CN103751281A - Traditional Chinese medicinal composition for treating ascites due to cirrhosis - Google Patents

Abstract

The invention relates to a medicine for treating ascites due to cirrhosis, particularly relates to a traditional Chinese medicinal composition for treating ascites due to cirrhosis, which is prepared from traditional Chinese medicinal herbs as raw materials. The traditional Chinese medicinal composition is characterized in that the effective ingredient is prepared from the following raw materials: 13-19 g of Astragalus membranaceus, 13-19 g of Salvia miltiorrhiza, 13-19 g of Stephania tetrandra, 10-15 g of Achyranthes bidentata, 10-15 g of Atractylodes macrocephala, 10-15 g of Rhizoma Atractylodis, 15-20 g of gizzard membrane of Gallus gallus domesticus, and 15-20 g of Herba Patriniae. The traditional Chinese medicine provided by the invention has synergistic drug action, has effects of strengthening the middle-jiao, invigorating qi, clearing away heat and toxic materials, inducing diuresis, alleviating edema, promoting blood circulation, dispelling blood stasis, tonifying liver and kidney, and so on, and has remarkable therapeutic effect on treating ascites due to cirrhosis.

Description

A kind of Chinese medicine composition for the treatment of cirrhotic ascites

Technical field

The present invention relates to treat the medicine of cirrhotic ascites, especially a kind of Chinese medicine composition of take the treatment cirrhotic ascites that vegetable Chinese herbal medicine makes as raw material.

Background technology

Cirrhotic ascites is commonly called as hepatic ascites.Cirrhotic ascites is a kind of chronic hepatopathy.Hepatocellular by bulk type, nodular type, diffuse type becomes, downright bad, regeneration; Regeneration, necrosis, impel the contraction of tissue fibers hypertrophy and cicatrix, causes liver qualitative change hard, forms liver cirrhosis.Cirrhosis, liver hypofunction causes portal hypertension, causes splenomegaly, and the protein liquid that not absorbing of protein and vitamin leaked out, has formed ascites symptoms.The cause of disease that causes liver cirrhosis is a lot, is mainly wherein due to viral hepatitis, as hepatitis B, hepatitis C etc.Also have due to the factor long-term damage of the aspects such as alcoholic liver, fatty liver, cholestasis, medicine, nutrition simultaneously.

The traditional Chinese medical science thinks, hepatic ascites belongs to " tympanites ", " ascites " category, and it is relevant that its mechanism of mainly falling ill is gathered with diet, feelings will, jaundice etc.Eating and drinking without temperance, if be addicted to drink immoderate, diet is uncontrolled, impairing the spleen and stomach, insufficiency of the spleen dysfunction of the spleen in transportation and transformation, turbid damp accumulate poly-in the burnt air resister of stopping up, liver is lost bar and reaches, and QI and blood stasis is more insufficiency of the spleen, QI failing to transform into body fluid, and then involve in kidney, the kidney being in charge of discharge and retention of body fluid, suffers from a deficiency of the kidney out entire unfavorable, and water is turbid gradually gradually many, becomes eventually edema.That is to say, excessive consumption of alcohol, eating and drinking too much at one meal meeting impairing the spleen and stomach, turbid damp is gathered in the internal organs such as liver, spleen, loses the ability of transmitting and distributing the fluids, damages gradually kidney, causes suffering from a deficiency of the kidney.The draining of suffering from a deficiency of the kidney is unfavorable and cause edema.In addition, feelings will is hindered, and feelings will is not smooth, and mechanism of qi loses in bar and reaches, so that depression of liver-QI, qi depression to blood stasis for a long time, and perverse and unreasonable manner and violate taste, causes dysfunction of the spleen in transportation and transformation, water-damp retention.The traditional Chinese medical science is thought liver controlling conveyance and dispersion, has the comprehensive physiological functions such as dredging, bar reach, liter is sent out, freely let out, and after feelings will impairing the liver, involves taste, also can cause the dysfunction of the spleen in transportation and transformation of water, occurs ascites.

At present, doctor trained in Western medicine is mainly that ascites is treated in the eliminating that adopts diuretic to increase water, sodium, but can easily cause water, electrolyte disturbance like this, therefore in treatment, will reduce the amount of the Western medicine such as diuretic as far as possible.The traditional Chinese medical science is particular about qi and blood tonifying, and liver-nourishing kidney-boosting be take and improved albumin, adjustment albumen ratio, enhancing human body immunity function as main, and can promote liver cell regeneration to improve liver function, in treatment cirrhotic ascites, has unique advantage.Therefore spy of the present invention has further preferably adopted a kind of Chinese medicine composition for the treatment of cirrhotic ascites.

Summary of the invention

The deficiency existing in order to overcome prior art treatment cirrhotic ascites, the invention provides a kind ofly prepare conveniently, medicine source is wide, cost is low, the Chinese medicine composition of the treatment cirrhotic ascites of evident in efficacy, reliable effect.

The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition for the treatment of cirrhotic ascites, it is characterized in that: the crude drug of making effective ingredient by following weight is: Radix Astragali 13-19 gram, Radix Salviae Miltiorrhizae 13-19 gram, Radix Stephaniae Tetrandrae 13-19 gram, Radix Achyranthis Bidentatae 10-15 gram, Rhizoma Atractylodis Macrocephalae 10-15 gram, Rhizoma Atractylodis 10-15 gram, Endothelium Corneum Gigeriae Galli 15-20 gram, Herba Patriniae 15-20 gram.

Usage: one day potion, be decocted in water for oral dose, patient can take for one day at twice, for the difficult patient that takes traditional Chinese medicine, can be on a small quantity sub-service repeatedly.It within 15 days, is a course for the treatment of.

The preferred technical solution of the present invention is: a kind of Chinese medicine composition for the treatment of cirrhotic ascites, is characterized in that: the crude drug of making effective ingredient by following weight is: 16 grams of the Radixs Astragali, 16 grams of Radix Salviae Miltiorrhizaes, 16 grams of Radixs Stephaniae Tetrandrae, 13 grams of Radix Achyranthis Bidentataes, 13 grams of the Rhizoma Atractylodis Macrocephalaes, 13 grams of Rhizoma Atractylodis, 18 grams of Endothelium Corneum Gigeriae Galli, 18 grams of Herba Patriniae.

Pharmacological action

The Radix Astragali: energy invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, lack of appetite, loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema.

Radix Salviae Miltiorrhizae: there is blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, the effect that relieving restlessness is calmed the nerves.

Radix Stephaniae Tetrandrae: there is inducing diuresis to remove edema; The effect of wind-expelling pain-stopping.Cure mainly edema; Dysuria; Rheumatic arthralgia; Beriberi swells and ache; Scabies skin ulcer is swollen; The diseases such as hypertension.

Radix Achyranthis Bidentatae: promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, relieving stranguria by diuresis, ignite (blood) is descending.Cure mainly soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Amenorrhea due to stagnation of blood; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; Lump in the abdomen; Retention of placenta; Pyretic stranguria; Stranguria with blood; Traumatic injury; Carbuncle malignant boil; Laryngopharynx swelling and pain.

The Rhizoma Atractylodis Macrocephalae: there is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.

Rhizoma Atractylodis: drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity is preesed, rheumatic arthralgia, anemofrigid cold, nyctalopia.

Endothelium Corneum Gigeriae Galli: promoting digestion and invigorating the stomach, arresting seminal emission.Removing food stagnancy is stagnant, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.

Herba Patriniae: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing.

The invention has the beneficial effects as follows, each component of Chinese medicine of the present invention all adopts natural raw material of Chinese medicine, and its configuration is simple, and medicine source is wide, cost is low.This herbal medicine efficacy synergism, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, and inducing diuresis to remove edema, blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, the effects such as diuresis poison holding, have remarkable result to treatment cirrhotic ascites.

Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:

Clinical data

Inventor collects outpatient service and inpatient's 68 examples of cirrhotic ascites in June, 2010 to 2011 altogether between year JIUYUE, male 40 examples, female's 28 examples, age 30-75 year.Be divided at random two groups, treatment group 34 examples wherein, male 19 examples, female's 15 examples; Age 30-75 year, the course of disease 1 year to 11 years, matched group 34 examples, male 21 examples, female's 13 examples, age 30-73 is between year, the course of disease 1 year to 12 years; The data there was no significant differences (P>0.05) such as two groups of sexes, age, have comparability.

Therapeutic Method

Matched group compound vitamin B, 2, every day 3 times; Glucurolactone sheet, 100mg, every day 3 times; Spironolactone Tablets, 40-80mg, every day 3 times; Hydrochlorothiazide tablet, 25mg, every day 3 times; Limit the absorption of water salt, a large amount of ascites can suitably be put ascites and supplemented the Supporting Therapys of suiting the medicine to the illness such as albumin simultaneously simultaneously.

Treatment group adds the Chinese medicine composition for the treatment of cirrhotic ascites with the present invention on the basis of matched group.Chinese medicine potion every day, divides and takes for 2-3 time.

Be 15 days courses for the treatment of the course for the treatment of.Four courses for the treatment of of mean treatment.

Observation index

Every day record patient urine amount, observe patient's abdominal circumference; Look into weekly Abdominal B type ultrasonography and observe ascites situation, look into the liver function indexs such as plasma albumin, bilirubin, blood sodium, urine sodium.Within every 2 weeks, sum up 1 time.After ascites disappears, follow-up is 6 months, observes ascites recurrence, the case of ascites showed increased.

Criterion of therapeutical effect

The criterion of therapeutical effect of the cirrhotic ascites of formulating for 1994 according to State Administration of Traditional Chinese Medicine is drafted, and in 30 days, liver function recovery is normal, transference cure, and ultrasound diagnosis ascites disappears, and spleen approaches normal for effective substantially; Hepatic function improvement or approaching normal in 45 days, symptom is clearly better or substantially disappears, and B ultrasonic shows that ascites is suspicious, and it is effective that splenomegaly has retraction in various degree; Above symptom improvement in 45 days is not obvious, and liver function is without taking a turn for the better or worsening as invalid.Therapeutic effect

Treatment statistical result is in Table 1

Table 1 liang group curative effect comparison

Group	Case load	Effective	Effectively	Invalid	Total effective rate (%)
						Treatment group	34	20	11	3	91.2
Matched group	34	13	10	11	67.6

Clinical observation shows, the treatment group of Chinese medicine and western medicine combination has obvious advantage than the matched group of simple employing Western medicine.

Model case:

Thank so-and-so, man, 46 years old, patient's liver cirrhosis medical history 5 years, conscious abdominal distention half a year, through hospital diagnosis: abdominal tympanites, umbilicus eye is outstanding, head and neck, breast, the back of the body etc. locate to see have spider angioma, low grade fever, thirst with desire to drink, constipation; oliguria and red; yellowish fur, pale tongue are fat, and stringy pulse is heavy, is diagnosed as cirrhotic ascites.So take the Chinese medicine composition that the present invention treats cirrhotic ascites, after two courses for the treatment of, symptom alleviates to some extent, and after two courses for the treatment of that hold on, ascites disappears, and liver function recovery is normal.

King so-and-so, man, 55 years old, patient's appetite was poor, hepatic facies, weak, the mental status is poor, two lower limb are treating serious edema caused, abdominal tympanites; Emaciated physique, abdominal distention, diarrhoea increase the weight of one week, and B ultrasonic shows after diagnosing: ascites (severe), and cirrhosis patients in decompensation, splenomegaly, is diagnosed as cirrhotic ascites.Take the Chinese medicine composition that the present invention treats cirrhotic ascites, after two courses for the treatment of, symptom alleviates to some extent, and after two courses for the treatment of that hold on, ascites disappears, and liver function recovery is normal.

The specific embodiment

A Chinese medicine composition for the treatment of cirrhotic ascites, is characterized in that: the crude drug of making effective ingredient by following weight is: 16 grams of the Radixs Astragali, 16 grams of Radix Salviae Miltiorrhizaes, 16 grams of Radixs Stephaniae Tetrandrae, 13 grams of Radix Achyranthis Bidentataes, 13 grams of the Rhizoma Atractylodis Macrocephalaes, 13 grams of Rhizoma Atractylodis, 18 grams of Endothelium Corneum Gigeriae Galli, 18 grams of Herba Patriniae.After first medicine being washed, with cold water soak 15-20 minute, then medicine is placed in the vessel of marmite, pottery or crock and so on (cannot use iron pan and aluminum pot), adds water to and do not have 5 centimetres of left and right of powder, decoct for the first time, after boiling with big fire, use instead little fire decoct 20-30 minute all right, medicine soup is poured in vessel, then decocts second time, the method that decocts second time is the same with first pass, just boils the little fire of rear use and decocts 15-20 minute.After having decocted, twice decoction extracting juice that removes slag, takes after merging.

Claims (2)

1. a Chinese medicine composition for the treatment of cirrhotic ascites, is characterized in that: the raw material of making effective ingredient by following weight is: Radix Astragali 13-19 gram, Radix Salviae Miltiorrhizae 13-19 gram, Radix Stephaniae Tetrandrae 13-19 gram, Radix Achyranthis Bidentatae 10-15 gram, Rhizoma Atractylodis Macrocephalae 10-15 gram, Rhizoma Atractylodis 10-15 gram, Endothelium Corneum Gigeriae Galli 15-20 gram, Herba Patriniae 15-20 gram.

2. treat according to claim 1 the Chinese medicine composition of cirrhotic ascites, it is characterized in that: the crude drug of making effective ingredient by following weight is: 16 grams of the Radixs Astragali, 16 grams of Radix Salviae Miltiorrhizaes, 16 grams of Radixs Stephaniae Tetrandrae, 13 grams of Radix Achyranthis Bidentataes, 13 grams of the Rhizoma Atractylodis Macrocephalaes, 13 grams of Rhizoma Atractylodis, 18 grams of Endothelium Corneum Gigeriae Galli, 18 grams of Herba Patriniae.