CN101584852B - Pharmaceutical preparation for getting rid of phlegm and retained fluid - Google Patents
Pharmaceutical preparation for getting rid of phlegm and retained fluid Download PDFInfo
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- CN101584852B CN101584852B CN2009101593639A CN200910159363A CN101584852B CN 101584852 B CN101584852 B CN 101584852B CN 2009101593639 A CN2009101593639 A CN 2009101593639A CN 200910159363 A CN200910159363 A CN 200910159363A CN 101584852 B CN101584852 B CN 101584852B
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- rhizoma atractylodis
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Abstract
A pharmaceutical preparation for getting rid of phlegm and retained fluid is used for wintercough in modern medicine belonging to cold syndrome of insufficiency of both the spleen and the kidney; the preparation is granular formulation, soft capsule and other appropriate pharmaceutical formulations prepared by boiling volatile and fat-soluble ingredients extracted by 150g of rhizoma atractylodis, 50g of Rhizoma Zingiberis, 50g of cinnamon, 150g of rhizoma atractylodis macrocephalae, 75g of stir-baked sinapis alba, 100g of stir-baked fructus perillae, 150g of stir-baked radish seed and 75g of raw honey-fried aconite and 50g of honey-fried licorice root.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to pharmaceutical preparation of a kind of getting rid of phlegm and retained fluid and preparation method thereof.
Background technology
Expectorant and drink all are the formed pathological products of body fluid dysbolismus.Generally with the thicker turbid expectorant that is called, clear rare drink that is called.Expectorant stagnates at lung, as seen breathes with cough and coughs up phlegm; Stagnation of phlegm is in the heart, and painstaking effort are not smooth, visible chest distress and palpitation symptoms; Mental confusion due to phlegm, then visible coma, dementia; The heart disturbed by phlegm-fire is then sent out to demented; Expectorant is stopped at stomach, stomach-QI being unable to descend normally, visible nausea and vomiting, gastral cavilty feeling of fullness; Violate in head on expectorant is turbid, as seen dizzy, dusk emits; Blocking in the pharynx then can appear in the mental disorder throat that condenses, gulp down not down, the disease that does not go out of telling.The disease characteristics of drink are; Drink is between intestinal, and then the borborygmus sound of wind or of flowing waters is sound; Drink is coerced at breast, fullness and distention in the chest and hypochondrium then, dragging pain due to cough and spitting; Drink is at chest and diaphragm, and is then uncomfortable in chest, and cough with asthma can not be put down for sleeping inly, and its shape is as swollen; Accumulated water overflowing into skin and muscles is then seen skin edema, lossless, and health is painful heavy.
The cold syndrome that the modern medicine chronic tracheitis belongs to deficiency of spleen-YANG and kidneyYANG adopts the phlegm and retained fluid pills treatment more.This medicine is recorded in 12 in Chinese medicine promulgated by the ministries or commissions of the Central Government according to Traditional Chinese medical theory prescription and quilt.Because the progress of modern Chinese medicine preparation process makes and prescription can be made medicine more efficiently.
The invention scheme:
Medicament of the present invention is made by following medical material:
Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g,
Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g
Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g
Medicament of the present invention is made by the following method:
Volatility and liposoluble constituent that Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g extract, granule, soft capsule and other the suitable pharmaceutical dosage forms made with the decocting liquid of raw material Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g.
Medicament of the present invention can also be made by the following method:
Fructus Perillae, Semen Raphani, Semen Sinapis Albae steamed respectively about 30 minutes, and with the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi Rhizoma Atractylodis, Rhizoma Zingiberis supercritical extraction volatile oil and liposoluble constituent, the medicinal residues after supercritical extraction device are in addition collected; Medicinal residues such as volatile oil adopts cyclodextrin to solidify enclose, Fructus Perillae and Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae decoct with water three times, and 2 hours for the first time, second and third time each 1.5 hours, filter, filtrate merges, and is condensed into thick paste, with above-mentioned thick paste and solidified volatile oil and adjuvant mix homogeneously, drying, promptly.
Medicament of the present invention can also be made by the following method:
Fructus Perillae, Semen Raphani, Semen Sinapis Albae steamed respectively about 30 minutes, and with the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi Rhizoma Atractylodis, Rhizoma Zingiberis supercritical extraction volatile oil and liposoluble constituent, the medicinal residues after supercritical extraction device are in addition collected; Medicinal residues such as Fructus Perillae and Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae decoct with water three times, and 2 hours for the first time, second and third time each 1.5 hours filtered, filtrate merges, and is condensed into thick paste, is dried and crushed into fine powder, with above-mentioned fine powder and volatile oil and liposoluble constituent, adjuvant mix homogeneously, make soft capsule, promptly.
Effect of the present invention:
The phlegm and retained fluid pills process for super-critical extracting is to the influence research of Th1/Th2 cytokine in the rat model serum (IFN-γ, IL-4, IL-5) content.
Along with going deep into of molecular immunology research, discovery T lymphocyte is being controlled multiple air flue chronic inflammatory reaction.Research in recent years thinks that (T helper cell Th) exists the relation of interactive adjustment, i.e. the Th1/Th2 function balance to helper T cell between two kinds of hypotype Th1 and the Th2.As the unbalance of Th1/Th2 in the asthmatic patient body due to the phlegm retention is the important mechanisms of asthma morbidity.Th1 emiocytosis IFN-γ, cytokines such as IL-2, IL-3, the immunne response of mediation and cell toxicant and local inflammation-related participates in cellullar immunologic response; Th2 emiocytosis IL-4, cytokines such as IL-5, IL-13 stimulate B cell proliferation and produce antibody, and are relevant with humoral immunization.Th1 and Th2 are regulating the balance (Th1/Th2 balance) of the normal immunne response of body each other in the mode of mutual antagonism.When body was subjected to the specific antigen stimulation, this balance was broken, and allergen starts the Th2 polarization and replys
[12], the immunoreation of Th1 type weakens, and the immunoreation of Th2 type is then increased unusually
[13], abnormal immune occurs and reply.
1 experiment material
1.1 laboratory animal
Select cleaning level SD rat for use, male, monthly age 6-9 month, body weight 150-180 gram, totally 48.Observed three days at the experiment indoor feeding before the experiment, 6 in every cage, sub-cage rearing, the ad lib water inlet, feedstuff is the synthetic rat feed of standard particle.Laboratory ventilation, daylighting condition are good, about 20 ℃ of room temperatures.
1.2 experimental drug
1. phlegm and retained fluid pills preparation of the present invention: the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi are ground into 80 order mixings altogether; Fructus Perillae, Semen Raphani, Semen Sinapis Albae steamed respectively about 30 minutes, and oil is got in squeezing, steamed repeatedly and pressed three times, merged fatty oil, and medicinal residues device are in addition collected; Rhizoma Atractylodis, Rhizoma Zingiberis are pulverized, and extract volatile oil with 6 times of water gaging steam distillations respectively, and medicinal residues device are in addition collected; Medicinal residues such as Fructus Perillae and Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae add 5～12 times of amounts of water and decoct three times, and 2 hours for the first time, second and third time each 1.5 hours, filter, filtrate merges, and is condensed into 50～60 ℃ of following relative densities and is 1.05～1.15 thick paste, with above-mentioned medicated powder, fatty oil and adjuvant mix homogeneously, oven dry, be ground into fine powder, make granule, spray into volatile oil, mixing is made.
2. the commercially available finished product of dexamethasone acetate and phlegm and retained fluid pills.
1.3 main agents and test kit
Egg protein (ovalbumin, OVA) 8g/ bottle, deactivation bordetella pertussis vaccine 2ml/ prop up, aluminium hydroxide 500g/ bottle, rat IFN-γ, IL-5 enzyme linked immunological kit, rat IL-4 enzyme linked immunological kit.
2 experimental techniques
2.1 experiment grouping
48 healthy male rats are chosen in experiment, and body weight 150-180g is divided into four groups and numbering at random by body weight:
A group: 10 of normal control groups
B group: 14 of model control group
C group: 12 of commercially available phlegm and retained fluid pills treatment groups
D group: 12 of phlegm and retained fluid pills preparation for treating groups of the present invention
2.2 model copy
To model group and each treatment group respectively at the 1st day, the 8th day, every Mus is respectively with two groin, abdomen, the front foot sole of the foot totally 4 subcutaneous injection antigen liquids (containing the suspension that OVA100mg, about 5 * 109/ml of deactivation bordetella pertussis stock solution and aluminium hydroxide dry powder 100mg make) 0.2ml, simultaneously lumbar injection 0.2ml antigen liquid sensitization; The normal control group is carried out subcutaneous, lumbar injection with equivalent physiologic saline for substitute antigen liquid.Beginning in the 15th day places (in the transparent plastic casing with cover of homemade 50cm * 30cm * 20cm) in the closed unit with the modeling rat during 8-9 every night, gives suctions that atomize of 2%OVA solution, and the atomizing flow is 3ml/min, and lasting at every turn 20min excites asthma; The normal control group is with the suction that in kind atomizes of equivalent normal saline.Observe the reaction of modeling rat, agitation to occur, to tremble hair, cough, ventral breathing, rapid breathing, lip, eyes, ears cyanosis very then appear, twitch, after the symptom such as fall, get two rats at random and make the pathology sections observation, typical airway inflammation performances such as bronchial mucosa and Submucosa tissue have a large amount of EOS to soak into, bronchial wall thickens, proliferation of smooth muscle, luminal stenosis, tissue mucosa mild hyperaemia edema are considered as the sign that model excites success.
2.3 treatment administration
After the modeling success, the 15th day begins atomizing, and asthma excites the back gastric infusion, 1 time/day, continues 14 days.(dosage is converted according to document)
1. A group, B organize: every Mus is irritated stomach with distilled water 3ml;
2. C group, D organize: it is that 3ml irritates stomach that every Mus is dissolved with distilled water with phlegm and retained fluid pills 27.5g/ (kgd).
2.4 observation index
1. serum I FN-γ, IL-4, IL-5 assay: adopt double antibodies sandwich enzyme linked immunological absorption (ELISA) method to measure.
2.5 collection of specimens and index detect
Serum preparation: excite back 24h in last, rat is anaesthetized with 25% urethane (10ml/kg) lumbar injection, dorsal position is fixed; Cut off skin of neck, a property separation exposes common carotid artery and gets blood 2-3ml, leave standstill 30min after, it is centrifugal that (3000rpm/min 15min), draws supernatant, and it is to be measured to put into the Eppendof pipe.Assay method: concrete operations reference reagent box description.
3 date processing
(x ± S) expression uses the one factor analysis of variance method to all measurement datas, relatively checks with q between group with mean ± standard deviation; Relatively checking between two sample averages with t.Date processing adopts SPSS13.0 statistics software.
4. respectively organize the variation of rat blood serum Th1/Th2 cytokine (IFN-γ, IL-4, IL-5) content
4.1 influence to serum T h1 cytokine IFN-γ content
Table 1 phlegm and retained fluid pills supercritical extraction system is to the influence of IFN-γ content in the rat blood serum
4.2.2 influence to serum T h2 cytokine IL-4 content
Table 2 phlegm and retained fluid pills supercritical extraction system is to the influence of IL-4 content in the rat blood serum
4.2.3 influence to serum T h2 cytokine IL-5 content
Table 3 phlegm and retained fluid pills supercritical extraction system is to the influence of IL-5 content in the rat blood serum
Conclusion:
1 phlegm and retained fluid pills supercritical extraction system can raise the IFN-γ content that reduces in the experimental rat model of asthma serum, simultaneously IL-4 and the IL-5 content that raises in the serum is had inhibitory action, and the IL-4 inhibitory action is obvious.Therapeutic effect is better than the commercial preparation.
2 phlegm and retained fluid pills preparation of the present invention may be by influencing cytokine expression and effect, influence the differentiation of Th cell and the excessive defense function that apoptosis improves body, reduce the detrimental effect of immunne response to body, the immune function of two-ways regulation body reaches the purpose of treatment, supercritical extraction can more reservation effective ingredient, test is more remarkable with matched group difference as stated above.
Specific embodiment:
Embodiment 1: a kind of getting rid of phlegm and retained fluid the preparation of drug particles
Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g,
Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g
Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g
Dextrin: 30g
Starch: 25g
Microcrystalline Cellulose: 30g
This medicine is by crude drug: Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g extract volatility or liposoluble constituent, fine powder that the water extract of its medicinal residues and raw material Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g and Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g are ground into and dextrin, starch, microcrystalline Cellulose: use 75% alcohol granulation, drying, promptly.
Embodiment 2: a kind of getting rid of phlegm and retained fluid the preparation of drug particles
Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g,
Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g
Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g
Cera Flava 25g;
Olive oil 200g
Propylene glycol 1g
Soybean lecithin 3g
1. the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi are ground into altogether 80 order mixings; Fructus Perillae, Semen Raphani, Semen Sinapis Albae steamed respectively about 30 minutes, and oil is got in squeezing, steamed repeatedly and pressed three times, merged fatty oil, and medicinal residues device are in addition collected; Rhizoma Atractylodis, Rhizoma Zingiberis are pulverized, and extract volatile oil with 6 times of water gaging steam distillations respectively, and medicinal residues device are in addition collected; Medicinal residues such as Fructus Perillae and Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae add 5～12 times of amounts of water and decoct three times, 2 hours for the first time, second and third time each 1.5 hours, filter, filtrate merges, and is condensed into 50～60 ℃ of following relative densities and is 1.05～1.15 thick paste, with above-mentioned medicated powder, fatty oil and adjuvant mix homogeneously, oven dry is ground into fine powder
2. modulate capsule liquid: get above-mentioned medicated powder, add volatility and liposoluble constituent and Cera Flava, olive oil, propylene glycol, soybean lecithin, stir, grind homogenizing, promptly get soft capsule liquid;
3. get gelatin, water mixing, in heating in water bath dissolving down, add glycerol, antiseptic, additives, stir, after the vacuumize degassing, insulation is left standstill, and it is standby to make the capsule material;
4. make soft capsule: capsule liquid is encapsulated in the capsule material of compositions such as glycerol, gelatin, water with preparation soft capsule equipment.
Embodiment 3: a kind of getting rid of phlegm and retained fluid supercritical extraction preparation
Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g,
Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g
Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g
Embodiment 3: a kind of getting rid of phlegm and retained fluid supercritical extraction preparation
Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g,
Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g
Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g
The Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi are ground into 80 order mixings altogether; Fructus Perillae, Semen Raphani, Semen Sinapis Albae steamed respectively about 30 minutes, and oil is got in squeezing, steamed repeatedly and pressed three times, merged fatty oil, and medicinal residues device are in addition collected; Rhizoma Atractylodis, Rhizoma Zingiberis are pulverized, and extract volatile oil with 6 times of water gaging steam distillations respectively, and medicinal residues device are in addition collected; Medicinal residues such as Fructus Perillae and Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae add 5～12 times of amounts of water and decoct three times, 2 hours for the first time, second and third time each 1.5 hours filters, and filtrate merges, be condensed into 50～60 ℃ of following relative densities and be 1.05～1.15 thick paste, with above-mentioned medicated powder, fatty oil and adjuvant mix homogeneously, oven dry is ground into fine powder, make granule, spray into volatile oil.Mixing, the granule of making, soft capsule and other suitable pharmaceutical dosage forms.
Embodiment 4: a kind of getting rid of phlegm and retained fluid the preparation of drug particles
Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g,
Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g
Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g
Cera Flava 25g;
Olive oil 200g
Propylene glycol 1g
Soybean lecithin 3g
The Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi are ground into 80 order mixings altogether; Fructus Perillae, Semen Raphani, Semen Sinapis Albae steamed respectively about 30 minutes, and oil is got in squeezing, steamed repeatedly and pressed three times, merged fatty oil, and medicinal residues device are in addition collected; Rhizoma Atractylodis, Rhizoma Zingiberis are pulverized, and extract volatile oil with 6 times of water gaging steam distillations respectively, and medicinal residues device are in addition collected; Medicinal residues such as Fructus Perillae and Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae add 5～12 times of amounts of water and decoct three times, 2 hours for the first time, second and third time each 1.5 hours filters, and filtrate merges, be condensed into 50～60 ℃ of following relative densities and be 1.05～1.15 thick paste, get above-mentioned medicated powder, add volatility and liposoluble constituent and Cera Flava, olive oil, propylene glycol, soybean lecithin, stir, grind homogenizing, promptly get soft capsule liquid; Get gelatin, water mixing, in heating in water bath dissolving down, add glycerol, antiseptic, additives, stir, after the vacuumize degassing, insulation is left standstill, and it is standby to make the capsule material;
Make soft capsule: capsule liquid is encapsulated in the capsule material of compositions such as glycerol, gelatin, water with preparation soft capsule equipment.
Embodiment 5: a kind of getting rid of phlegm and retained fluid the preparation of drug particles
Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g,
Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g
Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g
Dextrin: 15g
Starch: 50g
Microcrystalline Cellulose: 30g
Make 500 bags.
The Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi are ground into 80 order mixings altogether; Fructus Perillae, Semen Raphani, Semen Sinapis Albae steamed respectively about 30 minutes, and oil is got in squeezing, steamed repeatedly and pressed three times, merged fatty oil, and medicinal residues device are in addition collected; Rhizoma Atractylodis, Rhizoma Zingiberis are pulverized, and extract volatile oil with 6 times of water gaging steam distillations respectively, and medicinal residues device are in addition collected; Medicinal residues such as Fructus Perillae and Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae add 5～12 times of amounts of water and decoct three times, and 2 hours for the first time, second and third time each 1.5 hours, filter, filtrate merges, and is condensed into 50～60 ℃ of following relative densities and is 1.05～1.15 thick paste, with above-mentioned medicated powder, fatty oil and medical starch, evenly, drying, pulverize, add starch, granulate, drying sprays into volatile oil, mixing, incapsulate, make capsule.
Embodiment 6: a kind of getting rid of phlegm and retained fluid the preparation of drug particles
Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g,
Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g
Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g
Cera Flava 25g;
Olive oil 200g
Propylene glycol 1g
Soybean lecithin 3g
Raw material Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g are crushed to 40～200 orders, drop in the extraction kettle, extraction kettle, extraction-container I, basin are heated respectively, (extracting pressure 20mPa when reaching selected parameter, 55 ℃ of extraction temperature, resolve pressure 6.5mPa, 65 ℃ of resolution temperatures, extraction time 5h); , open the CO2 gas cylinder system is pressurizeed, when reaching selected pressure, the beginning cycling extraction, and keep constant temperature and pressure.After the extraction time of waiting to reach selected,, get brown xanchromatic oily extract promptly from extraction-container I discharge hole for discharge; The decocting liquid concentrate drying of Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g is pulverized;
Get above-mentioned medicated powder, add volatility and liposoluble constituent and Cera Flava, olive oil, propylene glycol, soybean lecithin, stir, grind homogenizing, promptly get soft capsule liquid; Get gelatin, water mixing, in heating in water bath dissolving down, add glycerol, antiseptic, additives, stir, after the vacuumize degassing, insulation is left standstill, and it is standby to make the capsule material; Make soft capsule: capsule liquid is encapsulated in the capsule material of compositions such as glycerol, gelatin, water with preparation soft capsule equipment.
Embodiment 7: a kind of getting rid of phlegm and retained fluid the preparation of drug particles
Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g,
Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g
Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g
Dextrin: 30g
Starch: 25g
Microcrystalline Cellulose: 30g
Make 500 bags.
Raw material Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g are crushed to 40～200 orders, drop in the extraction kettle, extraction kettle, extraction-container I, basin are heated respectively, (extracting pressure 12 ~ 22mPa when reaching selected parameter, 35 ~ 75 ℃ of extraction temperature, resolve pressure 5 ~ 9mPa, 55 ~ 75 ℃ of resolution temperatures, the extraction time 2 ~ 6h), opening the CO2 gas cylinder pressurizes to system, when reaching selected pressure, the beginning cycling extraction, and keep constant temperature and pressure.After the extraction time of waiting to reach selected,, get brown xanchromatic oily extract promptly from extraction-container I discharge hole for discharge; The decocting liquid concentrate drying of Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g is pulverized;
With the decocting liquid of raw material Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g and dextrin, starch, microcrystalline Cellulose: use 75% alcohol granulation, drying, promptly.
Embodiment 8: a kind of getting rid of phlegm and retained fluid supercritical extraction preparation
Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g,
Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g
Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g
Above-mentioned raw materials Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g are crushed to 40～200 orders, drop in the extraction kettle, extraction kettle, extraction-container I, basin are heated respectively, (extracting pressure 20mpa when reaching selected parameter, 55 ℃ of extraction temperature, resolve pressure 6.5mPa, 65 ℃ of resolution temperatures, extraction time 5h); , open the CO2 gas cylinder system is pressurizeed, when reaching selected pressure, the beginning cycling extraction, and keep constant temperature and pressure.After the extraction time of waiting to reach selected,, get brown xanchromatic oily extract promptly from extraction-container I discharge hole for discharge.
Embodiment 9: a kind of getting rid of phlegm and retained fluid the preparation of drug particles
Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g,
Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g
Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g
Cera Flava 25g;
Olive oil 200g
Propylene glycol 1g
Soybean lecithin 3g
Raw material Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g are crushed to 40～200 orders, drop in the extraction kettle, extraction kettle, extraction-container I, basin are heated respectively, (extracting pressure 20mpa when reaching selected parameter, 55 ℃ of extraction temperature, resolve pressure 6.5mPa, 65 ℃ of resolution temperatures, extraction time 5h); , open the CO2 gas cylinder system is pressurizeed, when reaching selected pressure, the beginning cycling extraction, and keep constant temperature and pressure.After the extraction time of waiting to reach selected,, get brown xanchromatic oily extract promptly from extraction-container I discharge hole for discharge; The decocting liquid concentrate drying of Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g is pulverized;
Get above-mentioned medicated powder, add volatility and liposoluble constituent and Cera Flava, olive oil, propylene glycol, soybean lecithin, stir, grind homogenizing, promptly get soft capsule liquid; Get gelatin, water mixing, in heating in water bath dissolving down, add glycerol, antiseptic, additives, stir, after the vacuumize degassing, insulation is left standstill, and it is standby to make the capsule material; Make soft capsule: capsule liquid is encapsulated in the capsule material of compositions such as glycerol, gelatin, water with preparation soft capsule equipment.
Embodiment 8: a kind of getting rid of phlegm and retained fluid the preparation of drug particles
Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g,
Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g
Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g
Dextrin: 30g
Starch: 25g
Microcrystalline Cellulose: 30g
Make 500 bags.
Raw material Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g are crushed to 40～200 orders, drop in the extraction kettle, extraction kettle, extraction-container I, basin are heated respectively, (extracting pressure 12～22mPa when reaching selected parameter, 35～75 ℃ of extraction temperature, resolve pressure 5～9mPa, 55～75 ℃ of resolution temperatures, the extraction time 2～6h), opening the CO2 gas cylinder pressurizes to system, when reaching selected pressure, the beginning cycling extraction, and keep constant temperature and pressure.After the extraction time of waiting to reach selected,, get brown xanchromatic oily extract promptly from extraction-container I discharge hole for discharge; The decocting liquid concentrate drying of Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g is pulverized;
With the decocting liquid of raw material Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g and dextrin, starch, microcrystalline Cellulose: use 75% alcohol granulation, drying, promptly.
Claims (1)
1. the pharmaceutical preparation of a getting rid of phlegm and retained fluid is characterized in that it is to be prepared from by following method:
(1) raw material is formed: Rhizoma Atractylodis 150g, Rhizoma Zingiberis 50g, Cortex Cinnamomi 50g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Semen Sinapis Albae (parched) 75g, Fructus Perillae (parched) 100g, Semen Raphani (parched) 150g, Radix Aconiti Lateralis Preparata 75g, Radix Glycyrrhizae Preparata 50g;
(2) preparation process:
(I) above-mentioned raw materials Rhizoma Atractylodis, Rhizoma Zingiberis, Cortex Cinnamomi, Rhizoma Atractylodis Macrocephalae (parched), Semen Sinapis Albae (parched), Fructus Perillae (parched), Semen Raphani (parched) are crushed to 40～200 orders, drop in the extraction kettle, extraction kettle, extraction-container I, basin are heated respectively, when reaching selected parameter, extracting pressure 20mPa, 55 ℃ of extraction temperature are resolved pressure 6.5mPa, 65 ℃ of resolution temperatures, extraction time 5h; Open CO
2Gas cylinder pressurizes to system, when reaching selected pressure, beginning cycling extraction, and keep constant temperature and pressure, after the extraction time of waiting to reach selected, from extraction-container I discharge hole for discharge, brown xanchromatic oily extract, standby;
(II) Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae Preparata decoct with water, and decocting liquid concentrates, and drying is pulverized, and gets water extract, and is standby;
(III) get above-mentioned oily extract, water extract and Cera Flava, olive oil, propylene glycol, soybean lecithin, stir, grind homogenizing, get soft capsule liquid, standby;
(IV) get gelatin, water mixing, in heating in water bath dissolving down, add glycerol, antiseptic, additives, stir, after the vacuumize degassing, insulation is left standstill, and makes the capsule material, and is standby;
(V) with preparation soft capsule equipment capsule liquid is encapsulated in the capsule material of glycerol, gelatin, water, antiseptic, additives composition, makes soft capsule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009101593639A CN101584852B (en) | 2009-07-11 | 2009-07-11 | Pharmaceutical preparation for getting rid of phlegm and retained fluid |
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| CN2009101593639A CN101584852B (en) | 2009-07-11 | 2009-07-11 | Pharmaceutical preparation for getting rid of phlegm and retained fluid |
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| CN101584852B true CN101584852B (en) | 2011-09-07 |
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| CN102327591B (en) * | 2011-10-05 | 2013-05-01 | 蔡兆凯 | Phlegm-eliminating pill |
| CN102580030B (en) * | 2012-03-06 | 2013-11-06 | 北京千基恒饮料销售有限公司 | External traditional Chinese medicine composition having effect of reducing blood sugar, preparation prepared from the external traditional Chinese medicine composition, and their preparation method |
| CN103300292A (en) * | 2013-06-27 | 2013-09-18 | 叶建斌 | Moist cake for descending qi and reducing phlegm and preparation method |
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