CN101677569B - 2-氰基苯基稠合杂环化合物及其组合物和用途 - Google Patents

2-氰基苯基稠合杂环化合物及其组合物和用途 Download PDF

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Publication number
CN101677569B
CN101677569B CN200880016706.XA CN200880016706A CN101677569B CN 101677569 B CN101677569 B CN 101677569B CN 200880016706 A CN200880016706 A CN 200880016706A CN 101677569 B CN101677569 B CN 101677569B
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pyrimidin
benzonitrile
pyrido
dihydro
methyl
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CN101677569A (zh
Inventor
魏志良
M·A·J·当克藤
J·金凯德
M·G·凯利
D·奥马赫尼
王展
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Evotec GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
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  • Hematology (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880016706.XA 2007-04-17 2008-03-31 2-氰基苯基稠合杂环化合物及其组合物和用途 Expired - Fee Related CN101677569B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92510907P 2007-04-17 2007-04-17
US60/925,109 2007-04-17
US1051208P 2008-01-08 2008-01-08
US61/010,512 2008-01-08
PCT/US2008/004208 WO2008130481A1 (en) 2007-04-17 2008-03-31 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof

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CN101677569A CN101677569A (zh) 2010-03-24
CN101677569B true CN101677569B (zh) 2014-01-22

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US (2) US8076345B2 (enExample)
EP (1) EP2139334B1 (enExample)
JP (1) JP5498374B2 (enExample)
CN (1) CN101677569B (enExample)
CA (1) CA2682692A1 (enExample)
CY (1) CY1114382T1 (enExample)
DK (1) DK2139334T3 (enExample)
ES (1) ES2427999T3 (enExample)
HR (1) HRP20130867T1 (enExample)
PL (1) PL2139334T3 (enExample)
PT (1) PT2139334E (enExample)
WO (1) WO2008130481A1 (enExample)

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AU2014253493B2 (en) * 2010-07-06 2016-04-14 Novartis Ag Tetrahydro-pyrido-pyrimidine derivatives
UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
AU2012277391A1 (en) * 2011-06-27 2013-12-19 Novartis Ag Solid forms and salts of tetrahydro-pyrido-pyrimidine derivatives
DK2790705T3 (en) 2011-12-15 2018-03-12 Novartis Ag Use of inhibitors of the activity or function of PI3K
CN103497149A (zh) * 2013-10-08 2014-01-08 南京复兴生物科技有限公司 一种5-氨甲基吡啶衍生物的制备方法
RS63014B1 (sr) 2014-12-09 2022-04-29 Bayer Ag 1,3-tiazol-2-il supstituisani benzamidi
US10183937B2 (en) 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
WO2017049498A1 (zh) * 2015-09-23 2017-03-30 前湾医药科技（深圳）有限公司 一种咪唑并吡啶类化合物与在制备pi3k抑制剂中的应用
KR20210146288A (ko) * 2019-03-01 2021-12-03 레볼루션 메디슨즈, 인크. 이환식 헤테로사이클릴 화합물 및 이의 용도
BR112021022099A2 (pt) 2019-05-31 2021-12-28 Chiesi Farm Spa Derivados de amino quinazolina como inibidores de p2x3
BR112021020279A2 (pt) 2019-05-31 2021-12-14 Chiesi Farm Spa Derivados de piridopirimidinas como inibidores de p2x3
WO2022028506A1 (zh) * 2020-08-06 2022-02-10 北京泰德制药股份有限公司 Sos1抑制剂、包含其的药物组合物及其用途
AU2021388923A1 (en) 2020-11-27 2023-05-25 Chiesi Farmaceutici S.P.A. Amino quinazoline derivatives as p2x3 inhibitors
ES3023558T3 (en) 2020-11-27 2025-06-02 Chiesi Farm Spa Phthalazine derivatives as p2x3 inhibitors
ES3026782T3 (en) 2020-11-27 2025-06-12 Chiesi Farm Spa (aza)quinoline 4-amines derivatives as p2x3 inhibitors
AU2023406476A1 (en) 2022-12-02 2025-06-05 Neumora Therapeutics, Inc. Methods of treating neurological disorders

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EP2139334B1 (en) 2013-07-03
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EP2139334A4 (en) 2011-06-22
US20080275037A1 (en) 2008-11-06
HRP20130867T1 (hr) 2013-10-25
DK2139334T3 (da) 2013-09-23
JP5498374B2 (ja) 2014-05-21
US20120149700A1 (en) 2012-06-14
CY1114382T1 (el) 2016-08-31
JP2010524930A (ja) 2010-07-22
WO2008130481A1 (en) 2008-10-30
EP2139334A1 (en) 2010-01-06
ES2427999T3 (es) 2013-11-05
PL2139334T3 (pl) 2013-11-29
US8076345B2 (en) 2011-12-13
CN101677569A (zh) 2010-03-24

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