CN101669497B - Mite-killing combination - Google Patents
Mite-killing combination Download PDFInfo
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- CN101669497B CN101669497B CN 200910206544 CN200910206544A CN101669497B CN 101669497 B CN101669497 B CN 101669497B CN 200910206544 CN200910206544 CN 200910206544 CN 200910206544 A CN200910206544 A CN 200910206544A CN 101669497 B CN101669497 B CN 101669497B
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- CN
- China
- Prior art keywords
- tebufenpyrad
- bifenazate
- mite
- miticide
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000005658 Tebufenpyrad Substances 0.000 claims abstract description 89
- ZZYSLNWGKKDOML-UHFFFAOYSA-N tebufenpyrad Chemical compound CCC1=NN(C)C(C(=O)NCC=2C=CC(=CC=2)C(C)(C)C)=C1Cl ZZYSLNWGKKDOML-UHFFFAOYSA-N 0.000 claims abstract description 87
- 239000005653 Bifenazate Substances 0.000 claims abstract description 85
- VHLKTXFWDRXILV-UHFFFAOYSA-N bifenazate Chemical compound C1=C(NNC(=O)OC(C)C)C(OC)=CC=C1C1=CC=CC=C1 VHLKTXFWDRXILV-UHFFFAOYSA-N 0.000 claims abstract description 85
- 239000000642 acaricide Substances 0.000 claims abstract description 18
- 241001454293 Tetranychus urticae Species 0.000 claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 13
- 239000004530 micro-emulsion Substances 0.000 claims abstract description 9
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 7
- 239000000839 emulsion Substances 0.000 claims abstract description 6
- 239000000375 suspending agent Substances 0.000 claims abstract description 6
- 239000004480 active ingredient Substances 0.000 claims abstract description 4
- 241000952063 Polyphagotarsonemus latus Species 0.000 claims abstract description 3
- 241000344246 Tetranychus cinnabarinus Species 0.000 claims abstract description 3
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 33
- 241000488581 Panonychus citri Species 0.000 claims description 11
- 238000009736 wetting Methods 0.000 claims description 8
- 239000003814 drug Substances 0.000 abstract description 50
- 230000000694 effects Effects 0.000 abstract description 13
- 230000002195 synergetic effect Effects 0.000 abstract description 10
- 229940079593 drug Drugs 0.000 abstract description 9
- 239000000575 pesticide Substances 0.000 abstract description 9
- 241000607479 Yersinia pestis Species 0.000 abstract description 4
- 241000238876 Acari Species 0.000 abstract 2
- 241000488583 Panonychus ulmi Species 0.000 abstract 1
- 241001454294 Tetranychus Species 0.000 abstract 1
- 239000004495 emulsifiable concentrate Substances 0.000 abstract 1
- 238000010790 dilution Methods 0.000 description 28
- 239000012895 dilution Substances 0.000 description 28
- 238000012360 testing method Methods 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 12
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- 231100000419 toxicity Toxicity 0.000 description 8
- 230000001988 toxicity Effects 0.000 description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 230000002045 lasting effect Effects 0.000 description 6
- 235000011430 Malus pumila Nutrition 0.000 description 5
- 235000015103 Malus silvestris Nutrition 0.000 description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 description 5
- LRWZZZWJMFNZIK-UHFFFAOYSA-N 2-chloro-3-methyloxirane Chemical compound CC1OC1Cl LRWZZZWJMFNZIK-UHFFFAOYSA-N 0.000 description 4
- 241000220225 Malus Species 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 238000009313 farming Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000002917 insecticide Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 235000013616 tea Nutrition 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- 229920001732 Lignosulfonate Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 238000000593 microemulsion method Methods 0.000 description 2
- 210000004681 ovum Anatomy 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 239000004563 wettable powder Substances 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- ADYKPXIKPPZOQF-UHFFFAOYSA-N 1,1'-biphenyl;hydrazine Chemical class NN.C1=CC=CC=C1C1=CC=CC=C1 ADYKPXIKPPZOQF-UHFFFAOYSA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 244000141359 Malus pumila Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 231100001225 mammalian toxicity Toxicity 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a miticide combination and application thereof. The mite-killing combination contains such active ingredients as bifenazate and tebufenpyrad in a mass portion ratio of 100:1-1:50 and can be prepared into micro-emulsion, wettable powders, water dispersible granules, suspending agent, aqueous emulsion or emulsifiable concentrates. The mite-killing combination has good synergistic effects, can retard the drug fastness of pests and prolong the service life of pesticide varieties. The combination is applied to controlling various mites on the cash crops, oil crops and foodcrops, is especially suitable for controlling panonychus ulmi, tetranychus urticae koch, tetranychus cinnabarinus, tetranychus truncates, polyphagotarsonemus latus and rust mites, and has the effect sobviously higher than the effects of the single two drugs.
Description
Technical field
The present invention relates to a kind of miticide composition, be specifically related to miticide composition and the application on the crop control of pest mite thereof that a kind of active component contains tebufenpyrad.
Background technology
The evil mite occurs from generation to generation many, and fertility is strong, and under suitable temperature and humidity conditions, evil mite quantity can increase rapidly within a short period of time exponentially, thereby easily miticide is developed immunity to drugs, and gives simultaneously the crop harms such as fruit tree, paddy rice, vegetables.Be the various harmful mite that control is day by day serious, countries in the world are all at the continuous miticide of development of new.In miticide development and application process, delaying evil mite pesticide resistance or cross resistance is to prolong the product key factor in service life, rationally use miticide, control access times and dosage, the miticide of different mechanism of action is used alternatingly or uses with and just seems particularly important.
Bifenazate (Bifenazate) is biphenyl hydrazine class miticide, is a kind of γ-aminobutyric acid (GABA) antagonist, but further result of study has not yet to see report.Be mainly used in preventing and treating tetranychid, predatism benefit mite is not had negative effect; Low to mammalian toxicity.
Tebufenpyrad (Tebufenpyrad) is the amide-type miticide, and it is a kind of Mitochondria In Developing Flight Muscle of Insects respiration inhibitor, and its mechanism of action is to suppress the electronics transmission at site I place.This product drug effect is rapid, and to the two spotted spider mite ovum, become the mite effect all better, the lasting period can reach more than 40 days, and certain resistance of rainwater washing against ability is arranged.Tebufenpyrad all has immediate effect and characteristics efficient, that the lasting period is long to various mite classes each vegetative period.
Administering evil mite pesticide resistance is an important subject, and the miticide of the different mechanisms of action mixes, and the complex preparation of notable synergistic effect is arranged again simultaneously, helping to delay the evil mite develops immunity to drugs, thereby prolong the service life of pesticide species, reduce using dosage, environmental contamination reduction.
Summary of the invention
The object of the present invention is to provide the application on control of pest mite of a kind of synergetic pesticide composition and said composition.
Technical scheme of the present invention is the biological activity determination that the miticide of the different mechanisms of action of employing carries out different proportionings, determines the synergy proportioning.Take the synergy proportioning preparation suitable as effective ingredient is mixed with, be used for the harmful mite on the control crops, can effectively reduce the usage amount of medicament, reduce drug cost, the generation of delaying drug resistance, thus minimizing is to the pollution of environment.
The present invention kills the mite synergistic composition, it is characterized in that effective ingredient is comprised of Bifenazate and tebufenpyrad, and its ratio of quality and the number of copies is 100: 1～1: 50, is preferably 50: 1～1: 20.Described active ingredient is present in the composition with the synergy effective dose, and the better mass fraction of effective ingredient Bifenazate is 1%～50%, the better mass fraction of tebufenpyrad is 1%～20%, and all the other are insecticides adjuvant and excipient (or filler).
The present invention is mixed with microemulsion, wetting powder, water dispersible granules, suspending agent, aqueous emulsion or missible oil take active ingredient Bifenazate and tebufenpyrad as main with insecticides adjuvant, excipient (or filler).Described auxiliary agent is determined according to formulation.
The present invention kills the mite synergistic composition take Bifenazate and tebufenpyrad as main active, can prevent and treat the various harmful mite on economic crops, oil crop and the cereal crops.Described harmful mite comprises Panonychus citri, Tetranychus urticae, Tetranychus cinnabarinus, Mite, yellow tea mite, rust mite.
The present invention compared with prior art, can produce following beneficial effect: after Bifenazate and tebufenpyrad are mixed, can be in a drug the double harmful mite of controlling crop growth different developmental phases in the phase, as ovum with become mite all can prevent and treat, improved control efficiency, and had the good lasting period; Mixed Pharmacy can prevent and overcome the pest mite class and develop immunity to drugs, and prolongs the service life of pesticide species.
Embodiment
In order better to understand essence of an invention, below in conjunction with example technology contents of the present invention is described in detail, but content of the present invention do not limit to so, can not therefore be interpreted as the restriction to claim of the present invention.In the embodiment of the invention in the used former medicine of Bifenazate Bifenazate content be 97%, tebufenpyrad content is 96% in the former medicine of used tebufenpyrad.
Embodiment 1:
Preparation 100g 24% Bifenazate tebufenpyrad microemulsion (Bifenazate: tebufenpyrad is 7: 1), the mass ratio of each component is respectively:
The former medicine 3.13g of the former medicine 21.65g of Bifenazate tebufenpyrad
The newborn 2201#10g dimethylbenzene 20g of farming
Epoxychloropropane 5g ethylene glycol 0.6g
The surplus deionized water
Above raw material is prepared the microemulsion method routinely drop into mixing, fully stir and make 100g 24% Bifenazate tebufenpyrad microemulsion.
Embodiment 2:
Preparation 100g 24% Bifenazate tebufenpyrad (Bifenazate: tebufenpyrad is 23: 1) microemulsion, the mass ratio of each component is respectively:
The former medicine 1.05g of the former medicine 23.72g of Bifenazate tebufenpyrad
The newborn 600#10g dimethylbenzene 30g of farming
Epoxychloropropane 5g propane diols 0.5g
The surplus deionized water
Above raw material is prepared the microemulsion method routinely drop into mixing, fully stir and make 100g 24% Bifenazate tebufenpyrad microemulsion.
Embodiment 3:
Preparation 100g 48% Bifenazate tebufenpyrad (Bifenazate: tebufenpyrad is 7: 1) wetting powder, the mass ratio of each component is respectively:
The former medicine 6.25g of the former medicine 43.30g of Bifenazate tebufenpyrad
The withered powder 15g of tea polyvinyl alcohol 8g
Surplus diatomite
Above raw material is prepared the wettable powder agent method routinely drop into to mix, in mixture input air flow cracker, be crushed to and meet fineness requirement, make the 100g 48% Bifenazate tebufenpyrad wetting powder that meets quality standard.
Embodiment 4:
Preparation 100g 48% Bifenazate tebufenpyrad (Bifenazate: tebufenpyrad is 47: 1) wetting powder, the mass ratio of each component is respectively:
The former medicine 1.05g of the former medicine 48.46g of Bifenazate tebufenpyrad
Draw withered powder 10g polyvinyl alcohol 8g
Surplus diatomite
Above raw material is prepared the wettable powder agent method routinely drop into to mix, in mixture input air flow cracker, be crushed to and meet fineness requirement, make the 100g 48% Bifenazate tebufenpyrad wetting powder that meets quality standard.
Embodiment 5:
Preparation 100g 50.5% Bifenazate tebufenpyrad (Bifenazate: tebufenpyrad is 100: 1) water dispersible granules, the mass ratio of each component is respectively:
The former medicine 0.53g of the former medicine 51.55g of Bifenazate tebufenpyrad
The withered powder 10g of tea lignosulfonates 8g
Polyvinyl alcohol 8g sodium chloride 10g
Surplus diatomite
Above-mentioned raw materials is configured the slurry that the water-dispersible grain agent method makes spraying usefulness routinely, slurry is quantitatively sent to carried out atomized drying in the drying tower, make 100g50.5% Bifenazate tebufenpyrad water dispersible granules.
Embodiment 6:
Preparation 100g 51% Bifenazate tebufenpyrad (Bifenazate: tebufenpyrad is 1: 50) water dispersible granules, the mass ratio of each component is respectively:
The former medicine 52.10g of the former medicine 1.05g of Bifenazate tebufenpyrad
The withered powder 10g of tea lignosulfonates 8g
Polyvinyl alcohol 8g bentonite 10g
Surplus diatomite
Above-mentioned raw materials is configured the slurry that the water-dispersible grain agent method makes spraying usefulness routinely, slurry is quantitatively sent to carried out atomized drying in the drying tower, make 100g 51% Bifenazate tebufenpyrad water dispersible granules.
Embodiment 7:
Preparation 100g 48% Bifenazate tebufenpyrad (Bifenazate: tebufenpyrad is 1: 47) suspending agent, the mass ratio of each component is respectively:
The former medicine 49.00g of the former medicine 1.05g of Bifenazate tebufenpyrad
Aliphatic alcohol sulfate 10g pectin 8g
Isoamyl alcohol 5g linseed oil 5g
Benzoic acid 0.3g ethylene glycol 0.5g
The surplus deionized water
Above raw material is prepared the suspending agent method routinely drop into mixing, ball milling is 2.0～4.0 hours in ball mill, so that the particle diameter of Bifenazate and tebufenpyrad all gets 100g 48% Bifenazate tebufenpyrad suspending agent when 4 μ m are following.
Embodiment 8:
Preparation 100g 24% Bifenazate tebufenpyrad (Bifenazate: tebufenpyrad is 1: 23) aqueous emulsion, the mass ratio of each component is respectively:
The former medicine 24.00g of the former medicine 1.05g of Bifenazate tebufenpyrad
The newborn 2201#10g dimethylbenzene 30g of farming
Acetone 4g polyvinyl alcohol 5g
Xanthans 2g benzoic acid 0.3g
Propane diols 0.5g surplus deionized water
Above raw material is prepared the aqueous emulsion method routinely drop into mixing, in the emulsion dispersion still, fully stir and make 100g 24% Bifenazate tebufenpyrad aqueous emulsion.
Embodiment 9:
Preparation 100g 24% Bifenazate tebufenpyrad (Bifenazate: tebufenpyrad is 1: 7) missible oil, the mass ratio of each component is respectively:
The former medicine 21.88g of the former medicine 3.10g of Bifenazate tebufenpyrad
The newborn 2201#10g cyclohexane 15g of farming
Epoxychloropropane 5g surplus dimethylbenzene
Former medicine is configured the missible oil method routinely with agricultural newborn 2201#, cyclohexane, epoxychloropropane, dimethylbenzene mix, make the 100g 24% Bifenazate tebufenpyrad missible oil that meets national standard.
Determination of activity embodiment 1:
Subjects is the female one-tenth mite of citrus red mite (crm) (Panonychus citri McGregor).
Test method is with reference to People's Republic of China's agricultural industry criteria " farm-chemical indoor determination test rule " insecticidal n Y/T 1154.7-2006, and the slide infusion process is adopted in test.
Carry out statistical analysis with the DPS data processing software, calculate the LC of each medicament
50, estimate the activity of reagent agent with this.
The co-toxicity coefficient of mixture (CTC value) calculates by following formula:
In the formula:
ATI---mixture actual measurement toxicity index;
The LC of S---standard insecticide
50, unit is every liter (mg/L) of milligram;
The LC of M---mixture
50, unit is every liter (mg/L) of milligram.
TTI＝TIA×PA+TIB×PB
In the formula:
The theoretical toxicity index of TTI---mixture;
TIA----A medicament toxicity index;
The percentage composition of PA-----A medicament in mixture, unit are percentage;
TIB----B medicament toxicity index;
The percentage composition of PB-----B medicament in mixture, unit are percentage.
In the formula:
The CTC----co-toxicity coefficient;
ATI---mixture actual measurement toxicity index;
The theoretical toxicity index of TTI---mixture.
The co-toxicity coefficient of built agent (CTC): CTC 〉=120 show as synergistic effect; CTC≤80 show as antagonism; 80＜CTC＜120 show as summation action.
Each single dose of table 1 and mixture thereof are to the toxicity test result of the female one-tenth mite of citrus red mite (crm) 48h
| The medicament title | LC 50(mg/L) | ATI | TTI | Co-toxicity coefficient CTC |
| Bifenazate (A) | 11.96 | 100 | - | - |
| Tebufenpyrad (B) | 1.17 | 1022.22 | - | - |
| A∶B＝100∶1 | 8.03 | 148.94 | 109.13 | 136.48 |
| A∶B＝47∶1 | 7.71 | 155.12 | 119.21 | 130.12 |
| A∶B＝23∶1 | 6.42 | 186.29 | 138.43 | 134.58 |
| A∶B＝7∶1 | 2.35 | 508.94 | 215.28 | 236.41 |
| A∶B＝1∶7 | 1.02 | 1172.55 | 906.94 | 129.29 |
| A∶B＝1∶23 | 0.93 | 1286.02 | 983.79 | 130.72 |
| A∶B＝1∶47 | 0.96 | 1245.83 | 1003.01 | 124.21 |
| A∶B＝1∶50 | 0.90 | 1328.89 | 1013.09 | 132.34 |
Toxicity Determination result shows, Bifenazate, tebufenpyrad are to 48 hours LC of the female one-tenth mite of citrus red mite (crm)
50Be respectively: 11.96,1.17mg/L.Bifenazate: tebufenpyrad is 100: 1 to 1: 50 o'clock, and co-toxicity coefficient (CTC) shows to have synergistic effect, wherein Bifenazate all greater than 120: tebufenpyrad is 7: 1 o'clock, and co-toxicity coefficient (CTC) shows that greater than 230 synergistic effect is obvious.
Determination of activity embodiment 2:
Subjects is the female one-tenth mite of Tetranychus urticae (Tetranychus urticae Koah), and test medicine is Bifenazate and tebufenpyrad, and test method is with determination of activity embodiment 1.
Each single dose of table 2 and mixture thereof are to the toxicity test result of the female one-tenth mite of Tetranychus urticae 48h
| The medicament title | LC 50(mg/L) | ATI | TTI | Co-toxicity coefficient CTC |
| Bifenazate (A) | 10.14 | 100 | - | - |
| Tebufenpyrad (B) | 1.83 | 554.10 | - | - |
| A∶B＝100∶1 | 9.14 | 133.81 | 100.41 | 133.27 |
| A∶B＝47∶1 | 8.42 | 145.25 | 100.86 | 144.02 |
| A∶B＝23∶1 | 8.58 | 142.54 | 101.71 | 140.14 |
| A∶B＝7∶1 | 5.74 | 213.07 | 105.13 | 202.66 |
| A∶B＝1∶7 | 5.16 | 237.02 | 135.93 | 174.37 |
| A∶B＝1∶23 | 6.85 | 178.54 | 139.35 | 128.12 |
| A∶B＝1∶47 | 6.71 | 182.27 | 140.20 | 130.00 |
| A∶B＝1∶50 | 6.87 | 178.02 | 140.65 | 126.93 |
Toxicity Determination result shows, Bifenazate, tebufenpyrad are to 48 hours LC of the female one-tenth mite of Tetranychus urticae
50Be respectively: 10.14,1.83mg/L.Bifenazate: tebufenpyrad is 100: 1 to 1: 50 o'clock, and co-toxicity coefficient (CTC) is all greater than 120, and illustrate that each proportioning all has synergistic effect, especially Bifenazate: tebufenpyrad is 7: 1 o'clock, and co-toxicity coefficient (CTC) is greater than 220, and synergistic effect is remarkable.
Determination of activity embodiment 3:
Utilize among the embodiment 1 institute's preparaton to do following field control effectiveness test:
1, dispenser object
Citrus red mite (crm) (Panonychus citri McGregor) on citrus (the Citrus reticulata Banco) tree.
2, concentration design
1000,2000,3000 times of 24% Bifenazate tebufenpyrad ME dilutions; 2000 times of contrast medicament 24% Bifenazate SC dilutions, 2000 times of 10% tebufenpyrad WP dilutions.
3, test method
With reference to People's Republic of China's agricultural industry criteria " pesticide field efficacy medicine test criterion () " GB/T17980.7-2000.
4, results and analysis
Table 3 24% Bifenazate tebufenpyrad microemulsion (embodiment 1) control citrus red mite (crm) field control effectiveness test
24% Bifenazate tebufenpyrad microemulsion the results are shown in Table 3 to the field control effectiveness test of citrus red mite (crm).After the dispenser 3,7 days, the control efficiency that 24% Bifenazate tebufenpyrad ME dilution is 2000 times was significantly higher than the control efficiency same period of 2000 times of contrast medicament 24% Bifenazate SC dilutions, 2000 times of 10% tebufenpyrad WP dilutions; After the dispenser 14 days, the control efficiency that 24% Bifenazate tebufenpyrad ME dilution is 2000 times was significantly higher than the control efficiency of 2000 times of contrast medicament 24% Bifenazate SC dilutions, and is not obvious with the control efficiency difference of 2000 times of contrast medicament 10% tebufenpyrad WP dilutions; After the dispenser 21,35 days, the control efficiency that 24% Bifenazate tebufenpyrad ME dilution is 2000 times was significantly higher than the control efficiency same period of 2000 times of contrast medicament 24% Bifenazate SC dilutions, 2000 times of 10% tebufenpyrad WP dilutions.
Field test results shows, the effect of 2000 times of controls of 24% Bifenazate tebufenpyrad ME dilution citrus red mite (crm)s is better than the control efficiency of 2000 times of 24% Bifenazate SC dilutions, 2000 times of 10% tebufenpyrad WP dilutions; Its lasting effect is better than Bifenazate and tebufenpyrad.Show that built agent can reduce the medication number of times, thereby environmental contamination reduction reduces residue of pesticide.
Determination of activity embodiment 4:
Utilize among the embodiment 3 institute's preparaton to do following field control effectiveness test:
1, dispenser object
Tetranychus urticae (Tetranychus urticae Koah) on apple (the Malus pumila Mill) tree.
2, concentration design
2000,4000,6000 times of 48% Bifenazate tebufenpyrad WP dilutions; 2000 times of contrast medicament 24% Bifenazate SC dilutions, 2000 times of 10% tebufenpyrad WP dilutions.
3, test method
With reference to People's Republic of China's agricultural industry criteria " pesticide field efficacy medicine test criterion () " GB/T17980.7-2000.
4, results and analysis
Table 448% Bifenazate tebufenpyrad WP (embodiment 3) control apple Tetranychus urticae field control effectiveness test
48% Bifenazate tebufenpyrad wetting powder the results are shown in Table 4 to the field control effectiveness test of apple Tetranychus urticae.After the dispenser 3 days, the control efficiency that 48% Bifenazate tebufenpyrad WP dilution is 4000 times was significantly higher than the control efficiency of 2000 times of contrast medicament 24% Bifenazate SC dilutions, 2000 times of 10% tebufenpyrad WP dilutions; After the dispenser 7 days, the control efficiency that 48% Bifenazate tebufenpyrad WP dilution is 4000 times is significantly higher than the control efficiency of 2000 times of contrast medicament 24% tebufenpyrad SC dilutions, 2000 times of 10% tebufenpyrad WP dilutions, and is not obvious with the control efficiency difference of 2000 times of 48% Bifenazate tebufenpyrad WP dilutions; After the dispenser 14,21,35 days, the control efficiency that 48% Bifenazate tebufenpyrad WP dilution is 4000 times was significantly higher than the control efficiency same period of 2000 times of contrast medicament 24% Bifenazate SC dilutions, 2000 times of 10% tebufenpyrad WP dilutions.
Field test results shows, the effect of 48% Bifenazate tebufenpyrad WP control apple Tetranychus urticae is better than the independent use of 24% Bifenazate SC and 10% tebufenpyrad WP.Lasting effect is better than Bifenazate and tebufenpyrad.Show that the built agent lasting period rises appreciably, can reduce the medication number of times, and complex preparation is wetting powder, thereby can environmental contamination reduction.
Claims (5)
1. miticide composition, it is characterized in that: its active ingredient is Bifenazate and tebufenpyrad, wherein the ratio of quality and the number of copies of Bifenazate and tebufenpyrad is 100: 1～1: 50.
2. miticide composition according to claim 1, it is characterized in that: the preferred mass portion rate of Bifenazate and tebufenpyrad is 50: 1～1: 20 in the composition.
3. claim 1 or 2 described miticide compositions, it is characterized in that: composition is mixed with microemulsion, wetting powder, water dispersible granules, suspending agent, aqueous emulsion or missible oil.
4. described miticide composition according to claim 1 and 2, it is characterized in that: said composition is used for the various harmful mite on the control crop.
5. miticide composition according to claim 4 is characterized in that: said composition is used for control Panonychus citri, Tetranychus urticae, Tetranychus cinnabarinus, Mite, yellow tea mite, rust mite.
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