CN101605800B - 锂交换反应方法 - Google Patents

锂交换反应方法 Download PDF

Info

Publication number
CN101605800B
CN101605800B CN200880004269XA CN200880004269A CN101605800B CN 101605800 B CN101605800 B CN 101605800B CN 200880004269X A CN200880004269X A CN 200880004269XA CN 200880004269 A CN200880004269 A CN 200880004269A CN 101605800 B CN101605800 B CN 101605800B
Authority
CN
China
Prior art keywords
reagent
reaction
microreactor
lithium
fluids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200880004269XA
Other languages
English (en)
Chinese (zh)
Other versions
CN101605800A (zh
Inventor
多米尼克·罗贝热
威廉·奎特曼
马库斯·埃雅尔泽
伯廷·齐默尔曼
法比奥·拉伊诺内
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38179681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101605800(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lonza AG filed Critical Lonza AG
Publication of CN101605800A publication Critical patent/CN101605800A/zh
Application granted granted Critical
Publication of CN101605800B publication Critical patent/CN101605800B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Catalysts (AREA)
CN200880004269XA 2007-02-06 2008-02-01 锂交换反应方法 Expired - Fee Related CN101605800B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07002522 2007-02-06
EP07002522A EP1956023A1 (en) 2007-02-06 2007-02-06 Method for lithium exchange reactions
PCT/EP2008/000808 WO2008095646A1 (en) 2007-02-06 2008-02-01 Method for lithium exchange reactions

Publications (2)

Publication Number Publication Date
CN101605800A CN101605800A (zh) 2009-12-16
CN101605800B true CN101605800B (zh) 2013-01-09

Family

ID=38179681

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880004269XA Expired - Fee Related CN101605800B (zh) 2007-02-06 2008-02-01 锂交换反应方法

Country Status (17)

Country Link
US (1) US8198487B2 (https=)
EP (2) EP1956023A1 (https=)
JP (1) JP5394258B2 (https=)
CN (1) CN101605800B (https=)
AT (1) ATE478877T1 (https=)
BR (1) BRPI0807155A2 (https=)
CA (1) CA2674560A1 (https=)
DE (1) DE602008002321D1 (https=)
EA (1) EA015237B1 (https=)
ES (1) ES2351376T3 (https=)
HR (1) HRP20100627T1 (https=)
IL (1) IL199749A (https=)
MX (1) MX2009008352A (https=)
PL (1) PL2109616T3 (https=)
PT (1) PT2109616E (https=)
SI (1) SI2109616T1 (https=)
WO (1) WO2008095646A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010002695A (es) 2007-09-10 2010-04-01 Janssen Pharmaceutica Nv Proceso para la preparacion de compuestos utiles como inhibidores de transportador de glucosa dependiente de sodio (sglt).
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
KR101532412B1 (ko) 2009-07-10 2015-06-29 얀센 파마슈티카 엔.브이. 1-(β-Ｄ-글루코피라노실)-4-메틸-3-(5-(4-플루오로페닐)-2-티에닐메틸) 벤젠의 결정화 방법
SI2488515T1 (sl) * 2009-10-14 2017-04-26 Janssen Pharmaceutica Nv Postopek za pripravo spojin, ki so uporabne kot inhibitorji SGLT2
TWI599360B (zh) 2010-05-11 2017-09-21 健生藥品公司 醫藥調配物
RS55056B1 (sr) 2011-04-13 2016-12-30 Janssen Pharmaceutica Nv Proces za pripremu jedinjenja koja su korisna kao inhibitori sglt2
TWI542596B (zh) 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
CN111465588B (zh) * 2017-11-14 2023-04-28 雅宝德国有限责任公司 在连续流动条件下的有机锂工艺
DE102019008481A1 (de) * 2018-12-21 2020-06-25 Merck Patent Gmbh Kontinuierliches Verfahren zur Funktionalisierung von fluorierten Benzolverbindungen im Strömungsrohr
CN110510637B (zh) * 2019-08-22 2021-02-23 山东师范大学 一种锂循环合成氨的系统及工艺

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1500649A1 (de) * 2003-07-22 2005-01-26 CPC Cellular Process Chemistry Systems GmbH Verfahren zur Durchführung einer In-Situ-Quench Reaktion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19858856A1 (de) * 1998-12-19 2000-06-21 Merck Patent Gmbh Verfahren zur Herstellung von Arylmetallverbindungen und deren Umsetzung mit Elektrophilen
DE10028754A1 (de) * 2000-06-09 2001-12-13 Clariant Gmbh Verfahren zur Herstellung von alkoholischen Lösungen von Alkalialkoholaten
JP4639042B2 (ja) * 2003-09-29 2011-02-23 富士フイルムファインケミカルズ株式会社 ハロゲン−リチウム交換反応を用いる有機化合物の製造法
JP4794873B2 (ja) * 2005-03-03 2011-10-19 富士フイルムファインケミカルズ株式会社 ハロゲン−リチウム交換反応を用いる有機化合物の製造法
AT501927B1 (de) * 2005-05-23 2007-06-15 Dsm Fine Chem Austria Gmbh Verbessertes verfahren zur durchführung von ritterreaktionen, elektrophilen additionen an alkenen oder friedel-crafts-alkylierungen
AU2007298290A1 (en) * 2006-09-19 2008-03-27 Banyu Pharmaceutical Co., Ltd. Reaction apparatus, and reaction method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1500649A1 (de) * 2003-07-22 2005-01-26 CPC Cellular Process Chemistry Systems GmbH Verfahren zur Durchführung einer In-Situ-Quench Reaktion

Also Published As

Publication number Publication date
EP1956023A1 (en) 2008-08-13
IL199749A (en) 2013-02-28
HK1138008A1 (en) 2010-08-13
ES2351376T3 (es) 2011-02-03
JP2010518035A (ja) 2010-05-27
CA2674560A1 (en) 2008-08-14
IL199749A0 (en) 2010-04-15
EA015237B1 (ru) 2011-06-30
WO2008095646A1 (en) 2008-08-14
DE602008002321D1 (de) 2010-10-07
PL2109616T3 (pl) 2011-05-31
PT2109616E (pt) 2010-11-29
HRP20100627T1 (hr) 2010-12-31
EA200901037A1 (ru) 2010-02-26
EP2109616A1 (en) 2009-10-21
MX2009008352A (es) 2009-10-30
ATE478877T1 (de) 2010-09-15
JP5394258B2 (ja) 2014-01-22
EP2109616B1 (en) 2010-08-25
US20100113839A1 (en) 2010-05-06
US8198487B2 (en) 2012-06-12
SI2109616T1 (sl) 2010-12-31
BRPI0807155A2 (pt) 2014-04-22
CN101605800A (zh) 2009-12-16

Similar Documents

Publication Publication Date Title
CN101605800B (zh) 锂交换反应方法
CN103408601B (zh) 具有催化suzuki反应活性的异核双金属配合物及其制备方法
Yu et al. Amino group combined P/Ge and P/Sn Lewis pairs: synthesis and dipolar addition reactions to alkyne and aldehyde molecules
CN101495488B (zh) 在微反应器中的格里纳德型反应
CN108456235B (zh) 微反应器制备n,n-二甲基-(r)-1-[(s)-2-(二苯基膦)二茂铁基]乙胺
Begum et al. Synthesis and reactions of C-phosphanylated thiazol-2-thiones
HK1138008B (zh) 锂交换反应方法
Wang et al. Synthesis of rare earth metal complexes incorporating amido and enolate mixed ligands: Characterization and reactivity
Aroz et al. One-pot self-assembly of trinuclear silver (I) clusters containing propargyl alcohols and bis (diphenylphosphino) methane (dppm) ligands
Cheng et al. Reactions of Tp (NH [double bond, length as m-dash] CPh 2)(PPh 3) Ru–Cl with HC [triple bond, length as m-dash] CPh in the presence of H2O: insertion/hydration products
Lu et al. Synthesis of modified H4-BINOL ligands and their applications in the asymmetric addition of diethylzinc to aromatic aldehydes
CN112409114A (zh) 一种合成仲醇的方法
JP2011241173A (ja) 低原子価前周期金属化合物を用いたアルキンとアルケンからのシクロヘキサジエン類の製造方法
Lin et al. Rapid and practical synthesis of N-protected amino ketones in continuous flow via pre-deprotonation protocol
KR100330026B1 (ko) 케톤의 제조방법
Zhang Enantioselective and Diastereodivergent Conversion of Nitriles to Homoallylic Amines and Alcohols
CN119798317A (zh) 一种采用微通道反应器连续制备烷基磷酸二烷基酯的方法
CN116023264A (zh) 一种合成含α-手性三氟甲基的β-二羰基化合物的方法
Mitton Synthesis and Reactivity of Group 10 Silyl Pincer Complexes
Chan Mechanistic aspects of homogeneous catalytic asymmetric hydrogenation
HK1173718B (en) Grignard reactions in microreactors
HK1131786B (en) Grignard reactions in microreactors
JPH07258271A (ja) ベンゾ−１，４−ジシラシクロヘキセン誘導体及びその製造方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1138008

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1138008

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130109