CN101707869A - 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物 - Google Patents

具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物 Download PDF

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Publication number
CN101707869A
CN101707869A CN200880019839A CN200880019839A CN101707869A CN 101707869 A CN101707869 A CN 101707869A CN 200880019839 A CN200880019839 A CN 200880019839A CN 200880019839 A CN200880019839 A CN 200880019839A CN 101707869 A CN101707869 A CN 101707869A
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China
Prior art keywords
polymer conjugates
arbitrary
tumor
medicine
group
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CN200880019839A
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English (en)
Chinese (zh)
Inventor
桑·范
俞磊
赵刚
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Nitto Denko Corp
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Nitto Denko Corp
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Publication of CN101707869A publication Critical patent/CN101707869A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200880019839A 2007-05-09 2008-05-08 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物 Pending CN101707869A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91686507P 2007-05-09 2007-05-09
US60/916,865 2007-05-09
PCT/US2008/063126 WO2008141110A2 (en) 2007-05-09 2008-05-08 Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs

Publications (1)

Publication Number Publication Date
CN101707869A true CN101707869A (zh) 2010-05-12

Family

ID=39615769

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880019839A Pending CN101707869A (zh) 2007-05-09 2008-05-08 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物

Country Status (6)

Country Link
US (1) US20080279778A1 (enExample)
EP (1) EP2155253A2 (enExample)
JP (1) JP2010526917A (enExample)
CN (1) CN101707869A (enExample)
TW (1) TW200900083A (enExample)
WO (1) WO2008141110A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104244988A (zh) * 2012-03-05 2014-12-24 雷蒙特亚特特拉维夫大学有限公司 结合治疗活性剂的聚合物、其制备方法以及其用途
CN104582735A (zh) * 2012-04-12 2015-04-29 日东电工株式会社 共聚物缀合物
CN105143242A (zh) * 2013-04-26 2015-12-09 日东电工株式会社 大规模制备聚(谷氨酰基-谷氨酸盐)偶联物的方法
US9427474B2 (en) 2008-05-22 2016-08-30 Ramot At Tel-Aviv University Ltd. Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases
CN111635542A (zh) * 2020-07-14 2020-09-08 华熙生物科技股份有限公司 交联聚谷氨酸水凝胶及其制备方法

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US9393315B2 (en) 2011-06-08 2016-07-19 Nitto Denko Corporation Compounds for targeting drug delivery and enhancing siRNA activity
AU2006322254B2 (en) 2005-12-05 2012-08-02 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
CN101674852A (zh) * 2007-04-10 2010-03-17 日东电工株式会社 多功能聚谷氨酸盐药物载体
JP5341879B2 (ja) * 2007-05-09 2013-11-13 日東電工株式会社 疎水性化合物及びポリアミノ酸複合体を含む組成物
JP2011513412A (ja) * 2008-03-06 2011-04-28 日東電工株式会社 ポリマーパクリタキセル結合体を含む癌を治療するための薬学組成物
WO2009141826A2 (en) * 2008-05-22 2009-11-26 Ramot At Tel Aviv University Ltd. Novel conjugates of polymers having a therapeutically active agent and an angiogenesis targeting moiety attached thereto and uses thereof in the treatment of angiogenesis related diseases
EP2300021A4 (en) * 2008-05-22 2014-10-08 Univ Ramot CONJUGATE OF A POLYMER, ANTI-ANGIOGENESE AGENT AND TARGETING REST, AND USES THEREOF FOR THE TREATMENT OF BONE-RELATED ANGIOGENESIS STATES
CN102176923A (zh) * 2008-10-15 2011-09-07 日东电工株式会社 制备聚谷氨酸酯结合物的方法
WO2011059779A2 (en) * 2009-10-29 2011-05-19 Lucia Irene Gonzalez Ligand-targeted multi- stereoisomer peptide polymer conjugates and uses thereof
JP2013514977A (ja) * 2009-12-16 2013-05-02 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド 複数の物質の送達のための粒子
JP2013514443A (ja) * 2009-12-16 2013-04-25 日東電工株式会社 ポリグルタミン酸の制御された合成
US20120052015A1 (en) * 2010-08-26 2012-03-01 Nitto Denko Corporation End-capped polymers
US10196637B2 (en) 2011-06-08 2019-02-05 Nitto Denko Corporation Retinoid-lipid drug carrier
ES2402614B1 (es) * 2011-10-24 2014-03-18 Centro De Investigación Principe Felipe Sintesis controlada de poliglutamatos con baja polidispersidad y arquitecturas versátiles
WO2013169337A1 (en) 2012-05-07 2013-11-14 Nitto Denko Corporation Polymer conjugates with a linker
KR102135679B1 (ko) * 2013-11-19 2020-07-20 삼성전자주식회사 생분해성 폴리머를 포함하는 표적 친화성 물질 및 이의 용도
WO2015181882A1 (ja) * 2014-05-27 2015-12-03 株式会社島津製作所 分岐型両親媒性ブロックポリマーを用いた分子集合体及び薬剤搬送システム
SG10201609131YA (en) 2016-11-01 2018-06-28 Xylonix Ip Holdings Pte Ltd Zinc-pga compositions and methods for treating cancer
SG10201708886RA (en) 2017-10-30 2019-05-30 Xylonix Ip Holdings Pte Ltd α-PGA-ZINC COMPOSITIONS AND METHODS FOR TREATING CANCER
AU2019290345B2 (en) 2018-06-22 2025-07-10 Xylonix PTE. LTD. Oncology treatments using zinc agents
CN117377497A (zh) 2021-03-18 2024-01-09 翟伦尼克斯私人有限公司 药物聚合物缀合物

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Cited By (7)

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Publication number Priority date Publication date Assignee Title
US9427474B2 (en) 2008-05-22 2016-08-30 Ramot At Tel-Aviv University Ltd. Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases
CN104244988A (zh) * 2012-03-05 2014-12-24 雷蒙特亚特特拉维夫大学有限公司 结合治疗活性剂的聚合物、其制备方法以及其用途
US10155047B2 (en) 2012-03-05 2018-12-18 Ramot At Tel-Aviv University Ltd. Polymers having therapeutically active agents conjugated thereto, processes of preparing same and uses thereof
CN104582735A (zh) * 2012-04-12 2015-04-29 日东电工株式会社 共聚物缀合物
CN104582735B (zh) * 2012-04-12 2019-01-11 日东电工株式会社 共聚物缀合物
CN105143242A (zh) * 2013-04-26 2015-12-09 日东电工株式会社 大规模制备聚(谷氨酰基-谷氨酸盐)偶联物的方法
CN111635542A (zh) * 2020-07-14 2020-09-08 华熙生物科技股份有限公司 交联聚谷氨酸水凝胶及其制备方法

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Publication number Publication date
WO2008141110A2 (en) 2008-11-20
WO2008141110A3 (en) 2009-06-04
US20080279778A1 (en) 2008-11-13
EP2155253A2 (en) 2010-02-24
TW200900083A (en) 2009-01-01
JP2010526917A (ja) 2010-08-05

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Application publication date: 20100512