CN101730532B - 已知药理学活性化合物的用途 - Google Patents

已知药理学活性化合物的用途 Download PDF

Info

Publication number
CN101730532B
CN101730532B CN2008800234187A CN200880023418A CN101730532B CN 101730532 B CN101730532 B CN 101730532B CN 2008800234187 A CN2008800234187 A CN 2008800234187A CN 200880023418 A CN200880023418 A CN 200880023418A CN 101730532 B CN101730532 B CN 101730532B
Authority
CN
China
Prior art keywords
akg
purposes
elasticity
ketoglutarate
hypertension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2008800234187A
Other languages
English (en)
Chinese (zh)
Other versions
CN101730532A (zh
Inventor
斯特凡·G·彼任诺夫斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ENTRESS AB
Original Assignee
ENTRESS AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ENTRESS AB filed Critical ENTRESS AB
Publication of CN101730532A publication Critical patent/CN101730532A/zh
Application granted granted Critical
Publication of CN101730532B publication Critical patent/CN101730532B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN2008800234187A 2007-07-02 2008-06-27 已知药理学活性化合物的用途 Expired - Fee Related CN101730532B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0701602 2007-07-02
SE0701602-5 2007-07-02
PCT/SE2008/050797 WO2009005464A1 (en) 2007-07-02 2008-06-27 New use of known pharmacologically active chemical compounds

Publications (2)

Publication Number Publication Date
CN101730532A CN101730532A (zh) 2010-06-09
CN101730532B true CN101730532B (zh) 2012-05-30

Family

ID=40226336

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008800234187A Expired - Fee Related CN101730532B (zh) 2007-07-02 2008-06-27 已知药理学活性化合物的用途

Country Status (11)

Country Link
US (1) US20110039935A1 (https=)
EP (1) EP2173336B1 (https=)
JP (1) JP5735274B2 (https=)
KR (1) KR20100039874A (https=)
CN (1) CN101730532B (https=)
AU (1) AU2008271307B2 (https=)
BR (1) BRPI0814184A2 (https=)
CA (1) CA2691746C (https=)
EA (1) EA018554B1 (https=)
MX (1) MX2009013937A (https=)
WO (1) WO2009005464A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106163513A (zh) * 2014-02-12 2016-11-23 加利福尼亚大学董事会 用于治疗衰老和与年龄相关的疾病和症状的组合物和方法
JP6230140B2 (ja) 2014-03-20 2017-11-15 華為終端（東莞）有限公司 信号送信方法、ユーザ装置、及び基地局
EP3615029A4 (en) * 2017-04-25 2021-04-21 Buck Institute for Research on Aging FORMULATIONS TO EXTEND LIFE AND HEALTH
JP7499259B2 (ja) 2018-09-25 2024-06-13 ポンス デ レオン ヘルス デジグネイテッド アクティビティ カンパニー αケトグルタル酸カルシウムを製造するためのプロセス
JP2022536653A (ja) * 2019-06-10 2022-08-18 バック インスティチュート フォー リサーチ オン エージング 老化関連分泌表現型を修整する方法および組成物
WO2021262298A1 (en) * 2020-06-23 2021-12-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Electrophilic compounds and electrophilic prodrugs for treating aneurysm
CN117530940A (zh) * 2023-10-11 2024-02-09 四川大学华西第二医院 α-酮戊二酸在制备促髓鞘修复、改善神经炎症的药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1401758A (zh) * 2001-08-17 2003-03-12 杨志东 一种制备食疗保健醋的方法及用该方法生产的食疗保健醋

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9402027D0 (sv) * 1994-06-10 1994-06-10 Pharmacia Ab Energy substrates
JP2000093096A (ja) * 1998-09-21 2000-04-04 Snow Brand Milk Prod Co Ltd ゼリー状食品
DE19929993C2 (de) * 1999-06-30 2001-07-05 Sueddeutsche Kalkstickstoff Kreatin-alpha-ketoglutarate, Verfahren zu ihrer Herstellung und ihre Verwendung
US20040220265A1 (en) * 2002-07-25 2004-11-04 Celluar Sciences, Inc. Method for treating pulmonary disease states in mammals by altering indigenous in vivo levels of nitric oxide
US7194301B2 (en) * 2003-10-06 2007-03-20 Transneuronic, Inc. Method for screening and treating patients at risk of medical disorders
PL368572A1 (en) * 2004-06-17 2005-12-27 Sgp & Sons Ab Pharmaceutical compound for prevention and therapy of increased level of cholesterol, ldl and triglycerides as well as application of the pharmaceutical compound as an agent acting against atherosclerosis and used in circulatory system affections
PL370937A1 (pl) * 2004-10-29 2006-05-02 Sgp & Sons Ab Preparat żywieniowy i/lub farmaceutyczny do stosowania w profilaktyce i leczeniu niedoborów wchłaniania mikroelementów z przewodu pokarmowego oraz zastosowanie preparatu farmaceutycznego jako czynnika stymulującego wchłanianie mikroelementów z przewodu pokarmowego do krwi
US20100104548A1 (en) * 2005-06-24 2010-04-29 Albert Einstein College Of Medicine Of Yeshiva University Modulation of amino acid metabolism in the hypothalamus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1401758A (zh) * 2001-08-17 2003-03-12 杨志东 一种制备食疗保健醋的方法及用该方法生产的食疗保健醋

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
杨文.2420例体检者的脉压空腹血糖甘油三酯的分析.《心肺血管病杂志》.2005,第24卷(第4期),223-224. *

Also Published As

Publication number Publication date
BRPI0814184A2 (pt) 2015-03-03
KR20100039874A (ko) 2010-04-16
JP2010532348A (ja) 2010-10-07
CA2691746C (en) 2016-02-02
CN101730532A (zh) 2010-06-09
EP2173336B1 (en) 2016-03-30
EA018554B1 (ru) 2013-08-30
WO2009005464A1 (en) 2009-01-08
EP2173336A4 (en) 2010-11-10
HK1140423A1 (en) 2010-10-15
US20110039935A1 (en) 2011-02-17
MX2009013937A (es) 2010-04-30
EA201070084A1 (ru) 2010-10-29
EP2173336A1 (en) 2010-04-14
AU2008271307A1 (en) 2009-01-08
AU2008271307B2 (en) 2013-10-24
JP5735274B2 (ja) 2015-06-17
CA2691746A1 (en) 2009-01-08

Similar Documents

Publication Publication Date Title
CN101730532B (zh) 已知药理学活性化合物的用途
US8716249B2 (en) Compositions and methods for improving cardiovascular health
EA018007B1 (ru) Композиция, содержащая орнитин и фенилацетат или фенилбутират, для лечения печеночной энцефалопатии
JP2004532215A (ja) 睡眠時の自律的安定性に関するカンナビノイドの機能的役割
Domin et al. Neuroprotective effect of the group III mGlu receptor agonist ACPT-I after ischemic stroke in rats with essential hypertension
Man et al. Age-associated arterial remodelling
US20090325891A1 (en) Cartilage regeneration-promoting agent
US20070249717A1 (en) Preventive/therapeutic agent for visceral pain
JP4767542B2 (ja) 男性更年期が原因の異常の予防および／または治療のためのカルニチンの使用
HK1140423B (en) Use of known pharmacologically active chemical compounds
RU2454999C2 (ru) Лекарственное средство, применяющееся при поражениях хряща
JP5792137B2 (ja) 胃腸障害および関連障害の治療におけるコレシストキニン−１（ｃｃｋ１）受容体アンタゴニスト
CA3106895A1 (en) Nutritional compositions for enhancement of muscle performance
JP2002145767A (ja) 循環器疾患治療剤および健康食品
Lancien et al. Central pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) decrease the baroreflex sensitivity in trout
MXPA04010692A (es) Composicion para el tratamiento de la obesidad e hiperlipidemia.
JP2005112835A (ja) 高血圧治療用の新規医薬組成物並びに加工食品の製法
Harrison et al. Healthy ageing: the beneficial effect of dietary supplementation with alpha-ketoglutarate on arterial elasticity in elderly mice
CN120813343A (zh) 具有减少脂肪细胞效果的抗坏血酸和亚铁组合物
WO2021010824A1 (en) Oral disodium pyrophosphate for use in reducing calcification
JP2020023483A (ja) ジョイント機能改善用組成物
Fish The role of angiotensin II on vascular hypertrophy in genetic and renovascular hypertension
Maitra Studies on Flunixin Meglumine in Dogs Undergoing Anaesthesia and Surgery
HK1131340A1 (en) Compositions comprising alpha-ketoglutarate and their use for modulating muscle performance

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1140423

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1140423

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120530

Termination date: 20160627

CF01 Termination of patent right due to non-payment of annual fee