CN101696397B - 来自人胚胎干细胞的间充质细胞和成骨细胞 - Google Patents
来自人胚胎干细胞的间充质细胞和成骨细胞 Download PDFInfo
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- CN101696397B CN101696397B CN200910152133.XA CN200910152133A CN101696397B CN 101696397 B CN101696397 B CN 101696397B CN 200910152133 A CN200910152133 A CN 200910152133A CN 101696397 B CN101696397 B CN 101696397B
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/38—Vitamins
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/04—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from germ cells
-
- C—CHEMISTRY; METALLURGY
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- C12N2510/00—Genetically modified cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
Abstract
Description
Claims (6)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30373201P | 2001-07-06 | 2001-07-06 | |
US60/303,732 | 2001-07-06 | ||
CNA028135555A CN1636054A (zh) | 2001-07-06 | 2002-07-03 | 来自人胚胎干细胞的间充质细胞和成骨细胞 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA028135555A Division CN1636054A (zh) | 2001-07-06 | 2002-07-03 | 来自人胚胎干细胞的间充质细胞和成骨细胞 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101696397A CN101696397A (zh) | 2010-04-21 |
CN101696397B true CN101696397B (zh) | 2015-07-08 |
Family
ID=23173436
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910152133.XA Expired - Fee Related CN101696397B (zh) | 2001-07-06 | 2002-07-03 | 来自人胚胎干细胞的间充质细胞和成骨细胞 |
CNA028135555A Pending CN1636054A (zh) | 2001-07-06 | 2002-07-03 | 来自人胚胎干细胞的间充质细胞和成骨细胞 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA028135555A Pending CN1636054A (zh) | 2001-07-06 | 2002-07-03 | 来自人胚胎干细胞的间充质细胞和成骨细胞 |
Country Status (11)
Country | Link |
---|---|
US (4) | US20030021771A1 (zh) |
EP (1) | EP1412481B1 (zh) |
JP (1) | JP2004535808A (zh) |
CN (2) | CN101696397B (zh) |
AU (1) | AU2002322379B2 (zh) |
CA (1) | CA2453068C (zh) |
ES (1) | ES2539105T3 (zh) |
GB (1) | GB2392674B (zh) |
HK (1) | HK1141552A1 (zh) |
IL (2) | IL159578A0 (zh) |
WO (1) | WO2003004605A2 (zh) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
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US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
EP1366148A2 (en) * | 2001-01-24 | 2003-12-03 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES | Differentiation of stem cells to pancreatic endocrine cells |
US20030211605A1 (en) * | 2001-05-01 | 2003-11-13 | Lee Sang-Hun | Derivation of midbrain dopaminergic neurons from embryonic stem cells |
GB0222846D0 (en) | 2002-10-03 | 2002-11-06 | Choo Yen | Cell culture |
PT2457999T (pt) | 2002-12-16 | 2019-01-28 | Technion Res & Dev Foundation | Sistema de cultura para células estaminais pluripotentes |
US20030224411A1 (en) * | 2003-03-13 | 2003-12-04 | Stanton Lawrence W. | Genes that are up- or down-regulated during differentiation of human embryonic stem cells |
JP2005304443A (ja) * | 2004-04-26 | 2005-11-04 | Institute Of Physical & Chemical Research | 前駆間葉系幹細胞 |
EP1743023A1 (en) * | 2004-05-07 | 2007-01-17 | Wisconsin Alumni Research Foundation | Method of forming mesenchymal stem cells from embryonic stem cells |
US20050265980A1 (en) * | 2004-05-14 | 2005-12-01 | Becton, Dickinson And Company | Cell culture environments for the serum-free expansion of mesenchymal stem cells |
EP1809739B1 (en) | 2004-07-13 | 2014-10-15 | Asterias Biotherapeutics, Inc. | Medium for growing human embryonic stem cells |
KR101617319B1 (ko) | 2005-04-12 | 2016-05-02 | 메소블라스트, 아이엔씨. | 조직 비특이적인 알카리 포스파타제에 의한 다분화성 성체 세포의 분리 |
KR20130100221A (ko) | 2005-06-22 | 2013-09-09 | 제론 코포레이션 | 인간 배아 줄기 세포의 현탁 배양 |
JP4714741B2 (ja) * | 2005-07-29 | 2011-06-29 | 学校法人松本歯科大学 | 歯の再生方法 |
US8476070B2 (en) | 2005-08-29 | 2013-07-02 | Technion Research & Development Foundation Limited | Media for culturing stem cells |
AU2006285468A1 (en) * | 2005-09-02 | 2007-03-08 | Agency For Science, Technology And Research | Method of deriving progenitor cell line |
WO2008020815A1 (en) * | 2006-08-15 | 2008-02-21 | Agency For Science, Technology And Research | Mesenchymal stem cell conditioned medium |
GB0526664D0 (en) * | 2005-11-30 | 2006-02-08 | Plasticell Ltd | Method |
WO2007080591A2 (en) * | 2006-01-11 | 2007-07-19 | Technion Research & Development Foundation Ltd. | Adult stem cell-derived connective tissue progenitors for tissue engineering |
JP5170443B2 (ja) * | 2006-02-16 | 2013-03-27 | ユニヴェルシテ リブル ドゥ ブリュッセル | 骨髄幹細胞(bmsc)を骨分化させる方法およびその使用 |
WO2007122233A1 (en) * | 2006-04-25 | 2007-11-01 | Vrije Universiteit Brussel | Preparation of mesenchymal progenitor cells, particularly osteogenic progenitor cells |
US9040297B2 (en) | 2006-08-02 | 2015-05-26 | Technion Research & Development Foundation Limited | Methods of expanding embryonic stem cells in a suspension culture |
US8153359B2 (en) * | 2006-10-02 | 2012-04-10 | Cellartis Ab | Toxicity assay based on human blastocyst-derived stem cells and progenitor cells |
KR100937456B1 (ko) * | 2007-08-01 | 2010-01-19 | 한국생명공학연구원 | 인간배아줄기세포를 조골세포 직계열로 분화시키는 방법 |
US9487756B2 (en) * | 2009-03-20 | 2016-11-08 | Mesoblast, Inc. | Production of reprogrammed pluripotent cells |
SG176957A1 (en) | 2009-06-25 | 2012-02-28 | Geron Corp | Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes |
KR101135636B1 (ko) * | 2009-10-27 | 2012-04-17 | 서울대학교산학협력단 | 인간 만능줄기세포로부터 중배엽 줄기세포를 생산하는 방법 및 이에 의해 생성된 중배엽 줄기세포 |
CA2783437C (en) | 2009-11-12 | 2020-08-04 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
WO2011124741A1 (es) * | 2010-04-08 | 2011-10-13 | Fundación Progreso Y Salud | Uso de un medio de cultivo condicionado por células madre mesenquimales para la diferenciación de células madre pluripotentes humanas |
CA2828315A1 (en) | 2010-04-08 | 2011-10-13 | The University Court Of The University Of Edinburgh | Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof |
EP2582793B1 (en) | 2010-06-15 | 2017-09-06 | Cellular Dynamics International, Inc. | A compendium of ready-built stem cell models for interrogation of biological response |
US20140329314A1 (en) | 2011-03-29 | 2014-11-06 | Christopher O'Sullivan | Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells |
CN103083653B (zh) * | 2011-10-28 | 2015-07-22 | 辽宁成大动物药业有限公司 | 一种采用微载体高密度细胞培养技术生产猪瘟活疫苗的方法 |
CN103777009B (zh) * | 2012-10-18 | 2016-03-02 | 辽宁成大动物药业有限公司 | 一种使用辣根过氧化物酶标抗体检测猪瘟弱毒病毒滴度的方法 |
CA2945393C (en) | 2014-04-24 | 2021-03-23 | Board Of Regents, The University Of Texas System | Application of induced pluripotent stem cells to generate adoptive cell therapy products |
US11285177B2 (en) | 2018-01-03 | 2022-03-29 | Globus Medical, Inc. | Allografts containing viable cells and methods thereof |
CN108570448B (zh) * | 2018-01-26 | 2019-04-02 | 皓昇莱生物制药有限公司 | 一种高效的hPSCs向MSCs分化的方法 |
KR102241185B1 (ko) * | 2019-04-23 | 2021-04-16 | (주)셀라토즈테라퓨틱스 | 근골격계 줄기세포의 선택적 분화 조절방법 |
CN113462642A (zh) * | 2021-08-12 | 2021-10-01 | 呈诺再生医学科技(珠海横琴新区)有限公司 | 间充质干细胞的快速诱导分化方法、试剂盒及其应用 |
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US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US5654186A (en) * | 1993-02-26 | 1997-08-05 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
US5681701A (en) * | 1993-07-12 | 1997-10-28 | Mayo Foundation For Medical Education And Research | Immortalized human fetal osteoblastic cells |
US5691175A (en) * | 1993-07-12 | 1997-11-25 | Mayo Foundation For Medical Education And Research | Immortalized human fetal osteoblastic cells |
US5972703A (en) * | 1994-08-12 | 1999-10-26 | The Regents Of The University Of Michigan | Bone precursor cells: compositions and methods |
US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
GB9516268D0 (en) * | 1995-08-08 | 1995-10-11 | Danbiosyst Uk | Compositiion for enhanced uptake of polar drugs from the colon |
ATE288480T1 (de) * | 1995-11-16 | 2005-02-15 | Univ Case Western Reserve | Chondrogene in vitro induktion von menschlichen mensenchymalen stammzellen |
US6482231B1 (en) * | 1995-11-20 | 2002-11-19 | Giovanni Abatangelo | Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative |
US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
US6090622A (en) * | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
US6077987A (en) * | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
AU729377B2 (en) * | 1997-10-23 | 2001-02-01 | Asterias Biotherapeutics, Inc. | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
US6875607B1 (en) * | 1998-11-09 | 2005-04-05 | Es Cell International Pte Ltd | Embryonic stem cells |
AU759643B2 (en) * | 1999-07-20 | 2003-04-17 | University Of Southern California | Identification of pluripotent pre-mesenchymal, pre-hematopoietic progenitor cell |
BR0014864A (pt) * | 1999-10-15 | 2002-11-19 | Advanced Cell Tech Inc | Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem |
WO2001035968A1 (en) * | 1999-11-19 | 2001-05-25 | Children's Medical Center Corporation | Methods for inducing chondrogenesis and producing de novo cartilage in vitro |
GB0003930D0 (en) * | 2000-02-18 | 2000-04-12 | King S College London | Cell |
US20040224403A1 (en) * | 2001-12-07 | 2004-11-11 | Robarts Research Institute | Reconstituting hematopoietic cell function using human embryonic stem cells |
-
2002
- 2002-07-03 JP JP2003510764A patent/JP2004535808A/ja active Pending
- 2002-07-03 CN CN200910152133.XA patent/CN101696397B/zh not_active Expired - Fee Related
- 2002-07-03 US US10/189,154 patent/US20030021771A1/en not_active Abandoned
- 2002-07-03 CA CA2453068A patent/CA2453068C/en not_active Expired - Lifetime
- 2002-07-03 WO PCT/US2002/020998 patent/WO2003004605A2/en active Application Filing
- 2002-07-03 CN CNA028135555A patent/CN1636054A/zh active Pending
- 2002-07-03 AU AU2002322379A patent/AU2002322379B2/en not_active Ceased
- 2002-07-03 US US10/189,276 patent/US20030036194A1/en not_active Abandoned
- 2002-07-03 IL IL15957802A patent/IL159578A0/xx unknown
- 2002-07-03 EP EP02756367.5A patent/EP1412481B1/en not_active Expired - Lifetime
- 2002-07-03 GB GB0400481A patent/GB2392674B/en not_active Expired - Fee Related
- 2002-07-03 ES ES02756367.5T patent/ES2539105T3/es not_active Expired - Lifetime
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2003
- 2003-12-25 IL IL159578A patent/IL159578A/en unknown
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2005
- 2005-08-16 US US11/205,433 patent/US20050282274A1/en not_active Abandoned
- 2005-09-30 HK HK10107815.6A patent/HK1141552A1/zh not_active IP Right Cessation
- 2005-10-17 US US11/252,467 patent/US20060057720A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101696397A (zh) | 2010-04-21 |
ES2539105T3 (es) | 2015-06-26 |
WO2003004605A3 (en) | 2003-11-13 |
GB2392674B (en) | 2005-08-10 |
JP2004535808A (ja) | 2004-12-02 |
AU2002322379B2 (en) | 2007-02-15 |
EP1412481A2 (en) | 2004-04-28 |
US20050282274A1 (en) | 2005-12-22 |
US20030036194A1 (en) | 2003-02-20 |
IL159578A0 (en) | 2004-06-01 |
EP1412481A4 (en) | 2005-01-05 |
CN1636054A (zh) | 2005-07-06 |
US20060057720A1 (en) | 2006-03-16 |
HK1141552A1 (zh) | 2010-11-12 |
EP1412481B1 (en) | 2015-04-01 |
GB0400481D0 (en) | 2004-02-11 |
WO2003004605A2 (en) | 2003-01-16 |
CA2453068C (en) | 2018-02-20 |
CA2453068A1 (en) | 2003-01-16 |
GB2392674A (en) | 2004-03-10 |
IL159578A (en) | 2010-11-30 |
US20030021771A1 (en) | 2003-01-30 |
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