CN101677553A - 苯并咪唑及其药物组合物 - Google Patents

苯并咪唑及其药物组合物 Download PDF

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Publication number
CN101677553A
CN101677553A CN200880021064A CN200880021064A CN101677553A CN 101677553 A CN101677553 A CN 101677553A CN 200880021064 A CN200880021064 A CN 200880021064A CN 200880021064 A CN200880021064 A CN 200880021064A CN 101677553 A CN101677553 A CN 101677553A
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CN
China
Prior art keywords
aryl
ring
alkyl
expression
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880021064A
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English (en)
Chinese (zh)
Inventor
伊瓦奥·奥吉马
李昇烨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Publication of CN101677553A publication Critical patent/CN101677553A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880021064A 2007-04-20 2008-04-21 苯并咪唑及其药物组合物 Pending CN101677553A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91298007P 2007-04-20 2007-04-20
US60/912,980 2007-04-20
PCT/US2008/005084 WO2008130669A1 (en) 2007-04-20 2008-04-21 Benzimidazoles and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
CN101677553A true CN101677553A (zh) 2010-03-24

Family

ID=39875833

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880021064A Pending CN101677553A (zh) 2007-04-20 2008-04-21 苯并咪唑及其药物组合物

Country Status (17)

Country Link
US (1) US8232410B2 (cg-RX-API-DMAC10.html)
EP (1) EP2154966B1 (cg-RX-API-DMAC10.html)
JP (1) JP5400032B2 (cg-RX-API-DMAC10.html)
CN (1) CN101677553A (cg-RX-API-DMAC10.html)
AU (1) AU2008242488B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0810244A2 (cg-RX-API-DMAC10.html)
CA (1) CA2684594C (cg-RX-API-DMAC10.html)
DK (1) DK2154966T3 (cg-RX-API-DMAC10.html)
EA (1) EA016726B1 (cg-RX-API-DMAC10.html)
ES (1) ES2434693T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20131103T1 (cg-RX-API-DMAC10.html)
IN (1) IN2009KN03959A (cg-RX-API-DMAC10.html)
MX (1) MX2009011281A (cg-RX-API-DMAC10.html)
PL (1) PL2154966T3 (cg-RX-API-DMAC10.html)
PT (1) PT2154966E (cg-RX-API-DMAC10.html)
SI (1) SI2154966T1 (cg-RX-API-DMAC10.html)
WO (1) WO2008130669A1 (cg-RX-API-DMAC10.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103333170A (zh) * 2013-06-14 2013-10-02 清华大学 苯并咪唑类化合物及其用途
CN104395288A (zh) * 2012-04-12 2015-03-04 乔治城大学 用于治疗尤文肉瘤家族肿瘤的方法和组合物
CN106061951A (zh) * 2013-11-22 2016-10-26 纽约州立大学研究基金会 苯并咪唑及其在结核病治疗中的用途

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8232310B2 (en) 2006-12-29 2012-07-31 Georgetown University Targeting of EWS-FLI1 as anti-tumor therapy
US8039502B2 (en) 2007-07-24 2011-10-18 The Ohio State University Research Foundation Anti-infective agents against intracellular pathogens
US20120108823A1 (en) 2009-04-22 2012-05-03 The Ohio State University Research Foundation Anti-francisella agents
WO2011029920A1 (en) * 2009-09-11 2011-03-17 Probiodrug Ag Heterocylcic derivatives as inhibitors of glutaminyl cyclase
WO2013116823A1 (en) * 2012-02-02 2013-08-08 The Research Foundation Of State University Of New York Benzimidazoles and uses thereof
WO2013142326A1 (en) * 2012-03-23 2013-09-26 The Research Foundation Of State University Of New York 5-carbonylamino-/(sulfonamido-) substituted benz imidazoles and use thereof treatment of tuberculosis
CA2927148A1 (en) 2013-10-24 2015-04-30 Georgetown University Methods and compositions for treating cancer
WO2015138611A2 (en) 2014-03-11 2015-09-17 Colorado State University Research Foundation Methods for improved in vitro-in vivo efficacy determination
EP3157904B1 (en) * 2014-06-20 2020-11-18 Institut Pasteur Korea Anti-infective compounds
CN107108580B (zh) 2014-10-09 2020-06-30 英克特诺治疗公司 吲哚酮化合物及其用途
DK3436434T3 (da) 2016-03-31 2020-09-21 Oncternal Therapeutics Inc Indolin-analoger og anvendelser deraf
MX395539B (es) 2016-07-29 2025-03-25 Oncternal Therapeutics Inc Usos de compuestos de indolinona
CN111303092B (zh) * 2020-04-07 2021-05-25 山东昌邑灶户盐化有限公司 2,4-二硝基-6-氯苯胺衍生物、合成方法及其应用
KR20240035820A (ko) 2021-07-09 2024-03-18 플렉시움 인코포레이티드 Ikzf2를 조절하는 아릴 화합물 및 약학 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61170732A (ja) * 1985-01-25 1986-08-01 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US7405235B2 (en) 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
EP1805147B1 (en) * 2004-09-30 2014-08-13 Janssen Pharmaceutica NV Novel benzimidazole derivatives useful as selective androgen receptor modulators (sarms)
EP2008210A1 (en) 2006-03-15 2008-12-31 Csir Modulation of phosphoryl transferase activity of glutamine synthetase

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104395288A (zh) * 2012-04-12 2015-03-04 乔治城大学 用于治疗尤文肉瘤家族肿瘤的方法和组合物
CN104395288B (zh) * 2012-04-12 2016-12-14 乔治城大学 用于治疗尤文肉瘤家族肿瘤的方法和组合物
CN107011242A (zh) * 2012-04-12 2017-08-04 乔治城大学 用于治疗尤文肉瘤家族肿瘤的方法和组合物
CN107011242B (zh) * 2012-04-12 2020-08-07 乔治城大学 用于治疗尤文肉瘤家族肿瘤的方法和组合物
CN103333170A (zh) * 2013-06-14 2013-10-02 清华大学 苯并咪唑类化合物及其用途
CN103333170B (zh) * 2013-06-14 2016-08-10 清华大学 苯并咪唑类化合物及其用途
CN106061951A (zh) * 2013-11-22 2016-10-26 纽约州立大学研究基金会 苯并咪唑及其在结核病治疗中的用途

Also Published As

Publication number Publication date
PT2154966E (pt) 2013-11-13
PL2154966T3 (pl) 2014-03-31
IN2009KN03959A (cg-RX-API-DMAC10.html) 2015-08-28
US8232410B2 (en) 2012-07-31
CA2684594A1 (en) 2008-10-30
US20100256203A1 (en) 2010-10-07
JP5400032B2 (ja) 2014-01-29
AU2008242488A1 (en) 2008-10-30
EA016726B1 (ru) 2012-07-30
AU2008242488B2 (en) 2014-10-30
ES2434693T3 (es) 2013-12-17
EP2154966A4 (en) 2010-12-15
JP2010524947A (ja) 2010-07-22
HRP20131103T1 (hr) 2013-12-20
EA200901423A1 (ru) 2010-06-30
WO2008130669A1 (en) 2008-10-30
MX2009011281A (es) 2010-03-08
BRPI0810244A2 (pt) 2014-09-30
SI2154966T1 (sl) 2014-02-28
DK2154966T3 (da) 2013-11-18
CA2684594C (en) 2015-10-06
EP2154966A1 (en) 2010-02-24
EP2154966B1 (en) 2013-08-21

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