CN101664478A - Natural medicament against bone marrow and bone injuries caused by oncological radiotherapy and chemotherapy and preparation method thereof - Google Patents
Natural medicament against bone marrow and bone injuries caused by oncological radiotherapy and chemotherapy and preparation method thereof Download PDFInfo
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- CN101664478A CN101664478A CN200810042402A CN200810042402A CN101664478A CN 101664478 A CN101664478 A CN 101664478A CN 200810042402 A CN200810042402 A CN 200810042402A CN 200810042402 A CN200810042402 A CN 200810042402A CN 101664478 A CN101664478 A CN 101664478A
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Abstract
The invention relates to a natural medicament against bone marrow and bone injuries caused by oncological radiotherapy and chemotherapy and a preparation method thereof. The method is characterized bymodifying the inherent defects (undetermined process and chemical components contained in a medicinal material) of a Tibetan patient medicament-Xinnaoxin capsules to play the ultimate medicament effect of the Xinnaoxin capsules and saving the cost. Compared with the prior art, (1) the medicament overcomes the injury caused by an adverse medicament reaction to human issues and organs, such as theliver, the kidney, the stomach and the heart when Chinese and Western medicaments treat the tumor, and has the protection effect at the same time; (2) the medicament avoids the reduction of medicamenteffect caused by damaging effective components of glucoside, alkaloid and flavone in rhodiola rosea during the preparation of Nuodikang capsules and the side effect that the medicament irritates thestomach cold; and (3) the medicament has simple preparation and low cost.
Description
(1) technical field:
The present invention relates to a kind of natural Tibetan medicine field, specifically, relate to Tibetan's patent medicine-XINNAOXIN JIAONANG to anti-tumor disease put, chemotherapy causes bone (marrow, matter) damage and the improved preparation method of this medicine defective.
(2) background technology:
Oncosis is clinical more common, in the conference of the 18th world anticancer disease alliance, the research report that World Health Organization (WHO) delivers shows, whole world cancer condition will be serious day by day, new patient's number will be increased to 1,500 ten thousand by present every year 1000 ten thousand in 20 years from now on, and the number dead because of cancer also will increase to 1,000 ten thousand by annual 6000000.
According to the health ministry statistics, the nineties in 20th century, China's tumor incidence rose to 127 examples/100,000 people.China increases tumor patient 160-170 ten thousand people newly every year in recent years, and Estimate of Total Number is about 4,500,000 people.In China leukaemic 4,000,000 is arranged, and annual especially with three to 40,000 speed increment, wherein 50 percent is children, mainly concentrates between two to seven years old.
At present the effective method of treatment oncosis be put, chemotherapy, its side effect is serious, particularly: bone marrow and sclerotin injury.Therefore people seek a kind of treatment oncosis better effects if, low-cost medicine, and do not have natural drug bounce-back at a specified future date and that do not have toxic and side effects.
(3) summary of the invention:
One of the object of the invention: just provide a kind of medicine that chemotherapy causes bone marrow injury for the treatment of, this medicine can effectively improve the actual cure rate of this disease of treatment, and at a specified future date do not have bounce-back, and have no side effect.
Another one purpose of the present invention just provides the preparation method of this medicine.
I am through the practice of for many years market and discover, during the treatment oncosis with put, its side effect of embolic chemotherapy is: vomiting, anorexia, liver, kidney, the heart, bone marrow and sclerotin equivalent damage.And the rhodioside in Tibetan's patent medicine-XINNAOXIN JIAONANG has anti-bone marrow, heart and injury effect; The Rhodiola kirilowii (Regel) Maxim. flavonoid has antagonism liver, kidney, the heart, stomach and sclerotin injury effect; The Rhodiola kirilowii (Regel) Maxim. alkaloid has the effect of protection heart; Rhodiola kirilowii (Regel) Maxim. glycosides, Rhodiola kirilowii (Regel) Maxim. flavonoid, Fructus Hippophae, Fructus Lycii have immunoregulation effect; Fructus Hippophae in this medicine has emesis, appetizing effect; Rhodiola kirilowii (Regel) Maxim., Fructus Hippophae, Fructus Lycii contain polysaccharide, and Rhodiola kirilowii (Regel) Maxim. contains Bergeninum, and it has the effect of the damaging cells of reparation; Fructus Lycii in this medicine contains copper, ferrum, cobalt, polysaccharide and has blood tonification effect, and itself has the effect of tonifying liver, kidney; Rhodiola kirilowii (Regel) Maxim., Fructus Hippophae have antivirus action in this medicine.(rhodioside, flavone, alkaloid, sterols) in the Rhodiola kirilowii (Regel) Maxim., Fructus Hippophae (flavone, sterols, glycosides), Fructus Lycii contain (glycosides) and have leukemia resisting action; Therefore Tibetan's patent medicine-XINNAOXIN JIAONANG has anti-chemotherapy and causes bone (marrow, matter) damage and leukemic effect.
Any launch all has incomplete place, and XINNAOXIN JIAONANG also is like this.This medicine preparation has the following disadvantages:
(1) contain daucosterol in the Fructus Lycii in this prescription, its dissolubility in water is little, decocts drug effect and reduces.
(2) polysaccharide in the Rhodiola kirilowii (Regel) Maxim. in this prescription, polysaccharide is removed in alcohol extraction, and drug effect reduces.
(3) medical material Fructus Lycii, Rhodiola kirilowii (Regel) Maxim., the Fructus Hippophae chemical constituent in this prescription is uncertain, the drug quality instability.
For these reasons the former processing technology of Tibetan's patent medicine-XINNAOXIN JIAONANG is revised, simultaneously related medical material chemical composition content is carried out standardization and work out.Its prescription is:
Rhodiola kirilowii (Regel) Maxim. 1000g, Fructus Lycii 500g, fresh syrup of Fructrs Hippophae 143g, starch 140g make 1000 with above-mentioned.Medical material is all from the Qinghai-Tibet Platean.
Preparation technology of the present invention is: above-mentioned three flavor medical herbs are carried out the medical material pre-treatment, and wherein Rhodiola kirilowii (Regel) Maxim. and Fructus Lycii decoct with water secondary, and each 2 hours, collecting decoction filtered, and it is standby that filtrate adds the alcohol precipitation then; Fresh syrup of Fructrs Hippophae mixes with said extracted liquid, being concentrated into relative density is the clear paste of 1.05-1.10 (50 ℃), add starch, the heating mixing, spray drying (70 ℃-90 ℃) adds starch, mixing, incapsulating promptly, can also be technology extracting solution such as steam is carried, CO 2 fluid supercritical with the method for above-mentioned 3 flavor medicinal material extract effective ingredient, adds adjuvant.Can be mixed with the dosage form that needs according to common process is sheet, dissolved granule, oral liquid, drop pill.Every dress 0.5g, every contains rhodioside (C
14H
20O
7) meter, must not be less than 2.5mg.
Pharmacological research shows: the activities of antioxidant enzymes of this medicine enhancing body, reduce the lipid peroxidation of erythrocyte membrane damage, and improve microenvironment in the film, improve the oxygen carrier amount of body hemoglobin; But blood viscosity lowering, the mediation microcirculation, this helps the tissue oxygenation supply; Myocardial oxygen delivery improves, and can strengthen myocardial contraction, and the adjusting by blood circulation can make the transportation of circulation oxygen reach optimum level, makes the blood oxygen pressure of tissue reach top level.
Function cures mainly: leukemia, bone (marrow, matter) damage, anemia.Supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling.Be used for deficiency of both vital energy and Yin, the caused dizziness of stagnation of blood stasis, headache, cardiopalmus, asthma, weak etc., the erythrocytosis that anoxia causes.
Instructions of taking is: a twice-daily, one time 2.
Four. advantage of the present invention:
(1) the present invention is revised the inherent defective of Tibetan's patent medicine-XINNAOXIN JIAONANG, makes the drug effect performance ultimate attainment, has saved cost.
(2) the present invention has anti-bone (marrow, matter) damage, leukemia and anemia effect, has tonifying liver, kidney effect simultaneously concurrently.
(3) the present invention has the effect of anti-cardiovascular disease, compare with existing this medicine Nuodikang capsule of treatment, when it had overcome the effect of gastric irritation and the making of Nuodikang capsule, rhodioside, alkaloid, flavone effective ingredient destroyed, thereby when causing treating cardiovascular disease, drug effect reduces.Wherein mentioned component has following effect:
Rhodioside: (to anoxia, sugar deficiency injury neurocyte, cardiovascular) have protection and make to decide therapeutical effect, anti-tumor activity; can short rat breast cancer dwindle, treat gravis, antioxidation, have sedation and syngignoscism the pain relieving when can be used as premedicant thing and anesthesia.
Flavonoid: anticancer and inhibition tumor promotion; improve cardiovascular system activity; antiallergic; anti-inflammatory and antalgic; antiviral; the resisting oxidation free radical activity; cardiac-cerebral ischemia is damaged; hepatic injury; ARR protective effect; analgesia; protective effect to peptic ulcer; free radical resisting; antitumor; blood pressure lowering is arranged; blood fat reducing; anticoagulant; the disease of respiratory system, it is antibacterial to have an antiinflammatory; blood sugar lowering; antioxidation; anti-auxilliary penetrating; anticancer; antitumor and enhance immunity ability; remove free radical; antiinflammatory; blood lipid regulation; anti-HIV; the activity of resisting gram-positive bacteria; hemostasis.
Radix Rhodiolae polysaccharide: antiviral; anti-nociception; free radical resisting; strengthen the bone marrow hematogenesis function; radioprotective; (leukocyte; platelet) increases; main organs such as Liver and kidney there are effects such as protection; new and effective iron supplement agent; the tumor of laboratory animal has inhibitory action; energy human body immunity improving function; the accelerate blood microcirculation; improve the blood oxygen ability; eliminate interior free yl; anti-radiation; blood sugar lowering; protect the liver, defying age promotes albumen and DNA and RNA synthetic; has tangible antitumor; anti HIV-1 virus; improve function of immune system, blood sugar regulation; blood fat and cholesterol levels, blood pressure lowering etc.
(4) the present invention it overcome in, when the Drug therapy oncosis is treated in west (put, change), adverse effect is to the side effect of people's injuries of tissues and organss such as (liver, kidney, stomach, the hearts), it has protective effect simultaneously.
Claims (7)
1. the present invention relates to natural Tibetan patent medicine-XINNAOXIN JIAONANG putting of anti-tumor disease, treatment are caused bone (marrow, matter) damage and preparation, it is characterized in that: former Tibetan patent medicine-XINNAOXIN JIAONANG inherent shortcoming (technology, drug quality instability) is revised.
2. described according to claim 1, it is characterized in that process modification:
(1) prescription is: Rhodiola kirilowii (Regel) Maxim. 1000g, Fructus Lycii 500g, fresh syrup of Fructrs Hippophae 143g, starch 140g, the medical material chemical composition content that is adopted carry out standardization to be worked out, and makes 1000.
(2) make: above-mentioned Rhodiola kirilowii (Regel) Maxim., Fructus Lycii decoct with water secondary, each 2 hours, collecting decoction, filter, filtrate is also used the alcohol precipitation, fresh syrup of Fructrs Hippophae mixes with above-mentioned alcohol precipitation extract, and being concentrated into relative density is the clear paste of 1.05-1.10 (50 ℃), adds starch, the heating mixing, spray drying (70 ℃-90 ℃) adds starch, mixing, incapsulate, that is, can also be that steam is carried, CO 2 fluid supercritical technology extracting solution with the method for above-mentioned 3 flavor medicinal material extract effective ingredient, add adjuvant.Can be mixed with needed dosage form according to common process, i.e. sheet, granule, oral liquid, drop pill.
3. according to claim 1,2 described, it is characterized in that: every dress 0.5g, every contains rhodioside (C
14H
20O
7) meter, must not be less than 2.5mg.
4. according to claim 1,2,3 described, it is characterized in that crude drug source: they are from the Qinghai-Tibet Platean.
5. according to claim 1,2,3,4 described, it is characterized in that pharmacological research shows: the activities of antioxidant enzymes of this medicine enhancing body, reduce the lipid peroxidation of erythrocyte membrane damage, improve microenvironment in the film, improve the oxygen carrier amount of body hemoglobin; But blood viscosity lowering, the mediation microcirculation, this helps the tissue oxygenation supply; Myocardial oxygen delivery improves, and can strengthen myocardial contraction, and the adjusting by blood circulation can make the transportation of circulation oxygen reach optimum level, makes the blood oxygen pressure of tissue reach top level.
6. according to claim 1,2,3,4,5 described, it is characterized in that function cures mainly: leukemia, bone (marrow, matter) damage, anemia etc.
7. according to claim 1,2,3,4,5,6 described, it is characterized in that instructions of taking is: a twice-daily, one time 2.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810042402A CN101664478A (en) | 2008-09-03 | 2008-09-03 | Natural medicament against bone marrow and bone injuries caused by oncological radiotherapy and chemotherapy and preparation method thereof |
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| CN200810042402A CN101664478A (en) | 2008-09-03 | 2008-09-03 | Natural medicament against bone marrow and bone injuries caused by oncological radiotherapy and chemotherapy and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755560A (en) * | 2012-08-09 | 2012-10-31 | 南京中医药大学 | Traditional Chinese medicine compound reducing chemotherapy side reaction and preparation method and application thereof |
| CN104473959A (en) * | 2014-11-11 | 2015-04-01 | 济南星懿医药技术有限公司 | Pharmaceutical composition used for treating leukemia |
| CN104490979A (en) * | 2014-12-08 | 2015-04-08 | 新疆华世丹药物研究有限责任公司 | Application of rhodiola rosea extract in preparation of medicine resistant to adverse effects during radiotherapy and chemotherapy |
-
2008
- 2008-09-03 CN CN200810042402A patent/CN101664478A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755560A (en) * | 2012-08-09 | 2012-10-31 | 南京中医药大学 | Traditional Chinese medicine compound reducing chemotherapy side reaction and preparation method and application thereof |
| CN104473959A (en) * | 2014-11-11 | 2015-04-01 | 济南星懿医药技术有限公司 | Pharmaceutical composition used for treating leukemia |
| CN104490979A (en) * | 2014-12-08 | 2015-04-08 | 新疆华世丹药物研究有限责任公司 | Application of rhodiola rosea extract in preparation of medicine resistant to adverse effects during radiotherapy and chemotherapy |
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Open date: 20100310 |