CN101674823A - 用于与增强的5-脂氧合酶和/或白三烯活性有关的疾病(例如哮喘)的r-齐留通 - Google Patents
用于与增强的5-脂氧合酶和/或白三烯活性有关的疾病(例如哮喘)的r-齐留通 Download PDFInfo
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- CN101674823A CN101674823A CN200880004777A CN200880004777A CN101674823A CN 101674823 A CN101674823 A CN 101674823A CN 200880004777 A CN200880004777 A CN 200880004777A CN 200880004777 A CN200880004777 A CN 200880004777A CN 101674823 A CN101674823 A CN 101674823A
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- zileuton
- daily dose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87927307P | 2007-01-05 | 2007-01-05 | |
| US60/879,273 | 2007-01-05 | ||
| PCT/US2008/000101 WO2008085875A2 (en) | 2007-01-05 | 2008-01-04 | R-zileuton for use in conditions associated with increased 5-lipoxygenase and/or leukotriene activity (eg asthma) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101674823A true CN101674823A (zh) | 2010-03-17 |
Family
ID=39339861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880004777A Pending CN101674823A (zh) | 2007-01-05 | 2008-01-04 | 用于与增强的5-脂氧合酶和/或白三烯活性有关的疾病(例如哮喘)的r-齐留通 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100273868A1 (enExample) |
| EP (1) | EP2114399A2 (enExample) |
| JP (1) | JP2010515682A (enExample) |
| CN (1) | CN101674823A (enExample) |
| CA (1) | CA2674492A1 (enExample) |
| MX (1) | MX2009007247A (enExample) |
| WO (1) | WO2008085875A2 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829075A (zh) * | 2010-04-27 | 2010-09-15 | 中国人民解放军第三军医大学第一附属医院 | 苦柯胺a和苦柯胺b的用途 |
| CN102274213A (zh) * | 2010-06-10 | 2011-12-14 | 北京润德康医药技术有限公司 | 含有r(+)-齐留通的药用组合物 |
| CN102429872A (zh) * | 2011-11-25 | 2012-05-02 | 舒泰神(北京)生物制药股份有限公司 | 含齐留通的膜控型缓释微丸及其制备方法 |
| CN116528901A (zh) * | 2020-12-01 | 2023-08-01 | 瑞沃斯帕有限责任公司 | 用于治疗慢性阻塞性肺病、哮喘、肺炎、支气管炎、囊性纤维化和肺水肿的方法和组合物 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120232031A1 (en) * | 2009-10-19 | 2012-09-13 | Panmira Pharmaceuticals, Llc | Injectable formulations for intra-articular or peri-articular administration |
| EP2563359A1 (en) | 2010-04-30 | 2013-03-06 | Allergan, Inc. | Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase |
| ES2624710T3 (es) * | 2011-08-23 | 2017-07-17 | Cornerstone Therapeutics Inc. | Uso de zileutón en el tratamiento de pólipos nasales en pacientes con fibrosis quística |
| GB201118193D0 (en) * | 2011-10-21 | 2011-12-07 | Jagotec Ag | Improvements in or relating to oranic compounds |
| GB201118198D0 (en) * | 2011-10-21 | 2011-12-07 | Jagotec Ag | Improvements in or relating to organic compounds |
| WO2016062277A1 (zh) * | 2014-10-24 | 2016-04-28 | 朗齐生物医学股份有限公司 | 驱虫药用于制备抗癌医药组合物中的应用 |
| CN107847468A (zh) * | 2015-05-26 | 2018-03-27 | 纪念斯隆·凯特琳癌症中心 | 铁死亡和谷氨酰胺分解抑制剂及其治疗方法 |
| WO2024044654A2 (en) * | 2022-08-23 | 2024-02-29 | University Of Houston System | Parenteral compositions of zileuton and methods of use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08510252A (ja) * | 1993-05-10 | 1996-10-29 | セプラコール・インコーポレーテッド | 光学的に純粋な(+)‐ジロイトンを用いた方法および組成 |
| AU2007217770B2 (en) * | 2006-02-21 | 2011-09-08 | Cornerstone Therapeutics Inc. | New crystal forms and pharmaceutical compositions of (+) -R-zileuton |
-
2008
- 2008-01-04 WO PCT/US2008/000101 patent/WO2008085875A2/en not_active Ceased
- 2008-01-04 CN CN200880004777A patent/CN101674823A/zh active Pending
- 2008-01-04 US US12/521,965 patent/US20100273868A1/en not_active Abandoned
- 2008-01-04 MX MX2009007247A patent/MX2009007247A/es active IP Right Grant
- 2008-01-04 JP JP2009544925A patent/JP2010515682A/ja active Pending
- 2008-01-04 CA CA002674492A patent/CA2674492A1/en not_active Abandoned
- 2008-01-04 EP EP08712975A patent/EP2114399A2/en not_active Ceased
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829075A (zh) * | 2010-04-27 | 2010-09-15 | 中国人民解放军第三军医大学第一附属医院 | 苦柯胺a和苦柯胺b的用途 |
| CN101829075B (zh) * | 2010-04-27 | 2011-07-20 | 中国人民解放军第三军医大学第一附属医院 | 苦柯胺a和苦柯胺b的用途 |
| CN102274213A (zh) * | 2010-06-10 | 2011-12-14 | 北京润德康医药技术有限公司 | 含有r(+)-齐留通的药用组合物 |
| CN102429872A (zh) * | 2011-11-25 | 2012-05-02 | 舒泰神(北京)生物制药股份有限公司 | 含齐留通的膜控型缓释微丸及其制备方法 |
| CN116528901A (zh) * | 2020-12-01 | 2023-08-01 | 瑞沃斯帕有限责任公司 | 用于治疗慢性阻塞性肺病、哮喘、肺炎、支气管炎、囊性纤维化和肺水肿的方法和组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008085875A3 (en) | 2009-02-26 |
| MX2009007247A (es) | 2009-09-18 |
| JP2010515682A (ja) | 2010-05-13 |
| CA2674492A1 (en) | 2008-07-17 |
| EP2114399A2 (en) | 2009-11-11 |
| US20100273868A1 (en) | 2010-10-28 |
| WO2008085875A2 (en) | 2008-07-17 |
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