CN101687746A - 治疗性组合物 - Google Patents

治疗性组合物 Download PDF

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Publication number
CN101687746A
CN101687746A CN200880015398A CN200880015398A CN101687746A CN 101687746 A CN101687746 A CN 101687746A CN 200880015398 A CN200880015398 A CN 200880015398A CN 200880015398 A CN200880015398 A CN 200880015398A CN 101687746 A CN101687746 A CN 101687746A
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China
Prior art keywords
formula
compound
propofol
sec
butyl
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Pending
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CN200880015398A
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English (en)
Chinese (zh)
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T·E·詹金斯
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Signature Therapeutics Inc
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Pharmacofore Inc
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/06—Alkylated phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/045—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis by substitution of a group bound to the ring by nitrogen
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
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  • Otolaryngology (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200880015398A 2007-05-09 2008-05-08 治疗性组合物 Pending CN101687746A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92834507P 2007-05-09 2007-05-09
US92841607P 2007-05-09 2007-05-09
US60/928,416 2007-05-09
US60/928,345 2007-05-09
PCT/US2008/063088 WO2008141099A1 (en) 2007-05-09 2008-05-08 Therapeutic compounds

Publications (1)

Publication Number Publication Date
CN101687746A true CN101687746A (zh) 2010-03-31

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CN200880015398A Pending CN101687746A (zh) 2007-05-09 2008-05-08 治疗性组合物

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US (3) US8173849B2 (enExample)
EP (2) EP2392559A1 (enExample)
JP (1) JP2010526827A (enExample)
KR (1) KR20100017435A (enExample)
CN (1) CN101687746A (enExample)
AT (1) ATE540010T1 (enExample)
AU (1) AU2008251484A1 (enExample)
BR (1) BRPI0811284A2 (enExample)
CA (1) CA2685813A1 (enExample)
DK (1) DK2152651T3 (enExample)
ES (1) ES2380824T3 (enExample)
IL (1) IL201735A0 (enExample)
MX (1) MX2009012125A (enExample)
MY (1) MY147215A (enExample)
RU (1) RU2470907C2 (enExample)
WO (1) WO2008141099A1 (enExample)
ZA (1) ZA201007602B (enExample)

Cited By (8)

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CN102085185A (zh) * 2010-12-07 2011-06-08 西安力邦制药有限公司 无痛和低注射刺激的新型丙泊酚脂肪乳制剂配方和制备方法
CN102603488A (zh) * 2012-03-06 2012-07-25 陈艳明 一种制备高纯度丙泊酚的新方法
CN102731265A (zh) * 2012-06-12 2012-10-17 四川百利药业有限责任公司 一种高纯度丙泊酚的制备方法
CN104649867A (zh) * 2013-11-21 2015-05-27 辽宁药联制药有限公司 一种丙泊酚的制备方法
CN105384607A (zh) * 2014-08-22 2016-03-09 四川海思科制药有限公司 一种异丙基苯酚衍生物及其制备方法
CN105384604A (zh) * 2014-08-22 2016-03-09 四川海思科制药有限公司 一种异丙基苯酚衍生物及其制备方法
CN105384608A (zh) * 2014-08-22 2016-03-09 四川海思科制药有限公司 一种异丙基苯酚衍生物及其制备方法
CN105820040B (zh) * 2015-01-22 2018-07-24 四川海思科制药有限公司 一种异丙基苯酚衍生物及其制备方法

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DK2301908T3 (da) 2007-05-09 2014-09-15 Sowood Healthcare Llc (-)-stereoisomer af 2,6-di-sec-butylphenol og analoger dertil til frembringelse af en antiemetisk effekt, behandling af kvalme og opkastning og behandling af migræne
US20120283335A1 (en) * 2008-05-12 2012-11-08 Jenkins Thomas E Analogs of Propofol, Preparation Thereof and Use as Anesthetics
CN104768918B (zh) * 2012-11-02 2017-03-08 住友化学株式会社 化合物的外消旋体的制造方法
EP3189834B1 (en) * 2014-09-04 2024-01-17 Haisco Innovative Pharmaceutical PTE. LTD. Use of gabaa receptor reinforcing agent in preparation of sedative and anesthetic medicament
CN106278947B (zh) * 2015-05-19 2020-03-06 四川海思科制药有限公司 苯酚衍生物的晶型及其制备方法

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JP2010526827A (ja) 2010-08-05
US8350097B2 (en) 2013-01-08
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AU2008251484A1 (en) 2008-11-20
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US8173849B2 (en) 2012-05-08
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EP2392559A1 (en) 2011-12-07
IL201735A0 (en) 2010-06-16
HK1138830A1 (en) 2010-09-03
RU2009145541A (ru) 2011-06-20
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US20130217783A1 (en) 2013-08-22

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