CN101677569B - 2-氰基苯基稠合杂环化合物及其组合物和用途 - Google Patents

2-氰基苯基稠合杂环化合物及其组合物和用途 Download PDF

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Publication number
CN101677569B
CN101677569B CN200880016706.XA CN200880016706A CN101677569B CN 101677569 B CN101677569 B CN 101677569B CN 200880016706 A CN200880016706 A CN 200880016706A CN 101677569 B CN101677569 B CN 101677569B
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pyrimidin
benzonitrile
pyrido
dihydro
methyl
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CN101677569A (zh
Inventor
魏志良
M·A·J·当克藤
J·金凯德
M·G·凯利
D·奥马赫尼
王展
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Evotec GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Neurology (AREA)
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  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880016706.XA 2007-04-17 2008-03-31 2-氰基苯基稠合杂环化合物及其组合物和用途 Expired - Fee Related CN101677569B (zh)

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US92510907P 2007-04-17 2007-04-17
US60/925,109 2007-04-17
US1051208P 2008-01-08 2008-01-08
US61/010,512 2008-01-08
PCT/US2008/004208 WO2008130481A1 (en) 2007-04-17 2008-03-31 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof

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CN101677569A CN101677569A (zh) 2010-03-24
CN101677569B true CN101677569B (zh) 2014-01-22

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EP (1) EP2139334B1 (cg-RX-API-DMAC7.html)
JP (1) JP5498374B2 (cg-RX-API-DMAC7.html)
CN (1) CN101677569B (cg-RX-API-DMAC7.html)
CA (1) CA2682692A1 (cg-RX-API-DMAC7.html)
CY (1) CY1114382T1 (cg-RX-API-DMAC7.html)
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ES (1) ES2427999T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20130867T1 (cg-RX-API-DMAC7.html)
PL (1) PL2139334T3 (cg-RX-API-DMAC7.html)
PT (1) PT2139334E (cg-RX-API-DMAC7.html)
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PH12013502524A1 (en) * 2011-06-27 2014-01-27 Novartis Ag Solid forms and salts of tetrahydro-pyrido-pyrimidine derivatives
EA029473B1 (ru) 2011-12-15 2018-03-30 Новартис Аг Применение ингибиторов pi3k для лечения острой и церебральной малярии
CN103497149A (zh) * 2013-10-08 2014-01-08 南京复兴生物科技有限公司 一种5-氨甲基吡啶衍生物的制备方法
CR20170242A (es) 2014-12-09 2018-02-02 Bayer Ag Benzamidas sustituidas copn 1,3-tiazol-2-ilo
US10183937B2 (en) 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
WO2017049498A1 (zh) * 2015-09-23 2017-03-30 前湾医药科技（深圳）有限公司 一种咪唑并吡啶类化合物与在制备pi3k抑制剂中的应用
AU2020232616A1 (en) * 2019-03-01 2021-09-09 Revolution Medicines, Inc. Bicyclic heterocyclyl compounds and uses thereof
BR112021020279A2 (pt) 2019-05-31 2021-12-14 Chiesi Farm Spa Derivados de piridopirimidinas como inibidores de p2x3
BR112021022099A2 (pt) 2019-05-31 2021-12-28 Chiesi Farm Spa Derivados de amino quinazolina como inibidores de p2x3
WO2022028506A1 (zh) * 2020-08-06 2022-02-10 北京泰德制药股份有限公司 Sos1抑制剂、包含其的药物组合物及其用途
CN116601149A (zh) 2020-11-27 2023-08-15 奇斯药制品公司 作为p2x3抑制剂的氨基喹唑啉衍生物
ES3023558T3 (en) 2020-11-27 2025-06-02 Chiesi Farm Spa Phthalazine derivatives as p2x3 inhibitors
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EP2139334B1 (en) 2013-07-03
US20120149700A1 (en) 2012-06-14
ES2427999T3 (es) 2013-11-05
HRP20130867T1 (hr) 2013-10-25
US8076345B2 (en) 2011-12-13
EP2139334A4 (en) 2011-06-22
JP5498374B2 (ja) 2014-05-21
US20080275037A1 (en) 2008-11-06
JP2010524930A (ja) 2010-07-22
WO2008130481A1 (en) 2008-10-30
CA2682692A1 (en) 2008-10-30
PL2139334T3 (pl) 2013-11-29
DK2139334T3 (da) 2013-09-23
CY1114382T1 (el) 2016-08-31
CN101677569A (zh) 2010-03-24
EP2139334A1 (en) 2010-01-06

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