CN101700392B - Traditional Chinese medicine composite for curing obesity fatty liver - Google Patents
Traditional Chinese medicine composite for curing obesity fatty liver Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composite for curing obesity fatty liver, which is prepared by the following raw medicinal materials in parts by weight: 20 parts of common burreed rhizome, 20 parts of Zedoary, 20 parts of hawthorns, 15 parts of polygonum multiflorum, 10 parts of oriental waterplantain rhizome, 10 parts of silymarin, 10 parts of barbary wolfberry fruit, 15 parts of Salvia miltiorrhiza bge, 15 parts of radix curcumae, 12 parts of bupleurum, 15 parts of patrinia scabiosaefolia, 20 parts of spreading hedyotis herb, 15 parts of semen coicis, 15 parts of atractylis ovata, 10 parts of absinthin, 10 parts of indigowoadroot and 5 parts of liquorice. The traditional Chinese medicine composition invention takes natural traditional Chinese medicine as raw materials and has small toxic and side effects and confirmed curative effect, and the total effective rate of the traditional Chinese medicine composition for curing obesity fatty liver is 92.7%.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of obese fatty liver, belong to the field of Chinese medicines.
Background technology
Fatty liver is meant because the pathological changes of the interior fatty overheap of the hepatocyte that a variety of causes causes.The positive serious threat compatriots' of fatty liver disease health becomes the second largest hepatopathy that is only second to viral hepatitis, has been acknowledged as the common cause of disguised liver cirrhosis.According to the cause of disease, fatty liver is divided into obesity-related, ethanol, medicine etc.Wherein obese fatty liver accounts for more than 60% of whole fatty livers.Fatty liver can cause serious liver class diseases such as liver cirrhosis, hepatocarcinoma with state of an illness delay.
The overweight people has excessive edible high-carbonhydrate diet custom mostly, because a large amount of saccharic enters liver, has surpassed the storage capability of the synthetic sugar of liver, makes unnecessary sugar be converted into fatty acid, and picked-up sugar is many more, and fatty acid is just many more, and the fatty liver degree is also heavier.The clinical manifestation of obese fatty liver is asymptomatic, or fatigue and weak, uncomfortable liver area, distension are arranged, even dull pain, anorexia, face acne etc.
The treatment of obese fatty liver doctor trained in Western medicine at present is with on the basis of losing weight, and emphasizes on the basis of Diet Therapy and exercise therapy, adds and uses the medicine auxiliary treatment.The Chinese traditional treatment fatty liver is common at present method of treatment such as removing dampness heat clearing away, depressed liver-energy dispersing and QI regulating, invigorating the spleen for dissipating phlegm, blood circulation promoting and blood stasis dispelling, the kidney invigorating and essence nourishing, or integrated use, proper as medication, often can obtain ideal curative effect.
Summary of the invention
In order to overcome the shortcoming that above-mentioned prior art exists, the invention provides a kind of Chinese medicine composition that can effectively treat obese fatty liver.
Technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of obese fatty liver, it is characterized in that, make: rhizoma sparganic 20, Rhizoma Curcumae 20, Fructus Crataegi 20, Radix Polygoni Multiflori 15, Rhizoma Alismatis 10, Herba Silybi mariani 10, Fructus Lycii 10, Radix Salviae Miltiorrhizae 15, Radix Curcumae 15, Radix Bupleuri 12, Herba Patriniae 15, Herba Hedyotidis Diffusae 20, Semen Coicis 15, the Rhizoma Atractylodis Macrocephalae 15, Herba Artemisiae Scopariae 10, Radix Isatidis 10, Radix Glycyrrhizae 5 by following raw medicaments in portion by weight.
Collocation method: be decocted in water for oral dose, every day, potion was taken at twice.
This Chinese medicine composition single-dose amount of the present invention is: rhizoma sparganic 20g, Rhizoma Curcumae 20g, Fructus Crataegi 20g, Radix Polygoni Multiflori 15g, Rhizoma Alismatis 10g, Herba Silybi mariani 10g, Fructus Lycii 10g, Radix Salviae Miltiorrhizae 15g, Radix Curcumae 15g, Radix Bupleuri 12g, Herba Patriniae 15g, Herba Hedyotidis Diffusae 20g, Semen Coicis 15g, Rhizoma Atractylodis Macrocephalae 15g, Herba Artemisiae Scopariae 10g, Radix Isatidis 10g, Radix Glycyrrhizae 5g.
Fatty liver is expectorant is turbid, due to the blood stasis, how because of surfeit delicious food savoury, the defeated cloth of transporting and transforming function of the spleen and stomach is not normal, suffocating of liver and gall transfer reach not smooth, the middle burnt resistance of stopping up.The strongly fragrant soil of wood is stopped up bringing about the spread of body fluid's imbalance, is condensed into expectorant, turbidization of phlegm-damp, and wine fat is cream, hinders in venation, stops up the QI and blood that stagnates, and causes stagnation of blood stasis then.So stagnation of liver-QI with deficiency of the spleen, the retardance of phlegm-turbidity and blood stasis blood is the main pathogenesis of primary disease.Control suitable soothing liver and strengthening spleen, dampness removing reduces phlegm, the blood stasis and smoothing collaterals of living.Rhizoma sparganic, Rhizoma Curcumae, Herba Patriniae repercussive eliminating stagnation in the side, the circulation of qi promoting removing food stagnancy; Radix Salviae Miltiorrhizae, Radix Curcumae blood circulation promoting and blood stasis dispelling, QI regulating by alleviation of mental depression; Herba Hedyotidis Diffusae, Radix Isatidis and Radix Glycyrrhizae heat-clearing and toxic substances removing, Herba Artemisiae Scopariae and Herba Silybi mariani clearing away damp-heat, depressed liver-energy dispersing and function of gallbladder promoting; Fructus Lycii and Radix Bupleuri nourishing the liver and kidney, but the Rhizoma Atractylodis Macrocephalae, Semen Coicis, Fructus Crataegi strengthening the spleen and stomach, it is wet to eliminate the phlegm; Radix Polygoni Multiflori, Rhizoma Alismatis loosening bowel to relieve constipation, all medicines are shared, and curative effect is preferable.
The pharmacological action of each Chinese medicine:
Rhizoma sparganic: hot, bitter, flat.Return liver, spleen channel.Function with cure mainly: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain.
Rhizoma Curcumae: hot, bitter, temperature.Return liver, spleen channel.Function with cure mainly: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.
Fructus Crataegi: sour, sweet, tepor.Return spleen, stomach, Liver Channel.Function with cure mainly: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.Be used for meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.Be used for meat stagnation, dysentery is not well.
Radix Polygoni Multiflori: bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Detoxifcation, eliminating carbuncle, loosening bowel to relieve constipation.Be used for the scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.
Rhizoma Alismatis: sweet, cold.Return kidney, urinary bladder channel.Function with cure mainly: diuresis, clearing away damp-heat.Be used for dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.
Herba Silybi mariani: hardship, cold.Return liver, gallbladder meridian.Function with cure mainly: heat-clearing and toxic substances removing, 'Shugan Lidan '.Be used for dampness-heat in the liver and gallbladder, hypochondriac pain, jaundice.
Fructus Lycii: sweet, flat.Return liver, kidney channel.Function with cure mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Radix Salviae Miltiorrhizae: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Radix Curcumae: hot, bitter, cold.Return liver, the heart, lung meridian.Function with cure mainly: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine.
Radix Bupleuri: hardship is slightly cold.Return liver, gallbladder meridian.Function with cure mainly: reconciling superficies and interior, soothing the liver, yang invigorating.Be used for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Herba Patriniae: have in the Compendium of Material Medica: Herba Patriniae, kind evacuation of pus removing blood stasis, so Zhong Jing controls carbuncle, and ancient prescription married woman section all uses it.
Herba Hedyotidis Diffusae: sweet, light, be slightly cold.Return stomach, lung, large intestine, urinary bladder channel.Effect: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, promoting urination to remove dampness.
Semen Coicis: sweet, light, cold.Return spleen, stomach, lung meridian.Function with cure mainly: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, clearing away heat and discharging pus.Be used for edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Function with cure mainly: invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.Be used for insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, frequent fetal movement.
Herba Artemisiae Scopariae: bitter, hot, be slightly cold.Return spleen, stomach, liver, gallbladder meridian.Function with cure mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.Be used for the jaundice oliguria, the eczema pruritus; Infectious jaundice type hepatitis.
Radix Isatidis: hardship, cold.GUIXIN, stomach warp.Function with cure mainly: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.Be used for maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
The invention has the beneficial effects as follows: the present invention is a raw material with natural Chinese medicine, and toxic and side effects is little, and determined curative effect is 92.7% with traditional Chinese medicine composition for treating obese fatty liver total effective rate of the present invention.
One, clinical observation
1. clinical data: be selected from inpatient's totally 110 examples that have complete data year January in January, 2008 to 2009.Be divided into treatment at random and organize 55 examples, matched group 55 examples.The treatment group age is 20-62 year, average 40.2 years old, and course of disease 1-15, the matched group age is in 18-64 year, and average 39.8 years old, course of disease 1.5-18, the age and the course of disease be through X 2 test, no statistically-significant difference (p＞0.05).
2. diagnostic criteria:
(1) eating and drinking too much at one meal, hobby delicious food greasy food promptly have at ordinary times takes in dietary habit higher fatty acid, high heat.
(2) the overweight body weight is above standard body weight more than 10%.
(3) clinical manifestation is asymptomatic, or fatigue and weak, uncomfortable liver area, distension are arranged, even dull pain, anorexia, face acne etc.
(4) liver function test of the slight obese fatty liver of lab testing can not have any unusual; In, severe can occur alanine aminotransferase (glutamate pyruvate transaminase) (ALT) and aspartate aminotransferase (glutamic oxaloacetic transaminase, GOT) (AST) raise, ALT/AST ratio is greater than 1; The globulin ratio raises, and albumin, globulin are out of proportion; The serum phosphatase level raises, most of patients raises (especially triacylglycerol rising) with blood fat, is the feature performance of fatty liver, or companion's hypercholesterolemia.
(5) ultrasound diagnosis liver B-type ultrasonography, visible fatty liver image, that is: the strong echo in hepatic region, the contrast of Liver and kidney brightness district descends, sclerosis of blood vessels in the liver, gallbladder wall disappears.
3. Therapeutic Method: the treatment group is taken medicine of the present invention, divides oral meal every day 3 times, and 2 days is a course of treatment, matched group essentiale capsule, and each 2, every day 2 times is oral.Two groups of patients all keep on a diet, and the other medicines of stopping using were added up curative effect after 3 months.
4. efficacy assessment standard: cure: 1. transference cure, blood fat, liver function are normal, and B ultrasonic shows that the fatty liver wave mode disappears, and liver bounces back to normally; 2. produce effects: symptom disappears substantially, and blood fat, liver function are bordering on normally, and B ultrasonic shows that the fatty liver wave mode disappears substantially, and liver obviously retraction is bordering on normal; 3. effective: symptom is most of to disappear, and blood fat, liver function take a turn for the better, and B ultrasonic shows that the fatty liver wave mode reduces, and liver slightly bounces back; 4. invalid: improvement is not seen in symptom and every inspection.
5. therapeutic outcome: two groups of therapeutic outcomes are as shown in table 1:
Table 1 liang group cure rate synopsis
| Group | Example is inferior | Recovery from illness/example | Produce effects/example | Significant figure/example | Invalid number/example | Total effective rate (%) |
| The treatment group | 55 | 40 | 6 | 5 | 4 | 92.7 |
| Matched group | 55 | 35 | 7 | 5 | 8 | 85.5 |
Through X 2 test, two groups of effective percentage compare, and difference has highly significant (P＜0.001).
Two, model case
Case 1: Lu, woman, 39 years old, the patient has and has a liking for oily custom, body weight is 85 kilograms before the treatment, the upper right abdomen discomfort from 2008, weak companion's both sides of the chest distending pain, be diagnosed as obese fatty liver through the B ultrasonic demonstration, successively in hospital of a few family through integrative therapy 1 year, poor effect begins to take medicine of the present invention from January, 2009, after taking 3 months, all diseases all disappear.B ultrasonic shows that liver recovers normal, the 12kg that loses weight, and waistline reduces 10 centimetres.
Case 2: Lee, man, 40 years old.The patient is fat gradually from health over 2005, abdominal distention, and from right side of body dull pain over 2008, the upper abdomen distension, borborygmus, the loose stool, extremity are aching and tired unable.Examine and see the body constitution obesity, stomach wall is thick, and corpulent tongue is big, and there is indentation on the limit, and body of the tongue is light red, and tongue is thick in vain, and stringy pulse is slow.B ultrasonic is shown fatty liver.After friend's introduction was taken medicine of the present invention, taken 3 months, all diseases all disappeared.B ultrasonic shows that liver recovers normal, loses weight 10 kilograms.
The specific embodiment
Embodiment 1:
Proportioning: rhizoma sparganic 20, Rhizoma Curcumae 20, Fructus Crataegi 20, Radix Polygoni Multiflori 15, Rhizoma Alismatis 10, Herba Silybi mariani 10, Fructus Lycii 10, Radix Salviae Miltiorrhizae 15, Radix Curcumae 15, Radix Bupleuri 12, Herba Patriniae 15, Herba Hedyotidis Diffusae 20, Semen Coicis 15, the Rhizoma Atractylodis Macrocephalae 15, Herba Artemisiae Scopariae 10, Radix Isatidis 10, Radix Glycyrrhizae 5.
Collocation method: be decocted in water for oral dose, every day, potion was taken at twice.
Claims (1)
1. Chinese medicine composition for the treatment of obese fatty liver, it is characterized in that, make: rhizoma sparganic 20, Rhizoma Curcumae 20, Fructus Crataegi 20, Radix Polygoni Multiflori 15, Rhizoma Alismatis 10, Herba Silybi mariani 10, Fructus Lycii 10, Radix Salviae Miltiorrhizae 15, Radix Curcumae 15, Radix Bupleuri 12, Herba Patriniae 15, Herba Hedyotidis Diffusae 20, Semen Coicis 15, the Rhizoma Atractylodis Macrocephalae 15, Herba Artemisiae Scopariae 10, Radix Isatidis 10, Radix Glycyrrhizae 5 by following raw medicaments in portion by weight.
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| CN106668633A (en) * | 2017-01-24 | 2017-05-17 | 杨少军 | Pleione bulbocodioides lipid-eliminating formula |
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| CN101015668A (en) * | 2007-01-16 | 2007-08-15 | 李卓伦 | Fatty liver treating medicine |
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| CN101015668A (en) * | 2007-01-16 | 2007-08-15 | 李卓伦 | Fatty liver treating medicine |
Non-Patent Citations (4)
| Title |
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| 丁舸等.中医药治疗脂肪肝研究现状.《时珍国医国药》.2007,第18卷(第07期),1776-1777. * |
| 王希光.脂肪肝中医治疗概述.《甘肃中医》.2005,第18卷(第03期),40-42. * |
| 郭伟.脂肪肝中医治疗研究进展.《中医药临床杂志》.2007,第19卷(第04期),417-418. * |
| 钟燕春.中医药治疗脂肪肝进展.《辽宁中医药大学学报》.2008,第10卷(第02期),64-65. * |
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