CN101720323A - 具有抗癌活性的化合物 - Google Patents

具有抗癌活性的化合物 Download PDF

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Publication number
CN101720323A
CN101720323A CN200880019414A CN200880019414A CN101720323A CN 101720323 A CN101720323 A CN 101720323A CN 200880019414 A CN200880019414 A CN 200880019414A CN 200880019414 A CN200880019414 A CN 200880019414A CN 101720323 A CN101720323 A CN 101720323A
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CN
China
Prior art keywords
amino
methyl
compound
diketone
trifluoromethyl
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Pending
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CN200880019414A
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English (en)
Chinese (zh)
Inventor
河边拓己
石坦真知代
佐藤卓治
山本清香
长谷川容子
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Canbas Co Ltd
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Canbas Co Ltd
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Publication date
Application filed by Canbas Co Ltd filed Critical Canbas Co Ltd
Priority to CN201510578313.XA priority Critical patent/CN105175394B/zh
Publication of CN101720323A publication Critical patent/CN101720323A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN200880019414A 2007-04-11 2008-04-11 具有抗癌活性的化合物 Pending CN101720323A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510578313.XA CN105175394B (zh) 2007-04-11 2008-04-11 具有抗癌活性的化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91125807P 2007-04-11 2007-04-11
US60/911,258 2007-04-11
PCT/IB2008/003036 WO2009031040A2 (en) 2007-04-11 2008-04-11 Compounds with anti-cancer activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510578313.XA Division CN105175394B (zh) 2007-04-11 2008-04-11 具有抗癌活性的化合物

Publications (1)

Publication Number Publication Date
CN101720323A true CN101720323A (zh) 2010-06-02

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US (2) US8084454B2 (cg-RX-API-DMAC7.html)
EP (4) EP4074704A1 (cg-RX-API-DMAC7.html)
JP (2) JP5635396B2 (cg-RX-API-DMAC7.html)
KR (1) KR101475311B1 (cg-RX-API-DMAC7.html)
CN (2) CN101720323A (cg-RX-API-DMAC7.html)
AU (1) AU2008294410B2 (cg-RX-API-DMAC7.html)
BR (2) BR122022005149B1 (cg-RX-API-DMAC7.html)
CA (4) CA2913840C (cg-RX-API-DMAC7.html)
DK (2) DK2152692T3 (cg-RX-API-DMAC7.html)
ES (3) ES2732230T3 (cg-RX-API-DMAC7.html)
HU (2) HUE059861T2 (cg-RX-API-DMAC7.html)
IL (4) IL309201A (cg-RX-API-DMAC7.html)
MX (3) MX2009011025A (cg-RX-API-DMAC7.html)
NZ (1) NZ580237A (cg-RX-API-DMAC7.html)
RU (1) RU2482111C2 (cg-RX-API-DMAC7.html)
WO (1) WO2009031040A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200906960B (cg-RX-API-DMAC7.html)

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CA2684037A1 (en) 2009-03-12
CA3030510A1 (en) 2009-03-12
BR122022005149B1 (pt) 2022-09-27
IL289165B2 (en) 2024-05-01
HK1139143A1 (zh) 2010-09-10
DK2152692T3 (en) 2016-09-26
EP2152692B1 (en) 2016-06-15
KR101475311B1 (ko) 2014-12-23
RU2482111C2 (ru) 2013-05-20
ZA200906960B (en) 2010-12-29
US20110092514A1 (en) 2011-04-21
JP5635396B2 (ja) 2014-12-03
ES2927954T3 (es) 2022-11-14
DK3567035T3 (da) 2022-09-05
EP3567035A1 (en) 2019-11-13
US8084454B2 (en) 2011-12-27
EP3088397B1 (en) 2019-04-10
EP2152692A2 (en) 2010-02-17
CA2913840C (en) 2019-03-05
RU2009141619A (ru) 2011-05-20
IL289165B1 (en) 2024-01-01
IL242883B (en) 2022-01-01
JP2014012706A (ja) 2014-01-23
MX374896B (es) 2025-03-04
CN105175394A (zh) 2015-12-23
ES2594704T3 (es) 2016-12-22
US8415357B2 (en) 2013-04-09
US20080275057A1 (en) 2008-11-06
AU2008294410B2 (en) 2012-09-06
CN105175394B (zh) 2018-06-08
HUE059861T2 (hu) 2023-01-28
IL289165A (en) 2022-02-01
BRPI0810911B1 (pt) 2022-05-17
CA3030510C (en) 2023-03-14
MX2020009403A (es) 2022-03-31
KR20090128560A (ko) 2009-12-15
WO2009031040A2 (en) 2009-03-12
JP2010523644A (ja) 2010-07-15
AU2008294410A1 (en) 2009-03-12
EP3088397A1 (en) 2016-11-02
WO2009031040A3 (en) 2009-05-14
BRPI0810911A2 (pt) 2021-03-30
EP4074704A1 (en) 2022-10-19
EP2152692B9 (en) 2020-03-25
HUE029370T2 (hu) 2017-02-28
CA2684037C (en) 2016-02-16
IL201380A0 (en) 2010-05-31
MX2009011025A (es) 2010-01-25
EP3567035B1 (en) 2022-06-01
CA2913840A1 (en) 2009-03-12
ES2732230T3 (es) 2019-12-12
NZ580237A (en) 2012-06-29
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