CN101605800B - 锂交换反应方法 - Google Patents

锂交换反应方法 Download PDF

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Publication number
CN101605800B
CN101605800B CN200880004269XA CN200880004269A CN101605800B CN 101605800 B CN101605800 B CN 101605800B CN 200880004269X A CN200880004269X A CN 200880004269XA CN 200880004269 A CN200880004269 A CN 200880004269A CN 101605800 B CN101605800 B CN 101605800B
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China
Prior art keywords
reagent
reaction
microreactor
lithium
fluids
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Expired - Fee Related
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CN200880004269XA
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English (en)
Chinese (zh)
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CN101605800A (zh
Inventor
多米尼克·罗贝热
威廉·奎特曼
马库斯·埃雅尔泽
伯廷·齐默尔曼
法比奥·拉伊诺内
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Lonza AG
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Lonza AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Catalysts (AREA)
CN200880004269XA 2007-02-06 2008-02-01 锂交换反应方法 Expired - Fee Related CN101605800B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07002522 2007-02-06
EP07002522A EP1956023A1 (en) 2007-02-06 2007-02-06 Method for lithium exchange reactions
PCT/EP2008/000808 WO2008095646A1 (en) 2007-02-06 2008-02-01 Method for lithium exchange reactions

Publications (2)

Publication Number Publication Date
CN101605800A CN101605800A (zh) 2009-12-16
CN101605800B true CN101605800B (zh) 2013-01-09

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ID=38179681

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CN200880004269XA Expired - Fee Related CN101605800B (zh) 2007-02-06 2008-02-01 锂交换反应方法

Country Status (17)

Country Link
US (1) US8198487B2 (https=)
EP (2) EP1956023A1 (https=)
JP (1) JP5394258B2 (https=)
CN (1) CN101605800B (https=)
AT (1) ATE478877T1 (https=)
BR (1) BRPI0807155A2 (https=)
CA (1) CA2674560A1 (https=)
DE (1) DE602008002321D1 (https=)
EA (1) EA015237B1 (https=)
ES (1) ES2351376T3 (https=)
HR (1) HRP20100627T1 (https=)
IL (1) IL199749A (https=)
MX (1) MX2009008352A (https=)
PL (1) PL2109616T3 (https=)
PT (1) PT2109616E (https=)
SI (1) SI2109616T1 (https=)
WO (1) WO2008095646A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS56990B1 (sr) 2007-09-10 2018-05-31 Janssen Pharmaceutica Nv Postupak za dobijanje jedinjenja koja su korisna kao inhibitori sglt
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
EP2451797B1 (en) 2009-07-10 2013-04-03 Janssen Pharmaceutica, N.V. CRYSTALLISATION PROCESS FOR 1-(ß-D-GLUCOPYRANOSYL)-4-METHYL-3-[5-(4-FLUOROPHENYL)-2-THIENYLMETHYL]BENZENE
HUE031375T2 (en) * 2009-10-14 2017-07-28 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of sglt2
SG10201506114UA (en) 2010-05-11 2015-09-29 Janssen Pharmaceutica Nv Pharmaceutical formulations comprising 1 - (beta-d-glucopyranosyl) - 2 -thienylmethylbenzene derivatives as inhibitors of sglt
EP2697218B1 (en) 2011-04-13 2016-05-25 Janssen Pharmaceutica NV Process for the preparation of compounds useful as inhibitors of sglt2
TWI542596B (zh) 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
ES2917410T3 (es) * 2017-11-14 2022-07-08 Albemarle Germany Gmbh Procesos con organolitio bajo condiciones de flujo continuo
DE102019008481A1 (de) * 2018-12-21 2020-06-25 Merck Patent Gmbh Kontinuierliches Verfahren zur Funktionalisierung von fluorierten Benzolverbindungen im Strömungsrohr
CN110510637B (zh) * 2019-08-22 2021-02-23 山东师范大学 一种锂循环合成氨的系统及工艺

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1500649A1 (de) * 2003-07-22 2005-01-26 CPC Cellular Process Chemistry Systems GmbH Verfahren zur Durchführung einer In-Situ-Quench Reaktion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19858856A1 (de) * 1998-12-19 2000-06-21 Merck Patent Gmbh Verfahren zur Herstellung von Arylmetallverbindungen und deren Umsetzung mit Elektrophilen
DE10028754A1 (de) * 2000-06-09 2001-12-13 Clariant Gmbh Verfahren zur Herstellung von alkoholischen Lösungen von Alkalialkoholaten
JP4639042B2 (ja) * 2003-09-29 2011-02-23 富士フイルムファインケミカルズ株式会社 ハロゲン−リチウム交換反応を用いる有機化合物の製造法
JP4794873B2 (ja) * 2005-03-03 2011-10-19 富士フイルムファインケミカルズ株式会社 ハロゲン−リチウム交換反応を用いる有機化合物の製造法
AT501927B1 (de) * 2005-05-23 2007-06-15 Dsm Fine Chem Austria Gmbh Verbessertes verfahren zur durchführung von ritterreaktionen, elektrophilen additionen an alkenen oder friedel-crafts-alkylierungen
JPWO2008035633A1 (ja) * 2006-09-19 2010-01-28 萬有製薬株式会社 反応装置及び反応方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1500649A1 (de) * 2003-07-22 2005-01-26 CPC Cellular Process Chemistry Systems GmbH Verfahren zur Durchführung einer In-Situ-Quench Reaktion

Also Published As

Publication number Publication date
BRPI0807155A2 (pt) 2014-04-22
US20100113839A1 (en) 2010-05-06
HK1138008A1 (en) 2010-08-13
ATE478877T1 (de) 2010-09-15
DE602008002321D1 (de) 2010-10-07
HRP20100627T1 (hr) 2010-12-31
WO2008095646A1 (en) 2008-08-14
CN101605800A (zh) 2009-12-16
EA015237B1 (ru) 2011-06-30
JP2010518035A (ja) 2010-05-27
US8198487B2 (en) 2012-06-12
PL2109616T3 (pl) 2011-05-31
IL199749A (en) 2013-02-28
EP2109616B1 (en) 2010-08-25
JP5394258B2 (ja) 2014-01-22
SI2109616T1 (sl) 2010-12-31
EP2109616A1 (en) 2009-10-21
IL199749A0 (en) 2010-04-15
CA2674560A1 (en) 2008-08-14
EP1956023A1 (en) 2008-08-13
PT2109616E (pt) 2010-11-29
EA200901037A1 (ru) 2010-02-26
ES2351376T3 (es) 2011-02-03
MX2009008352A (es) 2009-10-30

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