CN101707869A - 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物 - Google Patents

具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物 Download PDF

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Publication number
CN101707869A
CN101707869A CN200880019839A CN200880019839A CN101707869A CN 101707869 A CN101707869 A CN 101707869A CN 200880019839 A CN200880019839 A CN 200880019839A CN 200880019839 A CN200880019839 A CN 200880019839A CN 101707869 A CN101707869 A CN 101707869A
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China
Prior art keywords
polymer conjugates
arbitrary
tumor
medicine
group
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CN200880019839A
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English (en)
Chinese (zh)
Inventor
桑·范
俞磊
赵刚
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Nitto Denko Corp
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Nitto Denko Corp
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Publication of CN101707869A publication Critical patent/CN101707869A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200880019839A 2007-05-09 2008-05-08 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物 Pending CN101707869A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91686507P 2007-05-09 2007-05-09
US60/916,865 2007-05-09
PCT/US2008/063126 WO2008141110A2 (en) 2007-05-09 2008-05-08 Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs

Publications (1)

Publication Number Publication Date
CN101707869A true CN101707869A (zh) 2010-05-12

Family

ID=39615769

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880019839A Pending CN101707869A (zh) 2007-05-09 2008-05-08 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物

Country Status (6)

Country Link
US (1) US20080279778A1 (https=)
EP (1) EP2155253A2 (https=)
JP (1) JP2010526917A (https=)
CN (1) CN101707869A (https=)
TW (1) TW200900083A (https=)
WO (1) WO2008141110A2 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104244988A (zh) * 2012-03-05 2014-12-24 雷蒙特亚特特拉维夫大学有限公司 结合治疗活性剂的聚合物、其制备方法以及其用途
CN104582735A (zh) * 2012-04-12 2015-04-29 日东电工株式会社 共聚物缀合物
CN105143242A (zh) * 2013-04-26 2015-12-09 日东电工株式会社 大规模制备聚(谷氨酰基-谷氨酸盐)偶联物的方法
US9427474B2 (en) 2008-05-22 2016-08-30 Ramot At Tel-Aviv University Ltd. Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases
CN111635542A (zh) * 2020-07-14 2020-09-08 华熙生物科技股份有限公司 交联聚谷氨酸水凝胶及其制备方法

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US9393315B2 (en) 2011-06-08 2016-07-19 Nitto Denko Corporation Compounds for targeting drug delivery and enhancing siRNA activity
CA2631704A1 (en) 2005-12-05 2007-06-14 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
CN101674852A (zh) * 2007-04-10 2010-03-17 日东电工株式会社 多功能聚谷氨酸盐药物载体
CA2683590A1 (en) * 2007-05-09 2008-11-20 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
WO2009111271A1 (en) * 2008-03-06 2009-09-11 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
US8703114B2 (en) * 2008-05-22 2014-04-22 Ramot At Tel-Aviv University Ltd. Conjugate of a polymer, an anti-angiogenesis agent and a targeting moiety, and uses thereof in the treatment of bone related angiogenesis conditions
US8586019B2 (en) 2008-05-22 2013-11-19 Ramot At Tel-Aviv University Ltd. Conjugates of polymers having a therapeutically active agent and an angiogenesis targeting moiety attached thereto and uses thereof in the treatment of angiogenesis related diseases
JP2012505906A (ja) * 2008-10-15 2012-03-08 日東電工株式会社 ポリグルタメートコンジュゲートの調製方法
CA2779290A1 (en) * 2009-10-29 2011-05-19 Lucia Irene Gonzalez Ligand-targeted multi-stereoisomer peptide polymer conjugates and uses thereof
JP2013514443A (ja) * 2009-12-16 2013-04-25 日東電工株式会社 ポリグルタミン酸の制御された合成
IN2012DN05099A (https=) * 2009-12-16 2015-10-09 Brigham & Womens Hospital
US20120052015A1 (en) * 2010-08-26 2012-03-01 Nitto Denko Corporation End-capped polymers
US10196637B2 (en) 2011-06-08 2019-02-05 Nitto Denko Corporation Retinoid-lipid drug carrier
ES2402614B1 (es) * 2011-10-24 2014-03-18 Centro De Investigación Principe Felipe Sintesis controlada de poliglutamatos con baja polidispersidad y arquitecturas versátiles
ES2633765T3 (es) 2012-05-07 2017-09-25 Nitto Denko Corporation Conjugados poliméricos con un ligador
KR102135679B1 (ko) * 2013-11-19 2020-07-20 삼성전자주식회사 생분해성 폴리머를 포함하는 표적 친화성 물질 및 이의 용도
WO2015181882A1 (ja) * 2014-05-27 2015-12-03 株式会社島津製作所 分岐型両親媒性ブロックポリマーを用いた分子集合体及び薬剤搬送システム
SG10201609131YA (en) 2016-11-01 2018-06-28 Xylonix Ip Holdings Pte Ltd Zinc-pga compositions and methods for treating cancer
SG10201708886RA (en) 2017-10-30 2019-05-30 Xylonix Ip Holdings Pte Ltd α-PGA-ZINC COMPOSITIONS AND METHODS FOR TREATING CANCER
US20210128609A1 (en) 2018-06-22 2021-05-06 Xylonix Ip Holdings Pte. Ltd. Oncology treatments using zinc agents
KR20230158059A (ko) 2021-03-18 2023-11-17 자일로닉스 피티이. 엘티디 약학적 중합체 접합체

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9427474B2 (en) 2008-05-22 2016-08-30 Ramot At Tel-Aviv University Ltd. Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases
CN104244988A (zh) * 2012-03-05 2014-12-24 雷蒙特亚特特拉维夫大学有限公司 结合治疗活性剂的聚合物、其制备方法以及其用途
US10155047B2 (en) 2012-03-05 2018-12-18 Ramot At Tel-Aviv University Ltd. Polymers having therapeutically active agents conjugated thereto, processes of preparing same and uses thereof
CN104582735A (zh) * 2012-04-12 2015-04-29 日东电工株式会社 共聚物缀合物
CN104582735B (zh) * 2012-04-12 2019-01-11 日东电工株式会社 共聚物缀合物
CN105143242A (zh) * 2013-04-26 2015-12-09 日东电工株式会社 大规模制备聚(谷氨酰基-谷氨酸盐)偶联物的方法
CN111635542A (zh) * 2020-07-14 2020-09-08 华熙生物科技股份有限公司 交联聚谷氨酸水凝胶及其制备方法

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Publication number Publication date
WO2008141110A3 (en) 2009-06-04
WO2008141110A2 (en) 2008-11-20
US20080279778A1 (en) 2008-11-13
EP2155253A2 (en) 2010-02-24
TW200900083A (en) 2009-01-01
JP2010526917A (ja) 2010-08-05

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Application publication date: 20100512