CN101611009A - 喹啉衍生物 - Google Patents

喹啉衍生物 Download PDF

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Publication number
CN101611009A
CN101611009A CNA2007800346135A CN200780034613A CN101611009A CN 101611009 A CN101611009 A CN 101611009A CN A2007800346135 A CNA2007800346135 A CN A2007800346135A CN 200780034613 A CN200780034613 A CN 200780034613A CN 101611009 A CN101611009 A CN 101611009A
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Prior art keywords
methyl
phenyl
oxine
chloro
base
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Chinese (zh)
Inventor
瑟格弗雷德·赫吉米
凯文·迈克波里德
阿布德尔玛德基德·K·熙熙
一兰纳耶·卡尼可卡
王颖
斯蒂芬·李奥纳多·海耶斯
玛丽-皮尔勒·谷曼德
盖伊·思维格尼
丹尼尔·杜马斯
朱莉安·史密斯
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CHRONOGEN Inc
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CHRONOGEN Inc
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Publication of CN101611009A publication Critical patent/CN101611009A/zh
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    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/24—Oxygen atoms attached in position 8
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2007800346135A 2006-07-25 2007-07-25 喹啉衍生物 Pending CN101611009A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83293706P 2006-07-25 2006-07-25
US60/832,937 2006-07-25

Publications (1)

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CN101611009A true CN101611009A (zh) 2009-12-23

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EP (1) EP2079699A1 (fr)
JP (1) JP2009544631A (fr)
CN (1) CN101611009A (fr)
AU (1) AU2007280984A1 (fr)
CA (1) CA2658793A1 (fr)
RU (1) RU2009106461A (fr)
WO (1) WO2008014602A1 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
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CN102712596A (zh) * 2009-12-29 2012-10-03 波利化学公司 新的仲8-羟基喹啉-7-羧酰胺衍生物
CN102985407A (zh) * 2010-05-06 2013-03-20 阿维丁研究开发和商业有限责任公司 8-羟基-喹啉衍生物
CN105073714A (zh) * 2012-12-20 2015-11-18 奥尔德拉医疗公司 迫位原醇
CN105452224A (zh) * 2013-04-02 2016-03-30 安基生技制药股份有限公司 作为抗神经退化剂的多官能性喹啉衍生物
US10550085B2 (en) 2015-08-21 2020-02-04 Aldeyra Therapeutics, Inc. Deuterated compounds and uses thereof
CN111689944A (zh) * 2020-06-10 2020-09-22 中山大学 喹啉色胺杂联体及其在制备治疗阿尔茨海默病的药物中的应用
CN111920811A (zh) * 2018-06-13 2020-11-13 四川轻化工大学 一种治疗抗痛风、抗高尿酸血症的药物组合物ⅲ
US11007157B2 (en) 2013-01-23 2021-05-18 Aldeyra Therapeutics, Inc. Toxic aldehyde related diseases and treatment
US11129823B2 (en) 2016-05-09 2021-09-28 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
US11312692B1 (en) 2018-08-06 2022-04-26 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
CN114650988A (zh) * 2019-11-01 2022-06-21 詹森生物科技公司 作为二氢乳清酸脱氢酶(dhodh)抑制剂用于治疗癌症、自身免疫性和炎性疾病的氟化喹啉和喹喔啉衍生物
US11724987B2 (en) 2005-05-26 2023-08-15 Aldeyra Therapeutics, Inc. Compositions and methods of treating retinal disease
US12029735B2 (en) 2019-05-02 2024-07-09 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
US12064516B2 (en) 2020-05-13 2024-08-20 Aldeyra Therapeutics, Inc. Pharmaceutical formulations and uses thereof
US12098132B2 (en) 2020-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates

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WO2009151972A1 (fr) * 2008-05-28 2009-12-17 , The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of U.S. Army Medical Research And Materiel Command Inhibiteurs à petites molécules de neurotoxines botuliniques
US9000009B2 (en) * 2008-12-10 2015-04-07 The Trustees Of The University Of Pennsylvania Small molecule activators of mitochondrial function
US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
DK2427467T3 (en) 2009-05-07 2015-11-09 Univ Minnesota Triptolid prodrugs
WO2011041655A1 (fr) 2009-10-01 2011-04-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dérivés de la quinazolin-4-amine; et méthodes d'utilisation
US9814701B2 (en) 2009-12-11 2017-11-14 Aldeyra Therapeutics, Inc. Compositions and methods for the treatment of macular degeneration
EP2345642A1 (fr) * 2009-12-29 2011-07-20 Polichem S.A. Dérivés de 8-hydroxyquinoline-7-carboxamide secondaire pour une utilisation en tant qu'agents antifongiques
US8658170B2 (en) 2010-01-06 2014-02-25 Joseph P. Errico Combination therapy with MDM2 and EFGR inhibitors
EP2521553A4 (fr) * 2010-01-06 2013-08-28 Errico Joseph P Méthodes et compositions pour le développement de médicaments ciblés
CN102858763B (zh) * 2010-02-23 2015-01-21 康奈尔大学 脯氨酰羟化酶抑制剂及其使用方法
CA2799792A1 (fr) * 2010-05-18 2011-11-24 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Inhibiteurs de la 12-lipoxygenase humaine
MX2013015058A (es) 2011-06-24 2014-01-20 Amgen Inc Antagonistas de melastatina 8 de potencial receptor transitorio y su uso en tratamientos.
CA2839699A1 (fr) 2011-06-24 2012-12-27 Amgen Inc. Antagonistes de trpm8 et leur utilisation dans des traitements
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
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