CN1069058C - Compound medicament for treating chronic pelvic inflammation - Google Patents
Compound medicament for treating chronic pelvic inflammation Download PDFInfo
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- CN1069058C CN1069058C CN99115726A CN99115726A CN1069058C CN 1069058 C CN1069058 C CN 1069058C CN 99115726 A CN99115726 A CN 99115726A CN 99115726 A CN99115726 A CN 99115726A CN 1069058 C CN1069058 C CN 1069058C
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- rhizoma
- compound medicament
- medicament
- radix
- ethanol
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- 239000003814 drug Substances 0.000 title claims abstract description 52
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 title claims abstract description 14
- 230000001684 chronic effect Effects 0.000 title claims abstract description 14
- 150000001875 compounds Chemical class 0.000 title abstract description 11
- 238000000605 extraction Methods 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 34
- 239000007788 liquid Substances 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 14
- 238000012856 packing Methods 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 9
- 239000012567 medical material Substances 0.000 claims description 8
- 241000218176 Corydalis Species 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000010231 banlangen Substances 0.000 claims description 6
- 229940000425 combination drug Drugs 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000019634 flavors Nutrition 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 238000012546 transfer Methods 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000008297 liquid dosage form Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 15
- 210000000664 rectum Anatomy 0.000 abstract description 5
- 239000007920 enema Substances 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 206010037660 Pyrexia Diseases 0.000 abstract description 2
- 230000036737 immune function Effects 0.000 abstract description 2
- 238000012958 reprocessing Methods 0.000 abstract description 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 244000153955 Reynoutria sachalinensis Species 0.000 abstract 1
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 8
- 238000001990 intravenous administration Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 229940095399 enema Drugs 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 2
- 229960000282 metronidazole Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 241000213006 Angelica dahurica Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000001827 electrotherapy Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000008899 fufang danshen Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000003119 painkilling effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a compound medicament for treating chronic pelvic inflammation, which is prepared by that 11 traditional Chinese medicines of giant knotweed rhizome, etc. are prepared into physic liquor through extraction. The compound medicament is used by a rectum clyster mode; the use of the compound medicament is safe and reliable, and the compound medicament has no toxic or side effects; besides, the compound medicament has effects on resisting inflammation, inhibiting bacteria, alleviating pain, allaying a fever and enhancing immune functions with the cure rate of 24%, the obvious effective rate of 32% and the total effective rate of 94%. Because the compound medicament has a high concentration and a low dose, the compound medicament can prolong the detention time of the physic liquor in the recta, and the compound medicament can fully exert medicament effects and shorten a treatment course; besides, the physic liquor does not need reprocessing, which brings convenience to the use of patients.
Description
The invention belongs to the pure Chinese medicine compound medicaments preparation and the use of treatment chronic pelvic inflammatory disease.
Chronic pelvic inflammatory disease is one of commonly encountered disease, because its course of disease is long, easily outbreak repeatedly, has seriously influenced women's physical and mental health; And owing to state of an illness complexity, morbific pathogen differ, so many medicines are all undesirable." Journal of Traditional Chinese Medicine " 1993.34 (11): 680 reports are treated chronic pelvic inflammatory disease 42 examples, cure rate 20%, produce effects 31.9%, total effective rate 80.9% with Chinese medicine from intending the prescription decoction; Its contrast adopts ultrasound wave electrotherapy added with antibiotic to treat 32 examples, cure rate 21.9%, produce effects 25%, total effective rate 75%." Chinese combination of Chinese and Western medicine magazine " 1994.14 (3): 178 reports, with intending Chinese angelica rhizoma corydalis soup oral medication chronic pelvic inflammatory disease 112 examples certainly, 20～30 doses of first medications course of treatment, 10～12 doses of later per courses of treatment, carry out efficacy evaluation after three courses of treatment, cure rate 27.7%, produce effects 22.3%, total effective rate 95.5%." Chinese combination of Chinese and Western medicine magazine " 1994,14 (8): 505 reports, with 0.2% metronidazole injection 250ml, secondary intravenous drip every day, centre add with 5% glucose 500ml and add FUFANG DANSHEN ZHUSHEYE 16～24ml intravenous drip treatment chronic pelvic inflammatory disease 431 examples, and 7 days is a course of treatment, general 3～5 courses of treatment, its cure rate 52.79% takes a turn for the better 37.21%, total effective rate 90%; Contrast is with the intravenous drip of metronidazole injection 250ml secondary every day, and the centre adds with the antibiotic intravenous drip treats 43 examples, and 10 days is a course of treatment, cures 18.61% general 2～5 courses of treatment, takes a turn for the better 65.12%, total effective rate 83.73%." practical nursing magazine " 1995,11 (12): 25 reports, from intending prescription retention-enema treatment chronic pelvic inflammatory disease 116 examples, 10 days is a course of treatment, carries out curative effect 2～3 courses of treatment and judges produce effects 45%, total effective rate 93% with Chinese medicine.From above-mentioned document as can be seen, because chronic pelvic inflammatory disease cause of disease complexity, diseased region are special, pathogenic bacteria produces characteristics such as drug resistance is arranged, that doctor trained in Western medicine shows aspect treatment is unable to do what one wishes, weak curative effect, toxic and side effects are bigger, and Chinese herbal medicine can fundamentally solve the cause of disease, effect is remarkable, but traditional decoction therapy course of treatment is long, the medicine suffering how, and the long-term oral imapirment of the spleen and stomach that has; And the intravenous drug patient can't be voluntarily medical treatment and the course of treatment is long, drop is time-consuming influences work and abandoned by many people midway; Herbal retention enema treatment with its simple and easy to do, no wound, medicine without the intestines and stomach decomposition, absorbance height, treat advantages such as reliable and secure, more extensive patients is accepted, but it still has the following disadvantages: because medicament decocts for oneself, can not give full play to drug effect and inconvenience, and liquid dose big (100ml at least), short in the enteral retention time, more reduced drug effect, it also has the problem that the course of treatment is long, the patient can not be adhered in addition, and its prescription is not seen announcement.
Purpose of the present invention is exactly to propose a kind of pure Chinese medicine compound medicament for the treatment of chronic pelvic inflammatory disease and preparation method thereof, makes it that therapeutic effect is better, cure rate is higher, treatment cycle is shorter, use is more convenient.
The combination drug of treatment chronic pelvic inflammatory disease proposed by the invention, its pharmaceutical compositions and part by weight are: Rhizoma Polygoni Cuspidati 30, Cortex Phellodendri 10, Rhizoma Corydalis 10, Radix Salviae Miltiorrhizae 20, Rhizoma Chuanxiong 10, Rhizoma Cyperi 10, Caulis Sargentodoxae 15, Radix Achyranthis Bidentatae 10, Spica Prunellae 10, Radix Isatidis 10, Radix Glycyrrhizae 6, and be made into medicinal liquid, with the mode administration of rectum coloclysis.Medicaments preparation method of the present invention is: add 5～6 times 70% ethanol in Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Rhizoma Corydalis, extract 2 hours after-filtration with the heating and refluxing extraction method, ethanol in the filtrate is reclaimed obtain extracting solution again; The water that in Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Cyperi, Caulis Sargentodoxae, Radix Achyranthis Bidentatae, Spica Prunellae, Radix Isatidis, Radix Glycyrrhizae, adds 7～8 times in addition, decoct 2～3 hours after-filtration, filtrate is concentrated into below the crude drug weight, add ethanol to ethanol content 80%, leave standstill 24 hours after-filtration, reclaim ethanol in the filtrate, with the extracting solution that obtains with after aforementioned extracting solution mixes, transfer PH to 6,5～7, adding distil water is to 1: 1 of total crude drug content, more after filtration, become finished product after the packing, sterilization, packing.The using method of the prepared medicament of the present invention is: once-a-day, each 50ml heats to 38～40 ℃, and the preceding rectally of sleeping was lain on one's side 30～60 minutes, and 6 times is a course of treatment, needs 2～3 courses of treatment.
The prepared combination drug of the present invention proves that through toxicity test without any toxic and side effects and untoward reaction, it is safe and reliable; Prove to have the effect that antiinflammatory is antibacterial, pain relieving is brought down a fever and improve immunologic function through pharmacodynamics test; Observe through clinical trial, to 50 routine chronic pelvic inflammatory diseases after the treatment of two courses of treatment, its cure rate 24%, produce effects 32%, total effective rate 94%.Prepared medicament can prolong the retention time of medicinal liquid at rectum because concentration height, dosage are few, and medicinal liquid was not discharged from the same day, brings into play the effect that its heat-clearing and toxic substances removing, removing dampness remove band, stasis-dispelling and pain-killing, eliminating stagnation repercussive more fully, has shortened treatment cycle greatly; Also, need not reprocessing, bring convenience for patient's use because medicament has been made as finished product.This medicament has been declared health ministry examining.
Accompanying drawing 1 prepares the schematic flow sheet of combination drug for the present invention.
Illustrate the enforcement of technical solution of the present invention below in conjunction with accompanying drawing.
Combination drug of the present invention is pressed the preparation of 1000ml medicinal liquid, the amount of getting of various medical materials is: Rhizoma Polygoni Cuspidati 213g, Cortex Phellodendri 71g, Rhizoma Corydalis 71g, Radix Salviae Miltiorrhizae 142g, Rhizoma Chuanxiong 71g, Rhizoma Cyperi 71g, Caulis Sargentodoxae 106g, Radix Achyranthis Bidentatae 71g, Spica Prunellae 71g, Radix Isatidis 71g, Radix Glycyrrhizae 42g, total crude drug amount 1000g, be to contain 1: 1 crude drug composition by made medicinal liquid to determine, if the preparation amount of liquid medicine is big, then the crude drug amount also should be corresponding, only require in the ratio of aforementioned medical material and get it filled, the amount of getting of its various medical materials does not also require very strict, especially during mass production.Medicaments preparation method of the present invention is: add 6 times 70% ethanol in Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Rhizoma Corydalis, extract filtration in 2 hours with the heating and refluxing extraction method, carry out the reflux, extract, second time for 70% ethanol that adds 5 times in the filtering residue, ethanol does not extremely have the alcohol flavor with reclaiming the filtrate merging of secondary wherein again; At Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Cyperi, Caulis Sargentodoxae, Radix Achyranthis Bidentatae, Spica Prunellae, Radix Isatidis, the decocting that adds 8 times in the Radix Glycyrrhizae boils 3 hours after-filtration, carrying out decocting the second time for the water that adds 7 times in the filtering residue extracts again, being concentrated into filtrate merging of secondary is less than (being 645ml) below the crude drug weight, in concentrated solution, add ethanol to ethanol content and reach 80%, leave standstill 24 hours after-filtration, ethanol is to there not being the alcohol flavor in the recovery filtrate, the extracting solution of this extracting solution with aforesaid Rhizoma Polygoni Cuspidati etc. mixed, after transferring PH to 6.5, it is 1000ml that adding distil water makes the medicinal liquid total amount, the crude drug content that is medicinal liquid is 1: 1, more after filtration, packing, sterilization, become finished medicines after the packing.Its packing can be to be a packing (50ml) at every turn, also can be to be per course of treatment a packing (300ml).Owing to contain volatile oil in Rhizoma Chuanxiong, the Rhizoma Cyperi, this two flavors medicine can be adopted earlier and decoct distillatory method recovery distillate, the residual medicine dreg residual liquid is together decocted extraction with medical materials such as Radix Salviae Miltiorrhizaes again, and do not influence the extraction of postorder, the distillate that reclaims is carried out emulsifying, become emulsion, can finish as adding emulsifying agent (Tween 80) so that profit mixes, when aforementioned two kinds of extracting solution mix, the distillate after the emulsifying is together added mixing, and postorder require constant.
The prepared medicament of the present invention should use front end to be intubate, the rear end enteroclysm device as the medicinal liquid bottle in use; Medicinal liquid after will heating the earlier soft bottle of medicinal liquid of packing into puts intubate, and intubate is inserted into rectum by anus, and extruding medicinal liquid bottle makes medicinal liquid enter rectum, treats that the intact back of medicine liquid irrigation takes out intubate and get final product.
Claims (3)
1. combination drug that is used for the treatment of chronic pelvic inflammatory disease, medicinal liquid dosage form for rectally, it is characterized in that, medicament is made up of the active ingredient of following medical material, and its used medical material and part by weight are: Rhizoma Polygoni Cuspidati 30, Cortex Phellodendri 10, Rhizoma Corydalis 10, Radix Salviae Miltiorrhizae 20, Rhizoma Chuanxiong 10, Rhizoma Cyperi 10, Caulis Sargentodoxae 15, Radix Achyranthis Bidentatae 10, Spica Prunellae 10, Radix Isatidis 10, Radix Glycyrrhizae 6.
2. medicament according to claim 1, it is characterized in that, described medicaments preparation method is: add 5～6 times 70% ethanol in Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Rhizoma Corydalis, extract 2 hours after-filtration with the heating and refluxing extraction method, ethanol in the filtrate is reclaimed obtain extracting solution again; The water that in Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Cyperi, Caulis Sargentodoxae, Radix Achyranthis Bidentatae, Spica Prunellae, Radix Isatidis, Radix Glycyrrhizae, adds 7～8 times in addition, decoct 2～3 hours after-filtration, filtrate is concentrated into below the crude drug weight, add ethanol to ethanol content 80%, leave standstill 24 hours after-filtration, reclaim ethanol in the filtrate, with the extracting solution that obtains with after aforementioned extracting solution mixes, transfer PH to 6.5～7, adding distil water is to 1: 1 of total crude drug content, more after filtration, become finished product after the packing, sterilization, packing.
3. medicament according to claim 2, it is characterized in that, Rhizoma Chuanxiong, Rhizoma Cyperi two flavor medical materials earlier with decocting distillatory method processing, the residual medicine dreg residual liquid together being decocted extraction with medical material such as Radix Salviae Miltiorrhizae again, are together mixed the distillate that obtains with described two kinds of extracting solution after emulsifying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99115726A CN1069058C (en) | 1999-03-08 | 1999-03-08 | Compound medicament for treating chronic pelvic inflammation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99115726A CN1069058C (en) | 1999-03-08 | 1999-03-08 | Compound medicament for treating chronic pelvic inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1231924A CN1231924A (en) | 1999-10-20 |
| CN1069058C true CN1069058C (en) | 2001-08-01 |
Family
ID=5278643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99115726A Expired - Lifetime CN1069058C (en) | 1999-03-08 | 1999-03-08 | Compound medicament for treating chronic pelvic inflammation |
Country Status (1)
| Country | Link |
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| CN (1) | CN1069058C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101637552B (en) * | 2009-09-09 | 2011-05-18 | 苏州世林医药技术发展有限公司 | Chinese medicine compound for controlling chronic pelvic inflammation |
| CN101926961B (en) * | 2010-08-20 | 2011-11-16 | 刘锦 | Oral Chinese medicinal composition for treating pelvic inflammatory disease |
| CN102847123B (en) * | 2012-09-26 | 2013-12-11 | 张永红 | Drug for treating chronic pelvic inflammatory disease and preparation method of medicine |
| CN103356975B (en) * | 2013-08-06 | 2016-02-10 | 河南中医学院 | A kind of Chinese medicine keritherapy tincture for the treatment of chronic pelvic inflammatory disease |
-
1999
- 1999-03-08 CN CN99115726A patent/CN1069058C/en not_active Expired - Lifetime
Non-Patent Citations (3)
| Title |
|---|
| 福建中医学院学报1997，7(4) 2097.4.30 邱如卿，复方金刚藤治疗盆腔慢性炎症性包块30例临床观察 * |
| 福建中医学院学报1997，7(4) 2097.4.30 邱如卿，复方金刚藤治疗盆腔慢性炎症性包块30例临床观察;贵阳中医学院学报1998，20(3) 2098.3.31 戴伟瑛，宝光妇乐与甲硝唑合用治疗妇科急慢性炎症200例报告 * |
| 贵阳中医学院学报1998，20(3) 2098.3.31 戴伟瑛，宝光妇乐与甲硝唑合用治疗妇科急慢性炎症200例报告 * |
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| Publication number | Publication date |
|---|---|
| CN1231924A (en) | 1999-10-20 |
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