment.
Rice blast acid amides (fenoxanil), chemical name are N-(1-itrile group-1.2-dimethyl propyl)-2-(2,4 dichloro benzene oxygen base) propionamide; Belong to amide-type low toxicity bactericide; The melanin biosynthesis inhibitor has characteristics such as treatment, infiltration and inhibition sporulation, is mainly used in the control of rice blast.
Tmtd (thiram), chemical name are tetramethyl thiuram disulfide, belong to organosulfureous fungicide; It is a kind of bactericide of tool protective effect; Its has a broad antifungal spectrum is mainly used in and handles seed and soil, the seedling blight of control cereal class smut and various crop; Also can be used for spraying, prevent and treat some fruit trees, vegetable disease.
Kasugarnycin (kasugamycin) is the metabolite that actinomycetes produce; Inhale antibiotic in belonging to, have treatment and prevention effect concurrently, mainly disturb amino acid whose metabolism esterase system; Thereby influence the synthetic of protein; Suppress the mycelia elongation and cause cell granulationsization, but spore germination is not had influence, the rice blast on the paddy rice is had excellent preventive effect and therapeutic action.
Polyoxin (polyoxin) is the broad-spectrum antibiotics class, has the interior preferably conduction of inhaling, and its mechanism of action is to disturb the chitinous biosynthesis of bacterial cell wall; Germ tube is with after mycelium contacts medicament, and expand the part, breaks; Overflow cell inclusion, and can not normal development cause death, suppress germ in addition and produce spore and scab expansion effect; This medicine does not have toxicity to animal, and plant is not had poisoning.Be used to prevent and treat multiple fungal diseases such as paddy rice, wheat, vegetables fruit tree.
In give birth to rhzomorph (zhongshengmycin) and belong to N-glucosides class alkaline water soluble substance, the protective fungicide that fungicidal spectrum is wider, have tag, osmosis.Its effect: to bacterium is suppress bacterium protein synthetic, causes thalline dead; To fungi is to make the mold fungi deformation of filament, suppresses directly killing spores of spore germination and ability.Bacterial disease and part fungal disease to crops have very high activity, have certain production-increasing function simultaneously.
Wuyiencin is a kind of streptomycete series bactericidal agent; Belong to low toxicity, efficient, wide spectrum and the strong sterilization antibiotic medicament of interior absorption; Have protection and therapeutic action; Can suppress the synthetic of pathogen protein, and suppress pathogen thalline mycelial growth, sporulation, sprouting and influence the somatic cells membrane permeability.Can carry out induction of resistance to plant, all plants all have the certain basis resistance to pathogen, and the various plants disease fungus is had stronger inhibitory action.
Jinggangmeisu (jingangmycin) is the very strong agricultural antibiotic of systemic action; After the mycelia of Rhizoctonia solani Kuhn touches jinggangmeisu; Can be absorbed by somatic cells very soon and in thalline, conduct, disturb and the growth of inhibition somatic cells normal growth, thereby play therapeutic action.Jinggangmeisu also can be used for preventing and treating wheat sharp eyespot, false smut etc.
The inventor proves through a series of research; Flutolanil is mixed with the arbitrary fungicide active ingredient that is selected from tricyclazole, carbendazim, IBP, Isoprothiolane, rice blast acid amides, tmtd, kasugarnycin, polyoxin, middle living rhzomorph, Wuyiencin and jinggangmeisu the target bacterium is had extremely strong synergistic effect; Improve bactericidal activity greatly, thereby accomplished the present invention.
Summary of the invention
The object of the present invention is to provide a kind of mixed ratio reasonable, control efficiency is good, the Synergistic bactericidal composition that drug cost is low.
Another object of the present invention is to provide by formulations such as the formulated missible oil of this bactericidal composition, microemulsion, aqueous emulsion, suspending agent, aqua, wetting powder, water dispersible granules, granules.
Another object of the present invention is to provide the purposes that this bactericidal composition is used to prevent and treat rice sheath blight disease, rice blast.
Technical scheme of the present invention is described below:
A kind of bactericidal composition, the arbitrary fungicide active ingredient that it is characterized in that containing the flutolanil of synergy effective dose and be selected from tricyclazole, carbendazim, IBP, Isoprothiolane, rice blast acid amides, tmtd, kasugarnycin, polyoxin, middle living rhzomorph, Wuyiencin and jinggangmeisu.
Wherein, Flutolanil can change in very wide scope with the weight ratio that is selected from arbitrary fungicide active ingredient of tricyclazole, carbendazim, IBP, Isoprothiolane, rice blast acid amides, tmtd, kasugarnycin, polyoxin, middle living rhzomorph, Wuyiencin and jinggangmeisu; Be preferably 40: 1～1: 40, more preferably 10: 1～1: 10.
And the weight ratio of flutolanil and tricyclazole, carbendazim, IBP, Isoprothiolane, rice blast acid amides or tmtd further is preferably 1: 1～1: 10; The weight ratio of flutolanil and kasugarnycin, polyoxin, middle living rhzomorph or Wuyiencin further is preferably 10: 1～1: 1; The weight ratio of flutolanil and jinggangmeisu further is preferably 5: 1～1: 10.
Wherein, the weight ratio of flutolanil and tricyclazole further is preferably 1: 3～1: 8; The weight ratio of flutolanil and carbendazim further is preferably 1: 5; The weight ratio of flutolanil and IBP further is preferably 1: 1～1: 5; The weight ratio of flutolanil and Isoprothiolane further is preferably 2: 5; The weight ratio of flutolanil and rice blast acid amides further is preferably 1: 1; The weight ratio of flutolanil and tmtd further is preferably 1: 5; The weight ratio of flutolanil and kasugarnycin further is preferably 5: 1～8: 1; The weight ratio of flutolanil and polyoxin further is preferably 2: 1～7: 1; The weight ratio of flutolanil and middle living rhzomorph further is preferably 4: 1; The weight ratio of flutolanil and Wuyiencin further is preferably 4: 1～7: 1; The weight ratio of flutolanil and jinggangmeisu further is preferably 2: 1～1: 5.
Active component is 0.5% to 95% of a gross weight in the composition of the present invention.
Except the fungicidal activity composition, also can comprise functional aid in the bactericidal composition of the present invention.That is to say that the present composition can add other components such as functional aid, be mixed with the preparation of missible oil, aqueous emulsion, microemulsion, suspending agent, aqua, wetting powder, water dispersible granules or other formulations.
In these preparations; Except that active component; All contain surfactant, and also can contain thinners such as organic solvent or cosolvent, carrier (filler) or water, add other functional aids such as antifreeze, thickener, stabilizing agent, antifoaming agent, disintegrant in case of necessity according to different dosage form.Surfactant can be emulsifier, dispersant, wetting agent or bleeding agent.Surfactant can be nonionic with ion-type, also can be two or more compound uses.
Described emulsifier comprises alkylphenol-polyethenoxy (polyoxypropylene) ether, benzylphenol APEO, phenethyl phenol polyethenoxy ether, AEO, polyoxyethylene carboxylate, phenethyl phenol polyethenoxy polyethenoxy ether, castor oil ethylene oxide adduct, APES formaldehyde condensation products, and the phosphate of these compounds, alkyl benzene sulphonate (calcium salt or sodium salt) or directly use commercially available emulsifier monomer and composite product.Concrete example is like farming breast 500
#Series, 600
#Series, 1600
#Series, NP is serial, OP is serial, AEO is serial, 700
#, 400
#Serial and composite kind 2201,0203B, 2021B, 4103 etc., these all are emulsifier productions well known in the art, market is on sale.
Described dispersant, wetting agent, bleeding agent comprise lignosulfonates (sodium salt or calcium salt), Negel, condensation compound of methyl naphthalene sulfonic acid and formaldehyde sulphate, naphthalene sulfonic acid-formaldehyde condensation product, methanonaphthalene sodium sulfonate dibutyl naphthalene sulfonic acid-formaldehyde condensation product, N-methyl fatty acyl group sodium taurocholate, APES formaldehyde condensation products sulphate, polymerization of carboxylic acid sodium, APES phosphate, the withered powder of tea, saponin, lignosulfite, aliphatic alcohol sulfate, dodecyl sodium sulfate, alkylbenzenesulfonate, penetrant t, bleeding agent OT, fatty acid amide-N methyl taurine sodium salt, sodium sulfate of polyethenoxy ether of fatty alcohol, draw back powder, JFC; Can use separately, also can compoundly use.Above-mentioned surfactant all is materials well known in the art, can obtain through various commercial channel.
Described solvent, cosolvent comprise toluene, xylol, chlorobenzene, solvent naphtha, alpha-methyl-naphthalene, turpentine oil, carrene, chloroform, methyl alcohol, ethanol, isopropyl alcohol, butanols, isoamyl alcohol, cyclohexanone, isophorone, acetophenone, ethyl acetate, butyl acetate, N.N-dimethyl formamide, dimethyl sulfoxide (DMSO), methyl cellosolve, ethyl cellosolve etc.
Described antifreeze is ethylene glycol, glycerine, propane diols, urea, glycerine, ether diglycol, polyethylene glycol, isopropyl alcohol etc.
Described carrier, filler comprise white carbon, precipitated calcium carbonate, potter's clay, attapulgite, kaolin, diatomite, bentonite, sepiolite, zeolite, quartz sand, talcum powder, can use separately, also can two kinds or above mixing use.
Described disintegrant has sodium alginate, sodium carboxymethyl starch, sulfuric acid amine, bentonite, urea, calcium chloride.
Described antifoaming agent has bubble enemy, silicone, C
8-10Fatty alcohol, C
10-20Saturated fat acids (like capric acid, stearic acid etc.) and amide-type.
Described binding agent comprises starch, dextrin, gum Arabic, soybean protein, gelatine, sodium sulphate, gypsum, polyvinyl alcohol, polyethylene glycol, rosin, paraffin, CMC, sodium silicate.Can use separately, also can two or morely use with.
Can contain toner in the preparation, inorganic pigment iron oxide for example, titanium oxide or Prussian blue; Organic dyestuff is like A Lizhalin, azo dyes, metal phthalocyanine or kiton colors.In water-base preparation; For preventing moldy metamorphism; Need to add a certain amount of preservative, described preservative has Sodium Benzoate, polyformaldehyde, sorbitol, formalin, citric acid, to the yl benzoic acid methyl esters, face phenyl phenol sodium, 1,2-benzisothiazole-3-ketone (code name BIT) etc.
The product that the present invention describes can be the finished product preparation form to be provided, and promptly each material mixes in the composition, but the composition of composition also can provide directly mixing in bucket (jar) before using with independent preparation.Concentrate of the present invention mixes the concentration that obtains required active substance usually with water.
Composition of the present invention can be used for paddy rice.The product that composition of the present invention and carrier are processed use the field paddy field etc. of doing.
Composition of the present invention also can with other compound with weeding, desinsection or bactericidal property particularly the protective fungicide agent composition use, also can use with nematocide, protective agent, growth regulator, nutrient for plants or soil conditioner mixture.Composition of the present invention can be used by common method, like cast, injection, spraying.Amount of application of the present invention is with weather condition or crop state variation, and time of application can be before or after crop be susceptible.The duration of protective effect is usually relevant with the content of single compound in the composition, also relevant with extraneous factor, weather for example, but through using suitable formulation can slow down climatic influences.
The remarkable advantage of composition of the present invention: the one, composition shows extremely strong synergistic effect in certain ratio range; The bactericidal effect of mixed composition is significantly improved than its single agent; Thereby reduced using dosage; When reducing peasant's drug cost, reduced influence degree.The 2nd, interracial structure differs bigger, and the resistance that the application of said composition can delay single agent takes place and development.
Embodiment:
The present invention is elaborated with following specific embodiment, so that advantage of the present invention is more obvious, but the present invention is limited to these examples absolutely not.Percentage all is weight percentage in the prescription of all preparations, and the processing of biologically-active moiety is effective content.
One, preparation embodiment:
1, the preparation of missible oil
By the prescription requirement, add solvent, former medicine, emulsifier respectively, mix, use the hot bath heating for dissolving in case of necessity, promptly obtain transparence missible oil.Like embodiment 1～3 prescription.
Embodiment 1 (30% missible oil)
Flutolanil 5%, carbendazim 25%, agricultural newborn 500# 7.5%, agricultural newborn 600-2# 4.5%, methyl alcohol 8%, xylol complements to 100%.
Embodiment 2 (16% missible oil)
Flutolanil 4%, IBP 12%, agricultural newborn 507# 10%, agricultural newborn OX-653 3%, methyl alcohol 10%, xylol complements to 100%.
Embodiment 3 (10% missible oil)
Flutolanil 5%, rice blast acid amides 5%, agricultural newborn 500# 10%, agricultural newborn OX-635 5%, methyl alcohol 10%, xylol complements to 100%.
2, the preparation of wetting powder
By the prescription requirement, former medicine, various auxiliary agent and filler etc. are fully mixed, after ultrafine crusher is pulverized, promptly obtain converted products.Like embodiment 4～9 prescriptions.
Embodiment 4 (36% wetting powder)
Flutolanil 6%, tricyclazole 30%, lauryl sodium sulfate 1.5%, carboxymethyl cellulose 1%, sodium lignin sulfonate 10%, precipitated calcium carbonate complements to 100%.
Embodiment 5 (21% wetting powder)
Flutolanil 6%, Isoprothiolane 15%, lauryl sodium sulfate 1.5%, carboxymethyl cellulose 1%, sodium lignin sulfonate 10%, precipitated calcium carbonate complements to 100%.
Embodiment 6 (36% wetting powder)
Flutolanil 6%, tmtd 30%, neopelex 1%, white carbon 10%, sodium lignin sulfonate 10%, precipitated calcium carbonate complements to 100%.
Embodiment 7 (10% wetting powder)
Flutolanil 8%, middle living rhzomorph 2%, neopelex 1%, white carbon 10%, sodium lignin sulfonate 10%, precipitated calcium carbonate complements to 100%.
Embodiment 8 (12% wetting powder)
Flutolanil 10%, kasugarnycin 2%, alkyl amide taurate 2%, Fluhyzon formaldehyde condensation 5%, alkylphenol-polyethenoxy phosphate 5%, precipitated calcium carbonate complements to 100%.
Embodiment 9 (10% wetting powder)
Flutolanil 8%, polyoxin 2%, neopelex 1%, white carbon 10%, naphtholsulfonic acid formaldehyde condensation products sodium salt 10%, precipitated calcium carbonate complements to 100%.
3, the preparation of aqueous emulsion
Former medicine, solvent, emulsifier added with co-emulsifier be in the same place, make dissolving be even oil phase.Water, antifreeze etc. is mixed, becomes the homogeneous water.Under high-speed stirred, water is joined oil phase or oil phase is joined water, form the aqueous emulsion of favorable dispersibility.Like embodiment 10～12 prescriptions.
Embodiment 10 (24% aqueous emulsion)
Flutolanil 4%, tricyclazole 20%, polyvinyl alcohol 0.8%; In triphenylethylene phenol+oxirane, phosphorylation, the triethanolamine and 8.5%, alkyl-diethylene glycol ether-sodium sulfonate 2.5%, farming breast 2,201 13%; Dimethyl formamide 8%, ethylene glycol 5%, water complements to 100%.
Embodiment 11 (24% aqueous emulsion)
Flutolanil 4%, carbendazim 20%, polyvinyl alcohol 0.9%, alkylaryl polyoxyethylene propylene ether 8.5%, farming breast 2,201 15%, dimethyl formamide 12%, ethylene glycol 5%, water complements to 100%.
Embodiment 12 (12% aqueous emulsion)
Flutolanil 4%, jinggangmeisu 8%, polyvinyl alcohol 1.5%, alkylaryl polyoxyethylene propylene ether 10%, farming breast 2,201 15%, dimethyl formamide 15%, ethylene glycol 5%, water complements to 100%.
4, the preparation of water-dispersible granules
Former medicine and powder carrier, wetting spreader and binding agent etc. are mixed pulverizing, after adding water again and mediating, add in the comminutor that the certain specification screen cloth is housed and carry out granulation.And then through dry, screening (pressing the screen cloth scope) promptly gets granular product.Like embodiment 13～14 prescriptions.
Embodiment 13 (16% water-dispersible granules)
Flutolanil 8%, rice blast acid amides 8%, methyl naphthalene sulfonate formaldehyde condensate 12%, epoxidized polyether 5%, soluble starch 15%, gypsum complements to 100%.
Embodiment 14 (15% water-dispersible granules)
Flutolanil 12%, polyoxin 3%, methanonaphthalene sodium sulfonate 5%, epoxidized polyether 5%, sodium sulphate, gypsum complements to 100%.
5, the preparation of suspending agent
By the prescription requirement, be medium with water, former medicine, dispersant, suspending agent and antifreezing agent etc. are added in the sand milling still, carry out porphyrize, process suspending agent.Like embodiment 15～17 prescriptions.
Embodiment 15 (30% suspending agent)
Flutolanil 5%, tricyclazole 25%, methyl naphthalene sulfonate formaldehyde condensate 5.5%, white carbon 0.2%, aluminium-magnesium silicate 0.18%, ethylene glycol 4%, silicone a little, water complements to 100%.
Embodiment 16 (12% suspending agent)
Flutolanil 6%, rice blast acid amides 6%, calcium lignosulfonate 5%, white carbon 0.3%, ethylene glycol 4%, silicone a little, water complements to 100%.
Embodiment 17 (30% suspending agent)
Flutolanil 5%, tmtd 25%, methyl naphthalene sulfonic acid naphthaldehyde condensation compound 2.5%, bentonite 1.0%, farming breast 1,601 3%, glycerine 4%, silicone a little, water complements to 100%.
6, the preparation of microemulsion
Former medicine, solvent, emulsifier added with co-emulsifier be in the same place, make dissolving be even oil phase.Water, antifreeze etc. is mixed, becomes the homogeneous water.Under high-speed stirred, water is joined oil phase or oil phase is joined water, form the microemulsion of favorable dispersibility.Like embodiment 18～20 prescriptions.
Embodiment 18 (24% microemulsion)
Flutolanil 4%, tricyclazole 20%, propyl alcohol 7%, phenethyl phenol polyethenoxy ether 10%, carrene 10%, glycerine 5%, water complements to 100%.
Embodiment 19 (30% microemulsion)
Flutolanil 5%, carbendazim 25%, xylol 12%, phenyl xenol polyvinylether 15%, ring ethanol 8%, ethylene glycol 8%, water complements to 100%.
Embodiment 20 (12% microemulsion)
Flutolanil 4%, jinggangmeisu 8%, ethanol 6%, sodium alkyl benzene sulfonate 8%, the third hexanone 8%, propane diols 6%, water complements to 100%.
7, the preparation of aqua
By the prescription requirement, required solvent is injected reaction pot, add all pesticide original medicines then, stir and make its dissolving, add auxiliary agent more successively, emulsifier, last first alcohol and water is processed aqua.Like embodiment 21～22 prescriptions.
Embodiment 21 (12% aqua)
Flutolanil 10%, kasugarnycin 2%, dimethyl formamide 10%, Gao Jinsai ketone 1.5～6%, AEO 5%, APES 5%, fatty diglycollic amide 5%, sulfonic acid 2%, alcohol or water are mended to 100%.
Embodiment 22 (10% aqua)
Flutolanil 8%, polyoxin 2%, dimethyl formamide 10%, organic amine 1.5～6%, AEO 5%, APES 5%, fatty diglycollic amide 5%, sulfonic acid 2%, alcohol or water are mended to 100%.
Two, biological Examples:
The joint toxicity measuring of Test Example 1 flutolanil and tricyclazole
Supply the examination bacterium
Rice sheath blight disease (Thanatephorus cucumeris (Frank) Donk)
The experimental concentration design
The experimental concentration of combination medicament and the agent of flutolanil list is five concentration of 8,4,2,1,0.5 μ g/ml, and the concentration of treatment of tricyclazole list agent is 24,12,6,3,1.5 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Select for use broad bean susceptible variety (early give birth to 615) potted plant, the blade that clip same area, growing way be consistent, have petiole is put in the culture dish, and it is subsequent use to preserve moisture.Blade is fully soaked into 5s in the soup for preparing in advance, drop removes unnecessary soup, behind the natural air drying, by the cultivation of preserving moisture behind the marks for treatment.There is the one side of mycelia to be inoculated in diameter 5mm bacterium cake with inoculator and handles blade central authorities.30 leaves of every processing inoculation.The protectiveness test is the 24h inoculation after chemicals treatment, and the therapeutic test is the 24h inoculation before chemicals treatment.In conjunction with in be placed on climatic cabinate or thermostatic chamber has in the illumination humidistat, under the condition of 26 ℃～28 ℃ of temperature, relative moisture 80%～90%, cultivate.
Investigation and method of counting
By medicine inspecting institute of the Ministry of Agriculture " agricultural chemicals indoor bioassay test rule " method, look the blank incidence, with kind of calliper record each inoculation point scab length and width, represent scab diameter (mm of unit) with length and width mean value.Do regression analysis according to each medicament logarithm value and corresponding preventive effect probability value, calculate the EC of each medicament
50, according to Wadley bactericide mixture synergy evaluation assessment, calculates interactional ratio (be that SR＜0.5 is an antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) behind two single agent compositions.
Result of the test sees the following form 1.
The joint toxicity measuring result of table 1 flutolanil and tricyclazole
Result of the test shows: the weight ratio of flutolanil and tricyclazole is 1: 5 o'clock, and its interaction ratio is respectively 1.83, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of Test Example 2 flutolanils and carbendazim
Supply the examination bacterium
Rice sheath blight disease (Thanatephorus cucumeris (Frank) Donk)
The experimental concentration design
The experimental concentration of combination medicament and the agent of flutolanil list is five concentration of 20,10,5,2.5,1.25 μ g/ml, and the concentration of treatment of carbendazim list agent is 40,20,10,5,2.5 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Under aseptic technique, handle the sterilising medium that will melt in advance according to test and quantitatively add in the aseptic conical flask, from the low concentration to the high concentration, quantitatively draw soup successively, add respectively in the above-mentioned conical flask, fully shake up.To pour 3 above diameters into be in the culture dish of 9cm to equivalent then, and the pastille of processing respective concentration is dull and stereotyped.With cultured pathogen, under aseptic condition,, cut the bacterium cake from colony edge with the sterilization card punch of diameter 5mm, with inoculator the bacterium cake is inoculated in the dull and stereotyped central authorities of pastille, mycelia faces up, and covers the ware lid, puts in the incubator of preference temperature and cultivates.
Investigation and method of counting
By medicine inspecting institute of the Ministry of Agriculture " pesticide bioassay test standard " method, according to the growing state investigation cause of disease mycelia growing state of the bacterium in the blank culture dish.Use the kind of calliper colony diameter.Each bacterium colony with right-angled intersection method vertical survey diameter is respectively once got its mean value.Calculate the mycelial growth inhibition rate of each concentration of treatment according to investigation result to germ.Probability value according to each drug concentration logarithm value and corresponding spore germination relative inhibition is done regression analysis, calculates the EC of each medicament
50, according to Wadley bactericide mixture synergy evaluation assessment, calculates interactional ratio (be that SR＜0.5 is an antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) behind two single agent compositions.
Result of the test sees the following form 2.
The joint toxicity measuring result of table 2 flutolanil and carbendazim
Result of the test shows; The weight ratio of flutolanil and carbendazim is 1: 5 o'clock, and its interaction ratio is respectively 1.74, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of Test Example 3 flutolanils and IBP
Supply the examination bacterium
Rice blast (Pyricularia grisea (Cooke) Sacc.)
The experimental concentration design
The experimental concentration of combination medicament and the agent of flutolanil list is five concentration of 16,8,4,2,1 μ g/ml, and the concentration of treatment of IBP list agent is 32,16,8,4,2 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
With deionized water wash-out, filtration on medium or the diseased tissues, centrifugal (1000r/min) 5min removes supernatant, adds deionized water, and is centrifugal again with cultured disease fungus spore.At last with deionization with the spore resuspension to every milliliter 1 * 10
5Individual～1 * 10
7Individual spore, and add 0.5% glucose solution., from the low concentration to the high concentration, draw soup 0.5mL successively and add respectively in the small test tube with pipette or pipettor, draw the spore suspension 0.5mL for preparing then, make soup and spore suspension mixed in equal amounts even.Draw above-mentioned mixed liquor with micro sample adding appliance and drip on the concave slide, frame is put in the culture dish that has shallow seated groundwater then, and adding a cover preserves moisture is incubated in the incubator of preference temperature.
Investigation and method of counting
By medicine inspecting institute of the Ministry of Agriculture " agricultural chemicals indoor bioassay test rule " method,, check the spore germination situation of respectively handling when the blank spore germination rate reaches 90% when above.Every processing repeats 3 above visuals field of random observation, many 200 of investigation spore sum, and number and spore sum sprouted in record respectively.Spore germ tube length is regarded as sprouting greater than the short radius of spore.According to survey data, calculate the spore germination relative inhibition that each is handled.Probability value according to each drug concentration logarithm value and corresponding spore germination relative inhibition is done regression analysis, calculates the EC of each medicament
50, according to Wadley bactericide mixture synergy evaluation assessment, calculates interactional ratio (be that SR＜0.5 is an antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) behind two single agent compositions.
Result of the test sees the following form 3.
The joint toxicity measuring result of table 3 flutolanil and IBP
Result of the test shows; The weight ratio of flutolanil and IBP is 1: 3 o'clock, and its interaction ratio is respectively 1.97, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of Test Example 4 flutolanils and Isoprothiolane
Supply the examination bacterium
Rice blast (Pyricularia grisea (Cooke) Sacc.)
The experimental concentration design
The experimental concentration of combination medicament is five concentration of 8,4,2,1,0.5 μ g/ml, and the concentration of treatment of flutolanil and the agent of Isoprothiolane list is 12,6,3,1.5,0.75 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
With deionized water wash-out, filtration on medium or the diseased tissues, centrifugal (1000r/min) 5min removes supernatant, adds deionized water, and is centrifugal again with cultured disease fungus spore.At last with deionization with the spore resuspension to every milliliter 1 * 10
5Individual～1 * 10
7Individual spore, and add 0.5% glucose solution., from the low concentration to the high concentration, draw soup 0.5mL successively and add respectively in the small test tube with pipette or pipettor, draw the spore suspension 0.5mL for preparing then, make soup and spore suspension mixed in equal amounts even.Draw above-mentioned mixed liquor with micro sample adding appliance and drip on the concave slide, frame is put in the culture dish that has shallow seated groundwater then, and adding a cover preserves moisture is incubated in the incubator of preference temperature.
Investigation and method of counting
By medicine inspecting institute of the Ministry of Agriculture " agricultural chemicals indoor bioassay test rule " method,, check the spore germination situation of respectively handling when the blank spore germination rate reaches 90% when above.Every processing repeats 3 above visuals field of random observation, many 200 of investigation spore sum, and number and spore sum sprouted in record respectively.Spore germ tube length is regarded as sprouting greater than the short radius of spore.According to survey data, calculate the spore germination relative inhibition that each is handled.Probability value according to each drug concentration logarithm value and corresponding spore germination relative inhibition is done regression analysis, calculates the EC of each medicament
50, according to Wadley bactericide mixture synergy evaluation assessment, calculates interactional ratio (be that SR＜0.5 is an antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) behind two single agent compositions.
Result of the test sees the following form 4.
The joint toxicity measuring result of table 4 flutolanil and Isoprothiolane
Result of the test shows; The weight ratio of flutolanil and Isoprothiolane is 2: 5 o'clock, and its interaction ratio is respectively 1.88, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of Test Example 5 flutolanils and rice blast acid amides
Supply the examination bacterium
Rice blast (Pyricularia grisea (Cooke) Sacc.)
The experimental concentration design
The experimental concentration of combination medicament and the agent of rice blast acid amides list is five concentration of 6.4,3.2,1.6,0.8,0.4 μ g/ml, and the concentration of treatment of flutolanil list agent is 12,6,3,1.5,0.75 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Under aseptic technique, handle the sterilising medium that will melt in advance according to test and quantitatively add in the aseptic conical flask, from the low concentration to the high concentration, quantitatively draw soup successively, add respectively in the above-mentioned conical flask, fully shake up.To pour 3 above diameters into be in the culture dish of 9cm to equivalent then, and the pastille of processing respective concentration is dull and stereotyped.With cultured pathogen, under aseptic condition,, cut the bacterium cake from colony edge with the sterilization card punch of diameter 5mm, with inoculator the bacterium cake is inoculated in the dull and stereotyped central authorities of pastille, mycelia faces up, and covers the ware lid, puts in the incubator of preference temperature and cultivates.
Investigation and method of counting
By medicine inspecting institute of the Ministry of Agriculture " pesticide bioassay test standard " method, according to the growing state investigation cause of disease mycelia growing state of the bacterium in the blank culture dish.Use the kind of calliper colony diameter.Each bacterium colony with right-angled intersection method vertical survey diameter is respectively once got its mean value.Calculate the mycelial growth inhibition rate of each concentration of treatment according to investigation result to germ.Probability value according to each drug concentration logarithm value and corresponding spore germination relative inhibition is done regression analysis, calculates the EC of each medicament
50, according to Wadley bactericide mixture synergy evaluation assessment, calculates interactional ratio (be that SR＜0.5 is an antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) behind two single agent compositions.
Result of the test sees the following form 5.
The joint toxicity measuring result of table 5 flutolanil and rice blast acid amides
Result of the test shows; The weight ratio of flutolanil and rice blast acid amides is 1: 1 o'clock, and its interaction ratio is respectively 1.78, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of Test Example 6 flutolanils and tmtd
Rice blast (Pyricularia grisea (Cooke) Sacc.)
The experimental concentration design
The experimental concentration of combination medicament and the agent of flutolanil list is five concentration of 8,4,2,1,0.5 μ g/ml, and the concentration of treatment of tmtd list agent is 32,16,8,4,2 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Under aseptic technique, handle the sterilising medium that will melt in advance according to test and quantitatively add in the aseptic conical flask, from the low concentration to the high concentration, quantitatively draw soup successively, add respectively in the above-mentioned conical flask, fully shake up.To pour 3 above diameters into be in the culture dish of 9cm to equivalent then, and the pastille of processing respective concentration is dull and stereotyped.With cultured pathogen, under aseptic condition,, cut the bacterium cake from colony edge with the sterilization card punch of diameter 5mm, with inoculator the bacterium cake is inoculated in the dull and stereotyped central authorities of pastille, mycelia faces up, and covers the ware lid, puts in the incubator of preference temperature and cultivates.
Investigation and method of counting
By medicine inspecting institute of the Ministry of Agriculture " pesticide bioassay test standard " method, according to the growing state investigation cause of disease mycelia growing state of the bacterium in the blank culture dish.Use the kind of calliper colony diameter.Each bacterium colony with right-angled intersection method vertical survey diameter is respectively once got its mean value.Calculate the mycelial growth inhibition rate of each concentration of treatment according to investigation result to germ.Probability value according to each drug concentration logarithm value and corresponding spore germination relative inhibition is done regression analysis, calculates the EC of each medicament
50, according to Wadley bactericide mixture synergy evaluation assessment, calculates interactional ratio (be that SR＜0.5 is an antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) behind two single agent compositions.
Result of the test sees the following form 6.
The joint toxicity measuring result of table 6 flutolanil and tmtd
Result of the test shows; The weight ratio of flutolanil and tmtd is 1: 5 o'clock, and its interaction ratio is respectively 1.86, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of Test Example 7 flutolanils and kasugarnycin
Supply the examination bacterium
Rice blast (Pyricularia grisea (Cooke) Sacc.)
The experimental concentration design
The experimental concentration of combination medicament is five concentration of 4,2,1,0.5,0.25 μ g/ml; The experimental concentration of kasugarnycin list agent is 2.4,1.2,0.6,0.3,0.15 μ g/ml; The concentration of treatment of flutolanil list agent is 16,8,4,2,1 μ g/ml; Other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
With deionized water wash-out, filtration on medium or the diseased tissues, centrifugal (1000r/min) 5min removes supernatant, adds deionized water, and is centrifugal again with cultured disease fungus spore.At last with deionization with the spore resuspension to every milliliter 1 * 10
5Individual～1 * 10
7Individual spore, and add 0.5% glucose solution., from the low concentration to the high concentration, draw soup 0.5mL successively and add respectively in the small test tube with pipette or pipettor, draw the spore suspension 0.5mL for preparing then, make soup and spore suspension mixed in equal amounts even.Draw above-mentioned mixed liquor with micro sample adding appliance and drip on the concave slide, frame is put in the culture dish that has shallow seated groundwater then, and adding a cover preserves moisture is incubated in the incubator of preference temperature.
Investigation and method of counting
By medicine inspecting institute of the Ministry of Agriculture " agricultural chemicals indoor bioassay test rule " method,, check the spore germination situation of respectively handling when the blank spore germination rate reaches 90% when above.Every processing repeats 3 above visuals field of random observation, many 200 of investigation spore sum, and number and spore sum sprouted in record respectively.Spore germ tube length is regarded as sprouting greater than the short radius of spore.According to survey data, calculate the spore germination relative inhibition that each is handled.Probability value according to each drug concentration logarithm value and corresponding spore germination relative inhibition is done regression analysis, calculates the EC of each medicament
50, according to Wadley bactericide mixture synergy evaluation assessment, calculates interactional ratio (be that SR＜0.5 is an antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) behind two single agent compositions.
Result of the test sees the following form 7.
The joint toxicity measuring result of table 7 flutolanil and kasugarnycin
Result of the test shows; The weight ratio of flutolanil and kasugarnycin is 5: 1 o'clock, and its interaction ratio is respectively 1.84, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of Test Example 8 flutolanils and polyoxin
Supply the examination bacterium
Rice sheath blight disease (Thanatephorus cucumeris (Frank) Donk)
The experimental concentration design
The experimental concentration of combination medicament and the agent of polyoxin list is five concentration of 8,4,2,1,0.5 μ g/ml, and the concentration of treatment of flutolanil list agent is 16,8,4,1,0.5 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Under aseptic technique, handle the sterilising medium that will melt in advance according to test and quantitatively add in the aseptic conical flask, from the low concentration to the high concentration, quantitatively draw soup successively, add respectively in the above-mentioned conical flask, fully shake up.To pour 3 above diameters into be in the culture dish of 9cm to equivalent then, and the pastille of processing respective concentration is dull and stereotyped.With cultured pathogen, under aseptic condition,, cut the bacterium cake from colony edge with the sterilization card punch of diameter 5mm, with inoculator the bacterium cake is inoculated in the dull and stereotyped central authorities of pastille, mycelia faces up, and covers the ware lid, puts in the incubator of preference temperature and cultivates.
Investigation and method of counting
By medicine inspecting institute of the Ministry of Agriculture " pesticide bioassay test standard " method, according to the growing state investigation cause of disease mycelia growing state of the bacterium in the blank culture dish.Use the kind of calliper colony diameter.Each bacterium colony with right-angled intersection method vertical survey diameter is respectively once got its mean value.Calculate the mycelial growth inhibition rate of each concentration of treatment according to investigation result to germ.Probability value according to each drug concentration logarithm value and corresponding spore germination relative inhibition is done regression analysis, calculates the EC of each medicament
50, according to Wadley bactericide mixture synergy evaluation assessment, calculates interactional ratio (be that SR＜0.5 is an antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) behind two single agent compositions.
Result of the test sees the following form 8.
The joint toxicity measuring result of table 8 flutolanil and polyoxin
Result of the test shows; The weight ratio of flutolanil and polyoxin is 4: 1 o'clock, and its interaction ratio is respectively 1.91, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of Test Example 10 flutolanils and middle living rhzomorph
Supply the examination bacterium
Rice sheath blight disease (Thanatephorus cucumeris (Frank) Donk)
The experimental concentration design
Combination medicament and middle experimental concentration of giving birth to the agent of rhzomorph list are five concentration of 12,6,3,1.5,0.75 μ g/ml, and the concentration of treatment of flutolanil list agent is 4,2,1,0.5,0.25 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Under aseptic technique, handle the sterilising medium that will melt in advance according to test and quantitatively add in the aseptic conical flask, from the low concentration to the high concentration, quantitatively draw soup successively, add respectively in the above-mentioned conical flask, fully shake up.To pour 3 above diameters into be in the culture dish of 9cm to equivalent then, and the pastille of processing respective concentration is dull and stereotyped.With cultured pathogen, under aseptic condition,, cut the bacterium cake from colony edge with the sterilization card punch of diameter 5mm, with inoculator the bacterium cake is inoculated in the dull and stereotyped central authorities of pastille, mycelia faces up, and covers the ware lid, puts in the incubator of preference temperature and cultivates.
Investigation and method of counting
By medicine inspecting institute of the Ministry of Agriculture " pesticide bioassay test standard " method, according to the growing state investigation cause of disease mycelia growing state of the bacterium in the blank culture dish.Use the kind of calliper colony diameter.Each bacterium colony with right-angled intersection method vertical survey diameter is respectively once got its mean value.Calculate the mycelial growth inhibition rate of each concentration of treatment according to investigation result to germ.Probability value according to each drug concentration logarithm value and corresponding spore germination relative inhibition is done regression analysis, calculates the EC of each medicament
50, according to Wadley bactericide mixture synergy evaluation assessment, calculates interactional ratio (be that SR＜0.5 is an antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) behind two single agent compositions.
Result of the test sees the following form 10.
The joint toxicity measuring result of table 10 flutolanil and middle living rhzomorph
Result of the test shows; The weight ratio of flutolanil and middle living rhzomorph is 4: 1 o'clock, and its interaction ratio is respectively 1.85, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of Test Example 11 flutolanils and Wuyiencin
Supply the examination bacterium
Rice sheath blight disease (Thanatephorus cucumeris (Frank) Donk)
The experimental concentration design
The experimental concentration of combination medicament and the agent of Wuyiencin list is five concentration of 6,3,1.5,0.75,0.375 μ g/ml, and the concentration of treatment of flutolanil list agent is 16,8,4,2,1 μ g/ml, and other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Under aseptic technique, handle the sterilising medium that will melt in advance according to test and quantitatively add in the aseptic conical flask, from the low concentration to the high concentration, quantitatively draw soup successively, add respectively in the above-mentioned conical flask, fully shake up.To pour 3 above diameters into be in the culture dish of 9cm to equivalent then, and the pastille of processing respective concentration is dull and stereotyped.With cultured pathogen, under aseptic condition,, cut the bacterium cake from colony edge with the sterilization card punch of diameter 5mm, with inoculator the bacterium cake is inoculated in the dull and stereotyped central authorities of pastille, mycelia faces up, and covers the ware lid, puts in the incubator of preference temperature and cultivates.
Investigation and method of counting
By medicine inspecting institute of the Ministry of Agriculture " pesticide bioassay test standard " method, according to the growing state investigation cause of disease mycelia growing state of the bacterium in the blank culture dish.Use the kind of calliper colony diameter.Each bacterium colony with right-angled intersection method vertical survey diameter is respectively once got its mean value.Calculate the mycelial growth inhibition rate of each concentration of treatment according to investigation result to germ.Probability value according to each drug concentration logarithm value and corresponding spore germination relative inhibition is done regression analysis, calculates the EC of each medicament
50, according to Wadley bactericide mixture synergy evaluation assessment, calculates interactional ratio (be that SR＜0.5 is an antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) behind two single agent compositions.
Result of the test sees the following form 11.
The joint toxicity measuring result of table 11 flutolanil and Wuyiencin
Result of the test shows; The weight ratio of flutolanil and Wuyiencin is 4: 1 o'clock, and its interaction ratio is respectively 1.94, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
The joint toxicity measuring of Test Example 12 flutolanils and jinggangmeisu
Supply the examination bacterium
Rice sheath blight disease (Thanatephorus cucumeris (Frank) Donk)
The experimental concentration design
The experimental concentration of combination medicament and the agent of flutolanil list is five concentration of 2.4,1.2,0.6,0.3,0.15 μ g/ml; The concentration of treatment of jinggangmeisu list agent is 6,3,1.5,0.75,0.375 μ g/ml; Other establishes the blank of not dosing, and each is handled 4 times and repeats.
Test method
Under aseptic technique, handle the sterilising medium that will melt in advance according to test and quantitatively add in the aseptic conical flask, from the low concentration to the high concentration, quantitatively draw soup successively, add respectively in the above-mentioned conical flask, fully shake up.To pour 3 above diameters into be in the culture dish of 9cm to equivalent then, and the pastille of processing respective concentration is dull and stereotyped.With cultured pathogen, under aseptic condition,, cut the bacterium cake from colony edge with the sterilization card punch of diameter 5mm, with inoculator the bacterium cake is inoculated in the dull and stereotyped central authorities of pastille, mycelia faces up, and covers the ware lid, puts in the incubator of preference temperature and cultivates.
Investigation and method of counting
By medicine inspecting institute of the Ministry of Agriculture " pesticide bioassay test standard " method, according to the growing state investigation cause of disease mycelia growing state of the bacterium in the blank culture dish.Use the kind of calliper colony diameter.Each bacterium colony with right-angled intersection method vertical survey diameter is respectively once got its mean value.Calculate the mycelial growth inhibition rate of each concentration of treatment according to investigation result to germ.Probability value according to each drug concentration logarithm value and corresponding spore germination relative inhibition is done regression analysis, calculates the EC of each medicament
50, according to Wadley bactericide mixture synergy evaluation assessment, calculates interactional ratio (be that SR＜0.5 is an antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect) behind two single agent compositions.
Result of the test sees the following form 12.
The joint toxicity measuring result of table 12 flutolanil and jinggangmeisu
Result of the test shows; The weight ratio of flutolanil and jinggangmeisu is 1: 2 o'clock, and its interaction ratio is respectively 1.87, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
Though, the present invention has been done detailed description in the preceding text with general explanation and specific embodiments, on basis of the present invention, can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (3)
1. bactericidal composition is characterized in that containing the flutolanil and the middle living rhzomorph of synergy effective dose, and wherein the weight ratio of flutolanil and middle living rhzomorph is 4: 1.
2. missible oil, microemulsion, aqueous emulsion, suspending agent, aqua, wetting powder, water dispersible granules or granule that bactericidal composition according to claim 1 is formulated.
3. bactericidal composition according to claim 1 is used to prevent and treat the purposes of rice sheath blight disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102239938A CN101755845B (en) | 2009-11-23 | 2009-11-23 | Bactericide composition containing flutolanil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102239938A CN101755845B (en) | 2009-11-23 | 2009-11-23 | Bactericide composition containing flutolanil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101755845A CN101755845A (en) | 2010-06-30 |
| CN101755845B true CN101755845B (en) | 2012-06-27 |
Family
ID=42487350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102239938A Expired - Fee Related CN101755845B (en) | 2009-11-23 | 2009-11-23 | Bactericide composition containing flutolanil |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101755845B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102017947A (en) * | 2010-12-15 | 2011-04-20 | 广西安泰化工有限责任公司 | Kasugamycin and validamycin composition and preparation thereof |
| CN102067860B (en) * | 2011-01-13 | 2013-06-05 | 四川农业大学 | Bavistin microemulsion and preparation method thereof |
| CN103749496B (en) * | 2011-02-17 | 2015-09-09 | 陕西美邦农药有限公司 | A kind of bactericidal composition containing polyoxin and amides compound |
| CN103314967B (en) * | 2012-03-21 | 2016-02-17 | 陕西韦尔奇作物保护有限公司 | A kind of bactericidal composition containing fenhexamid |
| CN102626074B (en) * | 2012-04-01 | 2014-02-19 | 广西田园生化股份有限公司 | Ultra-low volume liquid containing flutolanil |
| CN104068033B (en) * | 2014-05-28 | 2015-06-24 | 深圳诺普信农化股份有限公司 | Fungicidal composition containing boscalid |
| CN104285991B (en) * | 2014-09-28 | 2016-05-18 | 江苏丘陵地区镇江农业科学研究所 | A kind of compound disinfectant that contains thiram and Isoprothiolane and application thereof |
| CN106614672A (en) * | 2016-12-16 | 2017-05-10 | 张宗斌 | Pesticide granules applied to dry seedling cultivation |
| CN107821428A (en) * | 2017-11-15 | 2018-03-23 | 惠州市永耐宝新材料有限公司 | A kind of composite synergistic agricultural chemicals |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1541537A (en) * | 2003-11-05 | 2004-11-03 | 中国农业科学院生物防治研究所 | Antibiotic agricultural chemicals wettable powder and its preparation method |
| CN101176458A (en) * | 2007-12-19 | 2008-05-14 | 深圳诺普信农化股份有限公司 | Composition with building action and containing middle living bacterium element as well as cardendazim |
| CN101473829A (en) * | 2008-12-18 | 2009-07-08 | 孙家隆 | Bactericide agent composition containing tiadinil and flutolanil |
-
2009
- 2009-11-23 CN CN2009102239938A patent/CN101755845B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1541537A (en) * | 2003-11-05 | 2004-11-03 | 中国农业科学院生物防治研究所 | Antibiotic agricultural chemicals wettable powder and its preparation method |
| CN101176458A (en) * | 2007-12-19 | 2008-05-14 | 深圳诺普信农化股份有限公司 | Composition with building action and containing middle living bacterium element as well as cardendazim |
| CN101473829A (en) * | 2008-12-18 | 2009-07-08 | 孙家隆 | Bactericide agent composition containing tiadinil and flutolanil |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101755845A (en) | 2010-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101755825B (en) | Bactericide composition containing thifluzamide | |
| CN101755845B (en) | Bactericide composition containing flutolanil | |
| CN103583532B (en) | Tetramycin complex and application | |
| CN101779676B (en) | Sterilization composition containing epoxiconazole | |
| CN101755797A (en) | Bactericide composition containing boscalid | |
| CN101755842B (en) | Bactericide composition containing kresoxim-methyl | |
| CN101755785B (en) | Bactericide composition containing famoxadone | |
| CN1994082B (en) | A compound bactericidal agent for controlling anthracnose of fruits and vegetables | |
| CN101779674B (en) | Sterilization composition containing tetraconazole | |
| CN100444731C (en) | Germicide composition | |
| CN101755799B (en) | Cyazofamid-containing bactericidal composition | |
| CN102197818A (en) | Bactericidal composition | |
| CN101755798A (en) | Bactericide composition containing fluazinam | |
| CN101779677A (en) | Sterilization composition containing penconazole | |
| CN101715771B (en) | Sterilizing composition containing imibenconazole | |
| CN104542645B (en) | A kind of Herbicidal combinations containing pyridine sulphur grass amine, clodinafop-propargyl and fluroxypyr | |
| CN101715775B (en) | Sterilizing composition containing ethirimol | |
| CN101755782A (en) | Bactericide composition containing cyprodinil | |
| CN103348982B (en) | A kind of Fungicidal mixture | |
| CN103828816A (en) | Mixed herbicide containing fenoxaprop-p-ethyl, clodinafop-propargyl and fluroxypyr | |
| CN103392715B (en) | A kind of bactericidal composition containing cyprodinil and captan | |
| CN101558757B (en) | Anti-insect and anti-mite composition containing spirodiclofen and nitenpyram | |
| CN101779660B (en) | Sterilization composition containing methyram | |
| CN102715173A (en) | Bactericidal composition containing phenylate diazole and fluoxastrobin and application of bactericidal composition | |
| CN103355309B (en) | Sterilization composition and preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: XINNONG DAZHENG BIOLOGICAL ENGINEERING CO., LTD., Free format text: FORMER OWNER: CHEN ZHANGYAN Effective date: 20110426 Free format text: FORMER OWNER: YOU WENLI |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Chen Weimin Inventor after: Chen Fan Inventor before: Chen Zhangyan Inventor before: You Wenli |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: CHEN ZHANGYAN YOU WENLI TO: CHEN WEIMIN CHEN FAN Free format text: CORRECT: ADDRESS; FROM: 350002 FUJIAN SINO-DASHING BIOLOGICAL ENGINEERING CO., LTD., 6/F, TAIYANGCHENG BUILDING, NO. 268, YANGQIAO WEST ROAD, FUZHOU CITY, FUJIAN PROVINCE TO: 350002 UNIT 6F, BUILDING 2, TAIYANGCHENG COMPREHENSIVE BUILDING, NO. 268, YANGQIAO WEST ROAD, FUZHOU CITY, FUJIAN PROVINCE |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20110426 Address after: Unit 6F No. 2 Yangqiao road Fuzhou Fujian province 350002 City 268 Sun City Building Applicant after: Xinnong Dazheng Biological Engineering Co., Ltd., Fujian Address before: Fuzhou City, Fujian province 350002 Yangqiao Road No. 268, Solar City Tower Rio de Janeiro, 6 floor Fujian sinodashing Bioengineering Co. Ltd. Applicant before: Chen Zhangyan Co-applicant before: You Wenli |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120627 Termination date: 20151123 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |