CN101669496A - Bifenazate and milbemectin miticide composition and application thereof - Google Patents
Bifenazate and milbemectin miticide composition and application thereof Download PDFInfo
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- CN101669496A CN101669496A CN 200910206543 CN200910206543A CN101669496A CN 101669496 A CN101669496 A CN 101669496A CN 200910206543 CN200910206543 CN 200910206543 CN 200910206543 A CN200910206543 A CN 200910206543A CN 101669496 A CN101669496 A CN 101669496A
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- bifenazate
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Abstract
The invention relates to a bifenazate and milbemectin-containing miticide composition and application thereof. The miticidal composition mainly contains bifenazate and milbemectin and is added with anadjuvant and an excipient to be prepared into micellar emulsion, wettable powder, suspension, aqueous emulsion or missible oil. A mass ratio of the bifenazate to the milbemectin is 200:1-1:500. The miticide composition has very excellent synergic action, can prevent and inhibit pest from becoming drug-fast and prolong service life of pesticide varieties. The composition is applicable to controlling various harmful mites on economic crops, oil crops and cereal crops, especially suitable for controlling tetrangchus urticae koch, panonychus, carminespider mite, truncate leaf mite, yellow tea mite and rust mite, and has obviously higher effect than separate use of two miticides.
Description
Technical field
The present invention relates to a kind of miticide composition and uses thereof, being specifically related to a kind of is the miticide composition and the application thereof of main active with Bifenazate and Mi Bai rhzomorph.
Background technology
The mite evil takes place from generation to generation many, and fertility is strong, and under suitable temperature and humidity conditions, evil mite quantity can increase rapidly within a short period of time exponentially, and miticide is easily developed immunity to drugs, and causes serious harm to crops such as fruit trees.Tetranychus urticae is that harm is big in the orchard in recent years, pesticide resistance is strong, one of harmful mite of difficult control.
Bifenazate (Bifenazate) is a biphenyl hydrazine class miticide, is a kind of γ-An Jidingsuan (GABA) antagonist, but further result of study has not yet to see report.Be mainly used in the control tetranychid, predatism benefit mite is not had negative effect; Low to mammalian toxicity.
More visiing rhzomorph (Milbemectin) and belong to a class together with Avermectin, is the GABA antagonist.More visiing rhzomorph is that the seventies in 20th century is by Japan three company's discovery altogether, commercialization in 1991.More visit rhzomorph and have widely mite spectrum extremely, all effective to all vegetative stages of phytophagy evil mite.
Development, promote the use of efficient, environmental protection, the complex preparation of synergistic effect is arranged, help to prevent and overcome harmful mite to develop immunity to drugs, help environmental protection.
Summary of the invention
The object of the present invention is to provide a kind of synergistic composition and application thereof that contains Bifenazate and Mi Bai rhzomorph.
The present invention be a kind of be the miticide composition and the application thereof of main active with Bifenazate and Mi Bai rhzomorph, it is characterized in that effective ingredient is made up of Bifenazate and Mi Bai rhzomorph, its ratio of quality and the number of copies is 200: 1～1: 50, is preferably 50: 1～1: 20.Described active ingredient is present in the composition with the synergy effective dose, and the better mass fraction that the better mass fraction of effective ingredient Bifenazate is 1%～50%, more visit rhzomorph is 0.1%～10%, and all the other are insecticides adjuvant and excipients (or filler).
The present invention is the mite synergistic composition extremely of main active with Bifenazate and Mi Bai rhzomorph, can prevent and treat the various harmful mite on economic crops, oil crop and the cereal crops.Described harmful mite comprises Panonychus citri, Tetranychus urticae, Tetranychus cinnabarinus, truncate leaf mite, yellow tea mite, rust mite.
The present invention is mixed with microemulsion, wetting powder, water dispersible granules, suspending agent, aqueous emulsion or missible oil based on active ingredient Bifenazate and Mi Bai rhzomorph with insecticides adjuvant, excipients (or filler).
After the invention has the advantages that Bifenazate and Mi Bai rhzomorph are mixed, synergistic effect is arranged, improved control efficiency, and prolonged the medicament lasting period; Mixed Pharmacy can prevent and overcome the pest mite class and develop immunity to drugs, and prolongs the service life of pesticide species.
Embodiment
The inventor is by a large amount of indoor formulation screening tests, and discovery Bifenazate and Mi Bai rhzomorph are mixed Tetranychus urticae, citrus red mite are had synergistic function, and field test results shows that also the effect of mixture preparation is better than the use of single agent.
In order better to understand essence of an invention, below in conjunction with example technology contents of the present invention is done detailed explanation, but content of the present invention do not limit to so, can not therefore be interpreted as restriction to claim of the present invention.In the embodiment of the invention in the used former medicine of Bifenazate Bifenazate content be 97%, rhzomorph content is more visitd in used more visiing in the former medicine of rhzomorph be 90%.
Embodiment 1:
Preparation 100g 20% Bifenazate is more visitd rhzomorph microemulsion (Bifenazate: more visiing rhzomorph is 19: 1), and the mass ratio of each component is respectively:
The former medicine 19.60g of Bifenazate more visits the former medicine 1.12g of rhzomorph
The newborn 600#10g dimethylbenzene 20g of farming
Epoxychloropropane 5g sorbic acid 0.5g
The surplus deionized water
Above raw material is prepared microemulsion method input routinely mix, fully stirring makes 100g 20% Bifenazate and more visits the rhzomorph microemulsion.
Embodiment 2:
Preparation 100g 10% Bifenazate is more visitd rhzomorph (Bifenazate: more visiing rhzomorph is 9: 1) microemulsion, and the mass ratio of each component is respectively:
The former medicine 9.28g of Bifenazate more visits the former medicine 1.12g of rhzomorph
The newborn 600#10g dimethylbenzene 20g of farming
Epoxychloropropane 5g propane diols 0.5g
The surplus deionized water
Above raw material is prepared microemulsion method input routinely mix, fully stirring makes 100g 10% Bifenazate and more visits the rhzomorph microemulsion.
Embodiment 3:
Preparation 100g 50% Bifenazate is more visitd rhzomorph (Bifenazate: more visiing rhzomorph is 49: 1) wetting powder, and the mass ratio of each component is respectively:
The former medicine 50.52g of Bifenazate more visits the former medicine 1.12g of rhzomorph
The withered powder 16g of tea polyvinyl alcohol 10g
Surplus diatomite
Above raw material is prepared wettable powder agent method input routinely mix, in mixture input air flow cracker, be crushed to and meet fineness requirement, make 100g 50% Bifenazate that meets quality standard and more visit the rhzomorph wetting powder.
Embodiment 4:
Preparation 100g 40.2% Bifenazate is more visitd rhzomorph (Bifenazate: more visiing rhzomorph is 200: 1) wetting powder, and the mass ratio of each component is respectively:
The former medicine 41.25g of Bifenazate more visits the former medicine 0.23g of rhzomorph
Draw withered powder 10g polyvinyl alcohol 8g
Surplus diatomite
Above raw material is prepared wettable powder agent method input routinely mix, in mixture input air flow cracker, be crushed to and meet fineness requirement, make 100g 40.2% Bifenazate that meets quality standard and more visit the rhzomorph wetting powder.
Embodiment 5:
Preparation 100g 25.5% Bifenazate is more visitd rhzomorph (Bifenazate: more visiing rhzomorph is 1: 50) water dispersible granules, and the mass ratio of each component is respectively:
The former medicine 0.52g of Bifenazate more visits the former medicine 27.78g of rhzomorph
The withered powder 10g of tea lignosulfonates 9g
Polyvinyl alcohol 8g bentonite 10g
Surplus diatomite
Above-mentioned raw materials is disposed the slurry that the water-dispersible grain agent method makes spraying usefulness routinely, slurry is quantitatively sent to carried out atomized drying in the drying tower, make 100g 25.5% Bifenazate and more visit the rhzomorph water dispersible granules.
Embodiment 6:
Preparation 100g 40% Bifenazate is more visitd rhzomorph (Bifenazate: more visiing rhzomorph is 1: 9) suspending agent, and the mass ratio of each component is respectively:
The former medicine 4.13g of Bifenazate more visits the former medicine 40.00g of rhzomorph
Aliphatic alcohol sulfate 10g pectin 9g
Isoamyl alcohol 5g linseed oil 6g
Benzoic acid 0.4g propane diols 0.4g
The surplus deionized water
Above raw material is prepared suspending agent method input routinely mix, ball milling is 2.0～4.0 hours in ball mill, makes the particle diameter of Bifenazate and Mi Bai rhzomorph all must more visit the rhzomorph suspending agent by 100g 40% Bifenazate when 4 μ m are following.
Embodiment 7:
Preparation 100g 20% Bifenazate is more visitd rhzomorph (Bifenazate: more visiing rhzomorph is 1: 19) aqueous emulsion, and the mass ratio of each component is respectively:
The former medicine 1.05g of Bifenazate more visits the former medicine 21.15g of rhzomorph
The newborn 2201#10g dimethylbenzene 20g of farming
Acetone 5g polyvinyl alcohol 5g
Xanthans 2g benzoic acid 0.3g
Ethylene glycol 0.5g surplus deionized water
Above raw material is prepared aqueous emulsion method input routinely mix, fully stirring makes 100g 20% Bifenazate and more visits the rhzomorph aqueous emulsion in the emulsification Scattered Kettle.
Embodiment 8:
Preparation 100g 10% Bifenazate is more visitd rhzomorph (Bifenazate: more visiing rhzomorph is 1: 1) missible oil, and the mass ratio of each component is respectively:
The former medicine 5.16g of Bifenazate more visits the former medicine 5.56g of rhzomorph
The newborn 2201#10g epoxychloropropane 6g of farming
Surplus dimethylbenzene
Former medicine is disposed the missible oil method routinely with agricultural newborn 2201#, epoxychloropropane, dimethylbenzene mix, make 100g 10% Bifenazate that meets the missible oil quality standard and more visit rhzomorph missible oil.
Determination of activity example 1:
Subjects is the female one-tenth mite of Tetranychus urticae (Tetranychus urticae Koah), and test medicine is Bifenazate and Mi Bai rhzomorph.
Test method is with reference to People's Republic of China's agricultural industry criteria " agricultural chemicals indoor bioassay test rule " insecticidal n Y/T 1154.7-2006, and the slide infusion process is adopted in test.
Carry out statistical analysis with the DPS data processing software, calculate the LC of each medicament
50, estimate the activity of reagent agent with this.
The co-toxicity coefficient of mixture (CTC value) calculates by following formula:
In the formula: ATI---mixture actual measurement toxicity index; The LC of S---standard insecticide
50, unit is every liter (mg/L) of milligram; The LC of M---mixture
50, unit is every liter (mg/L) of milligram.
TTI＝TIA×PA+TIB×PB
In the formula: the theoretical toxicity index of TTI---mixture; TIA----A medicament toxicity index; The percentage composition of PA-----A medicament in mixture, unit are percentage; TIB----B medicament toxicity index; The percentage composition of PB-----B medicament in mixture, unit are percentage.
In the formula: the CTC----co-toxicity coefficient; ATI---mixture actual measurement toxicity index; The theoretical toxicity index of TTI---mixture.
Composite dose co-toxicity coefficient (CTC): CTC 〉=120 show as synergistic effect; CTC≤80 show as antagonism; 80＜CTC＜120 show as summation action.
Each single agent of table 1 and mixture thereof are to the toxicity test result of the female one-tenth mite of Tetranychus urticae 48h
| The medicament title | ??LC 50(mg/L) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Bifenazate (A) | ??10.57 | ??100 | ??- | ??- |
| More visit rhzomorph (B) | ??0.53 | ??1994.34 | ??- | ??- |
| ??A∶B＝200∶1 | ??7.96 | ??132.79 | ??109.42 | ??121.35 |
| ??A∶B＝49∶1 | ??5.89 | ??179.46 | ??137.89 | ??130.15 |
| ??A∶B＝19∶1 | ??2.17 | ??487.10 | ??194.72 | ??250.16 |
| ??A∶B＝9∶1 | ??1.56 | ??677.56 | ??289.43 | ??234.10 |
| ??A∶B＝1∶1 | ??0.64 | ??1651.56 | ??1047.17 | ??157.72 |
| ??A∶B＝1∶9 | ??0.47 | ??2248.94 | ??1804.91 | ??124.60 |
| ??A∶B＝1∶19 | ??0.41 | ??2578.05 | ??1899.62 | ??135.71 |
| ??A∶B＝1∶50 | ??0.42 | ??2516.67 | ??1957.20 | ??128.59 |
Toxicity Determination result shows, Bifenazate, more visits rhzomorph to 48 hours LC of the female one-tenth mite of Tetranychus urticae
50Be respectively: 10.57,0.53mg/L.Bifenazate: more visiing rhzomorph is 200: 1 to 1: 50 o'clock, and co-toxicity coefficient (CTC) illustrates that all greater than 120 each proportioning all has synergistic effect, especially Bifenazate: more visiing rhzomorph is 19: 1 o'clock, and co-toxicity coefficient (CTC) is greater than 250, and synergistic effect is remarkable.
Determination of activity example 2:
Subjects is the female one-tenth mite of citrus red mite (crm) (Panonychus citri McGregor), and test medicine is Bifenazate and Mi Bai rhzomorph, and test method is with determination of activity example 1.
Each single agent of table 2 and mixture thereof are to the toxicity test result of the female one-tenth mite of citrus red mite (crm) 48h
| The medicament title | ??LC 50(mg/L) | ??ATI | ??TTI | Co-toxicity coefficient CTC |
| Bifenazate (A) | ??12.85 | ??100 | ??- | ??- |
| More visit rhzomorph (B) | ??0.78 | ??1647.44 | ??- | ??- |
| ??A∶B＝200∶1 | ??9.45 | ??135.98 | ??107.70 | ??126.26 |
| ??A∶B＝49∶1 | ??7.21 | ??178.22 | ??130.95 | ??136.10 |
| ??A∶B＝19∶1 | ??3.08 | ??417.21 | ??177.37 | ??235.22 |
| ??A∶B＝9∶1 | ??2.37 | ??542.19 | ??254.74 | ??212.84 |
| ??A∶B＝1∶1 | ??0.89 | ??1443.82 | ??873.72 | ??165.25 |
| ??A∶B＝1∶9 | ??0.58 | ??2215.52 | ??1492.70 | ??148.42 |
| ??A∶B＝1∶19 | ??0.62 | ??2072.58 | ??1570.07 | ??132.01 |
| ??A∶B＝1∶50 | ??0.51 | ??2519.61 | ??1617.10 | ??155.81 |
Toxicity Determination result shows, Bifenazate, more visits rhzomorph to 48 hours LC of the female one-tenth mite of citrus red mite (crm)
50Be respectively: 12.85,0.78mg/L.Bifenazate: more visiing rhzomorph is 200: 1 to 1: 50 o'clock, and co-toxicity coefficient (CTC) shows to have synergistic effect, wherein Bifenazate all greater than 120: more visiing rhzomorph is 19: 1 o'clock, and co-toxicity coefficient (CTC) shows that greater than 230 synergistic effect is obvious.
Determination of activity example 3:
Utilize among the embodiment 1 institute's preparaton to do following field control effectiveness test:
1, dispenser object
Tetranychus urticae (Tetranychus urticae Koah) on apple (the Malus pumila Mill) tree.
2, concentration design
20% Bifenazate is more visitd 1000,1500,2000 times of rhzomorph ME dilutions; Contrast medicament 24% Bifenazate SC dilution is more visitd 1500 times of rhzomorph ME dilutions for 1500 times, 2%.
3, test method
With reference to People's Republic of China's agricultural industry criteria " pesticide field efficacy medicine test criterion () " GB/T17980.7-2000.
4, result and analysis
Table 320% Bifenazate is more visitd rhzomorph microemulsion (embodiment 1) control apple Tetranychus urticae field control effectiveness test
Annotate: data are the mean value of 4 repetitions in the table; Preventive effect is the average correction preventive effect of each sub-district in the table; The Duncan method is adopted in significance test, and different English alphabets is illustrated on 5% level and reaches significant difference in the same column.
20% Bifenazate is more visitd the rhzomorph microemulsion field control effectiveness test of apple Tetranychus urticae be the results are shown in Table 3.After the dispenser 3 days, the control efficiency that 20% Bifenazate is more visitd 1500 times of rhzomorph ME dilutions was significantly higher than 1500 times, 2% control efficiency of more visiing 1500 times of rhzomorph ME dilutions of contrast medicament 24% Bifenazate SC dilution; After the dispenser 7 days, it is not obvious that 20% Bifenazate is more visitd 1500 times, 2% control efficiency differences of more visiing 1500 times of rhzomorph ME dilutions of control efficiency and contrast medicament 24% Bifenazate SC dilution of 2000 times of rhzomorph ME dilutions; After the dispenser 14 days, the control efficiency that 20% Bifenazate is more visitd 1500 times of rhzomorph ME dilutions was significantly higher than 1500 times, 2% control efficiency of more visiing 1500 times of rhzomorph ME dilutions of contrast medicament 24% Bifenazate SC dilution; After the dispenser 21 days, the control efficiency that 20% Bifenazate is more visitd 2000 times of rhzomorph ME dilutions was significantly higher than the control efficiency that contrast medicament 2% is more visitd 1500 times of rhzomorph ME dilutions, and is not obvious with the control efficiency difference of 1500 times of contrast medicament 24% Bifenazate SC dilutions.
Field test results shows, the control efficiency that 20% Bifenazate is more visitd rhzomorph ME is better than the independent use that 24% Bifenazate SC, 2% more visits rhzomorph ME, it is fine that 20% Bifenazate is more visitd quick-acting and the lasting effect of rhzomorph ME, the use of complex preparation has simultaneously reduced the usage amount of Bifenazate and Mi Bai rhzomorph, shows that complex preparation is better than the use of its single agent.
Claims (5)
1, a kind of miticide composition is characterized in that: it is the primary activity composition with Bifenazate and Mi Bai rhzomorph, is equipped with composite the forming of auxiliary agent and excipients (or filler), and wherein the ratio of quality and the number of copies of Bifenazate and Mi Bai rhzomorph is 200: 1～1: 50.
2, according to claim 1, it is characterized in that: the preferred mass portion rate of Bifenazate and Mi Bai rhzomorph is 50: 1～1: 20 in the said composition.
3, claim 1 or 2 described miticide compositions, it is characterized in that: said composition is mixed with microemulsion, wetting powder, water dispersible granules, suspending agent, aqueous emulsion or missible oil.
4,1 or 2 described miticide compositions is characterized in that: said composition is used to prevent and treat the various harmful mite on the crop.
5, according to claim 4, it is characterized in that: said composition is used to prevent and treat Tetranychus urticae, Panonychus citri, Tetranychus cinnabarinus, truncate leaf mite, yellow tea mite, rust mite.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734161A (en) * | 2013-12-28 | 2014-04-23 | 上海艳紫化工科技有限公司 | Mite-killing pesticide suspending agent |
| CN111226955A (en) * | 2018-11-29 | 2020-06-05 | 沈阳中化农药化工研发有限公司 | Insecticidal and acaricidal composition containing macrolide insect/acarid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2008517A1 (en) * | 2007-06-29 | 2008-12-31 | Bayer CropScience AG | Acaricide active agent combinations |
| CN101530109A (en) * | 2009-04-27 | 2009-09-16 | 陕西上格之路生物科学有限公司 | Bifenazate-containing insecticidal composition |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734161A (en) * | 2013-12-28 | 2014-04-23 | 上海艳紫化工科技有限公司 | Mite-killing pesticide suspending agent |
| CN103734161B (en) * | 2013-12-28 | 2015-08-12 | 上海艳紫化工科技有限公司 | Miticide farm chemical suspending agent |
| CN111226955A (en) * | 2018-11-29 | 2020-06-05 | 沈阳中化农药化工研发有限公司 | Insecticidal and acaricidal composition containing macrolide insect/acarid |
| CN111226955B (en) * | 2018-11-29 | 2021-11-19 | 沈阳中化农药化工研发有限公司 | Insecticidal and acaricidal composition containing macrolide insect/acarid |
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