CN101708280A - Chinese medicinal composition, preparation method and application thereof - Google Patents
Chinese medicinal composition, preparation method and application thereof Download PDFInfo
- Publication number
- CN101708280A CN101708280A CN200910196291A CN200910196291A CN101708280A CN 101708280 A CN101708280 A CN 101708280A CN 200910196291 A CN200910196291 A CN 200910196291A CN 200910196291 A CN200910196291 A CN 200910196291A CN 101708280 A CN101708280 A CN 101708280A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicine composition
- preparation
- rhizoma polygonati
- flos chrysanthemi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 39
- 239000000243 solution Substances 0.000 claims description 39
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- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
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- LRBQNJMCXXYXIU-PPKXGCFTSA-N Chinese gallotannin Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
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- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
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- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
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- 150000002576 ketones Chemical class 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a Chinese medicinal composition, wherein the components of the Chinese medicinal composition are the extracts of the following raw materials in part by weight: 1 to 99 parts of feverfew and 1 to 99 parts of radix polygonati officinalis. The invention also provides a preparation method and application of the Chinese medicinal composition. The Chinese medicinal composition of the invention is safe without stimulation, and can be used for preparing medicaments, cosmetics or foods for beautifying and removing beverage.
Description
Technical field
The present invention relates to natural medicine field, relate to a kind of Chinese medicine composition, its preparation method and application particularly.
Background technology
In the Asian countries, people are with Bai Weimei, and in the Central European area and the U.S., to whitening and the demand of speckle dispelling product also continues to increase.
People's skin color is decided by the biosynthetic intensity of melanocyte quantity, melanin concentration and melanin basically, and color is generally brown to the melanin of black and forms in the melanocyte of skin, transfers in the keratinocyte and gives dye.
People need very reliable and effective skin-whitening agents, and individual hereditary endogenous cause of ill and exopathogenic factors such as uv light exposure intensity, frequency have material impact to skin color.If the melanic melanocyte that forms in the application on human skin for a certain reason and skewness will produce the mottle more shallow or darker than the skin color of peripheral region so.
Tryrosinase is the rate-limiting enzyme that melanin generates.From L-tyrosine, form L-3 by copper bearing key enzyme tryrosinase, 4-dihydroxyphenylalanine (L-DOPA), this L-3, the 4-dihydroxyphenylalanine changes into dopachrome by tryrosinase again.Dopachrome is through utilizing different enzymatic several steps to be oxidized to melanin.
The most a kind of whitening agent of normal use was a hydroquinone in the past, and this material has tyrosinase inhibitory action preferably, but because it has cytotoxicity to melanocyte, and was stimulus object to skin, caused permanent white macula easily.Therefore, in Europe, Japan and South Africa, no longer allow this whitening agent to be used for cosmetics.And hydroquinone is extremely sensitive to Oxidation, very is difficult to stablize in cosmetic formulations.
Kojic acid (5-hydroxyl-2-methylol-pyrokomane) is a tyrosinase inhibitor, and the copper ion by the chelating tryrosinase suppresses its catalytic action, is a commercial whitening agent, but has the height sensitization, causes contact allergy.
Therefore, when searching has the composition of skin-whitening effect, target is normally sought the material of alap concentration restraint of tyrosinase, also must consider these materials that are used for cosmetics and/or drug products except having the high activity under alap concentration, also must safety.
So this area need be developed can the safe again Chinese medicine composition of whitening and speckle dispelling.
Summary of the invention
Purpose of the present invention just provides a kind of Chinese medicine composition of whitening and speckle dispelling.
Another purpose of the present invention provides the preparation method of this Chinese medicine composition.
A further object of the present invention provides medicine, cosmetics or the Application in Food of this Chinese medicine composition at the preparation whitening and speckle dispelling.
A first aspect of the present invention provides a kind of Chinese medicine composition, and described Chinese medicine composition component is the extract of following raw materials in part by weight:
Flos Chrysanthemi, 1-99; Rhizoma Polygonati Odorati, 1-99.
The weight portion of above-mentioned each raw material is: Flos Chrysanthemi, 10-90; Rhizoma Polygonati Odorati, 10-90.
The weight portion of above-mentioned each raw material is: Flos Chrysanthemi, 25-75; Rhizoma Polygonati Odorati, 25-75.
Above-mentioned Chinese medicine composition is the Chinese medicine composition that is used for whitening and speckle dispelling.
The said extracted thing is the water of above-mentioned raw materials or the extract of hydrophilic solvent.
Above-mentioned hydrophilic solvent is ethanol, methanol, glycerol, propylene glycol, butanediol or dipropylene glycol.
Above-mentioned hydrophilic solvent is ethanol or glycerol.
A second aspect of the present invention provides the application of above-mentioned Chinese medicine composition in the medicine of preparation whitening and speckle dispelling.
The said medicine dosage form is solution, ointment, membrane, Emulsion, tablet or powder.
A third aspect of the present invention provides the application of above-mentioned Chinese medicine composition in the cosmetics of preparation whitening and speckle dispelling.
Above-mentioned cosmetics are aerosol, solution, suspensoid, Emulsion, ointment, semifluid preparation.
A fourth aspect of the present invention provides the Application in Food of above-mentioned Chinese medicine composition at the preparation whitening and speckle dispelling.
A fifth aspect of the present invention provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:
(a) with after Rhizoma Polygonati Odorati and the Flos Chrysanthemi pulverizing, the aqueous solution of employing water or hydrophilic solvent extracts 1-3 back respectively and concentrates;
(b) Rhizoma Polygonati Odorati extracting solution and Flos Chrysanthemi extracting solution are mixed, promptly obtain described Chinese medicine composition.
Above-mentioned hydrophilic solvent is ethanol, methanol, glycerol, propylene glycol, butanediol or dipropylene glycol.
Above-mentioned steps (b) is also carried out following steps before:
(c) adsorb Rhizoma Polygonati Odorati extract and Flos Chrysanthemi extract concentrated solution respectively with non-polar resin, with eluent eluting extract concentrated solution.
Above-mentioned eluent is that volumetric concentration is 60%～95% ethanol water.
It is between the 1.0-1.2 that the said extracted thing is concentrated into relative density.
In the step (a), the weight ratio of Rhizoma Polygonati Odorati and Flos Chrysanthemi is 1: 9 to 9: 1.Preferable, the weight ratio of Rhizoma Polygonati Odorati and Flos Chrysanthemi is 1: 3 to 3: 1.
A sixth aspect of the present invention provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:
(d) Rhizoma Polygonati Odorati and Flos Chrysanthemi are pulverized the back mixing, adopt 1-3 back of extraction with aqueous solution of water or hydrophilic solvent to concentrate, promptly obtain described Chinese medicine composition semifinished product;
(e) with the Chinese medicine composition in the non-polar resin adsorption step (d), obtain the Chinese medicine composition finished product with the eluent eluting.
Above-mentioned eluent is that volumetric concentration is 60%～95% ethanol water.
It is between the 1.0-1.2 that the said extracted thing is concentrated into relative density.
In the step (d), the weight ratio of Rhizoma Polygonati Odorati and Flos Chrysanthemi is 1: 9 to 9: 1.Preferable, the weight ratio of Rhizoma Polygonati Odorati and Flos Chrysanthemi is 1: 3 to 3: 1.
A seventh aspect of the present invention provides a kind of Chinese medicine preparation, and described Chinese medicine preparation comprises above-mentioned Chinese medicine composition and pharmaceutically acceptable excipient.
Technical problem to be solved by this invention is in the majority with synthetic ingredient in the medicine that overcomes existing restraint of tyrosinase, the defective that side effect is bigger and a kind of Chinese medicine composition and application thereof are provided.Chinese medicine composition of the present invention has the effect of higher restraint of tyrosinase than single with a kind of Chinese medicine extract, can be applied in percutaneous drug administration preparation, cosmetics or food, the health product, play whiten, the effect of speckle dispelling.
Chinese medicine composition provided by the invention can be put on market by multiple peroral dosage form, is used to whiten and speckle dispelling.Certainly, Chinese medicine composition also can combine with pharmaceutical carriers such as excipient commonly used and preparationization.Also can add preparation additives such as some antiseptic, antioxidant, coloring agent, sweeting agent in case of necessity.
Can require according to the psychology of market demand and consumer to change dosage form, for example use dosage forms such as solution, ointment, membrane, Emulsion, tablet or powder.
Relatively Shi Yi excipient generally has lactose, white sugar, D-mannitol, starch, crystalline cellulose etc.Lubricant generally should adopt magnesium stearate, calcium stearate, Pulvis Talci etc.Solvent uses deionized water, ethanol, propylene glycol etc. usually.Antiseptic generally adopts methaform, benzylalcohol, dihydroxy acetic acid etc.Antioxidant is more suitable with sulphite, ascorbic acid etc. usually.
Chinese medicine composition provided by the invention also can prototype, aqueous solution dilution back uses as skin preparations for extenal use.Can certainly make certain preparation by combining, the consumption in cosmetics, pharmaceuticals market is provided as dosage forms such as aerosol, solution, suspensoid, Emulsion, ointment, semifluid preparations with pharmaceutical carrier.
Positive progressive effect of the present invention is: Chinese medicine composition of the present invention can be made Chinese medicine preparation, activity that can restraint of tyrosinase, thereby adjust melanic generation, reach whiten, the effect of speckle dispelling.Two kinds of medical materials are medicine-food two-purpose, and its side effect is little, and meet this ancient medication rule of drug matching, have higher pharmacologically active than single medicinal material, and lower drug use concentration.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example, usually according to normal condition, or the condition of advising according to manufacturer.Unless otherwise indicated, otherwise percentage ratio and umber calculate by weight.
The value that relative density among following each embodiment records when being 20 ℃.
The preparation of embodiment 1 Chinese medicine composition 1
Get Flos Chrysanthemi 10g, Rhizoma Polygonati Odorati 90g, preparation extracting solution A: volumetric concentration 30% ethanol water (V/V), configuration extraction liquid B: volumetric concentration 70% ethanol water (V/V), configuration eluent A: volumetric concentration 95% ethanol water (V/V), configuration eluent B: volumetric concentration 95% ethanol water (V/V), select non-polar resin post: HPD100 (Shanghai rub fast science equipment company limited), former medicine: extracting solution: portions of resin eluent=1: 20: 2: 5.
Flos Chrysanthemi is pulverized the back extracted 3 hours at 70 ℃ with extracting solution A, concentrated relative density is about between 1.0～1.2, through non-polar resin post absorb-elute, collects eluent A eluting section.Rhizoma Polygonati Odorati is pulverized the back extracted 3 hours at 70 ℃ with extracting solution B, concentrated relative density is about between 1.0～1.2, through non-polar resin post absorb-elute, collects eluent B eluting section.Two eluting sections are mixed, with the ethanol evaporate to dryness, be concentrated into the extractum shape, promptly get the compositions of Rhizoma Polygonati Odorati and Flos Chrysanthemi extract, promptly Chinese medicine composition 1.
The preparation of embodiment 2 Chinese medicine compositions 2
Get Flos Chrysanthemi 25g, Rhizoma Polygonati Odorati 75g pulverizes the back mixing and places extractor, and the deionized water that adds 10 times of weight decocts twice, and each 1 hour, extracting liquid filtering promptly obtained Chinese medicine composition 2 after concentrating.
The preparation of embodiment 3 Chinese medicine compositions 3
Get Flos Chrysanthemi 50g, Rhizoma Polygonati Odorati 50g, preparation extracting solution A: volumetric concentration 30% ethanol water (V/V), configuration extraction liquid B: volumetric concentration 70% ethanol water (V/V), configuration eluent A: volumetric concentration 95% ethanol water (V/V), configuration eluent B: volumetric concentration 95% ethanol water (V/V), select the non-polar resin post: HPD100, former medicine: extracting solution: portions of resin eluent=1: 20: 2: 5.
Flos Chrysanthemi is pulverized the back extracted 3 hours at 70 ℃ with extracting solution A, concentrated relative density is about between 1.0～1.2, through non-polar resin post absorb-elute, collects eluent A eluting section.Rhizoma Polygonati Odorati is pulverized the back extracted 3 hours at 70 ℃ with extracting solution B, concentrated relative density is about between 1.0～1.2, through non-polar resin post absorb-elute, collects eluent B eluting section.Two eluting sections are mixed, with the ethanol evaporate to dryness, be concentrated into the extractum shape, promptly get the compositions of Rhizoma Polygonati Odorati and Flos Chrysanthemi extract, promptly Chinese medicine composition 3.
The preparation of embodiment 4 Chinese medicine compositions 4
Get Flos Chrysanthemi 75g, Rhizoma Polygonati Odorati 25g pulverizes the back mixing and places extractor, adds 90 ℃ of reflux, extract, twice of 75% methanol solution of 5 times of weight, and each 1 hour, extracting liquid filtering promptly obtained Chinese medicine composition 4 after concentrating.
The preparation of embodiment 5 Chinese medicine compositions 5
Get Flos Chrysanthemi 90g, Rhizoma Polygonati Odorati 10g, preparation extracting solution A: volumetric concentration 30% ethanol water (V/V), configuration extraction liquid B: volumetric concentration 70% ethanol water (V/V), configuration eluent A: volumetric concentration 95% ethanol water (V/V), configuration eluent B: volumetric concentration 95% ethanol water (V/V), select the non-polar resin post: HPD100, former medicine: extracting solution: portions of resin eluent=1: 20: 2: 5.
Flos Chrysanthemi is pulverized the back extracted 3 hours at 70 ℃ with extracting solution A, concentrated relative density is about between 1.0～1.2, through non-polar resin post absorb-elute, collects eluent A eluting section.Rhizoma Polygonati Odorati is pulverized the back extracted 3 hours at 70 ℃ with extracting solution B, concentrated relative density is about between 1.0～1.2, through non-polar resin post absorb-elute, collects eluent B eluting section.Two eluting sections are mixed,, be concentrated into the extractum shape, promptly get the compositions of Rhizoma Polygonati Odorati and Flos Chrysanthemi extract, promptly get Chinese medicine composition 5 the ethanol evaporate to dryness.
Embodiment 6 tyrosinase inhibition rates measure 1
Get the potato tubers that 50g cleans, pre-cooling peeling chopping.Add 200ml phosphate buffer (0.1mol/L, pH 6.5) homogenate.Four layers of filtered through gauze slowly add the ammonium sulfate powder through grinding, and make to reach 30% saturation, in the centrifugal 15min of 8000r/min.Get supernatant and continue the ammonium sulfate of adding, make to reach 70% saturation, in the centrifugal 20min of 8000r/min through grinding.Precipitation is dissolved with phosphate buffer, is settled to 100ml, and-10 ℃ of refrigerators are preserved standby; Perhaps precipitation obtains thick tryrosinase lyophilized powder directly through vacuum lyophilization, and-70 ℃ of refrigerators are preserved standby.
With catechol (catechol) is substrate, and (Shanghai Techcomp Instrument Ltd., UV2300) absorbance under 420nm changes spectrophotometer.Reaction system is: the phosphate buffer and 0.5ml 50mmol/L catechol and the medicine to be detected that add 1.5ml 0.1mol/L pH 6.5 in the 3ml cuvette successively, put into the UV2300 ultraviolet spectrophotometer at 30 ℃ of following preheating 3min, add 0.5mL tryrosinase solution then and start reaction, in 120S, this reaction system light absorption value A is carried out time sweep.The substrate catechol is dissolved with phosphate buffer, and needs adapted on the same day.The 120S absorbance is reaction rate to the rate of change (Δ A/ Δ t) of time before getting, and is calculated as follows tyrosinase inhibition rate: tyrosinase inhibition rate=[(Vo-Vi)/Vo] * 100%.Vo is the reaction rate of enzyme when replacing sample with solvent in the formula; Vi is the reaction rate of enzyme when adding sample.Detection of drugs suppresses active under variable concentrations, to suppress percentage ratio-concentration mapping, obtains its half-inhibition concentration then.
Experiment divides 3 groups, is respectively Flos Chrysanthemi group (with the eluent A eluting section simmer down to extractum among the embodiment 1), Rhizoma Polygonati Odorati group (with the eluent B eluting section simmer down to extractum among the embodiment 1) and Chinese medicine composition 1.Each is organized water adjustment concentration to the preparation that every 1ml is equivalent to crude drug 1g and carries out the tyrosinase inhibition rate determination experiment.
| Medicine to be measured | The IC50 value of restraint of tyrosinase |
| The Flos Chrysanthemi group | ??14.1μg/ml |
| The Rhizoma Polygonati Odorati group | ??28.3μg/ml |
| Medicine to be measured | The IC50 value of restraint of tyrosinase |
| Chinese medicine composition 1 | ??9.3μg/ml |
Table 1. Flos Chrysanthemi extract, Rhizoma Polygonati Odorati extract and Chinese medicine composition 1 restraint of tyrosinase effect are relatively
By table 1 as seen, in three groups of medicines to be measured, inhibition effect to tryrosinase is Chinese medicine composition 1＞Flos Chrysanthemi group＞Rhizoma Polygonati Odorati group in proper order, and compositions obviously improves the inhibition effect of tryrosinase, illustrates that the component of the compositions of Rhizoma Polygonati Odorati, Flos Chrysanthemi extract has good synergism.
Embodiment 7 tyrosinase inhibition rates measure 2
Experiment divides 3 groups, is respectively Flos Chrysanthemi group (with the eluent A eluting section simmer down to extractum among the embodiment 1), Rhizoma Polygonati Odorati group (with the eluent B eluting section simmer down to extractum among the embodiment 1) and Chinese medicine composition 3.Each is organized water adjustment concentration to the preparation that every 1ml is equivalent to crude drug 1g and carries out the tyrosinase inhibition rate determination experiment.
| Medicine to be measured | The IC50 value of restraint of tyrosinase |
| The Flos Chrysanthemi group | ??14.1μg/ml |
| The Rhizoma Polygonati Odorati group | ??28.3μg/ml |
| Chinese medicine composition 3 | ??8.6μg/ml |
Table 2. Flos Chrysanthemi extract, Rhizoma Polygonati Odorati extract and Chinese medicine composition 3 restraint of tyrosinase effects are relatively
By table 2 as seen, in three groups of medicines to be measured, inhibition effect to tryrosinase is Chinese medicine composition 3＞Flos Chrysanthemi group＞Rhizoma Polygonati Odorati group in proper order, and compositions obviously improves the inhibition effect of tryrosinase, illustrates that the component of the compositions of Rhizoma Polygonati Odorati, Flos Chrysanthemi extract has good synergism.
Embodiment 8 tyrosinase inhibition rates measure 3
Experiment divides 3 groups, is respectively Flos Chrysanthemi group (with the eluent A eluting section simmer down to extractum among the embodiment 1), Rhizoma Polygonati Odorati group (with the eluent B eluting section simmer down to extractum among the embodiment 1) and Chinese medicine composition 5.Each is organized water adjustment concentration to the preparation that every 1ml is equivalent to crude drug 1g and carries out the tyrosinase inhibition rate determination experiment.
| Medicine to be measured | The IC50 value of restraint of tyrosinase |
| The Flos Chrysanthemi group | ??14.1μg/ml |
| The Rhizoma Polygonati Odorati group | ??28.3μg/ml |
| The compositions group of Rhizoma Polygonati Odorati, Flos Chrysanthemi extract | ??13.1μg/ml |
Table 3. Flos Chrysanthemi extract, Rhizoma Polygonati Odorati extract and compositions restraint of tyrosinase effect thereof are relatively
By table 3 as seen, in three groups of medicines to be measured, inhibition effect to tryrosinase is Chinese medicine composition 5＞Flos Chrysanthemi group＞Rhizoma Polygonati Odorati group in proper order, and compositions obviously improves the inhibition effect of tryrosinase, illustrates that the component of the compositions of Rhizoma Polygonati Odorati, Flos Chrysanthemi extract has good synergism.
The preparation of embodiment 9 Chinese medicine compositions 6
Get Flos Chrysanthemi 1g, Rhizoma Polygonati Odorati 99g pulverizes the back mixing and places extractor, and 20% butanediol solution (volumetric concentration) that adds 0.5 times of weight extracts three times for 90 ℃, and each 0.5 hour, extracting liquid filtering promptly obtained Chinese medicine composition 6 after concentrating.
The preparation of embodiment 10 Chinese medicine compositions 7
Get Flos Chrysanthemi 99g, Rhizoma Polygonati Odorati 1g pulverizes the back mixing and places extractor, and 80% glycerite (volumetric concentration) that adds 1 times of weight extracts three times for 30 ℃, each 16 hours, promptly obtains Chinese medicine composition 7 behind the extracting liquid filtering.
The preparation of embodiment 11 Chinese medicine compositions 8
Get Flos Chrysanthemi 40g, Rhizoma Polygonati Odorati 60g pulverizes the back mixing and places extractor, and 80% propylene glycol solution (volumetric concentration) that adds 1 times of weight extracts three times for 30 ℃, each 8 hours, promptly obtains Chinese medicine composition 8 behind the extracting liquid filtering.
The preparation of embodiment 12 Chinese medicine compositions 9
Get Flos Chrysanthemi 60g, Rhizoma Polygonati Odorati 40g, preparation extracting solution A: volumetric concentration 50% ethanol water (V/V), configuration extraction liquid B: volumetric concentration 70% ethanol water (V/V), configuration eluent A: volumetric concentration 60% ethanol water (V/V), configuration eluent B: volumetric concentration 60% ethanol water (V/V), select the non-polar resin post: HPD100, former medicine: extracting solution: portions of resin eluent=1: 10: 2: 4.
Flos Chrysanthemi is pulverized the back extracted 3 hours at 70 ℃ with extracting solution A, concentrated relative density is about between 1.0～1.2, through non-polar resin post absorb-elute, collects eluent A eluting section.Rhizoma Polygonati Odorati is pulverized the back extracted 3 hours at 70 ℃ with extracting solution B, concentrated relative density is about between 1.0～1.2, through non-polar resin post absorb-elute, collects eluent B eluting section.Two eluting sections are mixed, with the ethanol evaporate to dryness, be concentrated into the extractum shape, promptly get the compositions of Rhizoma Polygonati Odorati and Flos Chrysanthemi extract, promptly Chinese medicine composition 9.
The preparation of embodiment 13 Chinese medicine compositions 10
Get Flos Chrysanthemi 50g, Rhizoma Polygonati Odorati 50g pulverizes the back mixing and places extractor, and the 80% dipropylene glycol solution (volumetric concentration) that adds 1 times of weight extracts three times for 30 ℃, each 8 hours, promptly obtains Chinese medicine composition 10 behind the extracting liquid filtering.
The preparation of embodiment 14 Chinese medicine composition tablets
Get embodiment 1 Rhizoma Polygonati Odorati extract 15g, Flos Chrysanthemi extract 15g, starch 30g, lactose 40g, carboxymethyl starch sodium 5g, starch slurry (7%) is an amount of, magnesium stearate (1%) 1.25g prepares 1000 in tablet according to conventional method, and every contains 15mg Rhizoma Polygonati Odorati extract and 15mg Flos Chrysanthemi extract.
The preparation of embodiment 15 cleawhite over-night essences
Table 4 cleawhite over-night essences prescription
By the good above-mentioned material of proportioning weighing, earlier the middle mutually Carbopol 941 of A (rich profit company is revealed by the U.S.) is dispersed in the deionized water, stir evenly, add with the scattered hyaluronate sodium of butanediol then, after stirring, heat to 85-90 ℃, stir; Be cooled to 45-50 ℃ under stirring; Add the B phase, add an amount of antiseptic and essence, pH value is controlled at 5.0-7.0, and the discharging that stirs obtains cleawhite over-night essences.
The preparation of embodiment 16 whitening emulsion
The prescription of table 5 whitening emulsion
By the good above-mentioned material of proportioning weighing, earlier xanthan gum is dispersed in the glycerol, redispersion stirs in water and while elevated temperature to 85 ℃; With A fully, stir in 85 ℃ of dissolvings; Add the B phase before homogenizing, stirring and dissolving is even; AB is added to the middle mutually homogenizing (about 4 minutes) that stirs of C, and froth breaking is cooled to 50 ℃; Add the D phase, add an amount of essence and antiseptic, pH value is controlled at 5.0-7.0, and the discharging that stirs obtains whitening emulsion.
The preparation of embodiment 17 skin whiteners
The prescription of table 6 skin whitener
By the good above-mentioned material of proportioning weighing, earlier xanthan gum is dispersed in the glycerol, redispersion is elevated temperature to 85 ℃ in water and simultaneously, adds other components of B phase then, stirs; With A fully, stir in 85 ℃ of dissolvings; A is added to the middle mutually homogenizing that stirs of B, and about 4 minutes, froth breaking was cooled to 50 ℃; Add the C phase, add an amount of essence and antiseptic, pH value is controlled at 5.0-7.0, and the discharging that stirs obtains skin whitener.
The whiten preparation of water of embodiment 18
Chinese medicine composition 6: water=1: 4, the good material of weighing according to the above ratio.Water is heated to 85 ℃ earlier, kept 30 minutes, be cooled to 50 ℃; Add Chinese medicine composition 6, dissolving stirs fully, adds an amount of essence and antiseptic, and pH value is controlled at 5.0-7.0, and the discharging that stirs obtains to whiten water.
Embodiment 19 guinea pig skin stimulation tests
Get 0.5g Chinese medicine composition 1, adopt deionized water to be diluted to 100g and be configured to given the test agent.
Given the test agent adopts skin irritation test method (" cosmetics health standard " 2007 editions toxicology test methods) to test.
Laboratory animal: Cavia porcellus body weight 250g ~ 300g, occupancy permit number: syxk (Shanghai) 2004-0015, production licence number: scxk (Shanghai) 2004-0007.
Experimental result:, do not see irritant reaction through skin irritation test in 14 days.
The invention provides a kind of Chinese medicine composition of whitening and speckle dispelling, described Chinese medicine composition is that the extract of the Chinese medicine of following weight ratio makes.
Wherein, the weight ratio of Rhizoma Polygonati Odorati and Flos Chrysanthemi is 1: 99～99: 1, and is preferable, and the weight ratio of Rhizoma Polygonati Odorati and Flos Chrysanthemi is 1: 9～9: 1, and is better, and the weight ratio of Rhizoma Polygonati Odorati and Flos Chrysanthemi is 1: 3～3: 1.
Among the present invention, described Chinese medicine composition can be made by in following two kinds of methods any:
(1) presses above-mentioned part by weight with Rhizoma Polygonati Odorati and the Flos Chrysanthemi aqueous solution or the hydrophilic solvent extraction of the hydrophilic solvent of water, certain volume concentration respectively, two extracting solution are merged, get final product;
(2) by above-mentioned part by weight Rhizoma Polygonati Odorati and Flos Chrysanthemi are mixed, the aqueous solution of the hydrophilic solvent of water, certain volume concentration or hydrophilic solvent extract, and get final product;
Wherein, described hydrophilic solvent all is selected from the 1-3 kind in ethanol, methanol, glycerol, propylene glycol, butanediol and the dipropylene glycol.
The volumetric concentration of the hydrophilic solvent in method (1) or (2) is preferred 20～80%, and Rhizoma Polygonati Odorati and Flos Chrysanthemi are preferably the medical material after the pulverizing; The temperature of described extraction is 30 ℃～90 ℃.
Better, in method (1), before being merged, two extracting solution also comprise the following step: two extracting solution are concentrated, adsorb through non-polar resin respectively, it is 60%～95% ethanol water that eluant is volumetric concentration, collect the eluting part, the eluting of two kinds of medical materials is partially mixed, get final product;
Also comprise the following step in method (2): extracting solution is concentrated, and through non-polar resin absorption, eluant is that volumetric concentration is 60%～95% ethanol water then, collects the eluting part, gets final product.
The Chinese medicine composition color and luster that makes after absorption is more shallow, and is less to the color and luster influence of prescription.
Best, described Chinese medicine composition is made by in the following method any:
(1) press above-mentioned part by weight respectively with Rhizoma Polygonati Odorati and Flos Chrysanthemi pulverizing medicinal materials, use volumetric concentration more than or equal to 30% then respectively, the aqueous solution of preferred 30%～70% hydrophilic solvent or hydrophilic solvent extract, and concentrate, and make 2 kinds of Chinese medicine stock solutions; 2 kinds of Chinese medicine stock solutions are respectively through non-polar resin absorption, and eluant is the 60%-95% ethanol water, collects the eluting part, mixes, and gets final product; Wherein, described hydrophilic solvent is selected from the 1-3 kind in ethanol, methanol, glycerol, propylene glycol, butanediol and the dipropylene glycol; Extracting temperature is 30 ℃～90 ℃;
(2) press above-mentioned part by weight with Rhizoma Polygonati Odorati and Flos Chrysanthemi pulverizing medicinal materials, mix, use volumetric concentration more than or equal to 30% then, the aqueous solution of preferred 30%～70% hydrophilic solvent or hydrophilic solvent extract, and concentrate, and make Chinese medicine stock solution; This Chinese medicine stock solution is adsorbed through non-polar resin, and eluant is the 60%-95% ethanol water, collects the eluting part, gets final product; Wherein, described hydrophilic solvent is selected from the 1-3 kind in ethanol, methanol, glycerol, propylene glycol, butanediol and the dipropylene glycol; Extracting temperature is 30 ℃～90 ℃.
Among the present invention, when medical material was extracted, the number of times of extraction can be 1～3 time, and each time can be 0.5～16 hour.Chinese medicine composition of the present invention is safe and non-stimulating, can be used to prepare medicine, cosmetics or the food of whitening and speckle dispelling.
During the preparation cosmetics, those skilled in the art can select the essence or the antiseptic of any appropriate for use.As, antiseptic is generally selected parabens for use, benzoic acid/benzyl alcohol and derivant thereof, imidazolidinyl urea or methyl isothiazole beautiful jade ketone and chloro thing thereof etc.; Essence is generally selected for use according to actual needs.
The above description of this invention is not limited to scope of the present invention.For the person of ordinary skill of the art, can make various corresponding changes according to technical scheme provided by the invention, these changes all should belong to protection scope of the present invention.
Claims (16)
1. a Chinese medicine composition is characterized in that, described Chinese medicine composition component is the extract of following raw materials in part by weight:
Flos Chrysanthemi, 1-99; Rhizoma Polygonati Odorati, 1-99.
2. the described Chinese medicine composition of claim 1 is characterized in that, the weight portion of described each raw material is:
Flos Chrysanthemi, 10-90; Rhizoma Polygonati Odorati, 10-90.
3. the described Chinese medicine composition of claim 2 is characterized in that, the weight portion of described each raw material is:
Flos Chrysanthemi, 25-75; Rhizoma Polygonati Odorati, 25-75.
4. the described Chinese medicine composition of the arbitrary claim of claim 1 to 3 is characterized in that, described extract is the water of described raw material or the extract of hydrophilic solvent.
5. the described Chinese medicine composition of claim 4 is characterized in that, described hydrophilic solvent is ethanol, methanol, glycerol, propylene glycol, butanediol or dipropylene glycol.
6. the application of the described Chinese medicine composition of the arbitrary claim of claim 1 to 3 in the medicine of preparation whitening and speckle dispelling.
7. the described application of claim 6 is characterized in that, described pharmaceutical dosage form is solution, ointment, membrane, Emulsion, tablet or powder.
8. the application of the described Chinese medicine composition of the arbitrary claim of claim 1 to 3 in the cosmetics of preparation whitening and speckle dispelling.
9. the described application of claim 8 is characterized in that, described cosmetics are aerosol, solution, suspensoid, Emulsion, ointment, semifluid preparation.
10. the described Chinese medicine composition of the arbitrary claim of claim 1 to 3 is in the Application in Food of preparation whitening and speckle dispelling.
11. the preparation method of the described Chinese medicine composition of claim 1 is characterized in that, comprises the steps:
(a) with after Rhizoma Polygonati Odorati and the Flos Chrysanthemi pulverizing, the aqueous solution of employing water or hydrophilic solvent extracts 1-3 back respectively and concentrates;
(b) Rhizoma Polygonati Odorati extracting solution and Flos Chrysanthemi extracting solution are mixed, promptly obtain described Chinese medicine composition.
12. the preparation method of the described Chinese medicine composition of claim 11 is characterized in that, described hydrophilic solvent is ethanol, methanol, glycerol, propylene glycol, butanediol or dipropylene glycol.
13. the preparation method of claim 11 or 12 described Chinese medicine compositions is characterized in that, described step (b) is also carried out following steps before:
(c) adsorbing Rhizoma Polygonati Odorati extract and Flos Chrysanthemi extract concentrated solution respectively with non-polar resin, is 60%～95% ethanol water eluting extract concentrated solution with volumetric concentration.
14. the preparation method of the described Chinese medicine composition of claim 1 is characterized in that, comprises the steps:
(d) Rhizoma Polygonati Odorati and Flos Chrysanthemi are pulverized the back mixing, adopt 1-3 back of extraction with aqueous solution of water or hydrophilic solvent to concentrate, promptly obtain described Chinese medicine composition semifinished product;
(e), with volumetric concentration 60%～95% ethanol water eluting acquisition Chinese medicine composition finished product with the Chinese medicine composition in non-polar resin adsorption step (d).
15. the described preparation method of claim 14 is characterized in that, the weight ratio of described Rhizoma Polygonati Odorati and described Flos Chrysanthemi is 25: 75 to 75: 25.
16. a Chinese medicine preparation is characterized in that, described Chinese medicine preparation comprises described Chinese medicine composition of the arbitrary claim of claim 1 to 3 and pharmaceutically acceptable excipient.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690443A (en) * | 2013-12-23 | 2014-04-02 | 青岛安信医疗器械有限公司 | Skin care essence |
| CN105147991A (en) * | 2015-11-04 | 2015-12-16 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine combination for inhibiting melanin generation and preparation method and application thereof |
| CN106036850A (en) * | 2016-06-07 | 2016-10-26 | 成长动力（中国）股份有限公司 | Traditional Chinese medicine health product having chloasma removing effect and preparation method thereof |
| CN106819467A (en) * | 2016-12-31 | 2017-06-13 | 新昌县拜特夫农业科技有限公司 | With Chinese herbal composite feed additive and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461914A (en) * | 2007-12-17 | 2009-06-24 | 王清河 | Chinese medicine preparation for treating coryza and preparation method thereof |
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2009
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690443A (en) * | 2013-12-23 | 2014-04-02 | 青岛安信医疗器械有限公司 | Skin care essence |
| CN105147991A (en) * | 2015-11-04 | 2015-12-16 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine combination for inhibiting melanin generation and preparation method and application thereof |
| CN106036850A (en) * | 2016-06-07 | 2016-10-26 | 成长动力（中国）股份有限公司 | Traditional Chinese medicine health product having chloasma removing effect and preparation method thereof |
| CN106819467A (en) * | 2016-12-31 | 2017-06-13 | 新昌县拜特夫农业科技有限公司 | With Chinese herbal composite feed additive and preparation method thereof |
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