CN101754762A - 用于治疗神经炎症性疾病的包含哒嗪化合物的制剂 - Google Patents

用于治疗神经炎症性疾病的包含哒嗪化合物的制剂 Download PDF

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CN101754762A
CN101754762A CN200780023749A CN200780023749A CN101754762A CN 101754762 A CN101754762 A CN 101754762A CN 200780023749 A CN200780023749 A CN 200780023749A CN 200780023749 A CN200780023749 A CN 200780023749A CN 101754762 A CN101754762 A CN 101754762A
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M·沃特森
L·范埃尔迪克
W·胡
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NORTHWEST UNIVERSITY
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CN200780023749A 2006-04-28 2007-04-27 用于治疗神经炎症性疾病的包含哒嗪化合物的制剂 Pending CN101754762A (zh)

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US79632806P 2006-04-28 2006-04-28
US60/796,328 2006-04-28
PCT/US2007/010248 WO2007127375A2 (en) 2006-04-28 2007-04-27 Formulations containing pyridazine compounds for treating neuroinflammatory diseases

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CN101754762A true CN101754762A (zh) 2010-06-23

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US (2) US20090325973A1 (https=)
EP (1) EP2063894B1 (https=)
JP (1) JP2009535344A (https=)
CN (1) CN101754762A (https=)
AU (1) AU2007243280A1 (https=)
BR (1) BRPI0710938A2 (https=)
CA (1) CA2650625A1 (https=)
IL (1) IL194968A0 (https=)
MX (1) MX2008013843A (https=)
WO (1) WO2007127375A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE112010005848T5 (de) 2010-09-06 2013-07-04 Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences Amidverbindungen
CN103958481A (zh) * 2011-10-28 2014-07-30 因西必泰克新有限公司 可用于治疗的哒嗪衍生物

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2264014A1 (en) 2001-08-31 2010-12-22 Université Louis Pasteur Substituted pyridazines as anti-inflammatory agents and protein kinase inhibitors
CA2589106C (en) 2004-11-02 2015-07-21 Northwestern University Pyridazine compounds, compositions and methods and their use in treating inflammatory diseases
JP2008518955A (ja) 2004-11-02 2008-06-05 ノースウェスタン ユニバーシティ ピリダジン化合物および方法
US8158627B2 (en) 2006-04-28 2012-04-17 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
AU2007243280A1 (en) 2006-04-28 2007-11-08 Northwestern University Formulations containing pyridazine compounds for treating neuroinflammatory diseases
CA2681162C (en) 2007-03-15 2015-11-24 Novartis Ag Benzyl and pyridine derivatives as modulators of hedgehog pathway
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
US20100227793A1 (en) * 2009-03-04 2010-09-09 Scott Thomas Brady Compositions and Methods for Treating Amyotrophic Lateral Sclerosis
WO2011103091A1 (en) 2010-02-18 2011-08-25 Transtech Pharma, Inc. Phenyl-heteroaryl derivatives and methods of use thereof
WO2011156901A2 (en) * 2010-06-17 2011-12-22 Waratah Pharmaceuticals Inc. Compounds, compositions and methods for treatment of multiple sclerosis
EP4302834A3 (en) 2016-07-12 2024-07-17 Revolution Medicines, Inc. 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors
JP7240319B2 (ja) 2017-01-23 2023-03-15 レヴォリューション・メディスンズ，インコーポレイテッド アロステリックｓｈｐ２阻害剤としての二環式化合物
KR20190110588A (ko) 2017-01-23 2019-09-30 레볼루션 메디슨즈, 인크. 알로스테릭 shp2 억제제로서의 피리딘 화합물
CA3074690A1 (en) 2017-09-07 2019-03-14 Revolution Medicines, Inc. Shp2 inhibitor compositions and methods for treating cancer
TW201930292A (zh) * 2017-10-12 2019-08-01 美商銳新醫藥公司 作為變構ｓｈｐ２抑制劑的吡啶、吡嗪和三嗪化合物
JP7361693B2 (ja) 2017-12-15 2023-10-16 レヴォリューション・メディスンズ，インコーポレイテッド アロステリックｓｈｐ２阻害剤としての多環式化合物
JP2025508485A (ja) * 2022-02-23 2025-03-26 イムノケム セラピューティクス，エルエルシー 頭蓋内出血の治療

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE550427A (https=) * 1955-08-19
GB1345880A (en) 1971-06-18 1974-02-06 Cepbepe Pyridazine derivatives
FR2510998B1 (fr) * 1981-08-07 1986-01-10 Sanofi Sa Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2511366A1 (fr) * 1981-08-11 1983-02-18 Sanofi Sa Nouveaux derives de la pyridazine, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent
DE3217325A1 (de) 1982-05-08 1983-11-10 Hoechst Ag, 6230 Frankfurt 3-amino-6-aryl-1,2,4-triazolo(4,3-b)-pyridazine, ihre herstellung und ihre verwendung
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
ES8802151A1 (es) 1985-07-31 1988-04-01 Janssen Pharmaceutica Nv Un procedimiento para la preparacion de nuevos piridazinaminas.
US4654343A (en) * 1985-10-31 1987-03-31 American Cyanamid Company N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
FR2601011B1 (fr) * 1986-07-03 1988-10-28 Sanofi Sa Nouveaux derives tricycliques agonistes des recepteurs cholinergiques et medicaments en contenant
EP0351435B1 (en) * 1987-11-02 1993-08-04 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyridazine compounds and their medicinal uses
PT93060B (pt) 1989-02-07 1995-12-29 Sanofi Sa Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
ES2114654T3 (es) 1993-06-08 1998-06-01 Vertex Pharma Piridazinas como inhibidores de la enzima de conversion de la interleuquina-1beta.
US5484940A (en) * 1994-11-28 1996-01-16 Grant; Francine S. Substituted 3-indolyl-5-pyrazolone compounds
GB9707693D0 (en) 1997-04-16 1997-06-04 Smithkline Beecham Plc Novel method of treatment
TWI241295B (en) 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
US6602872B1 (en) 1999-12-13 2003-08-05 Merck & Co., Inc. Substituted pyridazines having cytokine inhibitory activity
EP2264014A1 (en) * 2001-08-31 2010-12-22 Université Louis Pasteur Substituted pyridazines as anti-inflammatory agents and protein kinase inhibitors
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
EP1474401A2 (en) * 2002-02-05 2004-11-10 Novo Nordisk A/S Novel aryl- and heteroarylpiperazines
FR2847253B1 (fr) 2002-11-19 2007-05-18 Aventis Pharma Sa Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant
US20040167226A1 (en) * 2002-12-16 2004-08-26 Serafini Tito A. Methods for the treatment of pain and traumatic injury using benzamides and compositions containing the same
WO2005009976A1 (en) * 2003-07-29 2005-02-03 Novo Nordisk A/S Pyridazinyl- piperazines and their use as histamine h3 receptor ligands
TW200528455A (en) 2003-12-19 2005-09-01 Bristol Myers Squibb Co Azabicyclic heterocycles as cannabinoid receptor modulators
WO2005063761A1 (en) 2003-12-19 2005-07-14 Bristol-Myers Squibb Company Azabicyclic heterocycles as cannabinoid receptor modulators
US7220858B2 (en) * 2003-12-23 2007-05-22 Barbeau Pharma, Inc. Synthesis of hydrazine and chlorinated derivatives of bicyclic pyridazines
MY145822A (en) * 2004-08-13 2012-04-30 Neurogen Corp Substituted biaryl piperazinyl-pyridine analogues
JP2008518955A (ja) * 2004-11-02 2008-06-05 ノースウェスタン ユニバーシティ ピリダジン化合物および方法
CA2589106C (en) * 2004-11-02 2015-07-21 Northwestern University Pyridazine compounds, compositions and methods and their use in treating inflammatory diseases
WO2007127475A2 (en) 2006-04-28 2007-11-08 Northwestern University Pyridazines for demyelinating diseases and neuropathic pain
AU2007243280A1 (en) 2006-04-28 2007-11-08 Northwestern University Formulations containing pyridazine compounds for treating neuroinflammatory diseases
US8158627B2 (en) 2006-04-28 2012-04-17 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
WO2007130383A2 (en) 2006-04-28 2007-11-15 Northwestern University Compositions and treatments using pyridazine compounds and secretases
US20100168120A1 (en) 2006-04-28 2010-07-01 Neuromedix Inc. Salts of pyridazine compounds
AU2008223066A1 (en) 2007-03-02 2008-09-12 Northwestern University Compositions comprising derivatives of 3 -phenylpyridazine for treating seizure-related disorders

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE112010005848T5 (de) 2010-09-06 2013-07-04 Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences Amidverbindungen
US9238643B2 (en) 2010-09-06 2016-01-19 Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences Amide compounds
CN103958481A (zh) * 2011-10-28 2014-07-30 因西必泰克新有限公司 可用于治疗的哒嗪衍生物
CN106220572A (zh) * 2011-10-28 2016-12-14 因西必泰克新有限公司 哒嗪衍生物的化合物、用途、组合物和试剂盒及制备方法
CN103958481B (zh) * 2011-10-28 2017-06-30 因西必泰克新有限公司 可用于治疗的哒嗪衍生物
CN106220572B (zh) * 2011-10-28 2019-12-13 因西必泰克新有限公司 哒嗪衍生物的化合物、用途、组合物和试剂盒及制备方法

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US20090325973A1 (en) 2009-12-31
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CA2650625A1 (en) 2007-11-08
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US9408845B2 (en) 2016-08-09
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