CN101638435B - 一种蓝藻病毒蛋白n突变体、其修饰衍生物及应用 - Google Patents

一种蓝藻病毒蛋白n突变体、其修饰衍生物及应用 Download PDF

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CN101638435B
CN101638435B CN2009101920630A CN200910192063A CN101638435B CN 101638435 B CN101638435 B CN 101638435B CN 2009101920630 A CN2009101920630 A CN 2009101920630A CN 200910192063 A CN200910192063 A CN 200910192063A CN 101638435 B CN101638435 B CN 101638435B
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lcvn
mutant
sequence
protein
cvn
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CN101638435A (zh
Inventor
熊盛
陈伟
钱垂文
王一飞
北里海雄
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Jinan University
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Jinan University
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Priority to CN2009101920630A priority Critical patent/CN101638435B/zh
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Priority to PCT/CN2010/073124 priority patent/WO2011026351A1/zh
Priority to IN2837DEN2012 priority patent/IN2012DN02837A/en
Priority to JP2012527184A priority patent/JP5592490B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CN2009101920630A 2009-09-04 2009-09-04 一种蓝藻病毒蛋白n突变体、其修饰衍生物及应用 Expired - Fee Related CN101638435B (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN2009101920630A CN101638435B (zh) 2009-09-04 2009-09-04 一种蓝藻病毒蛋白n突变体、其修饰衍生物及应用
PCT/CN2010/073124 WO2011026351A1 (zh) 2009-09-04 2010-05-24 一种蓝藻病毒蛋白n 突变体、其修饰衍生物及应用
IN2837DEN2012 IN2012DN02837A (enrdf_load_stackoverflow) 2009-09-04 2010-05-24
JP2012527184A JP5592490B2 (ja) 2009-09-04 2010-05-24 シアノビリン−ｎ変異体、その修飾誘導体及びその応用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2009101920630A CN101638435B (zh) 2009-09-04 2009-09-04 一种蓝藻病毒蛋白n突变体、其修饰衍生物及应用

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CN101638435A CN101638435A (zh) 2010-02-03
CN101638435B true CN101638435B (zh) 2011-11-16

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CN2009101920630A Expired - Fee Related CN101638435B (zh) 2009-09-04 2009-09-04 一种蓝藻病毒蛋白n突变体、其修饰衍生物及应用

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JP (1) JP5592490B2 (enrdf_load_stackoverflow)
CN (1) CN101638435B (enrdf_load_stackoverflow)
IN (1) IN2012DN02837A (enrdf_load_stackoverflow)
WO (1) WO2011026351A1 (enrdf_load_stackoverflow)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101638435B (zh) * 2009-09-04 2011-11-16 暨南大学 一种蓝藻病毒蛋白n突变体、其修饰衍生物及应用
MX370715B (es) * 2013-02-05 2019-12-20 Agricultural Tech Res Inst Vacuna de subunidades anti-mycoplasma spp.
CN110903363A (zh) * 2019-11-26 2020-03-24 中国药科大学 一种蓝藻抗病毒蛋白n的制备方法及应用
CN111494604B (zh) * 2020-05-11 2022-05-06 中国药科大学 蓝藻抗病毒蛋白n在制备抗炎药物中的应用
US20230355708A1 (en) * 2020-09-29 2023-11-09 Drexel University Compositions for inhibiting viral entry and methods using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843882A (en) * 1995-04-27 1998-12-01 The United States Of America As Represented By The Department Of Health And Human Services Antiviral proteins and peptides
EP1488804A4 (en) * 2002-03-22 2006-10-25 Bipha Corp IMMUNOGLOBULIN / HYDROPHILIC PEPTIDE COMPLEXES
WO2004056852A2 (en) * 2002-12-19 2004-07-08 Nektar Therapeutics Al, Corp. Cyanovirin variant-polymer conjugates
CN101705241B (zh) * 2008-09-28 2012-06-06 暨南大学 重组蓝藻抗病毒蛋白的制备方法及应用
CN101638435B (zh) * 2009-09-04 2011-11-16 暨南大学 一种蓝藻病毒蛋白n突变体、其修饰衍生物及应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Gao X.L. et al.Soluble cytoplasmic expression, rapid purification, and characterization of cyanovirin-N as a His-SUMO fusion.《Applied Microbiology and Biotechnology》.2009,第85卷(第4期), *
吕锐 等.蓝藻抗病毒蛋白N基因的原核表达及重组蛋白的纯化和复性.《医学研究生学报》.2007,第20卷(第11期), *
庞峰等.蓝藻抗病毒蛋白N的研究进展.《中国海洋药物杂志》.2006,第25卷(第6期), *
黄小花等.蓝藻抗病毒蛋白-N在大肠杆菌中的表达及其抗体的制备.《中国免疫学杂志》.2007,第23卷(第12期), *

Also Published As

Publication number Publication date
JP2013503609A (ja) 2013-02-04
JP5592490B2 (ja) 2014-09-17
CN101638435A (zh) 2010-02-03
IN2012DN02837A (enrdf_load_stackoverflow) 2015-07-24
WO2011026351A1 (zh) 2011-03-10

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