CN101637552A - Chinese medicine compound for controlling chronic pelvic inflammation - Google Patents
Chinese medicine compound for controlling chronic pelvic inflammation Download PDFInfo
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- CN101637552A CN101637552A CN200910169558A CN200910169558A CN101637552A CN 101637552 A CN101637552 A CN 101637552A CN 200910169558 A CN200910169558 A CN 200910169558A CN 200910169558 A CN200910169558 A CN 200910169558A CN 101637552 A CN101637552 A CN 101637552A
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Abstract
The invention discloses a Chinese medicine compound taking six Chinese medicines including pulsatilla chinensis, cyperus rotundus, phellodendron, atractylodes, achyranthcs bidentata blume as a basic prescription, and an application thereof on the aspect of controlling chronic pelvic inflammation. Clinical trials confirm that the compound has obvious effects on controlling diseases such as chronicannexitis, chronic cervicitis, cervical erosion, and the like.
Description
Technical field
The invention belongs to the pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition and in the application that prevents and treats aspect the chronic pelvic inflammatory disease, this Chinese medicine composition basis prescription is made up of 6 flavor Chinese medicines such as the Radix Pulsatillae, Rhizoma Cyperi, Cortex Phellodendri, Rhizoma Atractylodis, Radix Achyranthis Bidentatae, Fructus Cnidii.
Background technology
We are Li Xiaoran professor clinical experience sides, cure mainly married woman's leukorrhagia.Its side comes from clinical, and it is original to make laws, and prescription is rigorous, its heat clearing and damp drying, and soothing the liver circulation of qi promoting, dissolving blood stasis and detoxication, the effect of dirt eliminating leukorrhagia stopping, just middle leukorrheal diseases are because of the pathogenesis of wet, heat, poison, the stasis of blood.It shows as leukorrhagia and increases, and obstinate is measured the rare or thickness of many matter, Se Bai or yellowish foul, and few abdomen dull pain, oliguria with reddish urine, or with pudendal pruritus.Indication is the pelvic cavity chronic inflammation.Clinical in lower abdomen, sacrum soreness of waist pain, through the row aggravation, have a dizzy spell, the anorexia loose stool, profuse leukorrhea is a cardinal symptom.
We add three wonderful balls by the Radix Pulsatillae, Rhizoma Cyperi to form.Cure mainly married woman's leukorrhagia." leukorrhagia woman give birth to and promptly have ", that the normal women intravaginal has is colourless on a small quantity, do not have the liquid of smelling, and moistens in vaginal orifice, becomes leukorrhagia.Be by spleen fortuneization, the kidney envelope is hidden, and appoints, is with two arteries and veins departments approximately.As deficiency of kidney-QI, dysfunction of the spleen in transportation, conception vessel lose solid, and dai channel is failed to keep an appointment, and it is too much leukorrhagia then to occur, or amount, color, matter, flavor are unusual, or with General Symptoms, under pathological band, i.e. and leukorrheal diseases.Leukorrheal diseases are meant that vagina flows out a kind of sticky liquid, and are as tears such as saliva, continuous continuous." women section card control about purport " cloud: " thing is arranged in the moon, dripping decline, continuous and descend, promptly so-called leukorrhagia is also ".Producing the main cause of leukorrheal diseases, is that turbid damp is made a bet, or deficiency of kidney-QI owing to stagnation of liver-QI with deficiency of the spleen, due to insufficiency of kidney-QI, particularly dai channel are solid.The "Fu Qingzhu works on obstetric" cloud: " husband's leukorrhagia all is a damp syndrome, and with band name person, because of dai channel can not retrain, and this disease is arranged ... condition is the void of temper in addition, irritability strongly fragrant, and the invading of dampness, the forcing of steam pacified to such an extent that do not become the disease of leukorrhagia ".On syndrome-classification, because of the color difference of leukorrhagia, can be divided into five kinds of leucorrhea, fulminant leucorrhagia with yellowish discharge, leucorrhea with bloody discharge, leukorrhagia with greenish discharge, black vaginal discharge, wherein also have and doublely see, as red and white leukorrhea, HUANGBAI(sic) band, multicolored vaginal discharge etc., clinical with leucorrhea, fulminant leucorrhagia with yellowish discharge for seeing more.
That leukorrhagia card mostly is is wet, hot, malicious, due to the stasis of blood, based on damp invasion of lower energizer.Reuse the Radix Pulsatillae in the event side and be monarch, the special heat clearing away of merit, removing heat from blood, detoxifcation, dampness, parasite killing.Can be at wet, the heat of the cause of disease, poison, the stasis of blood, again can removing dampness and killing parasites, pudendal pruritus under the treatment belt, main symptoms such as eczema carbuncle skin ulcer.Minister is with Rhizoma Cyperi, mainly goes into Liver Channel, is longer than dispersing the stagnated live-QI to relieve the stagnation of QI, and menstruction regulating and pain relieving cures mainly diseases such as distending pain over the hypochondrium due to the depression of liver-QI, distending pain of the breast, menoxenia, mass in the abdomen pain, " be the Directorate-General DG of disorder of QI, the chief commander of women section also ".Key medicine for gynecological's regulating menstruation.Assistant is with Cortex Phellodendri, Rhizoma Atractylodis, Radix Achyranthis Bidentatae, i.e. " three wonderful balls ", the sedimentation of Cortex Phellodendri bitter cold, heat clearing and damp drying, kind the damp and hot of the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels of dispelling; Rhizoma Atractylodis are hot to loose bitter dryly, is longer than drying damp and strengthening spleenly, and both having dispelled has become wet, again the wet source of Du Sheng; Radix Achyranthis Bidentatae energy wind-damp dispelling, invigorating the liver and kidney, and it is descending to draw blood (medicine), strengthens the merit of blood circulation promoting and blood stasis dispelling.Three medicines match, heat clearing and damp drying, and two arrogate to oneself its merit, make damp and hot must removing, and stasis of blood poison must be dispelled, and all diseases are explained by oneself.Fructus Cnidii has killing parasites for relieving itching, dispeiling pathogenic wind and removing dampness, the effect of warming the kidney to invigorate YANG.All medicines share, and play heat clearing and damp drying altogether, soothing the liver circulation of qi promoting, dissolving blood stasis and detoxication, dirt eliminating leukorrhagia stopping, the merit of killing parasites for relieving itching.
The Radix Pulsatillae is the dry root performance hardship of Ranunculaceae herbaceos perennial Radix Pulsatillae Pulsatilla chinesnsis (Bge.) Regel, and is cold.Return stomach, large intestine channel.The effect clearing away heat,cooling blood and removing toxin, removing dampness and killing parasites.Cure mainly leukorrhagia pudendal pruritus, eczema carbuncle skin ulcer.Shennong's Herbal: " the mad easy cold and heat ， lumps in the chest and abdomen of main pyrexial malaria, goiter is by blood and relieving pain." " property of medicine opinion ": " end stomachache and red fulminant dysentery, control toothache." " book on Chinese herbal medicine converges and says ": " removing heat from blood, repercussive are separated noxious dampness." " Bencao Jingshu ": " Radix Pulsatillae ... hardship can be let out down, hot can the dismission, and the energy heat extraction removing heat from blood of trembling with fear, all functions of tool are so know the master, the key medicine Yu of the removing heat from blood clots absorbing that nearly dispels the heat." chemical constituent: this product contains protoanemonin, aggregates into Anemonin, anemonol.Triterpene saponin is a pulchinenoside, and daucosterol etc. is still arranged.Pharmacological action: to staphylococcus aureus, bacillus pyocyaneus, dysentery bacterium, Bacillus typhi, Salmonella etc. all have tangible antibacterial action.Radix Pulsatillae decoct and contained saponin have tangible anti-ameba effect.This product has tangible killing action to trichomonas vaginitis, and influenza virus is also had slight inhibitory action.These product also have certain calmness, analgesia and anticonvulsant action in addition, and its aerial parts has the cardiotonic of similar Folium Digitalis Purpureae.
Rhizoma Cyperi is the dry rhizome of sedge dried tuber cyperus rotundus L..Performance suffering, little hardship, little sweet, flat.Return liver, spleen, tri-jiao channel.The effect depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving.This product has the merit of dispersing the stagnated live-QI to relieve the stagnation of QI, promoting QI to circulate and dispersing the agglomeration of the pathogens, menstruction regulating and pain relieving.Control menoxenia, dysmenorrhea, many and depressed liver-energy dispersing and QI regulating, drug for invigorating blood circulation and eliminating stasis are used together.Control distending pain of the breast, many and depressed liver-energy dispersing and QI regulating analgesic is equal to usefulness.This product and the Radix Aucklandiae all have the merit of regulating QI to relieve pain, and can help digestion by alleviating distention in middle-JIAO, all can be used for stagnation of QI in spleen and stomach, abdominal distention, all diseases of lack of appetite, but the two compatibility is used.But the Radix Aucklandiae property of medicine is dry partially, main goes into taste and large intestine, the gas that stagnates of kind accumulation of food in the stomach and intes tine due to indigestion, abdominal distention and the large intestine of controlling stagnation of QI in spleen and stomach let out the dysentery tenesmus, hold concurrently and can treat hypochondriac pain, jaundice, hernia pain and obstruction of qi in the chest and cardialgia, be the key medicine of regulating QI to relieve pain; Rhizoma Cyperi property is flat, mainly goes into Liver Channel, is longer than dispersing the stagnated live-QI to relieve the stagnation of QI, and menstruction regulating and pain relieving cures mainly diseases such as distending pain over the hypochondrium due to the depression of liver-QI, distending pain of the breast, menoxenia, mass in the abdomen pain, is the key medicine of gynecological's regulating menstruation.Compendium of Material Medica: " sharp three warmers are separated six kinds of stagnation-syndromes, and the diet that disappears gathers, phlegm retention feeling of fullness ， carbuncle abdominal distention, and beriberi is ended trusted subordinate, limbs, the head, all pains of tooth ear ... married woman's bleeding not during menses, month marquis is uncomfortable, tire all kinds of diseases and ailments in preceding puerperal "." be the Directorate-General DG of disorder of QI, the chief commander of women section also." " book on Chinese herbal medicine is looked for the truth ": " and Rhizoma Cyperi, the exclusive dissipating depression of QI gas that looses, with Radix Aucklandiae circulation of qi promoting, looks are with real different, Radix Aucklandiae abnormal smells from the patient hardship is bad, so ventilation is very prompt, this is then bitter and not very, so resolving depression is in the majority, and property and in the Radix Aucklandiae so can add and subtract discrepancy, is thought the circulation of qi promoting obstruction-removing prescription, otherwise suitable this and unsuitable those ears." chemical constituent: contain volatile oil.Main component is nopinene, Rhizoma Cyperi alkene, α-cyperone, β-cyperone, Pogostone, α-rotunol, β-rotunol, limonene in the oil.Still contain alkaloid, flavonoid and triterpenes etc. in addition.Pharmacological action: 5% Rhizoma Cyperi extractum all has inhibitory action to the laboratory animal isolated uterine, can reduce its contractility and tension force.Its volatile oil has slight estrogen-like effects.Its water decoction has the effect that reduces intestinal tube tonicity and antagonism second phthalein choline, and obviously increases bile flow, the protection hepatocyte function.Nutgrass galingale oil has inhibitory action to staphylococcus aureus.Its extract has inhibitory action to some fungus.The effect that the aqueous solution of common total alkaloids, glycoside, flavonoid and phenolic compound has heart tonifying and brings high blood pressure down.
Cortex Phellodendri is the bark that Rutaceae deciduous tree plant Cortex Phellodendri (Cortex Phellodendri) Phellodendron amurense Rupr. removes cork.The performance hardship, cold.Return kidney, bladder, large intestine channel.Effect: heat clearing and damp drying, pathogenic fire purging are removed and are steamed, and skin ulcer is treated in detoxifcation.This product is damp-heat in lower-JIAO clearly, and the leukorrhagia that cures mainly damp invasion of lower energizer is yellow turbid smelly dirty.Shennong's Herbal: " stagnation of pathogenic heat in the main the five internal organs the intestines and stomach, jaundice, perianal abscess, stopping leak profit, woman's whitish metrorrhagia, negative and positive phagedenoma "." Japan hanako materia medica ": " control hectic fever due to YIN-deficiency, liver heat removing makes eye bright, many tears, and the xerostomia heat in the heart kills infantile malnutrition worm ， Zhi ascarid epigastralgia, scabies.Processed with honey is controlled serious epistaxis." " Amplification on Materia Medica addendum ": " get Rhizoma Anemarrhenae nourishing YIN to lower pathogenic fire, get Rhizoma Atractylodis and remove damp and clearing heat, for controlling the flaccidity key medicine; Get Herba Asari and rush down the bladder fire, control aphtha of the mouth and tongue." this product main component is alkaloids.As berberine, phellodendrine, magnoline, palm leaf coculine etc., also contain obakulactone, obacunone, obacunonic acid and sterols.Pharmacological action: the Cortex Phellodendri antimicrobial spectrum is similar to Rhizoma Coptidis with antibacterial efficacy, to dysentery bacterium, and Bacillus typhi, tubercule bacillus, staphylococcus aureus, multiple malignant bacteria such as Hemolytic streptococcus all has inhibitory action; To some dermatophytes, leptospira, hepatitis B surface antigen also has inhibitory action; Platelet there is protective effect; External can impel the absorption of subcutaneous oozing of blood; In addition, effect such as also have function of gallbladder promoting, diuresis, blood pressure lowering, analgesic, antitussive, eliminate the phlegm, but its effect is not as Rhizoma Coptidis.Cortex Phellodendri also has blood sugar lowering and promotes the mouse antibodies nucleus formation.Heat clearing and damp drying is longer than in the sedimentation of Cortex Phellodendri bitter cold, clear damp-heat in lower-JIAO; Be lowered to kidney channel with system fire, reducing the asthenic fever mutually, so be the clear product of deficiency and excess two.Control the lower-JIAO syndrome because of being longer than, so saying of " Cortex Phellodendri being controled the inferior " arranged.All damp-heat accumulations are sent out to cards such as dysentery, jaundice, leukorrhagia, sufficient swelling and pain in knee, sores, are all key medicine.Its reducing the minister-fire effect, available fever due to yin deficiency, the hectic fever due to YIN-deficiency night sweat card controlled.
Rhizoma Atractylodis are the dry rhizome of Compositae herbaceos perennial Atractylodes lancea (Thunb.) DC. Atractylodes lancea (Thunb.) DC..The performance suffering, hardship, temperature.Return spleen, stomach, Liver Channel.Effect is drying damp and strengthening spleen, expelling wind and cold.This product dampness is turbid with damp eliminating, to turbid damp obstructing in middle-JIAO, and dysfunction of the spleen in transportation and the wet disease that causes is the most suitable, Shennong's Herbal: " main air cold-damp numbness, dead flesh convulsion cellulitis.Fry in shallow oil bait and obey for a long time, making light of one's life by commiting suicide, it is not hungry to prolong life." " Mingyi Bielu ": " and master's headache, expectorant water, swollen by edema due to wind pathogen knot between skin, except that completely reaching cholera, tells down incessantly spasm in the epigastrium, and the warming the stomach rapid digestion of food is had a liking for food." Compendium of Material Medica: " control the damp-phlegm prolonged fluid-retention, or hold blood stasis under the arm and become the nest capsule, and spleen is wet dirty, turbid drop leukorrhagia, lingering diarrhea hemorrhoidal hamorrhage." " beautiful Chinese catalpa medicine is separated ": " and dry native diuretic rushes down the drink expectorant, and the clots absorbing dissipating depression of QI goes Lou, and change addiction and remove disease ... the excessive muddiness of urinating clearly ".Chemical constituent: mainly contain volatile oil, the main atractylol (being the mixed crystallization thing of β-eucalyptol and hinesol) that contains in the oil.Other still contains a small amount of atractylone, vitamin A sample material, vitamin B and inulin.Pharmacological action: the enterospasm that its volatile oil has tangible anti-parasympathetic nervous medium acetylcholine to cause; The myenteron that sympathetic nerve medium epinephrine is caused is lax, and the Rhizoma Atractylodis preparation can promote the inhibiting amplitude recovery of adrenal gland. and atractylol has the effect of the gastrointestinal motility of promotion, and pipe smooth muscle is also had faint contraction.Rhzoma Atractylodis Lanceae volatile oil is to the central nervous system, and low dose is a sedation, makes spinal reflex hyperfunction simultaneously; Heavy dose then is inhibitory action.The Rhizoma Atractylodis decoct has hypoglycemic activity, simultaneously tool row sodium, the effect of row's potassium; Its vitamin A sample material can be treated nyctalopia and keratomalacia.
Radix Achyranthis Bidentatae is the root of Amaranthaceae Radix Achyranthis Bidentatae (Radix Achyranthis Bidentatae) Achyranthes bidentata BL..Performance hardship, sweet, sour, flat.Return liver, kidney channel.The effect promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, relieving stranguria by diuresis, ignite (blood) is descending.This moral character is kind descending, and promoting blood circulation to restore menstrual flow is used always and controlled all diseases of gynecological's multiparity, as diseases such as amenorrhea, dysmenorrhea, menoxenia, puerperal abdonimal pains.This product function is comprehensive, both promoting blood circulation to restore menstrual flow, relieving stranguria by diuresis, ignite (blood) is descending, invigorating the liver and kidney again, bone and muscle strengthening can be attacked and can be mended, can walk and can keep, the card of deficiency and excess all available and the anxiety of asthenia syndrome detesting purgation making an excessive case more excessive.The Radix Achyranthis Bidentatae kind has the branch of Radix Achyranthis Bidentatae and Radix Cyathulae clinically, and both effects are basic identical, but Radix Achyranthis Bidentatae is partial to tonifying liver and kidney and strengthening bones and muscles, and Radix Cyathulae is partial to blood circulation promoting and blood stasis dispelling.Shennong's Herbal: " main cold-damp flaccidity syndrome and arthralgia syndrome, spasm of the limbs, the gonalgia unable to flex and stretch the extremities, by vim and vigour, the fire of getting mildewed in warm conditions is mashed, induced abortion." Compendium of Material Medica: " and the disease that Radix Achyranthis Bidentatae is led, on the whole wine then can invigorating the liver and kidney, give birth to then removing stagnant blood, the two.It controls that waist kneecap pain, flaccidity of the lower limbs, the moon disappear, mistake is drowned, chronic malaria, all diseases of damaging the spleen and stomach weak breath, non-Qi Zhi mass in the abdomen of merit Yu 0, all pains of trusted subordinate, carbuncle malignant boil, incised wound folding wound, the larynx tooth of getting its invigorating the liver and kidney drenches pain, hematuria, produces all diseases through waiting tire, non-ly get the merit Yu that it removes stagnant blood? " " book on Chinese herbal medicine meets former ": " it is descending that Dan Xi speech Radix Achyranthis Bidentatae can draw all medicines, and muscles and bones gout infra person should add and uses it.Though general character is the walking muscle down, the product of right sliding profit, the non-eventually institute of person is unsuitable admittedly for vital essence ... collapse of QI, big easy rushing down, seminal emission is let out in dream, and pregnant metrorrhagia is all prohibited." " Bencao Jingshu ": " Radix Achyranthis Bidentatae is walked and can be mended, and property is kind descending, so go into Liver and kidney.Main cold-damp flaccidity syndrome and arthralgia syndrome, spasm of the limbs, gonalgia unable to flex and stretch the extremities person, the liver spleen is suffered from a deficiency of the kidney, and then the heresy visitor's of cold-damp forms numbness and sick spasm of the limbs, gonalgia unable to flex and stretch the extremities.This property of medicine is walked and descending, and it can be by cold-damp and eliminating impediment also must.Top capping liver then muscle is relaxed, the descending knee joint of then managing, and promoting the circulation of blood then pain ends.By vim and vigour, still cloud can be ventilated and be stagnated blood clotting also.The detailed property of medicine, gas is used as numbness.The fire of getting mildewed in warm conditions is mashed, the shrivelled disease of blood also, blood is capable and lives, oneself ends pain.Go into the liver promoting the circulation of blood, so induced abortion.The damaging the spleen and stomach weak breath, man's the moon disappears, and the old man loses the person that drowns, and all the time of kidney deficiency is also.The brain being the reservoir of the marrow, brain are discontented with then empty and pain.Waist is the internal organs of kidney, and the logical marrow of ridge is in brain, and the marrow of suffering from a deficiency of the kidney is few, then pain along the spinal column; Blood deficiency and heat is then turned white.Weakness with emaciation is fatigued, and then hinder and cut off, blood stored in the liver, kidney storing essence, high invigorating the liver and kidney, then hemapodium is and smart full, and all cards are from recover.The capable then month water of blood is from logical, and blood agglomeration is from loosing." " medicine justice ": " and Radix Achyranthis Bidentatae, sweet in the mouth can be mended, and is with puckery can holding back, and it is bitter down straight to hold concurrently, and goes into kidney with it.Lid kidney master closes the Tibetan, and arresting seminal emission is held back blood, and it is descending to draw all medicines.Give birth to a surname then, cure mainly that difficulty in urination pipe is puckery, nebulousurine pain in the penis, congestion retardance, mass in the abdomen condense, married woman's amenorrhea, puerperal malignant histocytosis, get it and invigorate blood circulation descending merit also.Processed with wine is ripe then to be mended, and cures mainly spasm of the limbs, waist knee joint skelalgia, iliacus stream pain, dry thirsty, the damp and hot flaccidity syndrome and arthralgia syndrome of malaria, oldly loses excessively, and the merit of getting its YIN nourishing of enriching blood also." " book on Chinese herbal medicine justice " " Radix Achyranthis Bidentatae, bitter in the mouth falls, beyond the resolving heat and reducing pathogenic fire, nothing left justice.Cure mainly at all times, sharp waist knee joint, the meridian dredging, broken silt is invigorated blood circulation, consumer product dredge stasis, clear sharp two just, all within this scope.Zhang Jingyue is called it and is walked twelve channels and collaterals, that is the meaning of dredge the meridian passage.In order to control all skin ulcers of throat ability to speak and stomach-fire toothache, the prompt effect arranged all closely again, then all excess-heat is jammed, and is scorching on the gas fire, gets its using pungent drugs for dispersion and bitter drugs for purgation a surname and leads to, and reaches ear under leading.But its property is directly down, though and can the sharp office of the meridian dredging, also strand all cards of knee joint foot shin only, the most prompt should, and the disease of the arm shoulder back of the body, Radix Achyranthis Bidentatae is celebrated in also non-bosom can be merit, then assigns with rhizome, rises also admittedly can not walk crosswise." " name of Radix Cyathulae does not see ancient book, and only a stone stupid " herbal classic is met the source " is called bosom product person length and do not had other palpus, and the unsmooth person of water channel should it; Thin and the duskiness of river product person, vital essence admittedly the person suitable it.The river product person of Radix Achyranthis Bidentatae specially is not good at sliding rushing down, and the power that a surname gets round by bribery then one rather has every advantage and not a single disadvantage, the hepatic and renal YIN deficiency, and machine-operated unfavorable person suitable it." " Records of Tradition Chinese and Western Medicine in Combination ": " and Radix Achyranthis Bidentatae was the product of tonification originally, and kind bleed blood is made a bet, and was to desire its passerby down with medication, permanent be tying-in.So kind control the pain in the lumbar region of suffering from a deficiency of the kidney and have a pain in the leg, or knee joint is painful can not bend and stretch, or the lower limb flaccidity can not appoint ground.The double woman of controlling closes blood depletion the moon, expedites the emergence of down tire.Kind again control drench painful, tonneau urine, all the kind descending effect of its power is also for this.So " not Lu " be called it again and controls aphtha toothache person, is what also? cover these cards, all because of its QI and blood with due to the burning hot rising, reusing Radix Achyranthis Bidentatae, to draw its QI and blood descending, and it is descending to draw its floating inducing vomiting fire, is healing also.Stupid because of realize this reason, in order to control cephalemia card, 5 product with Haematitum, Os Draconis, all heavy bob convergences of Concha Ostreae there's no one who doesn't or isn't prove effective conveniently, healing person is unequal to discipline.For its property is specially made a bet, all lower-jiao Qi dysfunction is not solid, and the card of all slippages is all avoided it.”
Chemical constituent: Achyranthes and Radix Cyathulae belong to each plant and all contain molting hormone.As containing ecdysone, inokosterone in the Radix Achyranthis Bidentatae.Radix Achyranthis Bidentatae and coarse wool Radix Achyranthis Bidentatae still contain triterpenoid saponin, produce oleanolic acid and sugar after the hydrolysis, contain 12 seed amino acids such as arginine in addition, and chemical compound and trace element such as ferrum, copper such as alkaloids, Coumarins.Whether pharmacological action: the total Saponin of Radix Achyranthis Bidentatae has tangible excitation to uterine smooth muscle, different and conceived different because of animal species to the effect in uterus, exempts from pregnant and unpregnancy uterus and all apparent excitation of Mouse Uterus to family; The unpregnancy person relaxes to the cat uterus, pregnant person's excitement; Radix Cyathulae extract has antifertility and implantation effect, and is the most remarkable with benzene extractives, and blood pressure lowering and diuresis are arranged.Contained insectean metamorphosis steroid hormone has strong protein synthesis facilitation, and contained molting hormone has effects such as shortening Bombyxmori Linnaeus length of time.Radix Achyranthis Bidentatae can reduce rat whole blood viscosity, packed cell volume, erythrocyte aggregation index, and anticoagulation is arranged; Radix Achyranthis Bidentatae alcohol preserved material has obviously inhibitory action to rat formaldehyde arthritis; The Saponin that extracts also has the obvious effect that promotes that inflammatory swelling disappears to the rat albumen arthritis.
Fructus Cnidii is the mature fruit of samphire cnidium monnieri Cnidium monnieri (L) Cuss..Performance suffering, hardship, temperature.Return kidney channel.Has killing parasites for relieving itching, dispeiling pathogenic wind and removing dampness, the effect of warming the kidney to invigorate YANG.Be usually used in treating the pudendum pruritus due to damp pathogen, eczema, scabies.Fry in shallow oil the soup washout and can treat women's pudendal pruritus, man's scrotum pruritus due to damp pathogen, eczema, scabies etc.This product has the effect of cold expelling dispeiling pathogenic wind and removing dampness.Cold-damp leukorrhagia due to can be used for suffering from a deficiency of the kidney, arthralgia chiefly caused by damp pathogen lumbago.Because of it has the merit of warming the kidney to invigorate YANG.It is infertile etc. to be used for impotence in male, women's cold womb due to the insufficiency of kidney-YANG.Shennong's Herbal: " main man's impotence pruritus due to damp pathogen swells and ache in married woman's the moon, removes stagnated QI, sharp joint, epilepsy, malignant boil." " Mingyi Bielu ": " warming the middle warmer and descending qi makes the dirty heat of married woman's, and the man is cloudy strong, and good color has been made us son." " property of medicine book on Chinese herbal medicine ": " and control man, woman's void, arthralgia chiefly caused by damp pathogen, malicious wind, Persistent Pain is gone man's pain in the lumbar region.Bathe man's the moon, go air-cooled, big Yiyang thing.Main strong wind itching over the body is fried in shallow oil being recovered of soup bath.Treat toothache and pediatric epilepsy scared." " Bencao Jingshu ": " and Fructus Cnidii, bitter in the mouth is flat; " not Lu " be hot sweet nontoxic; Modern detailed its abnormal smells from the patient, when the warm-dryness syndrome of must holding concurrently, sun also.So swell and ache in housewife people's the moon, man's impotence pruritus due to damp pathogen removes stagnated QI, sharp joint. malignant boil." not Lu " warming the middle warmer and descending qi makes the dirty heat of married woman's, and the man is cloudy strong, has made us son.Lid can dehumidify with bitter, temperature energy cold expelling, and suffering can be moistened kidney, and sweet energy strengthening the spleen is so can remove the wet disease of viscera connecting with this channel of all deficiency and coldness of married woman man.Cold-damp was both removed, and then disease is gone, performance Yiyang, thus disease, and have tonification also." " book on Chinese herbal medicine is newly organized ": " Fructus Cnidii, function are quite strange, and inside and outside all can executing controlled, and external treatment is good especially." " herbal classic is met former ": " Fructus Cnidii not only helps man's excessive fire, and the married woman that can loose is depressed, and non-wonderful reaching " herbal classic " be through justice, and the method that can not get contrary treatment is also." " book on Chinese herbal medicine justice ": " " herbal classic " is though claim its toil for Fructus Cnidii, the sudden and violent fiery and forthright product of temperature.So cure mainly in married woman's the moon and swell and ache, man's impotence pruritus due to damp pathogen, then all main cold-damp is sayed it, also asthenia of renal yang, Han Shui fills the air, and begins to think product for oral administration.”
The modern chemistry composition Study, Fructus Cnidii contains volatile oil, has told 27 compositions from oil, and main component is pinene, camphene, bornival, isoborneol etc. in the oil.Still contain Coumarins compositions such as osthole, as cnidimine, xanthotoxin etc.Its pharmacological action: this product can prolong mice pairing-season, increases uterus and ovary weight; Its extract also has androgen-like action, can increase mice prostate, seminal vesicle, levator ani weight.Staphylococcus aureus, bacillus pyocyaneus and dermatophytosis there is inhibitory action.Contained xanthotoxol has stronger antiinflammatory and analgesic activity.In addition, also have arrhythmia, bring high blood pressure down, effects such as eliminating phlegm and relieving asthma, slow down aging, promotion memory, local anaesthesia, antimutagenic, osteoporosis, spermicide.
Summary of the invention
A kind of Chinese medicine composition of preventing and treating chronic pelvic inflammatory disease is characterized in that said composition serves as basis side with the Radix Pulsatillae, Rhizoma Cyperi, Cortex Phellodendri, Rhizoma Atractylodis, Radix Achyranthis Bidentatae, Fructus Cnidii, and its percentage by weight is:
Radix Pulsatillae 20-25%
Rhizoma Cyperi 20-25%
Cortex Phellodendri 5-15%
Rhizoma Atractylodis 10-15%
Radix Achyranthis Bidentatae 10-15%
Fructus Cnidii 5-10%
Optimizing prescriptions: the percentage by weight of said composition is:
The Radix Pulsatillae 25%
Rhizoma Cyperi 25%
Cortex Phellodendri 10%
Rhizoma Atractylodis 15%
Radix Achyranthis Bidentatae 15%
Fructus Cnidii 10%
Chinese medicine composition of the present invention, one or more in the function Chinese medicines such as all right other the spleen strengthening and damp drying of compatibility, promoting QI circulation for relieving depression, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing.Invigorating the spleen to clear away damp pathogen medical instrument body refers to the Rhizoma Atractylodis Macrocephalae, Poria, the Fructus Kochiae, Semen Plantaginis, Semen Coicis etc.; Promoting QI circulation for relieving depression medical instrument body refers to Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Fructus Aurantii, Fructus Toosendan etc.; Blood circulation and stasis-eliminating medicine specifically refers to Radix Cyathulae, Rhizoma Corydalis, Radix Curcumae, Pollen Typhae etc.; Heat and toxic materials clearing away medicine specifically refers to Radix Sophorae Flavescentis, Radix Gentianae, Rhizoma Osmundae, Rhizoma Paridis, Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae etc.Wherein survival dose is conventional recommended amounts in each flavor.
Chinese medicine composition of the present invention is in the application that prevents and treats aspect the chronic pelvic inflammatory disease, diseases such as control chronic adnexitis, chronic cervicitis, cervical erosion, and disease is seen: lower abdomen pain, the leucorrhea amount is many, matter is rare or thickness etc.
Chinese medicine composition of the present invention can be made the various dosage forms of pharmaceutics document record according to conventional method, specifically refers to tablet, capsule, pill, granule, oral liquid, colloid, syrup etc., and its administering mode is an oral administration.
Capsule preparation method thereof is as follows:
1, the Radix Pulsatillae, Cortex Phellodendri, Radix Achyranthis Bidentatae, Fructus Cnidii decoction pieces are measured the 70-95% ethanol extractions 2-3 time with 10 times, each 1.0-2.0h, and merge extractive liquid, filters, and concentrating under reduced pressure reclaims ethanol and gets ethanol extract extractum 1.; Rhizoma Cyperi, Rhizoma Atractylodis are cut into decoction pieces and extract 2-3 time with 8 times of water gagings, each 1.0-3.0h, merge extractive liquid, filters, 2. concentrating under reduced pressure gets extractum, collect volatile oil, 2. 1. extractum merge with extractum, adds an amount of microcrystalline Cellulose and micropowder silica gel, use the conventional method wet granulation, the an amount of dissolve with ethanol of volatile oil evenly sprays on granule, and fill becomes capsule promptly.
2, the Radix Pulsatillae, Cortex Phellodendri, Radix Achyranthis Bidentatae, Fructus Cnidii decoction pieces are measured the 70-95% ethanol extractions 2-3 time with 10 times, each 1.0-2.0h, and merge extractive liquid, filters, and concentrating under reduced pressure reclaims ethanol and gets ethanol extract extractum 1.; Rhizoma Cyperi, Rhizoma Atractylodis are cut into decoction pieces and extract 2-3 time with 8 times of water gagings, each 1.0-3.0h, merge extractive liquid, filters, and 2. concentrating under reduced pressure gets extractum, collect volatile oil, 2. 1. extractum merge with extractum, adds an amount of microcrystalline Cellulose and micropowder silica gel, uses the conventional method wet granulation, volatile oil is made small soft capsule with conventional method, becomes capsule promptly with granule according to the fill of recipe quantity uniform mixing.
3, Rhizoma Cyperi, Rhizoma Atractylodis are broken into the coarse powder supercritical CO
2Extract 2-3 time, 1. combining extraction liquid gets extractum, and the Rhizoma Cyperi after the extraction, Rhizoma Atractylodis and the Radix Pulsatillae, Cortex Phellodendri, Radix Achyranthis Bidentatae, Fructus Cnidii coarse powder one are reinstated the 70-95% ethanol percolation, collects percolate, filter, concentrating under reduced pressure, reclaim extractum 2.; 2. 1. extractum merge with extractum, adds an amount of microcrystalline Cellulose and micropowder silica gel, uses the conventional method wet granulation, and volatile oil is made small soft capsule with conventional method, becomes capsule promptly with granule according to the fill of recipe quantity uniform mixing.
Embodiment one
Prescription is formed: the Radix Pulsatillae 25% Rhizoma Cyperi 25% Cortex Phellodendri 10% Rhizoma Atractylodis 15% Radix Achyranthis Bidentatae 15% Fructus Cnidii 10%
Method for making 1: the Radix Pulsatillae, Cortex Phellodendri, Radix Achyranthis Bidentatae decoction pieces are measured 80% ethanol extractions 2 times with 10 times, each 1.5h, and merge extractive liquid, filters, and concentrating under reduced pressure reclaims ethanol and gets ethanol extract extractum 1.; Rhizoma Cyperi, Rhizoma Atractylodis are cut into decoction pieces and extract 2 times with 8 times of water gagings, each 1.5h, merge extractive liquid, filters, 2. concentrating under reduced pressure gets extractum, collect volatile oil, 2. 1. extractum merge with extractum, adds an amount of microcrystalline Cellulose and micropowder silica gel, use the conventional method wet granulation, the an amount of dissolve with ethanol of volatile oil evenly sprays on granule, and fill becomes capsule promptly.
Method for making 2: the Radix Pulsatillae, Cortex Phellodendri, Radix Achyranthis Bidentatae decoction pieces are measured 95% ethanol extractions 2 times with 10 times, each 2.0h, and merge extractive liquid, filters, and concentrating under reduced pressure reclaims ethanol and gets ethanol extract extractum 1.; Rhizoma Cyperi, Rhizoma Atractylodis are cut into decoction pieces and extract 2 times with 8 times of water gagings, each 2.0h, merge extractive liquid, filters, and 2. concentrating under reduced pressure gets extractum, collect volatile oil, 2. 1. extractum merge with extractum, adds an amount of microcrystalline Cellulose and micropowder silica gel, uses the conventional method wet granulation, volatile oil is made small soft capsule with conventional method, becomes capsule promptly with granule according to the fill of recipe quantity uniform mixing.
Method for making 3: Rhizoma Cyperi, Rhizoma Atractylodis are broken into the coarse powder supercritical CO
2Extract 2 times, 1. combining extraction liquid gets extractum, and the Rhizoma Cyperi after the extraction, Rhizoma Atractylodis and the Radix Pulsatillae, Cortex Phellodendri, Radix Achyranthis Bidentatae powder coarse powder one are reinstated 70% ethanol percolation, collects percolate, filter, concentrating under reduced pressure, reclaim extractum 2.; 2. 1. extractum merge with extractum, adds an amount of microcrystalline Cellulose and micropowder silica gel, uses the conventional method wet granulation, and volatile oil is made small soft capsule with conventional method, becomes capsule promptly with granule according to the fill of recipe quantity uniform mixing.
Embodiment two
The Radix Pulsatillae 20% Rhizoma Cyperi 20% Cortex Phellodendri 10% Rhizoma Atractylodis 10% Radix Achyranthis Bidentatae 10% Fructus Cnidii 10%, the Rhizoma Atractylodis Macrocephalae 5%, Rhizoma Paridis 5%, Radix Sophorae Flavescentis 10%.
Method for making: the Radix Pulsatillae, Rhizoma Cyperi, Cortex Phellodendri, Rhizoma Atractylodis, Fructus Cnidii, Radix Achyranthis Bidentatae, the Rhizoma Atractylodis Macrocephalae are made decoction pieces in will writing out a prescription, and doubly measure 80% ethanol with 8-10 and carry secondary, and each 1.0-2.0h filters, and is condensed into extractum 1.; All the other pulverizing medicinal materials, mixing, medicinal material coarse powder is carried secondary with 8 times of water gagings, and each 1.5h filters, and is condensed into extractum 2., merges to concentrate, and makes capsule according to a conventional method.
Embodiment three
Prescription is formed: the Radix Pulsatillae 25% Rhizoma Cyperi 25% Cortex Phellodendri 5% Rhizoma Atractylodis 10% Radix Achyranthis Bidentatae 10% Fructus Cnidii 5%, Radix Gentianae 5%, Semen Coicis 5%, Fructus Toosendan 10%.
Method for making: the Radix Pulsatillae in will writing out a prescription, Rhizoma Cyperi, Cortex Phellodendri, Rhizoma Atractylodis, Radix Achyranthis Bidentatae, Fructus Cnidii are made decoction pieces, doubly measure 80% ethanol with 8-10 and carry secondary, and each 1.0-2.0h filters, concentrate extractum 1.; All the other pulverizing medicinal materials, mixing, medicinal material coarse powder is carried secondary with 8 times of water gagings, each 1.5h filters, concentrate extractum 2., merge and concentrate, make capsule according to a conventional method.
Embodiment four
Prescription is formed: the Radix Pulsatillae 20% Rhizoma Cyperi 20% Cortex Phellodendri 5% Rhizoma Atractylodis 10% Radix Achyranthis Bidentatae 10% Fructus Cnidii 5%, Pericarpium Arecae 10%, Herba Hedyotidis Diffusae 10%, Rhizoma Corydalis 10%.
Method for making: the Radix Pulsatillae in will writing out a prescription, Rhizoma Cyperi, Cortex Phellodendri, Rhizoma Atractylodis, Radix Achyranthis Bidentatae, Fructus Cnidii, Rhizoma Corydalis are made decoction pieces, doubly measure 80% ethanol with 8-10 and carry secondary, and each 1.0-2.0h filters, concentrate extractum 1.; All the other pulverizing medicinal materials, mixing, medicinal material coarse powder is carried secondary with 8 times of water gagings, each 1.5h filters, concentrate extractum 2., merge and concentrate, make capsule according to a conventional method.
Embodiment five
Prescription is formed: the Radix Pulsatillae 25% Rhizoma Cyperi 20% Cortex Phellodendri 5% Rhizoma Atractylodis 10% Radix Achyranthis Bidentatae 10% Fructus Cnidii 5%, Rhizoma Paridis 5%, Cortex Magnoliae Officinalis 10%, Semen Plantaginis 10%.
Method for making: the Radix Pulsatillae in will writing out a prescription, Rhizoma Cyperi, Cortex Phellodendri, Rhizoma Atractylodis, Radix Achyranthis Bidentatae, Fructus Cnidii, Cortex Magnoliae Officinalis are made decoction pieces, doubly measure 80% ethanol with 8-10 and carry secondary, and each 1.0-2.0h filters, concentrate extractum 1.; All the other pulverizing medicinal materials, mixing, medicinal material coarse powder is carried secondary with 8 times of water gagings, each 1.5h filters, concentrate extractum 2., merge and concentrate, make capsule according to a conventional method.
Embodiment six
Prescription is formed: the Radix Pulsatillae 25% Rhizoma Cyperi 5% Cortex Phellodendri 5% Rhizoma Atractylodis 5% Radix Achyranthis Bidentatae 10% Fructus Cnidii 10%, Semen Coicis 10%, Rhizoma Smilacis Glabrae 5%, Fructus Toosendan 5%.
Method for making: the Radix Pulsatillae in will writing out a prescription, Rhizoma Cyperi, Cortex Phellodendri, Rhizoma Atractylodis, Radix Achyranthis Bidentatae, Fructus Cnidii are made decoction pieces, doubly measure 80% ethanol with 8-10 and carry secondary, and each 1.0-2.0h filters, concentrate extractum 1.; All the other pulverizing medicinal materials, mixing, medicinal material coarse powder is carried secondary with 8 times of water gagings, each 1.5h filters, concentrate extractum 2., merge and concentrate, make capsule according to a conventional method.
Embodiment seven
Prescription is formed: the Radix Pulsatillae 25% Rhizoma Cyperi 22% Cortex Phellodendri 10% Rhizoma Atractylodis 10% Radix Achyranthis Bidentatae 10% Fructus Cnidii 5%, the Fructus Kochiae 5%, Semen Coicis 10%, Semen Plantaginis 3%.
Method for making: the every medical material in will writing out a prescription is made decoction pieces, doubly measures 80% ethanol with 8-10 and carries secondary, and each 2.0h filters, and is condensed into extractum 1.; All the other pulverizing medicinal materials, mixing, medicinal material coarse powder is carried secondary with 8 times of water gagings, and each 1.5h filters, and is condensed into extractum 2., merges to concentrate, and makes capsule according to a conventional method.
Embodiment eight: pharmacodynamic experiment
The present invention writes out a prescription and prepares the 50 routine clinical observations of capsule for treating chronic pelvic inflammatory disease
Pelvic inflammatory disease is meant the female sex organ inflammation, is one of common gynecological disease, frequently-occurring disease.And chronic pelvic inflammatory disease is many by the delay of acute pelvic inflammatory disease malpractice and cause, or because of onset slowly ignore treat due to.This disease symptoms is various, the time heavy when light, outbreak repeatedly, clinical course of treatment is long, delays with the passing of time not heal.The author treated 50 examples with capsule of the present invention to chronic pelvic inflammatory disease in 2000～2002 years, and established matched group 40 examples by randomly assigne and treat with FULE CHONGJI, through clinical observation and statistical procedures, had shown that capsule of the present invention is evident in efficacy, now was reported as follows.
1 clinical data
1.1 physical data is originally organized 90 examples and is clinic case, minimum 21 years old of age, maximum 47 years old.21～30 years old 35 examples, 31～40 years old 40 example, 41～47 years old 15 example.Full group patient is divided into treatment at random and organizes 50 examples, and 30.4 years old mean age, matched group 40 examples, have comparability at 31.2 years old mean age.
1.2 diagnostic criteria is according to the diagnostic criteria of " practical combination of Chinese and Western medicine diagnoses and treatment " chronic pelvic inflammatory disease.
1.3 how not obvious the general General Symptoms of symptom is, lower abdomen weigh down to expand, pain and waist can pain, behind tired, sexual life or the aggravation in menstrual period, and often with menoxenia, leucorrhoea grow in quantity etc.
1.4 the sign uterine activity is often limited, adhesion is fixed, in the uterus and ovary one side or bilateral can touch pallial siphuncle, and tenderness is arranged, during inflammation of pelvic connective tissue, a side or bilateral have lamellar to thicken, tenderness maybe can be beaten and enclosed mass.
1.5 square medicine is formed by the capsule of the prescription in the embodiment of the invention one according to method for making three preparations, 4 of every clothes, and every day 3 times, warm water delivery service, serveing on 1 month was 1 course of treatment.
Matched group is with FULE CHONGJI, medicine is formed: Caulis Lonicerae, Caulis Sargentodoxae, Folium Isatidis, Herba Taraxaci, Flos Moutan, Radix Paeoniae Rubra, Radix et Rhizoma Rhei (processed), Rhizoma Corydalis, Fructus Toosendan, Radix Glycyrrhizae etc.) every day 3 times, each 2 bags (every bag 6g is equivalent to crude drug 27.7g) are taken after mixing it with water, and serveing on 1 month is 1 course of treatment.The patient treatment time, the shortest is 1 course of treatment, and the longest is 3 courses of treatment.
2 criterions of therapeutical effect and therapeutic outcome
2.1 criterion of therapeutical effect is divided into healing, produce effects, improvement and invalid with reference to the criterion of therapeutical effect of " practical combination of Chinese and Western medicine diagnoses and treatment " chronic pelvic inflammatory disease.
Cure: symptom, woman examine and recover normal.
Produce effects: transference cure, woman's inspection also obviously improves.
Take a turn for the better: symptom, sign and inspection all have improvement.
Invalid: symptom and sign do not have improvement.
2.2 50 examples are organized in the therapeutic outcome treatment, 34 examples of fully recovering, produce effects 9 examples, effective 5 examples, invalid 2 examples.Cure rate 72%, obvious effective rate 14%, total effective rate 96%.
Matched group 40 examples, 17 examples of fully recovering, produce effects 7 examples, effective 7 examples, invalid 9 examples.Cure rate 47.5%, obvious effective rate 12.5%, total effective rate 77.5%.Two groups of curative effects are learned processing more by statistics, and highly significant difference (p＜0.01) is arranged.The results are shown in Table 1.
Two groups of clinical efficacies relatively before and after table 1 treatment
3 medical records for example
Lin is 35 years old, married.Because of lacking abdomen pain 2 years, increase the weight of January and go to a doctor in 2001-11-05 day.The patient has chronic pelvic inflammatory disease medical history 2 years surplus, once uses the Western medicine antibiotic therapy in hospital, the control of disease feelings.Nearly January because of fatigue after the few abdomen pain of sense, lumbosacral region weighs down pain to be done again, profuse leukorrhea, yellow skin matter is thick, the companion whole body is weak, lower abdomen weighed down and expanded obviously menstrual period, many through measuring, color is dark red piece, yellow and thin fur, tongue is dark red, deep and stringy pulse.Woman's inspection is shown: retroposition of uterus, increase, and the bilateral adnexa thickens, and left side attachment can be touched the big enclosed mass of Ovum Columba livia, and tenderness is obvious.Ultrasound diagnosis is shown: the visible inflammatory mass of left side attachment.Examine and be chronic pelvic inflammatory disease, Chinese medical discrimination belongs to stagnation of QI and blood, retention of damp-heat in the interior.Take capsule for treating of the present invention, take 2 courses of treatment continuously after, all diseases disappears, gynecologial examination is shown: retroposition of uterus is normal, the bilateral adnexa does not have the phenomenon of thickening, inflammatory mass disappears, no tenderness.Following up a case by regular visits to half a year does not send out.
4 discuss
Chronic pelvic inflammatory disease belongs to traditional Chinese medical science stomachache, dysmenorrhea, leukorrhagia, mass in the abdomen, menoxenia, disease category such as infertile.Its morbidity many with menstrual period, puerperal, the vessels of the uterus inanition experience gas of damp and hot evil poison, causes stagnation of QI-blood, the very then strongly fragrant rotten pus that becomes, damp-heat accumulation then blocks QI-blood circulation for a long time, the stasis of blood that wets friendship hinders and Xing Cheng Disorder piece.
Chronic pelvic inflammatory disease is common gynecological disease, difficult treatment, the touching characteristics that do not heal, are easy to recur is arranged in clinical.It also is a great problem in the gyniatrics.Pelvic infection mostly is the mixed infection of aerobe and anaerobe.We sum up the clinical experience for the treatment of primary disease for many years, in conjunction with the theoretical foundation of " the many stasis of bloods of prolonged illness ".Think damp invasion of lower energizer, it is the main pathogenesis of chronic pelvic inflammatory disease that the pyretic toxicity stasis of blood stagnates.Control dialectical thinking from wet, heat, poison, stasis of blood opinion, summed up and collect heat clearing away, dampness, blood stasis dispelling, detoxify, obtained clinical efficacy preferably in a side capsule for treating primary disease of the present invention into primary disease.Full side selects the medicine pathogenesis that links closely, and from clinical observation, can alleviate clinical symptoms and sign, can play immunoloregulation function again.By improving patient's cellular immune function and improving the pelvic cavity blood circulation, promote disappearing of inflammatory lesions and softening and absorption of proliferative lesion.Allomeric function and local patholoic change are obviously improved, embodied and given full play to the integrally-regulated characteristic of the traditional Chinese medical science, play the effect of strengthening vital QI to eliminate pathogenic factors.Observe during we use and do not see toxic and side effects and remarkable untoward reaction.The mechanism of action of its treatment pelvic inflammatory disease remains further to be studied in the clinical practice.
Modern medicine think that primary disease infects mainly due to operation wound in childbirth, puerperium, miscarriage, the uterine cavity and situation such as menstrual phase body defensive enginery is weak under, pathogen is invaded genitals, causes inflammation exudate and surrounding tissue adhesion formation pelvic inflammatory disease.We have used heat-clearing and toxic substances removing in treatment side, the medicine of blood circulation promoting and blood stasis dispelling and cool the blood dissipate blood stasis.According to modern pharmacological research, heat and toxic materials clearing away medicine has stronger inhibitory action to pathogen, the inflammatory infiltration and blood circulation promoting and blood stasis dispelling and cool the blood dissipate blood stasis medicine can dissipate, suppress fibrin and form, strengthen the peritoneum absorption function, antibacterial and toxin are absorbed into blood rapidly and excrete after with its deactivation metabolism by different approach, simultaneously can microcirculation improvement, by the softening outgrowth fibrous tissue of microcirculation improvement, decompose adhesion, help the absorption of enclosed mass.Along with the improvement of inflammatory infiltration, local symptom such as pain, leucorrhea are many, hemorrhage etc. also disappears thereupon or improves.In addition, we also observe, and therapeutic effect and course of disease relation are closer.Course of disease elder, the course of treatment is corresponding longer.Course of disease weak point person, the course of treatment is also shorter.This also points out us, and the patient long to the course of disease needs long treatment time.
Claims (7)
1, a kind of chronic pelvic inflammatory disease Chinese medicine composition of preventing and treating is characterized in that said composition serves as basis side with 6 flavor Chinese medicines such as the Radix Pulsatillae, Rhizoma Cyperi, Cortex Phellodendri, Rhizoma Atractylodis, Radix Achyranthis Bidentatae, Fructus Cnidii, and its percentage by weight is:
Radix Pulsatillae 20-25%
Rhizoma Cyperi 20-25%
Cortex Phellodendri 5-15%
Rhizoma Atractylodis 10-15%
Radix Achyranthis Bidentatae 10-15%
Fructus Cnidii 5-10%
2,, it is characterized in that the percentage by weight of said composition is according to the described Chinese medicine composition of claim 2:
The Radix Pulsatillae 25%
Rhizoma Cyperi 25%
Cortex Phellodendri 10%
Rhizoma Atractylodis 15%
Radix Achyranthis Bidentatae 15%
Fructus Cnidii 10%
3, according to the described Chinese medicine composition of claim 1-3, one or more in the function Chinese medicines such as it is characterized in that can also other the spleen strengthening and damp drying of compatibility, promoting QI circulation for relieving depression, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing.
4, according to the medicine of the described compatibility of claim 3, wherein invigorating the spleen to clear away damp pathogen medical instrument body refers to the Rhizoma Atractylodis Macrocephalae, Poria, the Fructus Kochiae, Semen Plantaginis, Semen Coicis etc.; Promoting QI circulation for relieving depression medical instrument body refers to Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Fructus Aurantii, Fructus Toosendan etc.; Blood circulation and stasis-eliminating medicine specifically refers to Radix Cyathulae, Rhizoma Corydalis, Radix Curcumae, Pollen Typhae etc.; Heat and toxic materials clearing away medicine specifically refers to Radix Sophorae Flavescentis, Radix Gentianae, Rhizoma Osmundae, Rhizoma Paridis, Rhizoma Smilacis Glabrae, Herba Hedyotidis Diffusae etc., and survival dose is conventional recommended amounts in each flavor.
5, according to the Chinese medicine composition of any one qualification among the claim 1-4 in the application that prevents and treats aspect the chronic pelvic inflammatory disease, diseases such as main control chronic adnexitis, chronic cervicitis, cervical erosion, disease is seen: lower abdomen pain, the leucorrhea amount is many, matter is rare or thickness etc.
6,, it is characterized in that and to make various dosage forms on the medicament book according to conventional method that its administering mode is oral or topical, the preferred oral administration according to the described Chinese medicine composition of claim 1-5.
7, according to the described Chinese medicine composition of claim 6, it is characterized in that making tablet, capsule, oral liquid, pill, granule, colloid, syrup, can also add to and make chewing gum and chewable tablet in the food, preferred capsule.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784664A (en) * | 2014-01-27 | 2014-05-14 | 贵州师范大学 | Dual-phase capsule for preventing and treating chronic pelvic inflammation and preparation method and detection method thereof |
| CN104189302A (en) * | 2014-09-29 | 2014-12-10 | 洛阳御平国生物科技有限公司 | Traditional Chinese medicine formula for treating pelvic inflammatory disease |
| CN105596371A (en) * | 2016-01-27 | 2016-05-25 | 林阳炎 | Agentia for treating cervical erosion and preparing method of agentia |
| CN107693723A (en) * | 2017-09-05 | 2018-02-16 | 夏季 | A kind of medicine for treating cervical erosion and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069058C (en) * | 1999-03-08 | 2001-08-01 | 薛东波 | Compound medicament for treating chronic pelvic inflammation |
| CN1364499A (en) * | 2001-01-12 | 2002-08-21 | 杨孟君 | Nano three wonderful medicine and its preparing method |
| CN101244141B (en) * | 2008-03-09 | 2011-11-09 | 林海 | Externally used Chinese medicine for treating mild colpitis |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103784664A (en) * | 2014-01-27 | 2014-05-14 | 贵州师范大学 | Dual-phase capsule for preventing and treating chronic pelvic inflammation and preparation method and detection method thereof |
| CN103784664B (en) * | 2014-01-27 | 2017-03-08 | 贵州师范大学 | A kind of prevent and treat biphasic capsule of chronic pelvic inflammatory disease and preparation method thereof and detection method |
| CN104189302A (en) * | 2014-09-29 | 2014-12-10 | 洛阳御平国生物科技有限公司 | Traditional Chinese medicine formula for treating pelvic inflammatory disease |
| CN105596371A (en) * | 2016-01-27 | 2016-05-25 | 林阳炎 | Agentia for treating cervical erosion and preparing method of agentia |
| CN107693723A (en) * | 2017-09-05 | 2018-02-16 | 夏季 | A kind of medicine for treating cervical erosion and preparation method thereof |
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