CN101677942B - 阿帕兹醌在制造切除膀胱肿瘤后治疗膀胱癌的药物的用途 - Google Patents

阿帕兹醌在制造切除膀胱肿瘤后治疗膀胱癌的药物的用途 Download PDF

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Publication number
CN101677942B
CN101677942B CN2008800159754A CN200880015975A CN101677942B CN 101677942 B CN101677942 B CN 101677942B CN 2008800159754 A CN2008800159754 A CN 2008800159754A CN 200880015975 A CN200880015975 A CN 200880015975A CN 101677942 B CN101677942 B CN 101677942B
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CN
China
Prior art keywords
bladder
tur
patients
use according
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN2008800159754A
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English (en)
Chinese (zh)
Other versions
CN101677942A (zh
Inventor
路吉·莱纳兹
尚塔·乔拉
马里奥·比尔
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Spectrum Pharmaceuticals Inc
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Spectrum Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2008800159754A 2007-03-13 2008-03-13 阿帕兹醌在制造切除膀胱肿瘤后治疗膀胱癌的药物的用途 Expired - Fee Related CN101677942B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89461007P 2007-03-13 2007-03-13
US60/894,610 2007-03-13
PCT/US2008/056912 WO2008112934A1 (en) 2007-03-13 2008-03-13 Intravesical apaziquone administration following transurethral resection for treating cancer

Publications (2)

Publication Number Publication Date
CN101677942A CN101677942A (zh) 2010-03-24
CN101677942B true CN101677942B (zh) 2013-10-30

Family

ID=39494173

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008800159754A Expired - Fee Related CN101677942B (zh) 2007-03-13 2008-03-13 阿帕兹醌在制造切除膀胱肿瘤后治疗膀胱癌的药物的用途

Country Status (17)

Country Link
US (1) US20080227841A1 (enExample)
EP (1) EP2134322B1 (enExample)
JP (2) JP5788143B2 (enExample)
KR (1) KR20090128479A (enExample)
CN (1) CN101677942B (enExample)
AR (1) AR065732A1 (enExample)
AU (1) AU2008224962B2 (enExample)
BR (1) BRPI0808804A2 (enExample)
CA (1) CA2680481C (enExample)
ES (1) ES2727257T3 (enExample)
IL (1) IL200899A0 (enExample)
MX (1) MX2009009777A (enExample)
NZ (1) NZ579609A (enExample)
RU (2) RU2480200C2 (enExample)
TW (1) TWI434684B (enExample)
WO (1) WO2008112934A1 (enExample)
ZA (1) ZA200906328B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201213486D0 (en) * 2012-07-30 2012-09-12 Univ Salford The Quinone compounds and their uses for the treatment of cancer
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2178305C1 (ru) * 2000-11-02 2002-01-20 Гарбер Александр Григорьевич Ирригационный раствор
ATE493126T1 (de) * 2001-11-01 2011-01-15 Spectrum Pharmaceuticals Inc Medizinische zusammensetzungen zur intravesikalen behandlung von blasenkrebs
RU2002121829A (ru) * 2002-08-07 2004-02-27 Сгму Способ лечения местнораспространенных форм рака мочевого пузыря

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Phase Ⅰ/Ⅱ pilot study of intravesical apaziquone (E09) for superficial bladder cancer;PURI ET AL;《JOURNAL OF UROLOGY》;20061001;第176卷(第4期);文章摘要，第1347页 *

Also Published As

Publication number Publication date
EP2134322A1 (en) 2009-12-23
CN101677942A (zh) 2010-03-24
TW200904410A (en) 2009-02-01
US20080227841A1 (en) 2008-09-18
CA2680481C (en) 2016-06-21
NZ579609A (en) 2012-01-12
CA2680481A1 (en) 2008-09-18
WO2008112934A1 (en) 2008-09-18
AU2008224962B2 (en) 2013-07-25
ES2727257T3 (es) 2019-10-15
BRPI0808804A2 (pt) 2014-08-19
MX2009009777A (es) 2009-11-26
AU2008224962A1 (en) 2008-09-18
JP2014028841A (ja) 2014-02-13
ZA200906328B (en) 2010-05-26
RU2480200C2 (ru) 2013-04-27
RU2012157329A (ru) 2014-07-10
EP2134322B1 (en) 2019-02-20
RU2623142C2 (ru) 2017-06-22
JP5788143B2 (ja) 2015-09-30
JP2010521488A (ja) 2010-06-24
KR20090128479A (ko) 2009-12-15
TWI434684B (zh) 2014-04-21
AR065732A1 (es) 2009-06-24
IL200899A0 (en) 2010-05-17
RU2009137770A (ru) 2011-04-20

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Granted publication date: 20131030

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